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Vincenzo Belcastro, Stephane Cano, Diego Marescotti, Stefano Acali, Ignacio Gonzalez-Suarez, Florian Martin, Filipe Bonjour, Nikolai V Ivanov, Manuel C Peitsch, Julia Hoeng
SUMMARY: GladiaTOX R package is an open-source, flexible solution to high-content screening data processing and reporting in biomedical research. GladiaTOX takes advantage of the "tcpl" core functionalities and provides a number of extensions: it provides a web-service solution to fetch raw data; it computes severity scores and exports ToxPi formatted files; furthermore it contains a suite of functionalities to generate pdf reports for quality control and data processing. AVAILABILITY AND IMPLEMENTATION: Software package written in R...
March 14, 2019: Bioinformatics
Hamed Benghuzzi, Michelle Tucci, Adel Mohamed, Ibrahim Farah
The specific aim of this study was to assess, histopathologically, the seminiferous tubules area and germ layers upon the exposure to sustained delivery of testosterone (TE) and dihydrotestosterone (DHT) through tricalcium phosphate lysine devices (TCPL). A total of 140 adult Male rats (280-320 gm) were randomly divided into four equal groups. Groups 1 and 2 animals were implanted with TCPL loaded with 40 mg TE and 40 mg DHT, respectively. Groups 3 and 4 animals served as a sham group (empty devices), and a control group...
April 2018: Biomedical Sciences Instrumentation
J J Tian, W Xu, Z H Lyu, J K Ma, P Cui, N Sa, H Y Cao
Objective: To evaluate the usefullness of flexible esophagoscopy and chromoendoscopy with Lugol's solution in the detection of synchronous esophageal neoplasm in patients with hypopharyngeal squamous cell carcinoma (HSCC). Methods: A retrospective review of 96 cases with HSCC that received surgical treatment from March 2016 to March 2017 was accomplished. In these patients, the site of origin were pyriform sinus ( n =75), posterior pharyngeal wall ( n =11) and postcricoid ( n =10). Esophagoscopy was prospectively performed on all patients before treatment for HSCC...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Kalyani Kamde, Rashmi Dahake, R A Pandey, Amit Bansiwal
Recently, removal of arsenic from different industrial effluent discharged using simple, efficient and low-cost technique has been widely considered. In this study, removal of arsenic (As) from real wastewater has been studied employing modified bio-oxidation followed by adsorptive filtration method in a novel continuous flow through the reactor. This method includes biological oxidation of ferrous to ferric ions by immobilized Acidothiobacillus ferrooxidans bacteria on granulated activated carbon (GAC) in fixed bed bio-column reactor with the adsorptive filtration unit...
January 8, 2018: Environmental Technology
Hui-Gang Wang, Mei Zhang, Min Guo
One-step solid state reaction method was proposed for the first time to realize the transformation of the Zn-containing EAFD from hazardous solid waste to multi-metal doped ferrite with enhanced magnetic property. The effect of Zn-containing EAFD to NiCl2 ·6H2 O mass ratio (RZE/N , g·g-1 ) on the phases transformation was investigated by X-ray diffraction (XRD), Scanning electron microscopy (SEM) and Raman spectroscopy. The as-synthesized samples were treated by toxicity characteristic leaching procedure (TCLP)...
October 5, 2017: Journal of Hazardous Materials
Dayne L Filer, Parth Kothiya, R Woodrow Setzer, Richard S Judson, Matthew T Martin
Motivation: Large high-throughput screening (HTS) efforts are widely used in drug development and chemical toxicity screening. Wide use and integration of these data can benefit from an efficient, transparent and reproducible data pipeline. Summary: The tcpl R package and its associated MySQL database provide a generalized platform for efficiently storing, normalizing and dose-response modeling of large high-throughput and high-content chemical screening data. The novel dose-response modeling algorithm has been tested against millions of diverse dose-response series, and robustly fits data with outliers and cytotoxicity-related signal loss...
February 15, 2017: Bioinformatics
Y Marion, G Lebreton, C Brévart, T Sarcher, A Alves, E Babin
OBJECTIVES: In advanced hypopharyngeal and cervical esophageal carcinoma, the choice of reconstruction technique after total circumferential pharyngolaryngectomy (TCPL) remains controversial. We studied results of digestive tract reconstruction using gastric pull-up, concomitant or secondary to TCPL or after failure of reconstruction. MATERIAL AND METHODS: Twenty-four patients treated by gastric pull-up after TCPL for advanced hypopharyngeal or cervical esophageal carcinoma between December 1998 and January 2011 were retrospectively reviewed...
