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Frank Stahnisch
For nearly fifteen years, the impact of modern neuroscience has become a central focus of public debate, not just following the Decade of the Brain in the United States. Newly developed options for manipulating the central nervous system (CNS) are not only of primary medical concern but have come to be regarded as extremely questionable in recent bioethical discourse. This article provides an in-depth comparison between modern neuromanipulative approaches from "Deep Brain Stimulation" (DBS) with methods from earlier historical periods...
2008: W├╝rzburger Medizinhistorische Mitteilungen
G Santoni, M C Perfumi, E Spreghini, S Romagnoli, M Piccoli
Substance P (SP) plays a major role in the regulation of the interaction between immune and nervous systems. SP administration stimulates Con A-induced proliferation of spleen and peripheral blood lymphocytes from normal and neonatally capsaicin treated rats, which correlated with enhanced IL-2 production and expression of activation antigens such as IL-2 receptor alpha chain (CD25) and RT1B MHC class II molecule. Moreover, SP markedly increased the percentage of CD5+ and CD4+ T lymphocytes in the peripheral blood of capsaicin-treated rats...
January 1, 1999: Journal of Neuroimmunology
G Nilsson, S Ahlstedt
We studied the neuroimmunomodulatory effect of capsaicin on the development of delayed-type hypersensitivity (DTH) reaction and antibody formation after reduction of neuropeptides in the peripheral sensoric nervous system. Rats were sensitized with picryl chloride on their shaved abdomen or by subcutaneous injections with picrylsulfonic acid (PSA). Manipulation of the content of neuropeptides in the sensory nerve system with capsaicin was performed 1 week before or after sensitization. An increase of the DTH reaction assessed as increased ear thickness after challenge was seen especially when the rats were given capsaicin after sensitization...
1989: International Archives of Allergy and Applied Immunology
G Nilsson, K Alving, S Ahlstedt
The effect of capsaicin treatment on the immune response, assessed as antibody formation in vivo and in vitro, was studied in ovalbumin (OA)-immunized rates. Rats were treated with capsaicin at 1-2 days of life or at adult age, before or after immunization. The levels of IgA, IgE and IgG antibodies as well as immunoglobulins were measured in serum and supernatants from cultured lymph node cells, spleen cells and peripheral blood lymphocytes. Capsaicin treatment affected the antibody levels depending on the timing of capsaicin treatment in relation to immunization...
1991: International Journal of Immunopharmacology
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