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Christopher Littlewood

Sean A Locke, Alex Van Dam, Monica Caffara, Hudson Alves Pinto, Danimar López-Hernández, Christopher A Blanar
Higher systematics within the Digenea, Carus 1863 have been relatively stable since a phylogenetic analysis of partial nuclear ribosomal markers (rDNA) led to the erection of the Diplostomida Olson, Cribb, Tkach, Bray, and Littlewood, 2003. However, recent mitochondrial (mt) genome phylogenies suggest this order might be paraphyletic. These analyses show members of two diplostomidan superfamilies are more closely related to the Plagiorchiida La Rue, 1957 than to other members of the Diplostomida. A recent phylogeny based on partial cytochrome c oxidase I also indicates one of the groups implicated, the Diplostomoidea Poirier, 1886, is non-monophyletic...
October 19, 2018: International Journal for Parasitology
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Zécri, Ross S Strang, Nadege Graveleau, Romain M Wolf, Nigel G Cooke, Alexander B Smith, Gregory J Hollingworth, Joachim Blanz, Sascha Gutmann, Gabriele Rummel, Amanda Littlewood-Evans, Christoph Burkhart
The predominant expression of phosphoinositide 3-kinase δ (PI3Kδ) in leukocytes and its critical role in B and T cell functions led to the hypothesis that selective inhibitors of this isoform would have potential as therapeutics for the treatment of allergic and inflammatory disease. Targeting specifically PI3Kδ should avoid potential side effects associated with the ubiquitously expressed PI3Kα and β isoforms. We disclose how morphing the heterocyclic core of previously discovered 4,6-diaryl quinazolines to a significantly less lipophilic 5,6,7,8-tetrahydropyrido[4,3- d ]pyrimidine, followed by replacement of one of the phenyl groups with a pyrrolidine-3-amine, led to a compound series with an optimal on-target profile and good ADME properties...
September 14, 2017: ACS Medicinal Chemistry Letters
Toby A Eyre, Ruth Clifford, Adrian Bloor, Lucy Boyle, Corran Roberts, Maite Cabes, Graham P Collins, Stephen Devereux, George Follows, Christopher P Fox, John Gribben, Peter Hillmen, Chris S Hatton, Tim J Littlewood, Helen McCarthy, Jim Murray, Andrew R Pettitt, Elizabeth Soilleux, Basile Stamatopoulos, Sharon B Love, Andrew Wotherspoon, Anna Schuh
Richter syndrome (RS) is associated with chemotherapy resistance and a poor historical median overall survival (OS) of 8-10 months. We conducted a phase II trial of standard CHOP-21 (cyclophosphamide, doxorubicin, vincristine, prednisolone every 21 d) with ofatumumab induction (Cycle 1: 300 mg day 1, 1000 mg day 8, 1000 mg day 15; Cycles 2-6: 1000 mg day 1) (CHOP-O) followed by 12 months ofatumumab maintenance (1000 mg given 8-weekly for up to six cycles). Forty-three patients were recruited of whom 37 were evaluable...
October 2016: British Journal of Haematology
S Dein, S Dein, R Littlewood, Y Oloyede, I B Krause, N Argenti
Millennialism and violence Michael Barkun (Ed.) London, Frank Cass, 1996, 177 pp. Evil and suffering in Jewish philosophy Oliver Leaman Cambridge, Cambridge University Press, 1995, 157 pp. Religion and the clinical practice of psychology Edward P. Shafranski (ed.) Washington DC, American Psychological Association, 1996, 619 pp., index, bibliographies, figures. Beyond reason: art and psychosis: works from the Prinzhorn Collection London, Hayward Gallery, 1997, £12.95, 195 pp., index, bibliography Madness and art: the life and works of Adolf Wölfli Walter Morgenthaler Lincoln, University of Nebraska Press, 1992, $35...
