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Intrauterine restriction growth

Jessica Mendoza-Ramirez, Albino Barraza-Villarreal, Leticia Hernandez-Cadena, Octavio Hinojosa de la Garza, José Luis Texcalac Sangrador, Luisa Elvira Torres-Sanchez, Marlene Cortez-Lugo, Consuelo Escamilla-Nuñez, Luz Helena Sanin-Aguirre, Isabelle Romieu
BACKGROUND: The Child-Mother binomial is potentially susceptible to the toxic effects of pollutants because some chemicals interfere with placental transfer of nutrients, thus affecting fetal development, and create an increased the risk of low birth weight, prematurity and intrauterine growth restriction. OBJECTIVE: To evaluate the impact of prenatal exposure to nitrogen oxides (NOx) on birth weight in a cohort of Mexican newborns. METHODOLOGY: We included 745 mother-child pair participants of the POSGRAD cohort study...
July 27, 2018: Annals of Global Health
Arsène Mekinian, Véronique Houfflin-Debarge, Kamilla Kolanska, Jonathan Cohen, Noémie Abisror, Marie Bornes, Gilles Kayem, Olivier Fain
Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone...
March 6, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Ochuwa Adiketu Babah, Monsurat Bolanle Aderolu, Ayodeji A Oluwole, Bosede B Afolabi
Introduction: Sickle cell disease in pregnancy carries increased risk of maternal and perinatal morbidity and mortality. Past studies on pregnancy complications in sickle cell disease women were limited by relatively small sample sizes, and use of retrospective and hospital discharge data. Study Design: This prospective case-control study compared booked pregnant Haemoglobin (Hb) SS women with AA controls from two tertiary centres in Lagos, in order to precisely identify their complication and mortality rates and identify associated factors...
January 2019: Nigerian Postgraduate Medical Journal
Kristin Thiele, Alexandra Maximiliane Hierweger, Julia Isabel Amambay Riquelme, María Emilia Solano, John P Lydon, Petra Clara Arck
Up to 10% of pregnancies in Western societies are affected by intrauterine growth restriction (IUGR). IUGR reduces short-term neonatal survival and impairs long-term health of the children. To date, the molecular mechanisms involved in the pathogenesis of IUGR are largely unknown, but the failure to mount an adequate endocrine and immune response during pregnancy has been proposed to facilitate the occurrence of IUGR. A cross talk between the pregnancy hormone progesterone and innate immune cell subsets such as dendritic cells (DCs) is vital to ensure adequate placentation and fetal growth...
2019: Frontiers in Endocrinology
Francisco Sales, Oscar A Peralta, Eileen Narbona, Sue McCoard, Raúl Lira, Mónica De Los Reyes, Antonio González-Bulnes, Víctor H Parraguez
Twinning and maternal nutritional restriction leads to fetal hypoxia, oxidative stress, and intrauterine growth restriction (IUGR) in near-term sheep pregnancies. Our aim was to determine the effect of oral supplementation of vitamins C and E in pregnant sheep on maternal and umbilical cord blood concentrations of vitamins C and E and the effects on fetal antioxidant status, growth, and placental efficiency. Sixteen single- and sixteen twin-bearing ewes, grazing natural Patagonian prairies, were selected after transrectal ultrasound at day 30 after mating...
March 8, 2019: Antioxidants (Basel, Switzerland)
Consolación Garcia-Contreras, Marta Vazquez-Gomez, Alicia Barbero, José Luis Pesantez, Angelo Zinellu, Fiammetta Berlinguer, Pedro Gonzalez-Añover, Jorge Gonzalez, Teresa Encinas, Laura Torres-Rovira, Yolanda Nuñez, Jaime Ballesteros, Miriam Ayuso, Susana Astiz, Beatriz Isabel, Cristina Ovilo, Antonio Gonzalez-Bulnes
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus...
March 8, 2019: International Journal of Molecular Sciences
Damian D Guerra, K Joseph Hurt
BACKGROUND: Gaso-transmitters are endogenous small gaseous messengers exemplified by nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S or sulfide). Gasotransmitters are implicated in myriad physiologic functions including many aspects of reproduction. OBJECTIVE: Comprehensively review basic mechanisms and functions of gasotransmitters during pregnancy from conception to uterine involution and highlight future research opportunities. . METHODS: We searched PubMed and Web of Science databases using combinations of keywords nitric oxide, carbon monoxide, sulfide, placenta, uterus, labor, and pregnancy...
