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Seza Ozen, Stephen D Marks, Paul Brogan, Noortje Groot, Nienke de Graeff, Tadej Avcin, Brigitte Bader-Meunier, Pavla Dolezalova, Brian M Feldman, Isabelle Kone-Paut, Pekka Lahdenne, Liza McCann, Clarissa Pilkington, Angelo Ravelli, Annet van Royen, Yosef Uziel, Bas Vastert, Nico Wulffraat, Sylvia Kamphuis, Michael W Beresford
OBJECTIVES: IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and treatment of IgAV in children. Accordingly, treatment regimens differ widely. The European initiative SHARE (Single Hub and Access point for paediatric Rheumatology in Europe) aims to optimize care for children with rheumatic diseases...
March 16, 2019: Rheumatology
Zachary Giano, Randolph D Hubach, Joseph M Currin, Denna L Wheeler
BACKGROUND: Past research identified individuals who experienced adverse childhood experiences (ACEs) are at a higher risk of drug use. There is evidence to suggest that identifying as a man who has sex with other men (MSM) may increase the likelihood of drug use when adverse childhood experiences are prevalent. However, research has not addressed if this association is present in both rural and urban MSM, as other studies found that rurality/urbanity is a key determinant in detrimental outcomes for MSM...
February 27, 2019: Drug and Alcohol Dependence
Katarzyna Regulska, Miłosz Regulski, Bartosz Karolak, Marek Murias, Beata Stanisz
Research on the concept of biological overlap between cardiovascular and oncological diseases is gaining momentum. In fact, in both conditions, the malfunction of common regulatory mechanisms, such as the renin-angiotensin system (RAS), sympathetic nervous system (SNS), coagulation cascade, sodium-potassium ATP-ases, and mevalonate pathway, occurs. Thus, targeting these mechanisms with well-known cardiology drugs, including angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs), β-adrenergic receptor blockers, statins, cardiac glycosides (CGs), and low-molecular-weight heparins (LMWHs), could be a novel, promising adjuvant strategy in cancer management...
March 13, 2019: Drug Discovery Today
Man-Man Xia, Mingxu Wang, Hong Jiang, Yan Liu, Le Ma, Chao Lu, Wei Zhang
AIMS: The objective of this study was to perform a meta-analysis to evaluate the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and susceptibility to atherosclerosis (AS). METHODS: MEDLINE, EMBASE, and the ISI Web of Science were searched for all eligible published studies concerning the relationship of ACE gene polymorphism with AS without language restrictions. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate this relationship under different genetic models using meta-analytic methods...
March 13, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Cécile Droz-Perroteau, Patrick Blin, Caroline Dureau-Pournin, Daniel Thomas, Nicolas Danchin, Jacques Tricoire, François Paillard, Serge Hercberg, Louis Guize, Estelle Guiard, Hélène Maïzi, Marie-Agnès Bernard, Jacques Bénichou, Nicholas Moore
BACKGROUND: Studies of survival after myocardial infarction (MI) are often based on intention to treat analyses of controlled trials. OBJECTIVES: Describe long-term survival after MI in France. METHODS: Six-year cohort study of patients recruited within 3 months after MI. Primary outcome was all-cause death. Vital status was verified in the national death registry. Analysis used Cox models with time-dependent variables and propensity scores...
February 25, 2019: Thérapie
Peter Bramlage, Stefanie Lanzinger, Gesine van Mark, Eva Hess, Simon Fahrner, Christoph H J Heyer, Mathias Friebe, Jochen Seufert, Thomas Danne, Reinhard W Holl
BACKGROUND: To evaluate the characteristics of type 2 diabetes (T2DM) patients with or without chronic kidney disease (CKD) in Germany. METHODS: Using combined DPV/DIVE registry data, the analysis included patients with T2DM at least ≥ 18 years old who had an estimated glomerular filtration rate (eGFR) value available. CKD was defined as an eGFR < 60 mL/min/1.73 m2 or eGFR ≥ 60 mL/min/1.73 m2 and albuminuria (≥ 30 mg/g). Median values of the most recent treatment year per patient are reported...
March 16, 2019: Cardiovascular Diabetology
Moghadese Mohammadian, Razieh Sahraei, Mousa Ghaemy
In the current study, hard water softening for the removal of Ca2+ and Mg2+ ions was performed using hydrogel beads based on Gum Tragacance (GT) modified by using 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) and poly(vinyl alcohol). The antibacterial spherical hydrogel beads were fabricated by instantaneous gelation of well dispersed mixture of poly(AMPS)-g-GT (1 g), poly(vinyl alcohol) (PVA, 1 g) flocculent, green-synthesized silver metal nanoparticles (AgNPs, 10 mg), and graphene oxide (GO, 10 mg) in the acetone solution of boric acid and then transferring into the different amounts (0...
