keyword
https://read.qxmd.com/read/37808181/the-toxcast-pipeline-updates-to-curve-fitting-approaches-and-database-structure
#1
JOURNAL ARTICLE
M Feshuk, L Kolaczkowski, K Dunham, S E Davidson-Fritz, K E Carstens, J Brown, R S Judson, K Paul Friedman
Introduction: The US Environmental Protection Agency Toxicity Forecaster (ToxCast) program makes in vitro medium- and high-throughput screening assay data publicly available for prioritization and hazard characterization of thousands of chemicals. The assays employ a variety of technologies to evaluate the effects of chemical exposure on diverse biological targets, from distinct proteins to more complex cellular processes like mitochondrial toxicity, nuclear receptor signaling, immune responses, and developmental toxicity...
2023: Frontiers in toxicology
https://read.qxmd.com/read/36817680/positron-emission-tomographic-studies-of-the-association-between-atherogenesis-and-aortitis-among-psoriatic-patients
#2
JOURNAL ARTICLE
Lin Li, Yinglin Ge, Xianghui Wan, Kunpeng Wu, Daliang Liu
INTRODUCTION: There is increased interest in the use of positron emission tomography (PET) in psoriatic patients. We used PET induced with tracer fluorine-18 (18 F) fluorodeoxyglucose (FDG) to study the association between the process of early-atherogenesis (eAg) and aortitis by quantifying enhanced aortic vascular inflammation along with calculation of total coronary plaque load (TCPL) and non-calcified atherosclerotic plaque load (NcAPL). In order to study the utility of aortitis in capturing eAg, we also assessed luminal stenosis atherosclerosis (LSA) and high-risk coronary plaques (HrCP)...
2023: Archives of Medical Science: AMS
https://read.qxmd.com/read/34791027/tcplfit2-an-r-language-general-purpose-concentration-response-modeling-package
#3
JOURNAL ARTICLE
Thomas Sheffield, Jason Brown, Sarah Davidson, Katie Paul Friedman, Richard Judson
SUMMARY: Many applications of chemical screening are performed in concentration or dose-response mode, and it is necessary to extract appropriate parameters, including whether the chemical/assay pair is active and if so, what are concentrations where activity is seen. Typically, multiple mathematical models or curve shapes are tested against the data to assess the best fit. There are several commercial programs used for this purpose as well as open-source libraries. A widely used system for managing high-throughput screening (HTS) concentration-response data is tcpl (ToxCast Pipeline)...
November 15, 2021: Bioinformatics
https://read.qxmd.com/read/34430465/clinical-and-dermoscopic-features-of-a-case-of-idiopathic-t-cell-pseudolymphoma
#4
Biswanath Behera, Rashmi Kumari, Devinder Mohan Thappa, Pampa Ch Toi
Cutaneous pseudolymphomas are a group of benign lymphocyte-rich infiltrates that can mimic cutaneous lymphomas either clinically and/or histologically. Idiopathic T-cell pseudolymphoma (TCPL) usually presents as a solitary nodule or plaque on the trunk or head. A clinicopathologic correlation is mandatory to arrive at a final diagnosis and rule out true lymphomas. There are only sparse dermoscopic reports on cutaneous pseudolymphomas. Hereby, we describe the clinical and dermoscopic features of a case of idiopathic TCPL in a 26-year-old man who presented with an asymptomatic thin reddish-brown "table tennis racquet"-shaped plaque on the right inframammary area...
July 2021: Indian Dermatology Online Journal
https://read.qxmd.com/read/33955307/bayesian-network-meta-analysis-of-the-efficacy-of-22-ventilation-strategies-in-premature-infants-with-respiratory-distress-syndrome
#5
JOURNAL ARTICLE
Yunyun Guo, Ling Fan
Introduction : Respiratory Distress Syndrome (RDS) is a common lung disease in the neonatal period. The infants are mostly premature, with a high mortality rate and many complications. Currently, respiratory support therapy is still one of the primary treatment measures for RDS in preterm infants. There are 22 modes of ventilation currently in use. Areas covered : We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, EMBASE, MEDLINE, CINAHL, and Web of Science by using a combination of Medical Subject Headings (MeSH) and text words...
