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Jingbao Zhang, Yanfei Gao, Changbo Ma, Yi Wang
BACKGROUND Murrayanine is a carbazole alkaloid derived from Murraya koenigii, which has been used in traditional Chinese medicine in the treatment of cancer. This study aimed to investigate the effects of murrayanine on human lung adenocarcinoma cells in vitro and to investigate the mechanisms of its action. MATERIAL AND METHODS A549 human lung adenocarcinoma cells and MRC-5 human lung fibroblasts were grown in culture, and an MTT assay determined cell viability. Cells were treated for 24 h with increasing doses of murrayanine (0, 9, 18, and 36 ┬ÁM)...
March 17, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Xin Zhao, Fengjiao Du, Xiaolin Liu, Qiuyan Ruan, Zhulian Wu, Chuan Lei, Yanfei Deng, Chan Luo, Jianrong Jiang, Deshun Shi, Fenghua Lu
Brain-derived neurotrophic factor (BDNF) has been discovered and characterized for several decades, yet its expression pattern in non-neuronal tissues like ovary and potential mechanism during oocyte maturation are still poorly understood. Thus the present study was devised to determine the expression pattern and mechanism of BDNF during buffalo oocyte maturation. The results revealed that BDNF was presented at different stages of buffalo ovarian follicles as well as during oocyte maturation and early embryo development...
February 23, 2019: Theriogenology
Yuan Ma, Yongjia Hu, Jiawen Wu, Junru Wen, Sen Li, Lijuan Zhang, Jie Zhang, Yanfei Li, Jue Li
Angiotensin II (AII) has been well known to induce cardiomyocyte hypertrophy. Epigallocatechin-3-gallate (EGCG) is the main active component of green tea and it has been shown to exhibit strong cardioprotective potential, although the underlying molecular mechanisms remain unclear. In this study, we investigated the role and mechanism of EGCG in preventing AII-induced cardiomyocyte hypertrophy using rat H9c2 cardiomyocytes cells. Reactive oxygen species assay, cell size, and mRNA expression of cardiac hypertrophy markers ANP and BNP were assessed in response to AII treatment...
March 16, 2019: Acta Biochimica et Biophysica Sinica
Yunqiu Zhang, Jiuyi Li, Kaikai Yi, Jing Feng, Zhengmin Cong, Zheng Wang, Yanfei Wei, Fan Wu, Wen Cheng, Ayaz Ali Samo, Paolo Salomoni, Qiong Yang, Yu Huang, Chunsheng Kang, Tao Jiang, Xiaolong Fan
Genomic instability (GI) drives tumor heterogeneity and promotes tumor progression and therapy resistance. However, causative factors underlying GI and means for clinical detection of GI in glioma are inadequately identified. We describe here that elevated expression of a gene module coexpressed with CDC20 (CDC20-M), the activator of the anaphase-promoting complex in the cell cycle, marks GI in glioma. The CDC20-M, containing 139 members involved in cell proliferation, DNA damage response, and chromosome segregation, was found to be consistently coexpressed in glioma transcriptomes...
March 15, 2019: Proceedings of the National Academy of Sciences of the United States of America
Yuhao Zhu, Naixing Zhang, Decheng Ren, Yan Bi, Fei Xu, Weibo Niu, Qianqian Sun, Zhenming Guo, Ruixue Yuan, Fan Yuan, Xi Wu, Yanfei Cao, Fengping Yang, Lu Wang, Li Du, Weidong Li, Yifeng Xu, Xingwang Li, Liping Zhu, Lin He, Lei Shi, Guang He, Tao Yu
Major depressive disorder (MDD) is a common mental disorder. Venlafaxine (VEN) is used to treat patients with MDD as an antidepressant of serotonin-norepinephrine reuptake inhibitor. In addition, current reports reveal that CYP enzymes mediate its metabolism, thereby affecting the treatment efficacy. The aim of this study was to test whether the genetic polymorphisms of CYP1A2 are associated with remission after VEN treatment for MDD. A total of 175 Han Chinese depressed patients have been recruited to accept a 6-week treatment with VEN...
March 2019: Clinical Neuropharmacology
Shengnan Zhao, Jinhua Li, Yang Zhou, Lingjing Huang, Yanfei Li, Juanjuan Xu, Chunmei Fu, Xia Guo, Jian Yang
Drugs are administered orally in the clinical treatment of hypertension. Antihypertensive peptides have excellent angiotensin converting enzyme inhibitors activity in vitro . However, the poor oral bioavailability and therapeutic effect of antihypertensive peptides were mainly caused by rapid degradation in gastrointestinal and the short circulation time in blood, which remain to be further optimized. Therefore, the novel oral peptide delivery system is urged to improve the oral absorption and efficacy of peptide drugs...
