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Peter O’Sullivan

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https://read.qxmd.com/read/30738173/activating-mutations-in-pik3cd-disrupt-the-differentiation-and-function-of-human-and-murine-cd4-t-cells
#1
Julia Bier, Geetha Rao, Kathryn Payne, Henry Brigden, Elise French, Simon J Pelham, Anthony Lau, Helen Lenthall, Emily S J Edwards, Joanne M Smart, Theresa S Cole, Sharon Choo, Avni Y Joshi, Roshini S Abraham, Michael O'Sullivan, Kaan Boztug, Isabelle Meyts, Paul E Gray, Lucinda J Berglund, Peter Hsu, Melanie Wong, Steven M Holland, Luigi D Notarangelo, Gulbu Uzel, Cindy S Ma, Robert Brink, Stuart G Tangye, Elissa K Deenick
BACKGROUND: Gain of function (GOF) mutations in PIK3CD cause a primary immunodeficiency characterized by recurrent respiratory tract infections, susceptibility to herpes virus infections and impaired antibody responses. Previous work revealed defects in CD8+ T and B cells that contribute to this clinical phenotype but less is understood about the role of CD4+ T cells in disease pathogenesis. OBJECTIVE: To dissect the effects of increased phosphoinositide-3 kinase (PI3K) signaling on CD4+ T cell function...
February 6, 2019: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/30737200/education-can-change-the-world-can-clinical-education-change-the-trajectory-of-individuals-with-back-pain
#2
EDITORIAL
Mary O'Keeffe, Peter B O'Sullivan, Kieran O'Sullivan
No abstract text is available yet for this article.
February 8, 2019: British Journal of Sports Medicine
https://read.qxmd.com/read/30710451/an-irish-national-diabetes-in-pregnancy-audit-aiming-for-best-outcomes-for-women-with-diabetes
#3
A M Egan, M J Brassill, E Brosnan, L Carmody, H Clarke, C Coogan Kelly, L Culliney, M Durkan, M Fenlon, P Ferry, G Hanlon, T Higgins, S Hoashi, A Khamis, B Kinsley, T Kinsley, B Kirwan, A Liew, C McGurk, C McHugh, M S Murphy, P Murphy, D O'Halloran, L O'Mahony, E O'Sullivan, M Nolan, M Peter, G Roberts, A Smyth, M Todd, A Tuthill, W A Wan Mahmood, O Yousif, F P Dunne
AIMS: The purpose of this study was to identify the number of pregnancies affected by pre-gestational diabetes in the Republic of Ireland; to report on pregnancy outcomes and to identify areas for improvement in care delivery and clinical outcomes. METHODS: Healthcare professionals caring for women with pre-gestational diabetes during pregnancy were invited to participate in this retrospective study. Data pertaining to 185 pregnancies in women attending 15 antenatal centres nationally were collected and analysed...
February 2, 2019: Diabetic Medicine: a Journal of the British Diabetic Association
https://read.qxmd.com/read/30699874/depression-symptomatology-correlates-with-event-related-potentials-in-parkinson-s-disease-an-affective-priming-study
#4
Nadeeka N W Dissanayaka, Tiffany R Au, Anthony J Angwin, Kartik K Iyer, John D O'Sullivan, Gerard J Byrne, Peter A Silburn, Rodney Marsh, George D Mellick, David A Copland
BACKGROUND: Depression is a predominant non-motor symptom of Parkinson's disease (PD), which is often under recognised and undertreated. To improve identification of depression in PD it is imperative to examine objective brain-related markers. The present study addresses this gap by using electroencephalography (EEG) to evaluate the processing of emotionally valanced words in PD. METHODS: Fifty non-demented PD patients, unmedicated for depression or anxiety, completed an affective priming task while EEG was simultaneously recorded...
February 15, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30582876/start-back-tool-risk-stratification-is-associated-with-changes-in-movement-profile-and-sensory-discrimination-in-low-back-pain-a-study-of-290-patients
#5
Martin Rabey, Michelle Kendell, Chris Godden, Jermaine Liburd, Hayley Netley, Ciaran O'Shaughnessy, Peter O'Sullivan, Anne Smith, Darren Beales
BACKGROUND: Investigation of movement and sensory profiles across STarT Back risk subgroups. METHODS: A chronic low back pain cohort (n = 290) were classified as low, medium or high risk using the STarT Back Tool, and completed a repeated spinal bending task and quantitative sensory testing. Pain summation, time taken and the number of protective behaviours with repeated bending were measured. Sensory tests included two-point discrimination, temporal summation, pressure/thermal pain thresholds and conditioned pain modulation...
