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Xiaohui Wang, Xingzhao Tu, Boming Deng, John Z H Zhang, Zhaoxi Sun
The equilibrium and nonequilibrium adaptive alchemical free energy simulation methods optimum Bennett's acceptance ratio and optimum crooks' equation (OCE), based on the statistically optimal bidirectional reweighting estimator named Bennett's Acceptance Ratio or Crooks' equation, perform initial sampling in the staging alchemical transformation and then determine the importance rank of different states via the time-derivative of the variance. The method is proven to give speedups compared with the equal time rule...
February 14, 2019: Journal of Computational Chemistry
Qi Zhang, Jianan Hu, Lijiao Wei, Ri Cao, Ruishu Ma, Huimin Song, Yi Jin
BACKGROUND: Mild cognitive impairment (MCI) can be a stage of pre-dementia. Although the traditional Chinese exercise (TCE) has benefits associated with cognitive functions, the effects of the TCE on cognitive functions of older patients with MCI remain controversial. This study performs a meta-analysis to quantify the efficiency of TCE for older individuals on cognitive and psychological outcomes. METHODS: A comprehensive database search was conducted on PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL (EBSCO), Web of Science, and four Chinese medical databases...
February 2019: Medicine (Baltimore)
Qin Yao, Xinyue Zhang, Yunnong Mu, Yajie Liu, Yu An, Baixiao Zhao
BACKGROUND: Chronic urticaria is a common disease affecting patients' quality of life, and leading to substantial burden to both patients and society. Many trials have shown that bloodletting therapy is effective in treating chronic urticaria. There are currently no systematic reviews of bloodletting therapy for chronic urticaria. This protocol aims to present the methods used to assess the effectiveness and safety of bloodletting therapy for patients with chronic urticaria. METHODS: The following databases will be searched from their inception: the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Scientific Journal Database (VIP database), and Wan-Fang Database...
February 2019: Medicine (Baltimore)
Qinghua Sun, Qiong Jia, Lijin Song, Liping Duan
BACKGROUND: Recent studies indicate that gut microbiota disorders potentially contribute to the pathogenesis of irritable bowel syndrome (IBS), which can be partly reflected by fecal short-chain fatty acids (SCFAs) generated from gut microbiota. Previous studies on SCFA alterations in patients with IBS have yielded conflicting results. No prior systematic review has been conducted on the alterations in fecal SCFAs in IBS patients. AIMS: We performed a meta-analysis to explore and clarify alterations in fecal SCFAs in IBS patients...
February 2019: Medicine (Baltimore)
M P Toniazzo, D Nodari, F W M G Muniz, P Weidlich
AIM: To evaluate the effectiveness of mobile applications and text messages, compared with conventional oral hygiene instructions, for improving oral health knowledge and/or reducing gingival inflammation, when delivered to adolescents, adults and mothers of young children. METHODS: Randomized clinical trials evaluating the use of mobile applications or text messages related to oral hygiene and/or oral health education were screened. A search was performed in the Medline-PubMed, Scopus and Embase databases and the gray literature...
February 13, 2019: Journal of Clinical Periodontology
Tal Mazor-Karsenty, Lilach Shalev, Shula Parush, Yoram Bonneh
This study examined whether sensory modulation disorder-sensory overresponsivity (SMD-SOR) and attention deficit hyperactivity disorder (ADHD) have a significant effect on the perception of aversive auditory stimuli. Participants were 66 young adult women. The diagnosis of SOR was made using the Sensory Responsiveness Questionnaire, and ADHD was diagnosed by a qualified psychiatrist or neurologist using criteria from the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.). Participants were presented with the Battery of Aversiveness to Sounds, short presentations of daily life sounds, and rated each sound stimulus verbally according to its perceived unpleasantness...
November 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Mohammad Vahid Jorat, Reza Tabrizi, Fariba Kolahdooz, Maryam Akbari, Maryamalsadat Salami, Seyed Taghi Heydari, Zatollah Asemi
OBJECTIVE: Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD. METHODS: The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018...
