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JOURNAL ARTICLE
Zhuxin Zhang, Le Li, Zhenhao Zhang, Zhao Hu, Yulong Xiong, Likun Zhou, Yan Yao
BACKGROUND: Substantial focus has been placed on atrial fibrillation (AF) treatment and associated stroke prevention rather than preventing AF itself. We employed Mendelian randomization (MR) approach to examine the causal relationships between 50 modifiable risk factors (RFs) and AF. METHODS: Instrumental variables for genetically predicted exposures were derived from corresponding genome-wide association studies (GWASs). Summary-level statistical data for AF were obtained from a GWAS meta-analysis (discovery dataset, N = 1,030,836) and FinnGen (validation dataset, N = 208,594)...
March 4, 2024: European Journal of Clinical Investigation
#22
JOURNAL ARTICLE
Huan Wang, Zhe Zhang, Linxuan Zou, Juewei Zhang, Zhuqiang Jia, Lin Zhao, Xin Han, Xiaohong Sun, Zhen Zhang, Junwei Zong, Shouyu Wang
BACKGROUND: Previous observational studies have demonstrated a correlation between metabolic syndrome related diseases and an elevated susceptibility to ulcers of lower limb. It has been suggested that this causal relationship may be influenced by the presence of peripheral artery disease (PAD). Nevertheless, the precise contribution of these factors as determinants of ulcers of lower limb remains largely unexplored. METHOD: This research incorporated information on hypertension, BMI, hyperuricemia, type 2 diabetes, PAD, and ulcers of lower limb sourced from the GWAS database...
2024: Frontiers in Endocrinology
#23
JOURNAL ARTICLE
Ou Wu, Ya Wu, Xingyu Zhang, Wei Liu, Hu Zhang, Saber Khederzadeh, Xi Lu, Xiao-Wei Zhu
To examine whether circulating interleukin-6 (IL-6) levels (CirIL6) have a causal effect on blood pressure using Mendelian randomization (MR) methods. We used data from genome-wide association studies (GWAS) of European ancestry to obtain genetic instruments for circulating IL-6 levels and blood pressure measurements. We applied several robust MR methods to estimate the causal effects and to test for heterogeneity and pleiotropy. We found that circulating IL-6 had a significant positive causal effect on systolic blood pressure (SBP) and pulmonary arterial hypertension (PAH), but not on diastolic blood pressure (DBP) or hypertension...
March 1, 2024: Immunogenetics
#24
JOURNAL ARTICLE
Wei Liu, Quan Lin, Zongjing Fan, Jie Cui, Yang Wu
BACKGROUND: Observational studies have indicated a potential association between education and cardiovascular diseases (CVDs). However, uncertainties regarding the causal relationship persist. Therefore, this study aimed to investigate whether higher levels of education causally reduce the risks of CVDs. METHODS: Employing a two-sample Mendelian randomization (MR) design, our study examined the relationship between education and ten different CVDs. Utilizing data from the IEU Open GWAS database, relevant single nucleotide polymorphisms (SNPs) were identified through stringent screening criteria...
2024: Frontiers in Cardiovascular Medicine
#25
JOURNAL ARTICLE
Zhiwei Xia, Yinjiang Liu, Chao Liu, Ziyu Dai, Xisong Liang, Nan Zhang, Wantao Wu, Jie Wen, Hao Zhang
BACKGROUND: Air pollution poses a major threat to human health by causing various illnesses, such as cardiovascular diseases. While plenty of research indicates a correlation between air pollution and hypertension, a definitive answer has yet to be found. METHODS: Our analyses were performed using the Genome-wide association study (GWAS) of exposure to air pollutants from UKB (PM2.5, PM10, NO2 , and NOX ; n = 423,796 to 456,380), essential hypertension from FinnGen (42,857 cases and 162,837 controls) and from UKB (54,358 cases and 408,652 controls) as a validated cohort...
2024: Frontiers in Public Health
#26
JOURNAL ARTICLE
Xiao-Ce Dai, Yi Yu, Si-Yu Zhou, Shuo Yu, Mei-Xiang Xiang, Hong Ma
BACKGROUND: Previous studies have shown an association between gut microbiota and cardiovascular diseases (CVDs). However, the underlying causal relationship remains unclear. This study aims to elucidate the causal relationship between gut microbiota and CVDs and to explore the pathogenic role of gut microbiota in CVDs. METHODS: In this two-sample Mendelian randomization study, we used genetic instruments from publicly available genome-wide association studies, including single-nucleotide polymorphisms (SNPs) associated with gut microbiota (n = 14,306) and CVDs (n = 2,207,591)...
February 26, 2024: BioData Mining
#27
REVIEW
David Curtis
BACKGROUND: Genetic variants causing diseases with hypertension as a secondary feature have previously been identified. Studies focussing on primary hypertension have utilised common and latterly rare genetic variants in attempts to elucidate the genetic contribution to the risk of primary hypertension. SUMMARY: Using genome-wide association studies (GWASs), associations of hypertension with hundreds of common genetic variants have been reported, implicating thousands of genes...