March 8, 2019: Biology of Reproduction
Ashley D Newsome, Gwendolyn K Davis, Osasu N Adah, Norma B Ojeda, Barbara T Alexander
Epidemiological studies report an inverse association between birth weight and risk for kidney disease that may differ between males and females, but studies investigating this association are limited. This study tested the hypothesis that male intrauterine growth-restricted offspring in a model of low birth weight induced by placental insufficiency in the rat exhibit enhanced renal injury in response to a persistent secondary renal insult while female growth-restricted offspring are protected. For this study, control offspring from sham-operated dams and growth-restricted offspring from reduced uterine perfusion dams underwent uninephrectomy or a sham procedure at 18 months of age...
2019: PloS One
Radhika Narang, Kathleen Carter, Colin Muncie, Yi Pang, Lir-Wan W Fan, Yangzheng Feng, Norma B Ojeda, Abhay J Bhatt
There is a lack of knowledge of factors preventing an adequate response to moderate hypothermia after hypoxic ischemic (HI) brain injury. We hypothesized that growth restriction from reduced intrauterine perfusion would predispose neonatal rats to have a worse outcome with HI brain injury. IUGR was induced by placental insufficiency in dams at 14 days of gestation. HI was induced at postnatal day (P) 10 by permanent right carotid artery ligation followed by 90 min of hypoxia (8% oxygen). Tests for early brain injury and neurobehavioral outcomes were subsequently done...
March 7, 2019: Journal of Neuroscience Research
Y Nozawa, M D H Hawlader, F Ferdous, R Raqib, F Tofail, E-C Ekström, Y Wagatsuma
Numerous studies have investigated the risk of developing asthma due to early-life experiences and environmental exposures. However, the influence of intrauterine growth restriction and postnatal undernutrition on childhood wheezing/asthma remains unclear. Thus, we examined the effects of both small for gestational age (SGA) and postnatal stunted growth on ever asthma among children in the rural areas in Bangladesh.Multiple follow-up studies were conducted in a cohort of randomized clinical trial of nutrition interventions during pregnancy (the MINIMat trial)...
March 7, 2019: Journal of Developmental Origins of Health and Disease
Ishmael M Inocencio, Graeme R Polglase, Suzanne L Miller, Arvind Sehgal, Amy Sutherland, Jamie Mihelakis, Anqi Li, Beth J Allison
Objective- The objective of this study was to investigate the effect of intravenous maternal sildenafil citrate (SC) administration on vascular function in growth-restricted fetal sheep. Approach and Results- Fetal growth restriction (FGR) results in cardiovascular adaptations that redistribute cardiac output to optimize suboptimal intrauterine conditions. These adaptations result in structural and functional cardiovascular changes, which may underlie postnatal neurological and cardiovascular sequelae. Evidence suggests SC, a potent vasodilator, may improve FGR...
March 7, 2019: Arteriosclerosis, Thrombosis, and Vascular Biology
Danielle K Bourque, Mireille Cloutier, Kristin D Kernohan, Eric Bareke, David Grynspan, Jean Michaud, Kym M Boycott
Neu-Laxova syndrome (NLS) is a lethal autosomal recessive microcephaly syndrome associated with intrauterine growth restriction (IUGR) and multiple congenital anomalies. Clinical features include central nervous system malformations, joint contractures, ichthyosis, edema, and dysmorphic facial features. Biallelic pathogenic variants in either the PHGDH or PSAT1 genes have been shown to cause NLS. Using exome sequencing, we aimed to identify the underlying genetic diagnosis in three fetuses (from one family) with prenatal skin edema, severe IUGR, micrognathia, renal anomalies, and arthrogryposis and identified a homozygous c...
March 5, 2019: American Journal of Medical Genetics. Part A
Nuria Balaguer, Inmaculada Moreno, María Herrero, Marta González, Felipe Vilella, Carlos Simón
BACKGROUND: Maternal-embryonic crosstalk between the endometrium and the preimplantation embryo is required for normal pregnancy. Our previous results demonstrated that maternal microRNAs secreted into the endometrial fluid, and specifically miR-30d, act as transcriptomic regulator of the pre-implantation embryo by the maternal intrauterine environment. OBJECTIVE: To investigate the reproductive and fetal effects of murine miR-30d deficiency at the maternal-embryonic interface according to the origin of its maternal or embryonic default...
February 28, 2019: American Journal of Obstetrics and Gynecology
Alfredo Perales-Puchalt, Nora Soberón, Mercedes Monterde, David Hervas-Marin, Miguel Foronda, Domingo Desantes, Inmaculada Soler, Alfredo Perales-Marin, Antonio Pellicer, Maria A Blasco
RESEARCH QUESTION: The study aimed to determine whether IVF or intrauterine growth restriction (IUGR) result in short neonatal telomeres, which could explain the higher risk of cardiovascular and metabolic disease described in these populations. DESIGN: This was an observational, analytical, cross-sectional, prospective study with controls in a tertiary hospital. The main outcome was to determine the leukocyte telomere length in 126 newborns and their mothers (n = 109)...