April 1998: Anthropology & Medicine
Christopher J Hawkey, Matthieu Allez, Miranda M Clark, Myriam Labopin, James O Lindsay, Elena Ricart, Gerhard Rogler, Montserrat Rovira, Jack Satsangi, Silvio Danese, Nigel Russell, John Gribben, Peter Johnson, Jerome Larghero, Catherine Thieblemont, Sandro Ardizzone, Daan Dierickx, Adalberto Ibatici, Timothy Littlewood, Francesco Onida, Urs Schanz, Severine Vermeire, Jean-Frederic Colombel, Jean-Paul Jouet, Elizabeth Clark, Riccardo Saccardi, Alan Tyndall, Simon Travis, Dominique Farge
IMPORTANCE: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. OBJECTIVE: To evaluate the effect of autologous HSCT on refractory Crohn disease. DESIGN, SETTING, AND PARTICIPANTS: Parallel-group randomized clinical trial conducted in 11 European transplant units from July 2007 to September 2011, with follow-up through March 2013. Patients were aged 18 to 50 years with impaired quality of life from refractory Crohn disease not amenable to surgery despite treatment with 3 or more immunosuppressive or biologic agents and corticosteroids...
December 15, 2015: JAMA: the Journal of the American Medical Association
Mario J N M Ouwens, Kavi J Littlewood, Christophe Sauboin, Bertrand Téhard, François Denis, Pierre-Yves Boëlle, Sophie Alain
PURPOSE: Varicella has a high incidence affecting the vast majority of the population in France and can lead to severe complications. Almost every individual infected by varicella becomes susceptible to herpes zoster later in life due to reactivation of the latent virus. Zoster is characterized by pain that can be long-lasting in some cases and has no satisfactory treatment. Routine varicella vaccination can prevent varicella. The vaccination strategy of replacing both doses of measles, mumps, and rubella (MMR) with a combined MMR and varicella (MMRV) vaccine is a means of reaching high vaccination coverage for varicella immunization...
April 1, 2015: Clinical Therapeutics
Kavi J Littlewood, Mario J N M Ouwens, Christophe Sauboin, Bertrand Tehard, Sophie Alain, François Denis
PURPOSE: Each year in France, varicella and zoster affect large numbers of children and adults, resulting in medical visits, hospitalizations for varicella- and zoster-related complications, and societal costs. Disease prevention by varicella vaccination is feasible, wherein a plausible option involves replacing the combined measles, mumps, and rubella (MMR) vaccine with the combined MMR and varicella (MMRV) vaccine. This study aimed to: (1) assess the cost-effectiveness of adding routine varicella vaccination through MMRV, using different vaccination strategies in France; and (2) address key uncertainties, such as the economic consequences of breakthrough varicella cases, the waning of vaccine-conferred protection, vaccination coverage, and indirect costs...
April 1, 2015: Clinical Therapeutics
Lawrence N Hudson, Tim Newbold, Sara Contu, Samantha L L Hill, Igor Lysenko, Adriana De Palma, Helen R P Phillips, Rebecca A Senior, Dominic J Bennett, Hollie Booth, Argyrios Choimes, David L P Correia, Julie Day, Susy Echeverría-Londoño, Morgan Garon, Michelle L K Harrison, Daniel J Ingram, Martin Jung, Victoria Kemp, Lucinda Kirkpatrick, Callum D Martin, Yuan Pan, Hannah J White, Job Aben, Stefan Abrahamczyk, Gilbert B Adum, Virginia Aguilar-Barquero, Marcelo A Aizen, Marc Ancrenaz, Enrique Arbeláez-Cortés, Inge Armbrecht, Badrul Azhar, Adrián B Azpiroz, Lander Baeten, András Báldi, John E Banks, Jos Barlow, Péter Batáry, Adam J Bates, Erin M Bayne, Pedro Beja, Åke