2024: Pulse (Basel, Switzerland)
#28
JOURNAL ARTICLE
Yongfei Song, Zequn Zheng, Jiale Hu, Jiangfang Lian
BACKGROUND AND AIM: The relationship between appendicular lean mass (ALM) and most cardiovascular events has been established, but the direct association between ALM and atrial fibrillation (AF) remains uncertain. METHODS AND RESULTS: Herein, we identified 494 single-nucleotide polymorphisms (SNPs) strongly associated with ALM as instrumental variables (P < 5E-8) based on a genome-wide association study (GWAS) with 450,243 European participants. Then, we employed five Mendelian randomization (MR) analysis methods to investigate the causal relationship between ALM and AF...
January 29, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#29
JOURNAL ARTICLE
Melika Marani, Vrinda Madan, Thomas K Le, Junwen Deng, Kevin K Lee, Emily Z Ma, Shawn G Kwatra
Pruritus has long been linked to hepatic dysfunction; however, there are limited data characterizing the association between liver disease and prurigo nodularis (PN), a chronic inflammatory skin disease featuring severe pruritis. We thus conducted a cross-sectional analysis of hepatic comorbidities in PN patients using TriNetX, a large global health research network. This analysis revealed that PN patients had a higher risk ( p < 0.001) of developing liver cirrhosis, acute and subacute hepatic failure, inflammatory liver disease, chronic hepatitis, nonalcoholic steatohepatitis, portal hypertension, fatty liver, chronic passive congestion of the liver, and hepatocellular carcinoma compared with healthy controls...
January 23, 2024: Genes
#30
JOURNAL ARTICLE
Xiao-Fang Wang, Xiao-Wen Zhang, Ya-Jun Liu, Xin-Yu Zheng, Meng-Ru Su, Xing-Hong Sun, Feng Jiang, Zhi-Nan Liu
BACKGROUND: Previous research has indicated a vital association between hypertension, intraocular pressure (IOP), and diabetic retinopathy (DR); however, the relationship has not been elucidated. In this study, we aim to investigate the causal association of hypertension, IOP, and DR. METHODS: The genome-wide association study (GWAS) IDs for DR, hypertension, and IOP were identified from the Integrative Epidemiology Unit (IEU) Open GWAS database. There were 33,519,037 single-nucleotide polymorphisms (SNPs) and a sample size of 1,030,836 for DR...
2024: Frontiers in Endocrinology
#31
JOURNAL ARTICLE
Ge Tian, Rong Zhou, Xingzhi Guo, Rui Li
Observational studies have indicated that high blood pressure (BP) may be a risk factor to frailty. However, the causal association between BP and frailty remains not well determined. The purpose of this bi-directional two-sample Mendelian randomization (MR) study was to investigate the causal relationship between BP and frailty. Independent single nucleotide polymorphisms (SNPs) strongly (P < 5E-08) associated with systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) were selected as instrumental variables...
February 15, 2024: Journal of Human Hypertension
#32
JOURNAL ARTICLE
Philip Harrer, Julica Inderhees, Chen Zhao, Barbara Schormair, Erik Tilch, Christian Gieger, Annette Peters, Olaf Jöhren, Thomas Fleming, Peter P Nawroth, Klaus Berger, Marco Hermesdorf, Juliane Winkelmann, Markus Schwaninger, Konrad Oexle
BACKGROUND: The dicarbonyl compounds methylglyoxal (MG), glyoxal (GO) and 3-deoxyglucosone (3-DG) have been linked to various diseases. However, disease-independent phenotypic and genotypic association studies with phenome-wide and genome-wide reach, respectively, have not been provided. METHODS: MG, GO and 3-DG were measured by LC-MS in 1304 serum samples of two populations (KORA, n = 482; BiDirect, n = 822) and assessed for associations with genome-wide SNPs (GWAS) and with phenome-wide traits...
February 13, 2024: EBioMedicine
#33
JOURNAL ARTICLE
Changhong Miao, Xinyi Xu, Shuoxuan Huang, Lingyi Kong, Zhiwei He, Yihan Wang, Kuang Chen, Lu Xiao
BACKGROUND: Recent studies have highlighted a connection between gut microbiota and hypertension, yet the precise nature of this relationship remains unclear. OBJECTIVE: This research aims to analyze the causal link between gut microbiota and hypertension, along with associated complications, utilizing two-sample bidirectional Mendelian randomization (MR). MATERIALS AND METHODS: Summary data from genome-wide association studies (GWAS) meta-analyses, including gut microbiota GWAS data from 24 cohorts, and the latest GWAS data for hypertension-related conditions were acquired...
February 8, 2024: Hellenic Journal of Cardiology: HJC
#34
JOURNAL ARTICLE
Ya Wang, Kai Li, Jiaxing Zeng, Shunyu Lu, Wangsheng Deng
BACKGROUND: It has been reported that diabetes and hypertension increase the adverse outcomes of coronavirus disease 2019 (COVID-19). Aside from the inherent factors of diabetes and hypertension, it remains unclear whether antidiabetic or antihypertensive medications contribute to the increased adverse outcomes of COVID-19. The effect of commonly used antidiabetic and antihypertensive medications on COVID-19 outcomes has been inconsistently concluded in existing observational studies...
