Weronika Szukala, Agata Lichawska-Cieslar, Roza Pietrzycka, Maria Kulecka, Izabela Rumienczyk, Michal Mikula, Iwona Chlebicka, Piotr Konieczny, Katarzyna Dziedzic, Jacek C Szepietowski, Giulia Fontemaggi, Janusz Rys, Jolanta Jura
BACKGROUND: Squamous cell carcinoma (SCC) of the skin is a common form of nonmelanoma skin cancer. Monocyte chemotactic protein 1-induced protein 1 (MCPIP1), also called Regnase-1, is an RNase with anti-inflammatory properties. In normal human skin, its expression is predominantly restricted to the suprabasal epidermis. The main aim of this study was to investigate whether MCPIP1 is involved in the pathogenesis of SCC. METHODS: We analyzed the distribution of MCPIP1 in skin biopsies of patients with actinic keratoses (AKs) and SCCs...
December 13, 2021: Journal of Experimental & Clinical Cancer Research: CR