keyword
https://read.qxmd.com/read/38348768/decoding-the-synergistic-potential-of-maz-51-and-zingerone-as-therapy-for-melanoma-treatment-in-alignment-with-sustainable-development-goals
#1
REVIEW
Kganya Letsoalo, Evangeline Nortje, Sean Patrick, Trevor Nyakudya, Yvette Hlophe
Melanoma, an invasive class of skin cancer, originates from mutations in melanocytes, the pigment-producing cells. Globally, approximately 132,000 new cases are reported each year, and in South Africa, the incidence stands at 2.7 per 100,000 people, signifying a worrisome surge in melanoma rates. Therefore, there is a need to explore treatment modalities that will target melanoma's signalling pathways. Melanoma metastasis is aided by ligand activity of transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor-C (VEGF-C) and C-X-C chemokine ligand 12 (CXCL12) which bind to their receptors and promote tumour cell survival, lymphangiogenesis and chemotaxis...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38020918/canonical-wnt-and-tgf-%C3%AE-bmp-signaling-enhance-melanocyte-regeneration-but-suppress-invasiveness-migration-and-proliferation-of-melanoma-cells
#2
JOURNAL ARTICLE
Esra Katkat, Yeliz Demirci, Guillaume Heger, Doga Karagulle, Irene Papatheodorou, Alvis Brazma, Gunes Ozhan
Melanoma is the deadliest form of skin cancer and develops from the melanocytes that are responsible for the pigmentation of the skin. The skin is also a highly regenerative organ, harboring a pool of undifferentiated melanocyte stem cells that proliferate and differentiate into mature melanocytes during regenerative processes in the adult. Melanoma and melanocyte regeneration share remarkable cellular features, including activation of cell proliferation and migration. Yet, melanoma considerably differs from the regenerating melanocytes with respect to abnormal proliferation, invasive growth, and metastasis...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/34104234/vitiligo-and-chronic-autoimmune-thyroiditis
#3
REVIEW
Florica Sandru, Mara Carsote, Simona Elena Albu, Mihai Cristian Dumitrascu, Ana Valea
Vitiligo, the discoloration of the skin, has different autoimmune mechanisms reflected by many biomarkers as shown by skin histology, staining for CD4 and CD8 T lymphocytes, chemokine ligand 9 or circulating cytokines such as interleukin (IL)-1 beta, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, antibodies, markers of oxidative stress, chemokines, and others. In this narrative review, we aim to overview vitiligo in relationship with chronic autoimmune thyroiditis. Regarding vitiligo, more than 50 different genetic loci have been associated with this disease, and the heritability is high...
March 2021: Journal of Medicine and Life
https://read.qxmd.com/read/33734022/ampk-dependent-phosphorylation-is-required-for-transcriptional-activation-of-tfeb-and-tfe3
#4
JOURNAL ARTICLE
Mathieu Paquette, Leeanna El-Houjeiri, Linda C Zirden, Pietri Puustinen, Paola Blanchette, Hyeonju Jeong, Kurt Dejgaard, Peter M Siegel, Arnim Pause
Increased macroautophagy/autophagy and lysosomal activity promote tumor growth, survival and chemo-resistance. During acute starvation, autophagy is rapidly engaged by AMPK (AMP-activated protein kinase) activation and MTOR (mechanistic target of rapamycin kinase) complex 1 (MTORC1) inhibition to maintain energy homeostasis and cell survival. TFEB (transcription factor E3) and TFE3 (transcription factor binding to IGHM enhancer 3) are master transcriptional regulators of autophagy and lysosomal activity and their cytoplasm/nuclear shuttling is controlled by MTORC1-dependent multisite phosphorylation...
December 2021: Autophagy
https://read.qxmd.com/read/32174800/sash1-promotes-melanin-synthesis-and-migration-via-suppression-of-tgf-%C3%AE-1-secretion-in-melanocytes-resulting-in-pathologic-hyperpigmentation
#5
JOURNAL ARTICLE
Hongzhou Cui, Shuping Guo, Hongxia He, Huina Guo, Yuliang Zhang, Binquan Wang
Dyschromatosis universalis hereditaria (DUH) is an autosomal dominant pigmentary genodermatosis characterized by the presence of patches of hyperpigmentation and hypopigmented macules distributed over the body, with most cases reported in Asia. DUH is a heterogeneous disease and a small portion of patients carry the ABCB6 variant. In the present study, exome sequencing of four generations of a Chinese family with DUH identified a c.1761C>G (p.Ser587Arg) mutation in exon 15 of SAM and SH3 domain containing 1 (SASH1) that was found to co-segregate in some family members...
