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https://read.qxmd.com/read/30772576/attributing-mortality-from-temperature-extremes-a-time-series-analysis-in-varanasi-india
#1
Nidhi Singh, Alaa Mhawish, Santu Ghosh, Tirthankar Banerjee, R K Mall
Climate extremes are often associated with increased human mortality and such association varies considerably with space and time. We therefore, aimed to systematically investigate the effects of temperature extremes, daily means and diurnal temperature variations (DTV) on mortality in the city of Varanasi, India during 2009-2016. Time series data on daily mortality, air quality (SO2 , NO2 , O3 and PM10 ) and weather variables were obtained from the routinely collected secondary sources. A semiparametric quasi-Poisson regression model estimated the effects of temperature extremes on daily all-cause mortality adjusting nonlinear confounding effects of time trend, relative humidity and air pollution; stratified by seasons...
February 7, 2019: Science of the Total Environment
https://read.qxmd.com/read/30772514/oxidized-alginate-hydrogels-with-the-ghk-peptide-enhance-cord-blood-mesenchymal-stem-cell-osteogenesis-a-paradigm-for-metabolomics-based-evaluation-of-biomaterial-design
#2
Michail E Klontzas, Supachai Reakasame, Raquel Silva, Jose C F Morais, Spyros Vernardis, Robert J MacFarlane, Manolis Heliotis, Eleftherios Tsiridis, Nicki Panoskaltsis, Aldo R Boccaccini, Athanasios Mantalaris
Oxidized alginate hydrogels are appealing alternatives to natural alginate due to their favourable biodegradability profiles and capacity to self-crosslink with amine containing molecules facilitating functionalization with extracellular matrix cues, which enable modulation of stem cell fate, achieve highly viable 3-D cultures, and promote cell growth. Stem cell metabolism is at the core of cellular fate (proliferation, differentiation, death) and metabolomics provides global metabolic signatures representative of cellular status, being able to accurately identify the quality of stem cell differentiation...
February 14, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30772386/procalcitonin-guided-antibiotic-discontinuation-and-mortality-in-critically-ill-adults-a-systematic-review-and-meta-analysis
#3
Dominique Pepper, Junfeng Sun, Chanu Rhee, Judith Welsh, John H Powers, Robert L Danner, Sameer S Kadri
BACKGROUND: Procalcitonin (PCT)-guided antibiotic discontinuation appears to decrease antibiotic use in critically ill patients, but its impact on survival remains less certain. METHODS: We searched PubMed, EMBASE, Scopus, Web of Science, and CENTRAL for RCTs of PCT-guided antibiotic discontinuation in critically ill adults reporting survival or antibiotic duration. Searches were conducted without language restrictions from inception to 07/23/2018. Two reviewers independently conducted all review stages; another adjudicated differences...
February 14, 2019: Chest
https://read.qxmd.com/read/30772141/a-novel-approach-to-detect-programed-death-ligand-1-pd-l1-status-and-multiple-tumor-mutations-using-a-single-non-small-cell-lung-cancer-nsclc-bronchoscopy-specimen
#4
Amanda Vannitamby, Shona Hendry, Tanvi Makadia, Janine Danks, John Slavin, Louis Irving, Daniel Steinfort, Steven Bozinovski
Multiple biomarkers are under evaluation to guide the use of immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC), including programed death ligand 1 (PD-L1) tumor cell staining. We have developed a new approach that accurately quantifies PD-L1 status and identifies multiple mutations by using a single bronchoscopy specimen. A novel molecular marker was identified to detect the presence of malignant cells in radial endobronchial ultrasound bronchial brushings from NSCLC (n = 15) and benign (n = 13) nodules by quantitative real-time RT-PCR (RT-qPCR)...
February 8, 2019: Journal of Molecular Diagnostics: JMD
https://read.qxmd.com/read/30771777/outcomes-in-different-age-groups-with-primary-ewing-sarcoma-of-the-spine-a-systematic-review-of-the-literature
#5
REVIEW
Garrett K Berger, Peyton L Nisson, Whitney S James, Kristen N Kaiser, R John Hurlbert
OBJECTIVEEwing sarcoma (ES) is among the most prevalent of bone sarcomas in young people. Less often, it presents as a primary lesion of the spine (5%-15% of patients with ES).METHODSA systematic literature search was performed, querying several scientific databases per PRISMA guidelines. Inclusion criteria specified all studies of patients with surgically treated ES located in the spine. Patient age was categorized into three groups: 0-13 years (age group 1), 14-20 years (age group 2), and > 21 (age group 3)...
February 15, 2019: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/30771769/correlation-of-perioperative-risk-scores-with-hospital-costs-in-neurosurgical-patients
#6
Sasha Vaziri, Joseph M Abbatematteo, Max S Fleisher, Alexander B Dru, Dennis T Lockney, Paul S Kubilis, Daniel J Hoh
OBJECTIVEThe American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) online surgical risk calculator uses inherent patient characteristics to provide predictive risk scores for adverse postoperative events. The purpose of this study was to determine if predicted perioperative risk scores correlate with actual hospital costs.METHODSA single-center retrospective review of 1005 neurosurgical patients treated between September 1, 2011, and December 31, 2014, was performed. Individual patient characteristics were entered into the NSQIP calculator...