February 13, 2019: Inflammopharmacology
Ming Xue, Xiwen Zhang, Feng Liu, Wei Chang, Jianfeng Xie, Jingyuan Xu, Yi Yang, Haibo Qiu
BACKGROUND: Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chloride content of intravenous crystalloid solutions on clinical outcomes among critically ill adult patients. METHODS: Electronic databases were searched up to June 1, 2018, for randomized trials of use of balanced crystalloids versus 0.9% saline solutions in critically ill adult patients...
February 13, 2019: Annals of Intensive Care
Joy Chakraborty, Joseph Cherng Kong, Wai Kin Su, Peter Gourlas, Christopher Gillespie, Timothy Slack, Bradley Morris, Nicholas Lutton
BACKGROUND: Acute appendicitis is the most common non-obstetric surgical presentation during pregnancy. There were concerns that laparoscopic appendicectomy increases the risk of foetal loss compared to an open approach. Therefore, with recent advances in perioperative care, it is likely the risk has changed. Here, we performed an updated meta-analysis assessing the safety of laparoscopic appendicectomy in pregnant women. METHODS: A meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
February 12, 2019: ANZ Journal of Surgery
Seong Hwan Kim, Chul-Won Ha, Yong-Beom Park, Eunwoo Nam, Jung-Eun Lee, Han-Jun Lee
INTRODUCTION: Mesenchymal stem cells (MSCs) have gained popularity for articular cartilage repair. However, efficacy of intra-articular MSCs in osteoarthritis remains unclear. In the setting of a meta-analysis of randomized controlled trials (RCTs), we aimed to investigate the efficacy of intra-articular MSCs on clinical outcomes and cartilage repair in patients with knee osteoarthritis. MATERIALS AND METHODS: PubMed, EMBASE, Cochrane Library, CINAHL, and Scopus were searched from inception to March 31, 2017...
February 11, 2019: Archives of Orthopaedic and Trauma Surgery
Xiaojian Shi, Jia Han, Jeremy Witchalls, Gordon Waddington, Roger Adams
QUESTION: Can manual therapy improve functional outcomes for individuals with chronic ankle instability? DESIGN: Systematic review with meta-analysis of randomized controlled trials. PARTICIPANTS: Individuals with chronic ankle instability. INTERVENTION: Manual therapy is defined as an intervention that involves joint mobilization, and mobilization with movement. OUTCOME MEASURE: The primary outcome is patient reported function (PRF) questionnaires scores, the secondary outcomes are ankle dorsiflexion range of motion (DFROM) and balance control...
February 7, 2019: Musculoskeletal Science & Practice
Victor Orozco-Olvera, Fuyuan Shen, Lucie Cluver
BACKGROUND: Risky sexual behaviors are associated with the transmission of sexually transmitted infections (STIs) and unwanted pregnancies, both major health concerns for youth worldwide. This review studies the effectiveness of narrated mass media programs in promoting safer sexual practices among youth in developed and developing countries. METHODS: Electronic and manual searches were conducted to identify experimental and quasi-experimental studies with robust counterfactual designs published between 1985 and the first quarter of 2017...
2019: PloS One
Gerard Dunleavy, Charoula Konstantia Nikolaou, Sokratis Nifakos, Rifat Atun, Gloria Chun Yi Law, Lorainne Tudor Car
BACKGROUND: There is a pressing need to implement efficient and cost-effective training to address the worldwide shortage of health professionals. Mobile digital education (mLearning) has been mooted as a potential solution to increase the delivery of health professions education as it offers the opportunity for wide access at low cost and flexibility with the portability of mobile devices. To better inform policy making, we need to determine the effectiveness of mLearning. OBJECTIVE: The primary objective of this review was to evaluate the effectiveness of mLearning interventions for delivering health professions education in terms of learners' knowledge, skills, attitudes, and satisfaction...
February 12, 2019: Journal of Medical Internet Research
Bin Tang, Jun Wang, Lin-Lin Luo, Qiu-Gen Li, Dan Huang
BACKGROUND The 2018 Global Initiative for Chronic Obstructive Lung Disease publication suggested that the combination of bronchodilator therapy of inhaled glucocorticoid/long-acting β₂ adrenoceptor agonist is more effective in improving pulmonary function and health status in the treatment of patients with acute exacerbations than the individual components; however, it is not known whether this also the case for stable chronic obstructive pulmonary disease (COPD). The purpose of this meta-analysis was to evaluate the effectiveness of budesonide/formoterol in the maintenance and relief therapy of patients with stable COPD...