December 24, 2018: European Journal of Pain: EJP
https://read.qxmd.com/read/30553986/physiotherapists-implicitly-evaluate-bending-and-lifting-with-a-round-back-as-dangerous
#6
J P Caneiro, Peter O'Sullivan, Anne Smith, Ingrid Rask Ovrebekk, Luke Tozer, Michael Williams, Magdalene Li Wen Teng, Ottmar V Lipp
BACKGROUND: Beliefs can be assessed using explicit measures (e.g. questionnaires) that rely on information of which the person is 'aware' and willing to disclose. Conversely, implicit measures evaluate beliefs using computer-based tasks that allow reduced time for introspection thus reflecting 'automatic' associations. Thus far, physiotherapists' beliefs about back posture and safety have not been evaluated with implicit measures. OBJECTIVES: (1) Evaluate implicit associations between bending lifting back posture (straight-back vs round-back) and safety (safe vs danger); (2) Explore correlations between implicit and explicit measures of beliefs towards vulnerability of the back...
December 8, 2018: Musculoskeletal Science & Practice
https://read.qxmd.com/read/30553985/how-do-manual-handling-advisors-and-physiotherapists-construct-their-back-beliefs-and-do-safe-lifting-posture-beliefs-influence-them
#7
David Nolan, Kieran O'Sullivan, John Stephenson, Peter O'Sullivan, Michael Lucock
BACKGROUND: The Back-Pain Attitudes (Back-PAQ) questionnaire measures back beliefs across 6 domains. Our previous study showed that manual handling advisors (MHAs) have more negative beliefs than physiotherapists (PTs), and those who think straight back lifting is safer than a rounder back have more negative beliefs. However, exactly which domains of the Back-PAQ are most negative is unknown. OBJECTIVES: Gain deeper understanding of how MHAs and PTs construct their back beliefs, and relate this safe lifting posture beliefs...
December 1, 2018: Musculoskeletal Science & Practice
https://read.qxmd.com/read/30523111/a-mechanistic-classification-of-clinical-phenotypes-in-neuroblastoma
#8
Sandra Ackermann, Maria Cartolano, Barbara Hero, Anne Welte, Yvonne Kahlert, Andrea Roderwieser, Christoph Bartenhagen, Esther Walter, Judith Gecht, Laura Kerschke, Ruth Volland, Roopika Menon, Johannes M Heuckmann, Moritz Gartlgruber, Sabine Hartlieb, Kai-Oliver Henrich, Konstantin Okonechnikov, Janine Altmüller, Peter Nürnberg, Steve Lefever, Bram de Wilde, Frederik Sand, Fakhera Ikram, Carolina Rosswog, Janina Fischer, Jessica Theissen, Falk Hertwig, Aatur D Singhi, Thorsten Simon, Wenzel Vogel, Sven Perner, Barbara Krug, Matthias Schmidt, Sven Rahmann, Viktor Achter, Ulrich Lang, Christian Vokuhl, Monika Ortmann, Reinhard Büttner, Angelika Eggert, Frank Speleman, Roderick J O'Sullivan, Roman K Thomas, Frank Berthold, Jo Vandesompele, Alexander Schramm, Frank Westermann, Johannes H Schulte, Martin Peifer, Matthias Fischer
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse...
December 7, 2018: Science
https://read.qxmd.com/read/30469124/physiotherapist-perceptions-of-optimal-sitting-and-standing-posture
#9
Vasileios Korakakis, Kieran O'Sullivan, Peter B O'Sullivan, Vasiliki Evagelinou, Yiannis Sotiralis, Alexandros Sideris, Konstantinos Sakellariou, Stefanos Karanasios, Giannis Giakas
BACKGROUND: Assessment of, and advice about, spinal posture is common when people with spinal pain present to physiotherapists. Most descriptions regarding optimal spinal posture have been qualitative in nature. OBJECTIVES: To determine the beliefs of physiotherapists regarding optimal sitting and standing posture. DESIGN: Online survey. METHOD: 544 Greek physiotherapists selected an optimal sitting (choice of seven) and standing (choice of five) posture, while providing justification for their choice...
