Sencai Lin, Junxiu He, Yinghua Zhou, Yu Bao, Xiuming Feng, Hong Cheng, Haiqing Cai, Sihan Hu, Lin Wang, Yuan Zheng, Mengdi Zhang, Qinghua Fan, Shifeng Wen, Yuanxin Lin, Chaoqun Liu, Xing Chen, Fei Wang, Xiaoting Ge, Xiaobo Yang
Exposure to metal mixtures compromises the immune system, with the complement system connecting innate and adaptive immunity. Herein, we sought to explore the relationships between blood cell metal mixtures and the third and fourth components of serum complement (C3, C4). A total of 538 participants were recruited in November 2017, and 289 participants were followed up in November 2021. We conducted a cross-sectional analysis at baseline and a longitudinal analysis over 4 years. Least Absolute Shrinkage and Selection Operator (LASSO) was employed to identify the primary metals related to serum C3, C4; generalized linear model (GLM) was further used to evaluate the cross-sectional associations of the selected metals and serum C3, C4...
March 16, 2024: Biological Trace Element Research