February 9, 2024: Medicine (Baltimore)
#35
JOURNAL ARTICLE
Evridiki-Pandora G Tsare, Maria I Klapa, Nicholas K Moschonas
BACKGROUND: It is valuable to analyze the genome-wide association studies (GWAS) data for a complex disease phenotype in the context of the protein-protein interaction (PPI) network, as the related pathophysiology results from the function of interacting polyprotein pathways. The analysis may include the design and curation of a phenotype-specific GWAS meta-database incorporating genotypic and eQTL data linking to PPI and other biological datasets, and the development of systematic workflows for PPI network-based data integration toward protein and pathway prioritization...
February 8, 2024: Human Genomics
#36
JOURNAL ARTICLE
Rufus O Akinyemi, Hemant K Tiwari, Vinodh Srinivasasainagendra, Onoja Akpa, Fred S Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O Osaigbovo, Olga A Mamaeva, Brian A Halloran, Joshua Akinyemi, Daniel Lackland, Olugbo Y Obiabo, Taofik Sunmonu, Innocent I Chukwuonye, Oyedunni Arulogun, Carolyn Jenkins, Abiodun Adeoye, Atinuke Agunloye, Okechukwu S Ogah, Godwin Ogbole, Adekunle Fakunle, Ezinne Uvere, Motunrayo M Coker, Akinkunmi Okekunle, Osahon Asowata, Samuel Diala, Mayowa Ogunronbi, Osi Adeleye, Ruth Laryea, Raelle Tagge, Sunday Adeniyi, Nathaniel Adusei, Wisdom Oguike, Paul Olowoyo, Olayinka Adebajo, Abimbola Olalere, Olayinka Oladele, Joseph Yaria, Bimbo Fawale, Philip Ibinaye, Olalekan Oyinloye, Yaw Mensah, Omotola Oladimeji, Josephine Akpalu, Benedict Calys-Tagoe, Hamisu A Dambatta, Adesola Ogunniyi, Rajesh Kalaria, Donna Arnett, Charles Rotimi, Bruce Ovbiagele, Mayowa O Owolabi
BACKGROUND: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. METHODS: Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke...
February 5, 2024: Genome Medicine
#37
JOURNAL ARTICLE
Shixuan Chen, Zhenzhen Chen, Xia Jiang, Chuyong Lin, Jing Ji
OBJECTIVES: Previous observational studies have suggested that gastroesophageal reflux disease (GERD) increases the risk of stroke, but the specific underlying mechanisms are unclear. We investigated the causal associations of GERD with stroke and its subtypes using Mendelian randomization (MR), and evaluated the potential mediating effects of modifiable stroke risk factors in the causal pathway. METHODS: Genetic instrumental variables for GERD were extracted from the latest genome-wide association study (GWAS) summary level data...
February 1, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#38
JOURNAL ARTICLE
Xiaofeng Lv, Fangqi Liang, Shanshan Liu, Xinmin Deng, Rui Lai, Jihang Du, Jian Luo
BACKGROUND: Knee osteoarthritis (KOA) is a common disabling joint disease that affects millions of people worldwide. Diet may play a role in the etiology and progression of KOA, but evidence for a causal relationship is limited. We aimed to investigate the causal impact of dietary intake on KOA risk using Mendelian randomization (MR). METHODS: We used summary-level data from genome-wide association studies (GWAS) including dietary intake (n = 335, 394-462, 342), and KOA (n = 403, 124)...
2024: PloS One
#39
JOURNAL ARTICLE
Chenwei Zhang, Yujia Xi, Yukai Zhang, Peiyun He, Xuesen Su, Yishan Li, Mengyuan Zhang, Haizhao Liu, Xiao Yu, Yiwei Shi
BACKGROUND: Multiple studies have highlighted a potential link between gut microbes and the onset of Pulmonary Arterial Hypertension (PAH). Nonetheless, the precise cause-and-effect relationship remains uncertain. OBJECTIVES: In this investigation, we utilized a two-sample Mendelian randomization (TSMR) approach to probe the presence of a causal connection between gut microbiota and PAH. METHODS: Genome-wide association (GWAS) data for gut microbiota and PAH were sourced from MiBioGen and FinnGen research, respectively...
January 29, 2024: Heart & Lung: the Journal of Critical Care
#40
JOURNAL ARTICLE
Xin Zhang, Shi-Liang Yu, Lu-Ming Qi, Li-Na Xia, Qing-Tang Yang
BACKGROUNDDue to the long time interval between exposure and outcome, it is difficult to infer the causal relationship between educational attainment (EA) and common chronic diseases. Therefore, we utilized Mendelian randomization (MR) to predict the causal relationships of EA with hypertension and type-2 diabetes (T2DM). METHODSA two-sample MR analysis was conducted using genome-wide association studies (GWASs) combined with inferential measurements. A GWAS meta-analysis including 1,131,881 European individuals was used to identify instruments for EA...
March 2024: SSM—Population Health
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