September 2021: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/33802758/fractionation-of-heavy-metals-in-multi-contaminated-soil-treated-with-biochar-using-the-sequential-extraction-procedure
#6
JOURNAL ARTICLE
Mahrous Awad, Zhongzhen Liu, Milan Skalicky, Eldessoky S Dessoky, Marian Brestic, Sonia Mbarki, Anshu Rastogi, Ayman El Sabagh
Heavy metals (HMs) toxicity represents a global problem depending on the soil environment's geochemical forms. Biochar addition safely reduces HMs mobile forms, thus, reducing their toxicity to plants. While several studies have shown that biochar could significantly stabilize HMs in contaminated soils, the study of the relationship of soil properties to potential mechanisms still needs further clarification; hence the importance of assessing a naturally contaminated soil amended, in this case with Paulownia biochar (PB) and Bamboo biochar (BB) to fractionate Pb, Cd, Zn, and Cu using short sequential fractionation plans...
March 17, 2021: Biomolecules
https://read.qxmd.com/read/33630264/organic-acid-leaching-was-an-efficient-approach-for-detoxification-of-metal-containing-plant-incineration-ash
#7
JOURNAL ARTICLE
Ronghui Liu, Zhuang Tian, Haina Cheng, Hongbo Zhou, Yuguang Wang
Metal-containing plant incineration ash (MPIA), which was the by-product for metal extraction from soil by phytoextraction process, contains various kinds of heavy metal that have post potential risk to the environment. This study investigated the leaching efficiency and metal redistribution of MPIA using organic acid as leaching agents. The MPIA before and after leaching was characterized using the toxicity characteristic leaching procedure (TCPL) test, X-ray diffraction, scanning electronic microscopy, and Fourier transform infrared spectroscopy...
February 25, 2021: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30873538/gladiatox-global-assessment-of-dose-indicator-in-toxicology
#8
JOURNAL ARTICLE
Vincenzo Belcastro, Stephane Cano, Diego Marescotti, Stefano Acali, Ignacio Gonzalez-Suarez, Florian Martin, Filipe Bonjour, Nikolai V Ivanov, Manuel C Peitsch, Julia Hoeng
SUMMARY: GladiaTOX R package is an open-source, flexible solution to high-content screening data processing and reporting in biomedical research. GladiaTOX takes advantage of the "tcpl" core functionalities and provides a number of extensions: it provides a web-service solution to fetch raw data; it computes severity scores and exports ToxPi formatted files; furthermore it contains a suite of functionalities to generate pdf reports for quality control and data processing. AVAILABILITY AND IMPLEMENTATION: Software package written in R...
March 14, 2019: Bioinformatics
https://read.qxmd.com/read/30498283/differential-histopathological-assessment-of-testicular-function-upon-long-term-exposure-to-sustained-delivery-of-testosterone-and-dihydrotestosterone
#9
JOURNAL ARTICLE
Hamed Benghuzzi, Michelle Tucci, Adel Mohamed, Ibrahim Farah
The specific aim of this study was to assess, histopathologically, the seminiferous tubules area and germ layers upon the exposure to sustained delivery of testosterone (TE) and dihydrotestosterone (DHT) through tricalcium phosphate lysine devices (TCPL). A total of 140 adult Male rats (280-320 gm) were randomly divided into four equal groups. Groups 1 and 2 animals were implanted with TCPL loaded with 40 mg TE and 40 mg DHT, respectively. Groups 3 and 4 animals served as a sham group (empty devices), and a control group...
April 2018: Biomedical Sciences Instrumentation
https://read.qxmd.com/read/29747255/-endoscopic-screening-for-upper-gastrointestinal-second-primary-malignancies-in-patients-with-hypopharyngeal-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
J J Tian, W Xu, Z H Lyu, J K Ma, P Cui, N Sa, H Y Cao
Objective: To evaluate the usefullness of flexible esophagoscopy and chromoendoscopy with Lugol's solution in the detection of synchronous esophageal neoplasm in patients with hypopharyngeal squamous cell carcinoma (HSCC). Methods: A retrospective review of 96 cases with HSCC that received surgical treatment from March 2016 to March 2017 was accomplished. In these patients, the site of origin were pyriform sinus ( n =75), posterior pharyngeal wall ( n =11) and postcricoid ( n =10). Esophagoscopy was prospectively performed on all patients before treatment for HSCC...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://read.qxmd.com/read/29283032/integrated-bio-oxidation-and-adsorptive-filtration-reactor-for-removal-of-arsenic-from-wastewater
#11
JOURNAL ARTICLE
Kalyani Kamde, Rashmi Dahake, R A Pandey, Amit Bansiwal
Recently, removal of arsenic from different industrial effluent discharged using simple, efficient and low-cost technique has been widely considered. In this study, removal of arsenic (As) from real wastewater has been studied employing modified bio-oxidation followed by adsorptive filtration method in a novel continuous flow through the reactor. This method includes biological oxidation of ferrous to ferric ions by immobilized Acidothiobacillus ferrooxidans bacteria on granulated activated carbon (GAC) in fixed bed bio-column reactor with the adsorptive filtration unit...