November 17, 2018: Musculoskeletal Science & Practice
https://read.qxmd.com/read/30468555/the-perspectives-of-physiotherapists-on-managing-nonspecific-low-back-pain-following-a-training-programme-in-cognitive-functional-therapy-a-qualitative-study
#10
Ian Cowell, Peter O'Sullivan, Kieran O'Sullivan, Ross Poyton, Alison McGregor, Ged Murtagh
BACKGROUND: It has long been acknowledged that nonspecific chronic low back pain (NSCLBP) is associated with a complex combination of biopsychosocial (BPS) factors, and recent guidelines advocate that the management of back pain should reflect this multidimensional complexity. Cognitive functional therapy (CFT) is a behaviourally oriented intervention that targets patients' individual BPS profiles. Although the efficacy of CFT has been demonstrated in primary care, little evidence exists about the training requirements of this approach...
November 23, 2018: Musculoskeletal Care
https://read.qxmd.com/read/30458741/borderline-grades-in-high-stakes-clinical-examinations-resolving-examiner-uncertainty
#11
Boaz Shulruf, Barbara-Ann Adelstein, Arvin Damodaran, Peter Harris, Sean Kennedy, Anthony O'Sullivan, Silas Taylor
BACKGROUND: Objective Structured Clinical Exams are used to increase reliability and validity, yet they only achieve a modest level of reliability. This low reliability is due in part to examiner variance which is greater than the variance of students. This variance often represents indecisiveness at the cut score with apparent confusion over terms such as "borderline pass". It is amplified by a well reported failure to fail. METHODS: A borderline grade (meaning performance is neither a clear pass nor a clear fail) was introduced in a high stakes undergraduate medical clinical skills exam to replace a borderline pass grade (which was historically resolved as 50%) in a 4 point scale (distinction, pass, borderline, fail)...
November 20, 2018: BMC Medical Education
https://read.qxmd.com/read/30423526/perceptions-of-physiotherapists-towards-the-management-of-non-specific-chronic-low-back-pain-from-a-biopsychosocial-perspective-a-qualitative-study
#12
Ian Cowell, Peter O'Sullivan, Kieran O'Sullivan, Ross Poyton, Alison McGregor, Ged Murtagh
BACKGROUND: Physiotherapists have been urged to embrace a patient-oriented biopsychosocial (BPS) framework for the management of non-specific chronic low back pain (NSCLBP). However, recent evidence suggests that providing broader BPS interventions demonstrates small differences in pain or disability compared to usual care. Little is known about how to integrate a BPS model into physiotherapy practice and the challenges it presents. OBJECTIVE: To explore the perceptions of physiotherapists' in primary care in England adopting a BPS approach to managing NSCLBP patients...
December 2018: Musculoskeletal Science & Practice
https://read.qxmd.com/read/30338678/tissue-oxygen-saturation-predicts-response-to-breast-cancer-neoadjuvant-chemotherapy-within-10-days-of-treatment
#13
Jeffrey M Cochran, David R Busch, Anaïs Leproux, Zheng Zhang, Thomas D O'Sullivan, Albert E Cerussi, Philip M Carpenter, Rita S Mehta, Darren Roblyer, Wei Yang, Keith D Paulsen, Brian Pogue, Shudong Jiang, Peter A Kaufman, So Hyun Chung, Mitchell Schnall, Bradley S Snyder, Nola Hylton, Stefan A Carp, Steven J Isakoff, David Mankoff, Bruce J Tromberg, Arjun G Yodh
Ideally, neoadjuvant chemotherapy (NAC) assessment should predict pathologic complete response (pCR), a surrogate clinical endpoint for 5-year survival, as early as possible during typical 3- to 6-month breast cancer treatments. We introduce and demonstrate an approach for predicting pCR within 10 days of initiating NAC. The method uses a bedside diffuse optical spectroscopic imaging (DOSI) technology and logistic regression modeling. Tumor and normal tissue physiological properties were measured longitudinally throughout the course of NAC in 33 patients enrolled in the American College of Radiology Imaging Network multicenter breast cancer DOSI trial (ACRIN-6691)...