Berg, Nicholas J Berry, Jake E Bicknell, Jochen H Bihn, Katrin Böhning-Gaese, Teun Boekhout, Céline Boutin, Jérémy Bouyer, Francis Q Brearley, Isabel Brito, Jörg Brunet, Grzegorz Buczkowski, Erika Buscardo, Jimmy Cabra-García, María Calviño-Cancela, Sydney A Cameron, Eliana M Cancello, Tiago F Carrijo, Anelena L Carvalho, Helena Castro, Alejandro A Castro-Luna, Rolando Cerda, Alexis Cerezo, Matthieu Chauvat, Frank M Clarke, Daniel F R Cleary, Stuart P Connop, Biagio D'Aniello, Pedro Giovâni da Silva, Ben Darvill, Jens Dauber, Alain Dejean, Tim Diekötter, Yamileth Dominguez-Haydar, Carsten F Dormann, Bertrand Dumont, Simon G Dures, Mats Dynesius, Lars Edenius, Zoltán Elek, Martin H Entling, Nina Farwig, Tom M Fayle, Antonio Felicioli, Annika M Felton, Gentile F Ficetola, Bruno K C Filgueiras, Steven J Fonte, Lauchlan H Fraser, Daisuke Fukuda, Dario Furlani, Jörg U Ganzhorn, Jenni G Garden, Carla Gheler-Costa, Paolo Giordani, Simonetta Giordano, Marco S Gottschalk, Dave Goulson, Aaron D Gove, James Grogan, Mick E Hanley, Thor Hanson, Nor R Hashim, Joseph E Hawes, Christian Hébert, Alvin J Helden, John-André Henden, Lionel Hernández, Felix Herzog, Diego Higuera-Diaz, Branko Hilje, Finbarr G Horgan, Roland Horváth, Kristoffer Hylander, Paola Isaacs-Cubides, Masahiro Ishitani, Carmen T Jacobs, Víctor J Jaramillo, Birgit Jauker, Mats Jonsell, Thomas S Jung, Vena Kapoor, Vassiliki Kati, Eric Katovai, Michael Kessler, Eva Knop, Annette Kolb, Ádám Kőrösi, Thibault Lachat, Victoria Lantschner, Violette Le Féon, Gretchen LeBuhn, Jean-Philippe Légaré, Susan G Letcher, Nick A Littlewood, Carlos A López-Quintero, Mounir Louhaichi, Gabor L Lövei, Manuel Esteban Lucas-Borja, Victor H Luja, Kaoru Maeto, Tibor Magura, Neil Aldrin Mallari, Erika Marin-Spiotta, E J P Marshall, Eliana Martínez, Margaret M Mayfield, Grzegorz Mikusinski, Jeffrey C Milder, James R Miller, Carolina L Morales, Mary N Muchane, Muchai Muchane, Robin Naidoo, Akihiro Nakamura, Shoji Naoe, Guiomar Nates-Parra, Dario A Navarrete Gutierrez, Eike L Neuschulz, Norbertas Noreika, Olivia Norfolk, Jorge Ari Noriega, Nicole M Nöske, Niall O'Dea, William Oduro, Caleb Ofori-Boateng, Chris O Oke, Lynne M Osgathorpe, Juan Paritsis, Alejandro Parra-H, Nicolás Pelegrin, Carlos A Peres, Anna S Persson, Theodora Petanidou, Ben Phalan, T Keith Philips, Katja Poveda, Eileen F Power, Steven J Presley, Vânia Proença, Marino Quaranta, Carolina Quintero, Nicola A Redpath-Downing, J Leighton Reid, Yana T Reis, Danilo B Ribeiro, Barbara A Richardson, Michael J Richardson, Carolina A Robles, Jörg Römbke, Luz Piedad Romero-Duque, Loreta Rosselli, Stephen J Rossiter, T'ai H Roulston, Laurent Rousseau, Jonathan P Sadler, Szabolcs Sáfián, Romeo A Saldaña-Vázquez, Ulrika Samnegård, Christof Schüepp, Oliver Schweiger, Jodi L Sedlock, Ghazala Shahabuddin, Douglas Sheil, Fernando A B Silva, Eleanor M Slade, Allan H Smith-Pardo, Navjot S Sodhi, Eduardo J Somarriba, Ramón A Sosa, Jane C Stout, Matthew J Struebig, Yik-Hei Sung, Caragh G Threlfall, Rebecca Tonietto, Béla Tóthmérész, Teja Tscharntke, Edgar C Turner, Jason M Tylianakis, Adam J Vanbergen, Kiril Vassilev, Hans A F Verboven, Carlos H Vergara, Pablo M Vergara, Jort Verhulst, Tony R Walker, Yanping Wang, James I Watling, Konstans Wells, Christopher D Williams, Michael R Willig, John C Z Woinarski, Jan H D Wolf, Ben A Woodcock, Douglas W Yu, Andrey S Zaitsev, Ben Collen, Rob M Ewers, Georgina M Mace, Drew W Purves, Jörn P W Scharlemann, Andy Purvis
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines...
