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GIST with liver metastasis finding

Shu Okamura, Tomohiro Kitahara, Koki Tamai, Takayuki Minoji, Hiroyuki Takabatake, Noriyuki Watanabe, Noriyuki Yamamura, Nariaki Fukuchi, Chikara Ebisui, Hideoki Yokouchi, Kazuhito Ohishi, Masakatsu Kinuta
Here, we report the case of a 66-year-old male patient who previously underwent resection of sigmoid colon cancer and its liver metastasis. His follow-up contrast-enhanced CT scan revealed a mass shadow at around the gastrosplenic ligament, which gradually increased in size. Because it could not be pathologically diagnosed by transgastric EUS-FNA, en bloc resection wasperformed surgically for the tumor in the greater omentum. Hematoxylin-eosin staining of the resected specimen showed fibroblast-like cellswith hyperplasia of bold collagen fibersand spindle-shaped nucleus...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Francisco J Maldonado, Shannon P Sheedy, Veena R Iyer, Stephanie L Hansel, David H Bruining, Cynthia H McCollough, William S Harmsen, John M Barlow, Joel G Fletcher
PURPOSE: To identify reproducible CT imaging features of small bowel gastrointestinal stromal tumors (GIST) that are associated with biologic aggressiveness. METHODS: Patients with histologically proven small bowel GISTs and CT enterography or abdominopelvic CT were included. Biologic aggressiveness was established based on initial histologic grading (very low risk to malignant), with "malignant" assigned if recurrence or metastases developed subsequently...
July 2018: Abdominal Radiology
Naoki Kubo, Nobumichi Takeuchi
Gastrointestinal stromal tumors (GISTs) are the most common type of gastrointestinal mesenchymal tumors, although metastasis to the perigastric lymph nodes is relatively rare, compared with liver or peritoneal metastasis. In this report, we describe a case of stomach GIST with a solitary simultaneous metastasis in the left axillary lymph node. A 68-year-old man was diagnosed with a large upper-stomach GIST, and computed tomography and positron emission tomography revealed masses in the left axilla and right mediastinum...
March 7, 2017: World Journal of Gastroenterology: WJG
Akihisa Suwa, Tetsuya Shimoda
A 12-year-old, 3.6-kg, spayed female domestic shorthaired cat had a 2-month history of anorexia and weight loss. Abdominal ultrasonography and computed tomography revealed an exophytic mass originating from the jejunum with very poor central and poor peripheral contrast enhancement. On day 14, surgical resection of the jejunum and mass with 5-cm margins and an end-to-end anastomosis were performed. Histopathological examination revealed the mass was a transmural, invasive cancer showing exophytic growth and originating from the small intestinal muscle layer...
March 23, 2017: Journal of Veterinary Medical Science
Naoko Mori, Tamaki Ichikawa, Jun Hashimoto, Tomohiro Yamashita, Misuzu Yamada, Kenichi Hirabayashi, Yutaka Imai
Cholangiolocellular carcinoma (CoCC) is a rare primary liver cancer. It is considered to originate from hepatic progenitor or stem cells. We report a rare case of a 74-year-old male with CoCC of the liver and duodenal gastrointestinal stromal tumor (GIST). Both tumors manifested tracer uptakes on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT); however, the uptake in hepatic tumor was extremely higher than that in the duodenal tumor. This finding was helpful to exclude the metastasis of GIST...
June 20, 2016: Tokai Journal of Experimental and Clinical Medicine
Emily F Mason, Jason L Hornick
Gastrointestinal stromal tumors (GISTs) that lack kinase mutations often show loss of function of the succinate dehydrogenase (SDH) complex, due to germline mutation or promoter hypermethylation. SDH-deficient GISTs are exclusive to the stomach and have a multinodular architecture. It has been suggested that conventional risk stratification criteria may not predict outcome for this group of tumors, although data are limited. Here, we report the clinical, histologic, and genetic findings from a large cohort of 76 SDH-deficient GISTs diagnosed from 2005 to 2015, identified on the basis of histologic features or family history (45 female/31 male; mean age at diagnosis 32 y; range 11 to 71 y; 10 patients 50 y of age or above)...
December 2016: American Journal of Surgical Pathology
Hao-Chen Wang, Tzu-Ying Li, Ying-Jui Chao, Ya-Chin Hou, Yuan-Shuo Hsueh, Kai-Hsi Hsu, Yan-Shen Shan
PURPOSE: KIT mutations, the most prevalent genetic event in gastrointestinal stromal tumors (GIST), are associated with malignant features and poor prognosis. Aggressive GISTs possess a high propensity to spread to the liver. This study aimed to explore the role of KIT mutations in GIST liver metastasis. EXPERIMENTAL DESIGN: A total of 170 GISTs were used to determine the association between KIT mutations and liver metastasis. Immunohistochemistry was performed to assess the correlation of KIT mutations with CXCR4 and ETV1 expression...