2019: Frontiers in Pharmacology
Yang Yang, Yanfei Li, Dong Yue, Wenbin Yue
This paper addresses an adaptive event-triggered consensus control problem for a class of second-order nonlinear multiagent systems (MASs) in an undirected communication topology. A novel adaptive distributed event-triggered consensus control scheme is presented for the MAS with unknown functions based on the definition of an auxiliary state, and the coefficient of the triggered function can be regulated adaptively with dependence on the auxiliary state error to ensure not only the control performance but also the efficiency of the network interactions...
March 12, 2019: IEEE Transactions on Cybernetics
Zhen Zhu, Tianyu Xiao, Xuejiao Chang, Yanfei Hua, Jinli Gao
BACKGROUND Liver cancer is one of the most commonly diagnosed cancers across the globe. The treatment is often difficult as it is diagnosed mostly at advanced stages. Moreover, the lack efficacious and less toxic drugs are another problem in the treatment of liver cancer. Against this background, in this study we evaluated the anticancer activity of morusinol against SK-HEP-1 liver cancer cells. MATERIAL AND METHODS The proliferation rate of liver cancer cell line was investigated by MTT assay. Autophagy was detected by transmission electron microscopy and cell cycle analysis was performed by flow cytometry...
March 12, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jun Chen, Hui-Hui Yang, Wen Yin, Yanfei Zhang, Yingjun Ma, Danping Chen, Yuzhi Xu, Si-Yang Liu, Li Zhang, Zong Dai, Xiaoyong Zou
Sensitive and accurate imaging of intracellular-specific microRNAs (miRNAs) in situ in living cells is seriously challenged by the susceptibility of nucleic acid probes and the low dynamics of the hybridization reaction in cellular environments. Herein, we engineer a set of new metastable dumbbell probes (Mx DPs) to overcome these key limitations by concurrently boosting transfection, anti-digestibility, assembly dynamics and nanostructural uniformity. The Mx DPs can maintain stable up to 16 h in living cells, and pro-duce uniform and dense DNA nanostructures rapidly (<2 h) and specifically from hybridization chain reaction (HCR)...
March 11, 2019: Analytical Chemistry
Yanfei Li, Cuiping Wang, Tingting Li, Linlin Ma, Fangzhou Fan, Yueling Jin, Junwei Shen
As the most severe manifestation of coronary artery disease, myocardial infarction (MI) is a complex and multifactorial pathophysiologic process. However, the pathogenesis that underlies MI remains unclear. Here, we generated a MI mouse model by ligation of the proximal left anterior descending coronary artery. The transcriptome and proteome, at different time points after MI, were detected and analysed. Immune-related pathways, cell cycle-related pathways, and extracellular matrix remodelling-related pathways were significantly increased after MI...
2019: Cell Death Discovery
Shaohua Gong, Yanfei Ding, Shanshan Hu, Lihong Ding, Zhixiang Chen, Cheng Zhu
Abiotic stresses usually affect plant growth and development, indirectly or directly causing crop production reduction and even plant death. To survive, plants utilize different mechanisms to adapt themselves to continuously changing surrounding environmental stresses. Homeodomain-leucine zipper (HD-Zip) transcription factors are unique to the plant kingdom and divided into four different subfamily (HD-Zip I~ IV). Many HD-Zip I members have been shown to play critical roles in the regulation of plant developmental processes, signaling networks and responses to environmental stresses...
March 9, 2019: Physiologia Plantarum
Guoxing Xu, Bin Fu, Haiyan Zhao, Yanfei Li, Ge Zhang, Ying Wang, Tao Xiong, Qian Zhang
A copper-catalyzed asymmetric reductive allyl-allyl cross-coupling reaction of allenes with allylic phosphates wherein allenes were used as allylmetal surrogates has been achieved for the first time. This protocol provides an efficient and straightforward route to optically active 1,5-dienes in a highly enantioselective and site-specific fashion. Furthermore, all-carbon quaternary stereogenic centers could also be constructed with this protocol. The versatility of the products is demonstrated through a diverse array of further transformations of the enantioenriched 1,5-dienes...
February 14, 2019: Chemical Science
Laiyuan Chong, Hui Guo, Yuming Zhang, Yanfei Hu, Yimen Zhang
Strains in graphene play a significant role in graphene-based electronics, but many aspects of the grain boundary effects on strained graphene remain unclear. Here, the relationship between grain boundary and strain property of graphene grown by chemical vapor deposition (CVD) on the C-face of SiC substrate has been investigated by Raman spectroscopy. It is shown that abundant boundary-like defects exist in the graphene film and the blue-shifted 2D-band frequency, which results from compressive strain in graphene film, shifts downward linearly as 1/La increases...
March 5, 2019: Nanomaterials
Haesung A Lee, Yanfei Ma, Feng Zhou, Seonki Hong, Haeshin Lee
Various methods have been developed in surface chemistry to control interface properties of a solid material. A selection rule among surface chemistries is compatibility between a surface functionalization tool and a target material. For example, alkanethiol deposition on noble metal surfaces, widely known as the formation of a self-assembled monolayer (SAM), cannot be performed on oxide material surfaces. One must choose organosilane molecules to functionalize oxide surfaces. Thus, the surface chemistry strictly depends on the properties of the surface...