December 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
Bing-Feng Zhang, Lei Xing, Peng-Fei Cui, Feng-Zhen Wang, Rong-Lin Xie, Jia-Liang Zhang, Mei Zhang, Yu-Jing He, Jin-Yuan Lyu, Jian-Bin Qiao, Bao-An Chen, Hu-Lin Jiang
The mitochondria-mediated apoptosis pathway is an effective option for cancer therapy due to the presence of cell-suicide weapons in mitochondria. However, anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as Bcl-2 protein, could allow the cancer cells to evade apoptosis, greatly reducing the efficacy of this type of chemotherapy. Here, we constructed a hierarchical targeted delivery system that can deliver siRNA and chemotherapeutic agents sequentially to tumor cells and mitochondria...
August 2015: Biomaterials
Changsong Wang, Libo Guo, Chunjie Chi, Xiaoyang Wang, Lei Guo, Weiwei Wang, Nana Zhao, Yibo Wang, Zhaodi Zhang, Enyou Li
INTRODUCTION: The effects of different mechanical ventilation (MV) modes on mortality outcome in infants with respiratory distress syndrome (RDS) are not well known. METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, EMBASE, MEDLINE, CINAHL, and Web of Science for studies published through April 2014 that assessed mortality in infants with RDS given different MV modes. We assessed studies for eligibility, extracted data, and subsequently pooled the data...
March 20, 2015: Critical Care: the Official Journal of the Critical Care Forum
Felix Adah, Hamed A Benghuzzi, Michelle A Tucci
This study investigated the effects of dual delivery of statin and vancomycin on angiogenesis during the healing process of a femoral defect injury using tricalcium phosphate lysine (TCPL) delivery system in an animal model. The experimental design consisted of 14 rats divided into the following three groups: Group I animals (n=5) served as the intact control without treatment. Group II animals (n=5) were subjected to a surgically induced defect (2 mm, midshaft of the right femur) and implanted (IM) with TCPL capsules loaded with vancomycin (20mg) (TCPL-AB)...
2014: Biomedical Sciences Instrumentation
Adel Mohamed, Gerri Wilson, Willaim Johnson, Michelle Tucci, Joseph A Cameron, Zelma Cason, Hamed Benghuzzi
Glucocorticoids have long been recognized to have beneficial effects in rheumatoid arthritis and asthma. Numerous clinical trials show the efficacy of short term low dose treatment to resolve inflammation. Despite the success of short term use, there is concern regarding chronic use of glucocorticoids because of the development of exogenous Cushing’s syndrome. Chronic variable stress models have detailed the effects of chronic stress exposure on body weight, plasma corticosteroid levels, ACTH levels, and adrenal weights, but limited studies detail the effects of the body systems induced by continuous exposure to glucocorticoids similar to that seen in exogenous Cushing’s syndrome...
2013: Biomedical Sciences Instrumentation
Hamed Benghuzzi, Zelma Cason, Michelle Tucci, Joseph A Cameron, Adel Mohamed
Stress has been shown to impair reproduction in many species and the hypothalamic pituitary axis (HPA) has been shown to be the target. Most of the literature evaluated the effects of acute stress and focused solely on the HPA. The literature is lacking in the area of chronic administration of corticosteroid use and effects on the estrous cycle and long term effects on the ovary. The objectives of this study were to use tricalcium phosphate drug delivery systems to deliver corticosterone in a sustained supraphysiological level and follow the estrous cycle over a 28 day period; then, harvest the ovaries to evaluate the morphology...
2011: Biomedical Sciences Instrumentation
La'toya Ross Richards, Hamed Benghuzzi, Micehlle Tucci
Osteomyelitis is usually treated with systemic antibiotics for prolonged periods of time. These therapies are often unsuccessful with an increase in complication risk to the patient. The development of local antibiotic carriers which are mechanically stable, and can degrade slowly are needed clinically to treat the large number of cases of osteomyelitis seen in a hospital setting. Tricalcium phosphate has been shown to deliver effect concentrations of various agents in a sustained manner over prolonged periods of time both in vitro and in vivo...