January 8, 2018: Environmental Technology
https://read.qxmd.com/read/28654789/utilization-of-zn-containing-electric-arc-furnace-dust-for-multi-metal-doped-ferrite-with-enhanced-magnetic-property-from-hazardous-solid-waste-to-green-product
#12
JOURNAL ARTICLE
Hui-Gang Wang, Mei Zhang, Min Guo
One-step solid state reaction method was proposed for the first time to realize the transformation of the Zn-containing EAFD from hazardous solid waste to multi-metal doped ferrite with enhanced magnetic property. The effect of Zn-containing EAFD to NiCl2 ·6H2 O mass ratio (RZE/N , g·g-1 ) on the phases transformation was investigated by X-ray diffraction (XRD), Scanning electron microscopy (SEM) and Raman spectroscopy. The as-synthesized samples were treated by toxicity characteristic leaching procedure (TCLP)...
October 5, 2017: Journal of Hazardous Materials
https://read.qxmd.com/read/27797781/tcpl-the-toxcast-pipeline-for-high-throughput-screening-data
#13
JOURNAL ARTICLE
Dayne L Filer, Parth Kothiya, R Woodrow Setzer, Richard S Judson, Matthew T Martin
Motivation: Large high-throughput screening (HTS) efforts are widely used in drug development and chemical toxicity screening. Wide use and integration of these data can benefit from an efficient, transparent and reproducible data pipeline. Summary: The tcpl R package and its associated MySQL database provide a generalized platform for efficiently storing, normalizing and dose-response modeling of large high-throughput and high-content chemical screening data. The novel dose-response modeling algorithm has been tested against millions of diverse dose-response series, and robustly fits data with outliers and cytotoxicity-related signal loss...
February 15, 2017: Bioinformatics
https://read.qxmd.com/read/27595525/gastric-pull-up-reconstruction-after-treatment-for-advanced-hypopharyngeal-and-cervical-esophageal-cancer
#14
JOURNAL ARTICLE
Y Marion, G Lebreton, C Brévart, T Sarcher, A Alves, E Babin
OBJECTIVES: In advanced hypopharyngeal and cervical esophageal carcinoma, the choice of reconstruction technique after total circumferential pharyngolaryngectomy (TCPL) remains controversial. We studied results of digestive tract reconstruction using gastric pull-up, concomitant or secondary to TCPL or after failure of reconstruction. MATERIAL AND METHODS: Twenty-four patients treated by gastric pull-up after TCPL for advanced hypopharyngeal or cervical esophageal carcinoma between December 1998 and January 2011 were retrospectively reviewed...
December 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://read.qxmd.com/read/26004233/mitochondria-apoptosis-pathway-synergistically-activated-by-hierarchical-targeted-nanoparticles-co-delivering-sirna-and-lonidamine
#15
JOURNAL ARTICLE
Bing-Feng Zhang, Lei Xing, Peng-Fei Cui, Feng-Zhen Wang, Rong-Lin Xie, Jia-Liang Zhang, Mei Zhang, Yu-Jing He, Jin-Yuan Lyu, Jian-Bin Qiao, Bao-An Chen, Hu-Lin Jiang
The mitochondria-mediated apoptosis pathway is an effective option for cancer therapy due to the presence of cell-suicide weapons in mitochondria. However, anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as Bcl-2 protein, could allow the cancer cells to evade apoptosis, greatly reducing the efficacy of this type of chemotherapy. Here, we constructed a hierarchical targeted delivery system that can deliver siRNA and chemotherapeutic agents sequentially to tumor cells and mitochondria...