December 21, 2018: Reproductive Biomedicine Online
Christine Contini, B Sophia Winkler, Nicolai Maass, Ibrahim Alkatout, Karl Winkler, Ulrich Pecks
OBJECTIVE: Preeclampsia and intrauterine growth restriction (IUGR) are related conditions. We aimed to characterise common lipid changes. METHODS: Triglyceride and cholesterol levels of patients 24-42 weeks of gestation with IUGR (n = 52), hypertensive IUGR (HIUGR, n = 28), and preeclampsia without IUGR (PE, n = 56) were compared to a control group (CTRL, n = 167). In addition, 60 sera (n = 10 of each pathology IUGR, HIUGR, PE (without IUGR) compared to n = 30 matched CTRL) of severe early onset cases <34 weeks of gestation were chosen and further analysed by ultracentrifugation lipid subfractionation including VLDL, IDL, LDL, and HDL composition...
January 2019: Pregnancy Hypertension
Christina Gougoula, Alexandra P Bielfeld, Sarah J Pour, Jan-S Krüssel, Martin Götte, W Peter M Benten, Dunja M Baston-Büst
BACKGROUND: Syndecan-1 is a heparan sulfate proteoglycan acting as a co-receptor for cytokines and growth factors mediating developmental, immunological and angiogenic processes. In human, the uteroplacental localization of Syndecan-1 and its reduced expression in pregnancy-associated pathologies, such as the intrauterine growth restriction, suggests an influence of Syndecan-1 in embryo-maternal interactions. The aim of the present study was to identify the effect of a reduced expression of Syndecan-1 on the reproductive phenotype of mice and their progenies...
March 2, 2019: Reproductive Biology and Endocrinology: RB&E
Mahboobeh Shirazi, Maryam Rabiei, Fatemeh Rahimi, Shirin Niroomanesh, Fateme Golshahi, Mitra Eftekhar Yazdi
Background: Chorionic villus sampling (CVS) and amniocentesis are two methods for prenatal diagnosis. The goal of this study was to compare amniocentesis and CVS-related complications in a large sample of Iranian women. Methods: Medical records of 1624 women who underwent amniocentesis or CVS due to medical indications between 2008 and 2016 were reviewed. Data regarding age, gravidity, parity, gestational age, type of procedure, neonatal weight (and percentile), trisomia, abortion, intrauterine growth restriction (IUGR), severe IUGR, preeclampsia, and gestational hypertension were recorded...
2019: International Journal of Preventive Medicine
Elena Toffol, Marius Lahti-Pulkkinen, Jari Lahti, Jari Lipsanen, Kati Heinonen, Anu-Katriina Pesonen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M Villa, Katri Räikkönen
OBJECTIVE: Maternal depressive symptoms during pregnancy have been associated with poor offspring sleep. Yet, it remains unknown whether depressive symptoms throughout pregnancy are more harmful to the child than depressive symptoms only during certain time periods in pregnancy, whether associations are specific to pregnancy stage, whether maternal symptomatology after pregnancy mediates or adds to the prenatal effects, and whether any effects are specific to some child sleep characteristics...
December 14, 2018: Sleep Medicine
Kalpashri Kesavan, Sherin U Devaskar
Intrauterine growth restriction (IUGR) is an important cause of fetal, perinatal and neonatal morbidity and mortality. IUGR occurs because of multiple reasons. Neonates with IUGR experience acute problems in the perinatal and early neonatal period that can be life-threatening. The unfavorable uterine environment causing growth restriction results in programming that predisposes IUGR infants to long-term health issues such as poor physical growth, metabolic syndrome, cardiovascular disease, neurodevelopmental impairment and endocrine abnormalities, warranting careful monitoring...
April 2019: Pediatric Clinics of North America
Ayser Hashem, Samar Dawood Sarsam
Background: Chorionic hematomas can be caused by the separation of the chorion from the endometrium, with an incidence of 3.1% of all pregnancies. It is the most common sonographic abnormality and the most common cause of first-trimester bleeding. Objectives: To evaluate the impact of subchorionic and retroplacental hematomas detected by ultrasound in the first trimester of pregnancy. Patients and Methods: A prospective observational case-control study was conducted at Elwiya Maternity Teaching Hospital on 100 pregnant ladies with subchorionic or retroplacental hematoma shown in ultrasound compared with 200 pregnant ladies without hematoma in the first trimester...
February 2019: Journal of Obstetrics and Gynaecology of India
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