March 9, 2019: Chemosphere
Michael S Wei, Robin H J Kemperman, Richard A Yost
Opioid addiction is an escalating problem that is compounded by the introduction of synthetic opiate analogues such as fentanyl. Screening methods for these compound classes are challenged by the availability of synthetically manufactured analogues, including isomers of existing substances. High-field asymmetric-waveform ion mobility spectrometry (FAIMS) utilizes an alternating asymmetric electric field to separate ions by their different mobilities at high and low fields as they travel through the separation space...
March 15, 2019: Journal of the American Society for Mass Spectrometry
Anelise Samara Nazari Formagio, Pedro Cruz de Oliveira Junior, Carla Roberta Ferreira Volobuff, Candida Aparecida Leite Kassuya, Diego Cegobia Ferreira, Claudia Andrea Lima Cardoso, Maria Helena Sarragiotto, Zefa Valdevina Pereira
Palicourea crocea (Sw.) Roem. and Schult., "douradinha," are used by treat inflammation (edema). Croceaine A (PC-1) was isolated from P. crocea (MEPC) leaves and studied for its antioxidant and anti-inflammatory activity, as well as concentrations of constituents and acute toxicity. The phenols and polyphenolics compounds and HPLC/DAD were determined. The antioxidant activity were evaluated for DPPH, ABTS, and MDA. MEPC (300, 100, and 300 mg/kg) and PC-1 (10 and 30 mg/kg) were tested for anti-inflammatory effects in paw edema, pleurisy, cold sensitivity, and mechanical hyperalgesia...
March 16, 2019: Inflammation
Etsuko Tsuda, Osamu Yamada, Masataka Kitano
BACKGROUND: The treatment of heart failure has changed with the use of angiotensin-converting enzyme inhibitors (ACEIs) and beta-blockers since the middle of the 1990s. However, the outcome in infantile dilated cardiomyopathy (DCM) when treated with them remains poorly understood. METHODS: We reviewed the medical records of infants with DCM within 24 months old in our hospital between 1979 and 2012, and compared the outcome in the later group (1997-2012) with that in the early group (1979-1996)...
March 12, 2019: Journal of Cardiology
Omar Hamoui, Mohamed I Omar, Frederick J Raal, Wafa Rashed, Abdoul Kane, Mohamed Alami, Paula Abreu, Walid Mashhoud, Alawi A Alsheikh-Ali
BACKGROUND: With development of cholesterol management guidelines by the American College of Cardiology/American Heart Association (ACC/AHA), more individuals at risk of cardiovascular disease may be eligible for statin therapy. It is not known how this affects statin eligibility in the Africa and Middle East Region. METHODS: Data were used from the Africa Middle East Cardiovascular Epidemiological (ACE) study. The percentage of subjects eligible for statins per the ACC/AHA 2013 cholesterol guidelines and the 2002 National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III) recommendations were compared...
March 15, 2019: BMC Cardiovascular Disorders
Soumen Ghosh, Jason C Asher, Laura Gagliardi, Christopher J Cramer, Niranjan Govind
We describe a new approach to extract information about an excited state wave function using a reduced orbital space molecular orbital decomposition approach for time-dependent density obtained from real-time dynamics. We also show how this information about the excited state wave function can be used to accelerate the convergence of real-time spectra and model excited state electron dynamics. We have combined this approach with our recent implementation of the real-time intermediate neglect of differential overlap for spectroscopy (INDO/S) to study the solvatochromic shift of Nile Red in acetone, ethanol, toluene and n-hexane solvents, and, for the first time, the excited state absorption spectra of coronene, 5,10,15,20-tetra(4-pyridyl)porphyrin (TPyP), zinc phthalocyanine, and nickel TPyP using a semiempirical Hamiltonian...
March 14, 2019: Journal of Chemical Physics
Rajesh Kanawade, Ajay Kumar, Dnyandeo Pawar, Kaushal Vairagi, Dattatray Late, Sudipta Sarkar, Ravindra K Sinha, Samir Mondal
In this research work we demonstrated negative axicon optical fiber tip filled with Polydimethylsiloxane (PDMS) as a sensor platform for volatile organic gases detection at room temperature. The response of the sensor was measured with various Volatile Organic Compounds (VOCs) such as Chloroform, Hexane, Isopropanol, Acetone, Toluene and Methanol in the concentration ranging from 5 to 200 ppm. The corresponding sensitivity and limit of detection (LOD) of the developed sensor for the measured VOCs were observed between the order of around 23...
March 4, 2019: Optics Express
Artur Rydosz, Andrzej Brudnik, Kamil Staszek
Metal oxide thin films such as copper oxide, titanium dioxide, and tin dioxide deposited by magnetron sputtering technology were verified as a gas-sensitive layer in microwave-based gas sensors operated at 2.4 GHz. The developed gas sensors were tested at room temperature (23 °C) and 50% relative humidity (RH) under exposure to 0⁻200 ppm of selected volatile organic compounds (acetone, ethanol, and methanol) that are of high interest in industry and biomedical applications. The highest responses to acetone were obtained for CuO-based gas sensors, to ethanol for SnO₂-based gas sensors, while for methanol detection both dioxides, SnO₂ and TiO₂, exhibited good sensitivity...