October 2018: Journal of Biomedical Optics
https://read.qxmd.com/read/30307900/correlations-between-the-active-straight-leg-raise-sleep-and-somatosensory-sensitivity-during-pregnancy-with-post-partum-lumbopelvic-pain-an-initial-exploration
#14
Darren John Beales, Odette Gaynor, Jasmine Harris, Robyn Fary, Peter Bruce O'Sullivan, Helen Slater, Thomas Graven-Nielsen, Thorvaldur Skuli Palsson
Background and aims For some women, lumbopelvic pain (LPP) developed during pregnancy becomes a continuing post-partum problem. Increased understanding of potential prognostic factors is required. This study investigated whether active straight leg raise (ASLR), sleep dysfunction and pressure pain sensitivity during pregnancy are correlated with LPP intensity and quality, disability, and physical health-related quality of life (HRQoL) post-partum. Methods An exploratory, prospective cohort study design was used...
October 11, 2018: Scandinavian Journal of Pain
https://read.qxmd.com/read/30303869/osteosarcoma-in-a-child-below-2-years-of-age-case-report-and-review-of-the-literature
#15
Edward M Pascoe, Matthew Free, Peter S Mackie, Leo Donnan, Mark O'Sullivan, Michael J Sullivan, John A Heath
BACKGROUND: Osteosarcoma in children below the age of 5 is extremely rare. OBSERVATION: We report on a previously well 14-month-old male infant, who presented with a reluctance to weight-bear on his right leg and had an associated limp. Plain imaging and a magnetic resonance imaging scan demonstrated a lytic lesion in the right distal femur. An open surgical biopsy confirmed the diagnosis of osteosarcoma. There was no significant family history of cancer and genetic screening for Li-Fraumeni syndrome was negative...
October 9, 2018: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/30232062/advice-to-athletes-with-back-pain-get-active-seriously
#16
EDITORIAL
Kieran O'Sullivan, Peter B O'Sullivan, Tim J Gabbett, Mary O'Keeffe
No abstract text is available yet for this article.
September 19, 2018: British Journal of Sports Medicine
https://read.qxmd.com/read/30211709/associations-between-musculoskeletal-pain-experience-and-pressure-and-cold-pain-sensitivity-a-community-based-cross-sectional-study-of-young-adults-in-the-raine-study
#17
Robert Waller, Anne J Smith, Peter B O'Sullivan, Helen Slater, Michele Sterling, Leon M Straker
OBJECTIVES: To investigate the cross-sectional associations between musculoskeletal pain experience and measures of pressure and cold pain sensitivity in young adults from the Western Australian Pregnancy Cohort (Raine) Study. PARTICIPANTS AND METHODS: In total, 917 participants were eligible for analysis if they provided data pertaining to musculoskeletal pain status at the 22-year follow-up and had data for at least 1 valid pain sensitivity test. Standardized protocols were used to assess pressure pain threshold (4 sites: lumbar spine, tibialis anterior, upper trapezius, and wrist) and cold pain threshold (wrist)...
January 2019: Clinical Journal of Pain
https://read.qxmd.com/read/30198186/anaphylaxis-caused-by-alginate-dressing
#18
Siobhan McCarthy, Veronika Dvorakova, Peter O'Sullivan, John F Bourke
No abstract text is available yet for this article.
September 10, 2018: Contact Dermatitis
https://read.qxmd.com/read/30179945/are-psychologic-factors-associated-with-shoulder-scores-after-rotator-cuff-surgery
#19
Alison M Thorpe, Peter B O'Sullivan, Tim Mitchell, Mark Hurworth, Jonathan Spencer, Grant Booth, Sven Goebel, Paul Khoo, Aaron Tay, Anne Smith
BACKGROUND: Psychologic factors are associated with pain and disability in patients with chronic shoulder pain. Recent research regarding the association of affective psychologic factors (emotions) with patients' pain and disability outcome after surgery disagrees; and the relationship between cognitive psychologic factors (thoughts and beliefs) and outcome after surgery is unknown. QUESTIONS/PURPOSES: (1) Are there identifiable clusters (based on psychologic functioning measures) in patients undergoing shoulder surgery? (2) Is poorer psychologic functioning associated with worse outcome (American Shoulder and Elbow Surgeons [ASES] score) after shoulder surgery? METHODS: This prospective cohort study investigated patients undergoing shoulder surgery for rotator cuff-related shoulder pain or rotator cuff tear by one of six surgeons between January 2014 and July 2015...
October 2018: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/30170998/the-lancet-series-on-low-back-pain-reflections-and-clinical-implications
#20
EDITORIAL
Kieran O'Sullivan, Peter B O'Sullivan, Mary O'Keeffe
No abstract text is available yet for this article.
August 31, 2018: British Journal of Sports Medicine
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