March 5, 2019: Accounts of Chemical Research
Yanxia Zhang, Yanfei Jin, Pengfei Xu
Stochastic resonance (SR) and stochastic bifurcations are investigated numerically in a nonlinear tri-stable system driven by colored noise and a harmonic excitation. The power spectral density, signal-to-noise ratio, stationary probability density (SPD), and largest Lyapunov exponent (LLE) are calculated to quantify SR, P-bifurcation, and D-bifurcation, respectively. The effects of system parameters, such as noise intensity and correlation time, well-depth ratio, and damping coefficient, on SR and stochastic bifurcations are explored...
February 2019: Chaos
Xiangsheng Luo, Jialiang Guo, Lu Liu, Xixi Zhao, Dongwei Li, Hui Li, Qihua Zhao, Yanfei Wang, Qiujin Qian, Yufeng Wang, Yan Song, Li Sun
Working memory impairment is a typical cognitive abnormality in patients with attention-deficit/hyperactivity disorder (ADHD) and is closely related to attention. Exploring the interaction between working memory and attention in patients with ADHD is of great significance for studying the pathological mechanism of this disease. In this study, electrophysiological markers of attention, posterior contralateral N2 (N2pc), and working memory, contralateral delay activity (CDA), were used to explore the relationship between these two cognitive abilities in patients with ADHD...
February 20, 2019: NeuroImage: Clinical
Xuelian Xiang, Ao Wang, Lei Tu, Xiaoping Xie, Meiyun Ke, Yunsheng Yang, Bo Jiang, Lin Lin, Ning Dai, Shengsheng Zhang, Lin Tao, Hong Xu, Xiaomei Liang, Xiucai Fang, Zhiwei Xia, Xin Wang, Jianuan Wu, Meifeng Wang, Hongjie Zhang, Yanfei Fang, Chen Shen, Jing Wang, Lihua Peng, Wenyan Li, Zhifeng Wang, Kun Wang, Na Liu, Xiaohua Hou
BACKGROUND: The results of the esophageal body motility differences between liquid and solid swallows from high-resolution manometry (HRM) studies are not consistent. The information of the frequency of ineffective liquid and solid bolus swallows in healthy individuals during HRM procedure is limited. The normative values of the HRM parameters of both liquid and solid swallows for Chinese population are lacking. METHODS: The esophageal HRM data of 101 healthy volunteers from multicenters in China were analyzed...
February 28, 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Jiazhuo Xie, Yuechao Yang, Bin Gao, Yongshan Wan, Yuncong C Li, Dongdong Cheng, Tiqiao Xiao, Ke Li, Yanan Fu, Jing Xu, Qinghua Zhao, Yanfei Zhang, Yafu Tang, Yuanyuan Yao, Zhonghua Wang, Lu Liu
Despite commercialized slow-release fertilizers coated with petrochemical polymers have revolutionarily promoted agricultural production, more research should be devoted to developing superhydrophobic biopolymer coatings with superb slow-release ability from sustainable and ecofriendly biomaterials. To inform the development of the superhydrophobic biopolymer-coated slow-release fertilizers (SBSF), the slow-release mechanism of SBSF needs to be clarified. Here, the SBSF with superior slow-release performance, water tolerance and good feasibility for large-scale production was self-assembly fabricated using a simple, solvent-free process...
February 28, 2019: ACS Nano
Yanfei Tang, Gary S Grest, Shengfeng Cheng
A potential strategy for controlling stratification in a drying suspension of bidisperse particles is studied using molecular dynamics simulations. When the suspension is maintained at a constant temperature during fast drying, it can exhibit "small-on-top" stratification with an accumulation (depletion) of smaller (larger) particles in the top region of the drying film, consistent with the prediction of current theories based on diffusiophoresis. However, when only the region near the substrate is thermalized at a constant temperature, a negative temperature gradient develops in the suspension because of evaporative cooling at the liquid-vapor interface...
February 26, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Yanfei Deng, Guiting Huang, Feng Chen, Eric David Testroet, Hui Li, Haiyang Li, Tianying Nong, Xiaoling Yang, Jiayu Cui, Deshun Shi, Sufang Yang
Adipose tissue-derived mesenchymal stem cells (ASCs) from livestock are valuable resources for animal reproduction and veterinary therapeutics. Previous studies have shown that hypoxic conditions were beneficial in maintaining the physiological activities of ASCs. However, the effects of hypoxia on buffalo ASCs (bASCs) remain unclear. In this study, the effects of hypoxia on proliferation, stemness, and reprogramming into induced pluripotent stem cells (iPSCs) of bASCs were examined. The results showed that the hypoxic culture conditions (5% oxygen) enhanced the proliferation and colony formation of bASCs...
February 25, 2019: Journal of Cellular Physiology
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