2020: International Journal of Biological Sciences
https://read.qxmd.com/read/30145155/inhibitory-effects-of-extracellular-superoxide-dismutase-on-ultraviolet-b-induced-melanogenesis-in-murine-skin-and-melanocytes
#6
JOURNAL ARTICLE
Hae-Young Kim, Shyam Kishor Sah, Sung S Choi, Tae-Yoon Kim
AIMS: Several anti-melanogenic molecules have been developed or identified, but their uses are limited due to either adverse effects or instability during the treatment. We aimed to evaluate the effects of extracellular superoxide dismutase (SOD3), a powerful antioxidant, as a candidate anti-melanogenic molecule. MAIN METHODS: UVB-induced reactive oxygen species (ROS) production and proliferation in melan-a cells was evaluated by 6-carboxy-2',7'-dichlorodihydrofluorescein diacetate staining and bromodeoxyuridine incorporation assay, respectively...
October 1, 2018: Life Sciences
https://read.qxmd.com/read/30099777/differential-expression-of-lncrnas-and-predicted-target-genes-in-normal-mouse-melanocytes-and-b16-cells
#7
JOURNAL ARTICLE
Kaiyuan Ji, Junzhen Zhang, Ruiwen Fan, Shanshan Yang, Changsheng Dong
Melanoma is a highly invasive and metastatic malignant skin tumor with poor prognosis. Although several widely studied pure melanoma cell lines are available, the precise mechanism underlying transformation of melanocyte to melanoma remains unclear. Long non-coding RNAs (lncRNAs) represent a vast category of non-coding RNA molecules, and increasing evidence suggests that lncRNAs are crucial for various biological processes, including those in the skin. Herein, lncRNA sequencing was performed on an Illumina HiSeq platform to identify lncRNAs expressed differently in murine B16 melanoma cells compared to normal mouse melanocytes...
November 2018: Experimental Dermatology
https://read.qxmd.com/read/28793632/active-nanofibrous-membrane-effects-on-gingival-cell-inflammatory-response
#8
JOURNAL ARTICLE
David-Nicolas Morand, Olivier Huck, Laetitia Keller, Nadia Jessel, Henri Tenenbaum, Jean-Luc Davideau
Alpha-melanocyte stimulating hormone (α-MSH) is involved in normal skin wound healing and also has anti-inflammatory properties. The association of α-MSH to polyelectrolyte layers with various supports has been shown to improve these anti-inflammatory properties. This study aimed to evaluate the effects of nanofibrous membrane functionalized with α-MSH linked to polyelectrolyte layers on gingival cell inflammatory response. Human oral epithelial cells (EC) and fibroblasts (FB) were cultured on plastic or electrospun Poly-#-caprolactone (PCL) membranes with α-MSH covalently coupled to Poly-L-glutamic acid (PGA-α-MSH), for 6 to 24 h...
October 27, 2015: Materials
https://read.qxmd.com/read/28697174/uv-radiation-promotes-melanoma-dissemination-mediated-by-the-sequential-reaction-axis-of-cathepsins-tgf-%C3%AE-1-fap-%C3%AE
#9
JOURNAL ARTICLE
Petra Wäster, Kyriakos Orfanidis, Ida Eriksson, Inger Rosdahl, Oliver Seifert, Karin Öllinger
BACKGROUND: Ultraviolet radiation (UVR) is the major risk factor for development of malignant melanoma. Fibroblast activation protein (FAP)-α is a serine protease expressed on the surface of activated fibroblasts, promoting tumour invasion through extracellular matrix (ECM) degradation. The signalling mechanism behind the upregulation of FAP-α is not yet completely revealed. METHODS: Expression of FAP-α was analysed after UVR exposure in in vitro co-culture systems, gene expression arrays and artificial skin constructs...
August 8, 2017: British Journal of Cancer
https://read.qxmd.com/read/27011171/melanocytes-affect-nodal-expression-and-signaling-in-melanoma-cells-a-lesson-from-pediatric-large-congenital-melanocytic-nevi
#10
JOURNAL ARTICLE
Naira V Margaryan, Alina Gilgur, Elisabeth A Seftor, Chad Purnell, Nicoleta C Arva, Arun K Gosain, Mary J C Hendrix, Luigi Strizzi
Expression of Nodal, a Transforming Growth Factor-beta (TGF-β) related growth factor, is associated with aggressive melanoma. Nodal expression in adult dysplastic nevi may predict the development of aggressive melanoma in some patients. A subset of pediatric patients diagnosed with giant or large congenital melanocytic nevi (LCMN) has shown increased risk for development of melanoma. Here, we investigate whether Nodal expression can help identify the rare cases of LCMN that develop melanoma and shed light on why the majority of these patients do not...