February 12, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Kevin A Juárez-Ornelas, J Oscar C Jiménez-Halla, Terumasa Kato, César R Solorio-Alvarado, Keiji Maruoka
The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Brønsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G*) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2 + ion, which is the nitrating species under neutral conditions...
February 12, 2019: Organic Letters
Kachorn Seresirikachorn, Nichana Suwanparin, Chanyanuch Srisunthornphanich, Wirach Chitsuthipakorn, Dichapong Kanjanawasee, Kornkiat Snidvongs
OBJECTIVE: To assess the prognostic factors that predict favorable outcomes of low-dose macrolides (LDMs) in treating chronic rhinosinusitis (CRS). METHODS: Randomized controlled trials studying the effects of LDMs in treating CRS were included. Data were pooled for meta-analysis. Primary outcome was Sino-Nasal Outcome Test (SNOT). Six prognostic factors: CRS subtypes, serum immunoglobulin (Ig)E level, membered lactone ring of macrolides, concurrent endoscopic sinus surgery (ESS), and dosage and duration of the LDMs were assessed by subgroup analyses...
February 11, 2019: Laryngoscope
Joseph Alvin R Santos, Anthea Christoforou, Kathy Trieu, Briar L McKenzie, Shauna Downs, Laurent Billot, Jacqui Webster, Mu Li
BACKGROUND: Iodine deficiency disorders (IDD) affect close to 1.9 billion people worldwide, and are a major public health concern in many countries. Among children, iodine deficiency is the main cause of potentially preventable deficits of central nervous system development and impairment of cognitive function, as well as goitre and hypothyroidism in people of all ages. Salt iodisation is the preferred strategy for IDD prevention and control, however, in some instances where salt is not the major condiment, alternate vehicles for iodine fortification have been considered...
February 12, 2019: Cochrane Database of Systematic Reviews
Haihong Gong, Qinghe Jiang, Dongchao Shen, Jinming Gao
Background: Neuromuscular electrical stimulation (NMES) has been suggested as an alternative rehabilitative therapy to enhance exercise performance and skeletal muscle function in adult patients with chronic lung disease. However, the results of individual studies have been inconsistent. We performed a meta-analysis to evaluate the effectiveness of NMES with regard to increasing exercise capacity, quadriceps strength, muscle mass, cross-sectional area, and quality of life and decreasing dyspnea in adult patients with chronic lung disease...
December 2018: Journal of Thoracic Disease
Virginia Boccardi, Mohsen Taghizadeh, Sina Amirjani, Sadegh Jafarnejad
The aim of the comprehensive meta-analysis was to systematically explore the reductive effect of α-lipoic acid (ALA) supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). The related records were selected from PubMed, Scopus, EMBASE, Cochrane library, and Persian databases including SID and Magiran from earliest date 1980 until August 2018. The heterogeneities were assessed by I2 test (I2 < 50%) and χ2 test on Cochrane's Q statistic. Standardized mean difference (SMD) and their 95% confidence intervals (CIs) were estimated for change in SBP and DBP...
February 11, 2019: Journal of Human Hypertension
Xiaozhi Li, Yixue Xue, Xiaobai Liu, Jian Zheng, Shuyuan Shen, Chunqing Yang, Jiajia Chen, Zhen Li, Libo Liu, Jun Ma, Teng Ma, Yunhui Liu
BACKGROUND: Glioma is the most common intracranial neoplasm with vasculogenic mimicry formation as one form of blood supply. Many RNA-binding proteins and long non-coding RNAs are involved in tumorigenesis of glioma. METHODS: The expression of ZRANB2, SNHG20 and FOXK1 in glioma were detected by real-time PCR or western blot. The function of ZRANB2/SNHG20/FOXK1 axis in glioma associated with vasculogenic mimicry formation was analyzed. RESULTS: ZRANB2 is up-regulated in glioma tissues and glioma cells...
February 11, 2019: Journal of Experimental & Clinical Cancer Research: CR
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