December 2014: Ecology and Evolution
Keith E Littlewood, Ashley M Shilling, Christopher J Stemland, Elisabeth B Wright, Mark A Kirk
BACKGROUND: Case-based discussion (CBD) is an established method for active learning in medical education. High-fidelity simulation has emerged as an important new educational technology. There is limited data from direct comparisons of these modalities. AIMS: The primary purpose of this study was to compare the effectiveness of high-fidelity medical simulation with CBD in an undergraduate medical curriculum for shock. METHODS: The subjects were 85 third-year medical students in their required surgery rotation...
2013: Medical Teacher
Ruth E Curran, Christopher R J Claxton, Laura Hutchison, Paul J Harradine, Iain J Martin, Peter Littlewood
Past publications have highlighted the influence of postdialysis plasma pH on the measured fraction unbound in plasma (fup). There is disparity in the industry as to which of two main methods is more suitable for controlling postdialysis plasma pH: the use of either a stronger buffer or a CO(2) atmosphere for the incubation. In the current study, it has been found that 10% CO(2) could be too high for the buffering capacities of both 100 mM sodium phosphate (pH 7.40 decreased to pH 6.90 after a 6-h incubation) and plasma (decreased below pH 7...
March 2011: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Magdalena Koziczak-Holbro, Amanda Littlewood-Evans, Bernadette Pöllinger, Jiri Kovarik, Janet Dawson, Gerhard Zenke, Christoph Burkhart, Matthias Müller, Hermann Gram
OBJECTIVE: We have previously reported that the kinase activity of interleukin-1 receptor-associated kinase 4 (IRAK-4) is important for Toll-like receptor and interleukin-1 receptor signaling in vitro. Using mice devoid of IRAK-4 kinase activity (IRAK-4 KD mice), we undertook this study to determine the importance of IRAK-4 kinase function in complex disease models of joint inflammation. METHODS: IRAK-4 KD mice were subjected to serum transfer-induced (K/BxN) arthritis, and migration of transferred spleen lymphocytes into joints and cartilage and bone degradation were assessed...
June 2009: Arthritis and Rheumatism
Jennifer M Bird, Rhian Fuge, Bhawna Sirohi, Jane F Apperley, Ann Hunter, John Snowden, Premini Mahendra, Donald Milligan, Jenny Byrne, Timothy Littlewood, Christopher Fegan, Grant McQuaker, Antonio Pagliuca, Peter Johnson, Amin Rahemtulla, Curly Morris, David I Marks et al.
The outcome of high-dose chemotherapy (HDT) was evaluated retrospectively in 27 patients with myeloma and four patients with AL amyloidosis with severe renal impairment. Twenty-three patients were receiving dialysis and the rest had a creatinine clearance of <20 ml/min. The median melphalan dose was 140 mg/m2 (range: 60-200 mg/m2), but 10 patients (37%) received 200 mg/m2. Myeloid and platelet engraftment were similar to that seen in patients without renal failure. Five of 27 patients died of transplant-related toxicity before the day 100...
August 2006: British Journal of Haematology
James O McInerney, D Timothy J Littlewood, Christopher J Creevey
It is likely that infectious diseases have shaped the evolution of many vertebrates, including humans. The etiological agents of disease continuously strive to evade the immune response and the immune response, in turn, seeks to change in order to keep pace with the invaders. This 'arms race' may be characterized by the selection for new variant hosts and new variant parasites. Here we discuss the utility of phylogenetics in detecting adaptive evolution at the molecular level and, for illustration, we concentrate on a family of surface-exposed proteins (the rifins) found in the recently sequenced genome of Plasmodium falciparum...
2003: Advances in Parasitology
Andrew J Peniket, Timothy J Littlewood, Christopher G Winearls
No abstract text is available yet for this article.
August 2003: Nephrology, Dialysis, Transplantation
Timothy J Littlewood, Martin Zagari, Christopher Pallister, Alan Perkins
Recombinant human erythropoietin (rHuEPO) is an effective treatment for anemia in patients with cancer, and recent studies show that over two-thirds of patients can be expected to respond with a large increase (>2 g/dl) in hemoglobin concentration. However, it would be helpful to identify likely responders and nonresponders before initiating treatment. Previous studies have suggested that high pretreatment endogenous erythropoietin levels are associated with a lower response to erythropoietin, especially in certain patient groups, such as patients with hematological malignancies, non-chemotherapy patients, or patients with myelodysplastic syndrome...
2003: Oncologist
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