March 15, 2019: Materials
Byung-Kwan Lim, Jin Joo Park, Sung-Ji Park, You-Jung Lee, Jin-Sook Kwon, Eun-Ji Kim, Dong-Ju Choi
An angiotensin receptor blocker (ARB) mitigates cardiac remodeling after myocardial infarction (MI). Here, we investigated the effect of fimasartan, a new ARB, on cardiac remodeling after MI. Sprague⁻Dawley rats were assigned into 3 groups: surgery only (sham group, n = 7), MI without (MI-only group, n = 13), and MI with fimasartan treatment (MI + Fima group, n = 16). MI was induced by the permanent ligation of the left anterior descending artery. Treatment with fimasartan (10 mg/kg) was initiated 24 h after MI and continued for 7 weeks...
March 15, 2019: Journal of Clinical Medicine
Michał Miłek, Dana Marcinčáková, Jaroslav Legáth
This experiment was conducted with extracts prepared from dandelion ( Taraxacum officinale F. H. Wigg) leaves and flowers, using the micelle-mediated extraction method, with the surface active compound Triton X-100 and water⁻acetone as the extraction solvents. Extracts were, first, examined for the content of total phenols and the antioxidant capacity. All extracts showed good anti-radical properties, especially for leaves, in comparison to the flower samples. Flavonoids (mainly luteolin derivatives) and phenolic acids, predominated among the determined polyphenols...
March 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Cristina Bertoni, Pasquale Naclerio, Emanuele Viviani, Simone Dal Zilio, Sergio Carrato, Alessandro Fraleoni-Morgera
The dynamic response of gas sensors based on poly(3-hexylthiophene) (P3HT) nanofibers(NFs) to gaseous acetone was assessed using a setup based on flow-injection analysis, aimed atemulating actual breath exhalation. The setup was validated by using a commercially available sensor.The P3HT NFs sensors tested in dynamic flow conditions showed satisfactory reproducibility down toabout 3.5 ppm acetone concentration, a linear response over a clinically relevant concentration range(3.5-35 ppm), excellent baseline recovery and reversibility upon repeated exposures to the analyte,short pulse rise and fall times (less than 1 s and about 2 s, respectively) and low power consumption(few nW), with no relevant response to water...
March 14, 2019: Sensors
Syed Awais Attique, Muhammad Hassan, Muhammad Usman, Rana Muhammad Atif, Shahid Mahboob, Khalid A Al-Ghanim, Muhammad Bilal, Muhammad Zohaib Nawaz
Cardiovascular diseases (CVDs) have become the leading cause of disability and death worldwide, particularly in low- and middle-income countries. Hypertension, a major cause of CVD progression, is widely attributable to genetic, behavioral, and environmental risk factors. Among the genetic reasons, angiotensin II enzyme, produced as a result of abnormal functioning of the renin⁻angiotensin system, is reported as the foremost cause of hypertension. A cascade of genes, including those encoding for WNK kinases (WNK1 and WNK4), Bp1, Bp2, angiotensinogen, and other enzymes, is involved in the conversion of angiotensin I to angiotensin II...
March 14, 2019: International Journal of Environmental Research and Public Health
Maria Del C Valdés Hernández, Tessa Case, Francesca M Chappell, Andreas Glatz, Stephen Makin, Fergus Doubal, Joanna M Wardlaw
Brain iron deposits (IDs) are inversely associated with cognitive function in community-dwelling older people, but their association with cognition after ischemic stroke, and whether that differs from microbleeds, is unknown. We quantified basal ganglia IDs (BGID) and microbleeds (BMBs) semi-automatically on brain magnetic resonance images from patients with minor stroke (NIHSS < 7), at presentation and 12 months after stroke. We administered the National Adult Reading Test (NART, estimates premorbid or peak adult cognition) and the Revised Addenbrooke's Cognitive Examination (ACE-R; current cognition) at 1 and 12 months after stroke...
March 14, 2019: International Journal of Molecular Sciences
J Sebastian Chahda, Neeraj Soni, Jennifer S Sun, Shimaa A M Ebrahim, Brian L Weiss, John R Carlson
Dipteran or "true" flies occupy nearly every terrestrial habitat, and have evolved to feed upon a wide variety of sources including fruit, pollen, decomposing animal matter, and even vertebrate blood. Here we analyze the molecular, genetic and cellular basis of odor response in the tsetse fly Glossina morsitans, which feeds on the blood of humans and their livestock, and is a vector of deadly trypanosomes. The G. morsitans antenna contains specialized subtypes of sensilla, some of which line a sensory pit not found in the fruit fly Drosophila...
March 2019: PLoS Genetics
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