March 22, 2016: International Journal of Molecular Sciences
https://read.qxmd.com/read/26677292/plasma-levels-of-interleukin-17-interleukin-23-and-transforming-growth-factor-%C3%AE-in-sudanese-patients-with-vitiligo-a-case-control-study
#11
JOURNAL ARTICLE
Ali Malik Osman, Maowia Mohamed Mukhtar, Khalid Hussein Bakheit, Hamdan Zaki Hamdan
BACKGROUND: Vitiligo is the most common pigmentary skin disorder. It is a multifactorial polygenic disease with epidermal melanocyte destruction. The cytokines profile found in vitiliginous patients was not fully elucidated. AIMS: We sought to assess the autoimmune nature of vitiligo by comparing plasma levels of interleukin (IL)-17, IL-23, and transforming growth factor beta (TGF-β) in adult Sudanese vitiligo patients with matched control individuals. SUBJECTS AND METHODS: Case-control study was conducted in Khartoum Dermatologic Teaching Hospital, in the period between July and December 2013...
November 2015: Indian Journal of Dermatology
https://read.qxmd.com/read/26526369/tgf-%C3%AE-induced-transcription-sustains-amoeboid-melanoma-migration-and-dissemination
#12
JOURNAL ARTICLE
Gaia Cantelli, Jose L Orgaz, Irene Rodriguez-Hernandez, Panagiotis Karagiannis, Oscar Maiques, Xavier Matias-Guiu, Frank O Nestle, Rosa M Marti, Sophia N Karagiannis, Victoria Sanz-Moreno
Cell migration underlies metastatic dissemination of cancer cells, and fast "amoeboid" migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated by extracellular signals and sustained over time by transcriptional changes is not fully understood. Transforming growth factor β (TGF-β) is well known to promote epithelial-to-mesenchymal transition (EMT) and contribute to metastasis, but melanocytes are neural crest derivatives that have undergone EMT during embryonic development...
November 16, 2015: Current Biology: CB
https://read.qxmd.com/read/26450788/dual-roles-of-rnf2-in-melanoma-progression
#13
JOURNAL ARTICLE
Kunal Rai, Kadir C Akdemir, Lawrence N Kwong, Petko Fiziev, Chang-Jiun Wu, Emily Z Keung, Sneha Sharma, Neha S Samant, Maura Williams, Jacob B Axelrad, Amiksha Shah, Dong Yang, Elizabeth A Grimm, Michelle C Barton, Denai R Milton, Timothy P Heffernan, James W Horner, Suhendan Ekmekcioglu, Alexander J Lazar, Jason Ernst, Lynda Chin
UNLABELLED: Epigenetic regulators have emerged as critical factors governing the biology of cancer. Here, in the context of melanoma, we show that RNF2 is prognostic, exhibiting progression-correlated expression in human melanocytic neoplasms. Through a series of complementary gain-of-function and loss-of-function studies in mouse and human systems, we establish that RNF2 is oncogenic and prometastatic. Mechanistically, RNF2-mediated invasive behavior is dependent on its ability to monoubiquitinate H2AK119 at the promoter of LTBP2, resulting in silencing of this negative regulator of TGFβ signaling...
December 2015: Cancer Discovery
https://read.qxmd.com/read/25656846/ewi-2-negatively-regulates-tgf-%C3%AE-signaling-leading-to-altered-melanoma-growth-and-metastasis
#14
JOURNAL ARTICLE
Hong-Xing Wang, Chandan Sharma, Konstantin Knoblich, Scott R Granter, Martin E Hemler
In normal melanocytes, TGF-β signaling has a cytostatic effect. However, in primary melanoma cells, TGF-β-induced cytostasis is diminished, thus allowing melanoma growth. Later, a second phase of TGF-β signaling supports melanoma EMT-like changes, invasion and metastasis. In parallel with these "present-absent-present" TGF-β signaling phases, cell surface protein EWI motif-containing protein 2 (EWI-2 or IgSF8) is "absent-present-absent" in melanocytes, primary melanoma, and metastatic melanoma, respectively, suggesting that EWI-2 may serve as a negative regulator of TGF-β signaling...
March 2015: Cell Research
https://read.qxmd.com/read/25649199/tgf-%C3%AE-may-control-the-switch-between-tumorigenic-growth-and-stem-cell-mesenchymal-potentially-drug-resistant-states
#15
JOURNAL ARTICLE
Jenna R Bordelon, James M Grichnik
No abstract text is available yet for this article.
