A Gordon Smith, J Robinson Singleton, Adrienne Aperghis, Christopher S Coffey, Peter Creigh, Merit Cudkowicz, Robin Conwit, Dixie Ecklund, Janel K Fedler, Anna Gudjonsdottir, Peter Hauer, David N Herrmann, Marianne Kearney, John Kissel, Elizabeth Klingner, Adam Quick, Cathy Revere, Amro Stino
IMPORTANCE: Cryptogenic sensory peripheral neuropathy (CSPN) is highly prevalent and often disabling due to neuropathic pain. Metabolic syndrome and its components increase neuropathy risk. Diet and exercise have shown promise but are limited by poor adherence. OBJECTIVE: To determine whether topiramate can slow decline in intraepidermal nerve fiber density (IENFD) and/or neuropathy-specific quality of life measured using the Norfolk Quality of Life-Diabetic Neuropathy (NQOL-DN) scale...
December 1, 2023: JAMA Neurology