2010: Biomedical Sciences Instrumentation
Michelle Tucci, Richard Lancaster, Scott Wingerter, James Woodall, George Russell, Hamed Benghuzzi
Demineralized bone matrix (DBM) has been shown to have osteoinductive properties, and demonstrated accelerated rate of bone regeneration. However, prior studies using DBM in young rats have not been consistent with results witnessed in an older rat population. There were two aims of this study: (1) to compare segmental bone defect healing in old rats treated with DBM versus young rats treated with DBM over time, and (2) to compare the number of cell types present at the fracture site in young and old animals during fracture repair...
2009: Biomedical Sciences Instrumentation
Arun Aneja, Cindel Krantz, Michelle Tucci, Hamed A Benghuzzi
Osteoporosis is a disease characterized by structural deterioration of bone tissue, leading to fragile bone with an increased risk for fractures. Bone morphogenetic proteins (BMPs) are supplemental bone graft materials that have osteoconductive properties of serving as a scaffold for bone to grow on and osteoinductive capability of stimulating the patient's own stem cells and growth factors to grow new bone. Osteoblast cells in osteoporotic bone have the ability to produce BMPs and other factors needed for adequate bone formation when activated, demonstrating that there are factors that can serve as stimulus for fracture repair in osteoporosis...
2009: Biomedical Sciences Instrumentation
Ham Benghuzzi, Michelle Tucci
The goal of this study is to investigate the pathophysiological changes, of both local and systemic control factors (cytokines and structural alterations), associated with continuous and sustained delivery of T and DHT using tricalcium-phosphate-lysine (TCPL) delivery devices. A total of 32 adult male Sprague Dawley rats were equally divided into four equal groups. Animals in group 1 were left untreated and served as intact control. Animals in group 2 were implanted with an empty ("sham") drug delivery device, and animals in groups 3 and 4 were implanted with a drug delivery carrier containing either DHT or T, respectively...
2008: Biomedical Sciences Instrumentation
Tyler Marks, Scott Wingerter, Laura Franklin, James Woodall, Michelle Tucci, George Russell, Ramesh Patel, Hamed Benghuzzi
Demineralized bone matrix (DBM) has been shown to possess osteoinductive capability and one of the specific bone morphogenetic proteins (BMPs) found within DBM that has been attributed with this osteoinductive ability is BMP-7, also known as osteogenic protein-1 (OP-1). The specific aims of this study were (1) to compare the treatment of segmental bone defects with OP-l and DBM in a rat femur model and (2) to determine the effects of the two treatments given at high and low doses via sustained release drug delivery...
2007: Biomedical Sciences Instrumentation
Scott Wingerter, Michelle Tucci, Joel Bumgardner, Ham Benghuzzi
The bone morphogenetic proteins (BMPs) carry a crucial role in bone formation and bone healing. Previous studies have identified the osteoinductive capabilities of demineralized bone matrix (DBM) and the individual factor osteogenic protein-1 (OP-1), also known as BMP-7. The purpose of this study is to identify the short-term healing effects of targeted drug delivery of demineralized bone matrix and osteogenic protein-1 following bony trauma in terms of mechanical strength and histological changes. Animals in Group 1 acted as the control and Group 2 received a unicortical drill defect and placement of a calcined tricalcium phosphate lysine (TCPL) capsule containing antibiotic (sham)...
2007: Biomedical Sciences Instrumentation
Felix Adah, Hamed Benghuzzi, Michelle Tucci, George Russell, Barry England
This study investigated the effects of dual delivery of statin and vancomycin on the healing process of a femoral defect injury using tricalcium phosphate lysine (TCPL) delivery system in an animal model. The experimental design consisted of 14 rats divided into the following three groups: Group I animals (n=5) served as the intact control without treatment. Group II animals (n=5) were subjected to a surgically induced defect (2 mm, midshaft of the right femur) and implanted (IM) with TCPL capsules loaded with vancomycin (20mg) (TCPL-AB)...
2007: Biomedical Sciences Instrumentation
Jaideep Singh, Sunil K Sinha, Paul Clarke, Steve Byrne, Steven M Donn
OBJECTIVE: To compare the efficacy and safety of volume-controlled (VC) ventilation to time-cycled pressure-limited (TCPL) ventilation in very low birth weight infants with respiratory distress syndrome (RDS). STUDY DESIGN: Newborns weighing between 600 and 1500 g and with a gestational age of 24 to 31 weeks who had RDS were randomized to receive either VC or TCPL ventilation and treated with a standardized protocol. The 2 modalities were compared by determining the time required to achieve a predetermined success criterion, on the basis of either the alveolar-arterial oxygen gradient <100 mm Hg or the mean airway pressure <8 cm H(2)O...
September 2006: Journal of Pediatrics
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