May 2015: Dermatologic Therapy
https://read.qxmd.com/read/25604047/increased-circulating-th17-cells-and-elevated-serum-levels-of-tgf-beta-and-il-21-are-correlated-with-human-non-segmental-vitiligo-development
#16
JOURNAL ARTICLE
Li Zhou, Yu-Ling Shi, Kai Li, Iltefat Hamzavi, Tian-Wen Gao, Richard H Huggins, Henry W Lim, Qing-Sheng Mi
Although non-segmental vitiligo (NSV) results from the autoimmune destruction of melanocytes, the detailed immune mechanisms have not yet been fully elucidated. Th17 cells have been identified to be implicated in human autoimmune diseases. In this study, the frequencies of peripheral blood Th17 cells and serum levels of IL-17A and Th17 cell-related cytokines were examined in 45 patients with active NSV compared to 45 race-, gender-, and age-matched healthy controls. Our results showed increased circulating Th17 cell frequencies and elevated serum IL-17A, TGF-β1, and IL-21 levels in patients with NSV...
May 2015: Pigment Cell & Melanoma Research
https://read.qxmd.com/read/25444235/regulation-of-pigmentation-by-micrornas-mitf-dependent-microrna-211-targets-tgf-%C3%AE-receptor-2
#17
JOURNAL ARTICLE
Xiaodan Dai, Chunbao Rao, Huirong Li, Yu Chen, Lilv Fan, Huiqin Geng, Shuang Li, Jia Qu, Ling Hou
There is growing evidence that microRNAs are important regulators of gene expression in a variety of cell types. Using immortalized cell lines and primary neural crest cell explants, we show that microRNA-211, previously implicated in the regulation of melanoma proliferation and invasiveness, promotes pigmentation in melanoblasts and melanocytes. Expression of this microRNA is regulated by the key melanocyte transcription factor MITF and regulates pigmentation by targeting the TGF-β receptor 2. Transfection with pre-miR-211 precursor molecules in melb-a and melan-a cells leads to a decrease in the expression of TGF-β receptor 2 and reduces the TGF-β signaling-mediated downregulation of two melanogenic enzymes, tyrosinase and tyrosinase-related protein 1...
March 2015: Pigment Cell & Melanoma Research
https://read.qxmd.com/read/24790680/insights-into-the-role-of-pax-3-in-the-development-of-melanocytes-and-melanoma
#18
JOURNAL ARTICLE
Jessica Diann Hathaway, Azizul Haque
Melanoma is the deadliest form of skin cancer in the United States with an increasing prevalence. However, the development of melanoma from a melanocyte precursor is still poorly defined. Understanding the molecules responsible for melanoma progression may lead to improved targeted therapy. One potential molecule is the paired box-3 (PAX-3) protein, which has been implicated in the development of melanocytes and malignant melanoma. In melanoma, the expression of PAX-3 is believed to be differentially regulated, and has been linked with malignancies and staging of the disease...
January 1, 2011: Open Cancer Journal
https://read.qxmd.com/read/24460977/fkbp51-increases-the-tumour-promoter-potential-of-tgf-beta
#19
JOURNAL ARTICLE
Simona Romano, Anna D'Angelillo, Paolo D'Arrigo, Stefania Staibano, Adelaide Greco, Arturo Brunetti, Massimiliano Scalvenzi, Rita Bisogni, Iris Scala, Maria Fiammetta Romano
BACKGROUND: FKBP51 (FKBP5 Official Symbol) is a large molecular weight component of the family of FK506 binding proteins (FKBP). In recent years, research studies from our laboratory highlighted functions for FKBP51 in the control of apoptosis and melanoma progression. FKBP51 expression correlated with the invasiveness and aggressiveness of melanoma. Since a role for TGF-β in the enhanced tumorigenic potential of melanoma cells is widely described, we hypothesized a cooperative effect between FKBP51 and TGF-β in melanoma progression...
January 27, 2014: Clinical and Translational Medicine
https://read.qxmd.com/read/23468969/effect-of-ndp-%C3%AE-msh-on-ppar-%C3%AE-and-%C3%AE-expression-and-anti-inflammatory-cytokine-release-in-rat-astrocytes-and-microglia
#20
JOURNAL ARTICLE
Lila Carniglia, Daniela Durand, Carla Caruso, Mercedes Lasaga
Brain inflammation plays a central role in numerous brain pathologies. Microglia and astrocytes are the main effector cells that become activated when an inflammatory process takes place within the central nervous system. α-melanocyte-stimulating hormone (α-MSH) is a neuropeptide with proven anti-inflammatory properties. It binds with highest affinity to the melanocortin receptor 4 (MC4R), which is present in astrocytes and upon activation triggers anti-inflammatory pathways. The aim of this research was to identify anti-inflammatory mediators that may participate in the immunomodulatory effects of melanocortins in glial cells...
2013: PloS One
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