July 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Katrine Hygum, Christian Nielsen Wulff, Torben Harsløf, Anders Kindberg Boysen, Philip Blach Rossen, Bente Lomholt Langdahl, Akmal Ahmed Safwat
BACKGROUND: Hypercalcemia is the most common oncologic metabolic emergency but very rarely observed in patients with gastrointestinal stromal tumour, which is a rare mesenchymal malignancy of the gastrointestinal tract. We describe a case of hypercalcemia caused by elevated levels of activated vitamin D in a patient with gastrointestinal tumour. Prior to this case report, only one paper has reported an association between hypercalcemia, gastrointestinal stromal tumours and elevated levels of vitamin D...
2015: BMC Cancer
Siripom Pinaikul, Piyanoot Woodtichartpreecha, Samornmas Kanngurn, Sombat Leelakiatpaiboon
OBJECTIVE: To characterize the CT features and to identify predictors of malignancy from CT of GISTs. MATERIAL AND METHOD: A retrospective review of CT images of 50 patients with pathologically and immunohistochemically proven GISTs was done by two radiologists and final interpretations were reached by consensus. Images were evaluated for site, size, contour boundary, growth pattern, enhancement pattern, degree of enhancement, necrosis, calcification, ulceration, perilesionalfat stranding, evidence ofbowel obstruction, and signs of malignancy...
November 2014: Journal of the Medical Association of Thailand
Chaoyong Shen, Haining Chen, Yuan Yin, Jiaju Chen, Bo Zhang, Zhixin Chen, Jiaping Chen
OBJECTIVES: Despite its rising popularity, reports on the use of preoperative imatinib mesylate (IM) in patients with advanced gastrointestinal stromal tumor (GIST) are limited. This study aims to explore the clinical efficacy of preoperative IM in patients with primarily unresectable or metastatic/recurrent GIST. METHODS: Between September 2009 and February 2014, patients with primarily unresectable or metastatic/recurrent GIST treated by a single medical team were recruited and considered for preoperative IM therapy...
November 2014: Clinics
Masaaki Iwatsuki, Hiroshi Takamori, Kojiro Eto, Kenji Shimizu, Katsuhiro Ogawa, Kensuke Yamamura, Nobuyuki Ozaki, Hideyuki Tanaka, Shinichi Sugiyama, Kenichi Ogata, Koichi Doi, Takihiro Kamio, Hideo Baba
INTRODUCTION: Extra-abdominal recurrence or metastasis of a gastrointestinal stromal tumor (GIST) is very rare. Chest wall recurrence of a resected gastric GIST is extremely rare. PRESENTATION OF CASE: A 64-year-old Japanese man had undergone proximal gastrectomy for a gastric submucosal tumor 11 years previously. The histopathological diagnosis was GIST (size, 8cm). He did not receive adjuvant therapy, and underwent imaging evaluations every 6 months for the first 5 years after surgery and then annually...
2015: International Journal of Surgery Case Reports
Hiroyuki Notani, Toru Kawamura, Taku Sato, Akihiro Hoshino, Yasushi Sato, Akira Nakajima
The patient was a 58-year-old man who visited our hospital with a chief complaint of rapidly aggravating feeling of epigastric distension and gastralgia. A giant mass, with a major axis of 22 cm, excluding the upper abdominal organs such as the stomach, liver, and pancreas and containing cystic and solid components was observed on abdominal computed tomography( CT). Laparotomy was performed with the aim of differentiating between a gastrointestinal stromal tumor (GIST) arising from the stomach or omentum and abdominal soft tissue tumors...
November 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Xian-Zhang Luo, Chang-Sheng Ming, Xiao-Ping Chen, Nian-Qiao Gong
Primary hepatic leiomyoma is a neoplasm of mesenchymal origin and occurs only rarely. Secondary to benign smooth muscle proliferation, it is usually found in adult women and is associated with Epstein-Barr virus (EBV) infection. Here, we report the 29(th) case of primary hepatic leiomyoma with its unique features related to diagnosis, treatment and developmental biology. A 48-year-old man, with an immunocompromised status, complained of pain in the upper quadrant of the abdomen. Serological analysis indicated no presence of hepatitis virus, no human immunodeficiency virus, and no EBV infection...