August 2015: Biomaterials
https://read.qxmd.com/read/25881121/mechanical-ventilation-modes-for-respiratory-distress-syndrome-in-infants-a-systematic-review-and-network-meta-analysis
#16
REVIEW
Changsong Wang, Libo Guo, Chunjie Chi, Xiaoyang Wang, Lei Guo, Weiwei Wang, Nana Zhao, Yibo Wang, Zhaodi Zhang, Enyou Li
INTRODUCTION: The effects of different mechanical ventilation (MV) modes on mortality outcome in infants with respiratory distress syndrome (RDS) are not well known. METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, EMBASE, MEDLINE, CINAHL, and Web of Science for studies published through April 2014 that assessed mortality in infants with RDS given different MV modes. We assessed studies for eligibility, extracted data, and subsequently pooled the data...
March 20, 2015: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/25405404/cholesterol-production-inhibitor-statin-increased-angiogenesis-in-surgically-created-femoral-defect-in-an-animal-model
#17
JOURNAL ARTICLE
Felix Adah, Hamed A Benghuzzi, Michelle A Tucci
This study investigated the effects of dual delivery of statin and vancomycin on angiogenesis during the healing process of a femoral defect injury using tricalcium phosphate lysine (TCPL) delivery system in an animal model. The experimental design consisted of 14 rats divided into the following three groups: Group I animals (n=5) served as the intact control without treatment. Group II animals (n=5) were subjected to a surgically induced defect (2 mm, midshaft of the right femur) and implanted (IM) with TCPL capsules loaded with vancomycin (20mg) (TCPL-AB)...
2014: Biomedical Sciences Instrumentation
https://read.qxmd.com/read/23686187/the-effects-of-sustained-delivery-of-corticosterone-on-the-adrenal-gland-of-male-and-female-rats-biomed-2013
#18
JOURNAL ARTICLE
Adel Mohamed, Gerri Wilson, Willaim Johnson, Michelle Tucci, Joseph A Cameron, Zelma Cason, Hamed Benghuzzi
Glucocorticoids have long been recognized to have beneficial effects in rheumatoid arthritis and asthma. Numerous clinical trials show the efficacy of short term low dose treatment to resolve inflammation. Despite the success of short term use, there is concern regarding chronic use of glucocorticoids because of the development of exogenous Cushing’s syndrome. Chronic variable stress models have detailed the effects of chronic stress exposure on body weight, plasma corticosteroid levels, ACTH levels, and adrenal weights, but limited studies detail the effects of the body systems induced by continuous exposure to glucocorticoids similar to that seen in exogenous Cushing’s syndrome...
2013: Biomedical Sciences Instrumentation
https://read.qxmd.com/read/21525619/evaluation-of-the-estrous-cycle-and-ovarian-function-following-sustained-delivery-of-corticosteroid-via-tcpl-delivery-biomed-2011
#19
JOURNAL ARTICLE
Hamed Benghuzzi, Zelma Cason, Michelle Tucci, Joseph A Cameron, Adel Mohamed
Stress has been shown to impair reproduction in many species and the hypothalamic pituitary axis (HPA) has been shown to be the target. Most of the literature evaluated the effects of acute stress and focused solely on the HPA. The literature is lacking in the area of chronic administration of corticosteroid use and effects on the estrous cycle and long term effects on the ovary. The objectives of this study were to use tricalcium phosphate drug delivery systems to deliver corticosterone in a sustained supraphysiological level and follow the estrous cycle over a 28 day period; then, harvest the ovaries to evaluate the morphology...
2011: Biomedical Sciences Instrumentation
https://read.qxmd.com/read/20467083/sustained-delivery-of-tobramycin-via-tcpl-delivery-system-to-effectively-treat-osteomyelitis-in-rats-biomed-2010
#20
JOURNAL ARTICLE
La'toya Ross Richards, Hamed Benghuzzi, Micehlle Tucci
Osteomyelitis is usually treated with systemic antibiotics for prolonged periods of time. These therapies are often unsuccessful with an increase in complication risk to the patient. The development of local antibiotic carriers which are mechanically stable, and can degrade slowly are needed clinically to treat the large number of cases of osteomyelitis seen in a hospital setting. Tricalcium phosphate has been shown to deliver effect concentrations of various agents in a sustained manner over prolonged periods of time both in vitro and in vivo...
2010: Biomedical Sciences Instrumentation
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