July 7, 2013: World Journal of Gastroenterology: WJG
Hirotada Kittaka, Terumasa Yamada, Kunihito Goto, Hisataka Ogawa, Tatsushi Shingai, Masaaki Motoori, Hidenori Takahashi, Kentaro Kishi, Shingo Noura, Isao Miyashiro, Masayuki Ohue, Hiroaki Ohigashi, Masahiko Yano, Osamu Ishikawa
We report a case of hepatic metastasis from gastric gastrointestinal stromal tumor (GIST), which was safely resected with preoperative imatinib therapy. A 60-year-old woman was hospitalized and underwent a treatment for hepatic SOL at another hospital prior to gastric GIST resection. Computed tomography revealed a tumor compressing the right and middle hepatic vein. The tumor volume decreased after an initiation of imatinib therapy aimed at preserving the middle hepatic vein. Although tumor volume was further decreased over the course of twelve months, a new lesion appeared, suggesting a progressive disease...
November 2011: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Junji Tanaka, Tadayuki Oshima, Kazutoshi Hori, Toshihiko Tomita, Yongmin Kim, Jiro Watari, Koushi Oh, Seiichi Hirota, Takayuki Matsumoto, Hiroto Miwa
A 65-year-old man received upper gastrointestinal endoscopy. At that time, no abnormalities were identified in the stomach except for a submucosal tumor approximately 1 cm in maximal diameter at the gastric cardia. Two months later, he developed tarry stools and anemia. Colonoscopy revealed no abnormal findings in the colon or terminal ileum. Upper gastrointestinal endoscopy was re-evaluated in our hospital. Macroscopically, the previously detected submucosal tumor had grown to 3.0 cm in maximal diameter and the tumor was exposed by extensive ulceration...
October 2010: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Ying-yong Hou, Xiong-zeng Zhu, Shao-hua Lu, Yang Zhou, Jun Hou, Yun-shan Tan, Kun-tang Shen, Jing Qin, Yi-hong Sun
OBJECTIVE: To determinate the clinicopathologic parameters in predicting the malignant behavior of gastrointestinal stromal tumor (GIST). METHODS: Eight hundred and forty cases of GIST were retrospectively reviewed. The tumors were classified as malignant if they met any of the following criteria: evidence of gross dissemination (including liver metastasis and/or peritoneal spread), evidence of microscopic dissemination (including lymph node metastasis, infiltration to vessels, fat tissue, nerves and/or mucosal tissue), or disease relapse...
May 2010: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Lizhi Zhang, Thomas C Smyrk, William F Young, Constantine A Stratakis, J Aidan Carney
Carney triad, as originally described in 1977, was the association of 3 tumors: gastric epithelioid leiomyosarcoma [later renamed gastrointestinal stromal tumor (GIST)], extra-adrenal paraganglioma, and pulmonary chondroma. The disorder affected mostly young women and was not familial. We studied the clinical and pathologic features of the gastric neoplasm in 104 patients with the syndrome. Most (88%) were young women (mean age, 22 y), and the usual presentation was gastric bleeding. The tumors, commonly antral-based (61%), were multifocal, and ranged from 0...
January 2010: American Journal of Surgical Pathology
Nittaya Chamadol, Vallop Laopaiboon, Julaluck Promsorn, Vajarapongsa Bhudhisawasd, Ake Pagkhem, Chawalit Pairojkul
OBJECTIVE: To describe anatomical distribution and CT findings of gastrointestinal stromal tumors in Srinagarind Hospital. MATERIAL AND METHOD: The abdominal CT images of 16 patients (12 men, 4 women: mean age 49 +/- 17SD) with pathologically proven GISTs during 1998-2005 were retrospectively reviewed. The tumor sites, sizes, borders, growth patterns, patterns of enhancement, and sign of malignancy were evaluated. The findings of benign and malignant GISTs were compared...
September 2009: Journal of the Medical Association of Thailand
Shao-Han Yin, Chuan-Miao Xie, Yun-Xian Mo, Zi-Lin Huang, Yan-Chun Lu, Xue-Wen Liu, Yun Zhang, Jian-Peng Li, Lie Zheng, Pei-Hong Wu
BACKGROUND AND OBJECTIVE: Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the digestive system. Imaging examination plays an important role in preoperative diagnosis and postoperative evaluation for it. This study was to describe the multi-slice spiral computed tomographic (MSCT) findings and pathologic features of GIST, and to analyze their correlation. METHODS: MSCT and pathologic reports of 49 patients with 53 pathologically confirmed GIST lesions were reviewed and compared...
September 2009: Ai Zheng, Aizheng, Chinese Journal of Cancer
Tassawar Hussain, Amjad Salamat, Muhammad Asif Farooq, Fayyaz Hassan, Muhammad Hafeez
OBJECTIVE: To determine common indications for requesting Endoscopic Ultrasound (EUS) and to describe the diagnosis made after endoscopic ultrasound/Fine-Needle Aspiration and Cytology (FNAC) during two years at a tertiary gastrointestinal unit. STUDY DESIGN: Cross-sectional descriptive study. PLACE AND DURATION OF STUDY: The study was carried out in Gastrointestinal Department of Military Hospital, Rawalpindi, from March 2006 to February 2008...
April 2009: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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