February 15, 2019: Journal of Neurosurgery
https://read.qxmd.com/read/30771346/development-and-validation-of-a-risk-calculator-for-adverse-perioperative-outcomes-for-women-with-ovarian-cancer
#7
Stephanie Cham, Ling Chen, Caryn M St Clair, June Y Hou, Ana I Tergas, Alexander Melamed, Cande V Ananth, Alfred I Neugut, Dawn L Hershman, Jason D Wright
BACKGROUND: Primary cytoreduction followed by platinum based chemotherapy is the primary treatment for advanced ovarian cancer. However neoadjuvant chemotherapy followed by interval debulking is an alternative option, particularly in those who may be poor surgical candidates. OBJECTIVE: The objective of this study was to determine factors associated with short term, significant perioperative morbidity and mortality for women undergoing surgery for ovarian cancer and to create a nomogram to predict the risk of adverse perioperative outcomes...
February 13, 2019: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/30771299/validity-of-a-rapid-and-simple-fluorometric-tripeptidyl-peptidase-1-tpp1-assay-using-dried-blood-specimens-to-diagnose-cln2-disease
#8
Zoltan Lukacs, Miriam Nickel, Simona Murko, Paulina Nieves Cobos, Angela Schulz, René Santer, Alfried Kohlschütter
PURPOSE: CLN2 disease is a genetic disorder caused by dysfunction of the lysosomal enzyme tripeptidyl peptidase 1 (TPP1) that belongs to the neuronal ceroid lipofuscinoses (NCL) and leads to epilepsy, dementia, and death in young persons. CLN2 disease has recently become treatable by enzyme replacement, which can only be effective when the disease is diagnosed early. We have investigated the reliability of a test for TPP1 deficiency in dried blood specimens (DBS) to detect CLN2 disease...
February 13, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/30771125/detection-of-outliers-in-pollutant-emissions-from-the-soto-de-ribera-coal-fired-power-plant-using-functional-data-analysis-a-case-study-in-northern-spain
#9
Fernando Sánchez-Lasheras, Celestino Ordóñez-Galán, Paulino José García-Nieto, Esperanza García-Gonzalo
For more than a century, air pollution has been one of the most important environmental problems in cities. Pollution is a threat to human health and is responsible for many deaths every year all over the world. This paper deals with the topic of functional outlier detection. Functional analysis is a novel mathematical tool employed for the recognition of outliers. This methodology is applied here to the emissions of a coal-fired power plant. This research uses two different methods, called functional high-density region (HDR) boxplot and functional bagplot...
February 15, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30770049/safety-of-80-vs-30-35-fraction-of-inspired-oxygen-in-patients-undergoing-surgery-a-systematic-review-and-meta-analysis
#10
REVIEW
Katharina Mattishent, Menaka Thavarajah, Ashnish Sinha, Adam Peel, Matthias Egger, Joseph Solomkin, Stijn de Jonge, Asad Latif, Sean Berenholtz, Benedetta Allegranzi, Yoon Kong Loke
BACKGROUND: Evidence-based guidelines from the World Health Organization (WHO) have recommended a high (80%) fraction of inspired oxygen (FiO2 ) to reduce surgical site infection in adult surgical patients undergoing general anaesthesia with tracheal intubation. However, there is ongoing debate over the safety of high FiO2 . We performed a systematic review to define the relative risk of clinically relevant adverse events (AE) associated with high FiO2 . METHODS: We reviewed potentially relevant articles from the WHO review supporting the recommendation, including an updated (July 2018) search of EMBASE and PubMed for randomised and non-randomised controlled studies reporting AE in surgical patients receiving 80% FiO2 compared with 30-35% FiO2 ...
March 2019: British Journal of Anaesthesia
https://read.qxmd.com/read/30768934/induction-of-labor-at-39-weeks-of-gestation-vs-expectant-management-for-low-risk-nulliparous-women-a-cost-effectiveness-analysis
#11
Alyssa R Hersh, Ashley E Skeith, James A Sargent, Aaron B Caughey
BACKGROUND: A large, recent multicenter trial found that induction of labor at 39 weeks for low-risk nulliparous women was not associated with an increased risk of cesarean delivery or adverse neonatal outcomes. OBJECTIVE: We sought to examine the cost-effectiveness and outcomes associated with induction of labor at 39 weeks versus expectant management for low-risk nulliparous women in the United States. STUDY DESIGN: A cost-effectiveness model using TreeAge software was designed to compare outcomes in women who were induced at 39 weeks versus expectantly managed...
February 12, 2019: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/30768461/american-society-for-enhanced-recovery-and-perioperative-quality-initiative-joint-consensus-statement-on-perioperative-management-of-patients-on-preoperative-opioid-therapy
#12
David A Edwards, Traci L Hedrick, Jennifer Jayaram, Charles Argoff, Padma Gulur, Stefan D Holubar, Tong J Gan, Michael G Mythen, Timothy E Miller, Andrew D Shaw, Julie K M Thacker, Matthew D McEvoy
Enhanced recovery pathways have quickly become part of the standard of care for patients undergoing elective surgery, especially in North America and Europe. One of the central tenets of this multidisciplinary approach is the use of multimodal analgesia with opioid-sparing and even opioid-free anesthesia and analgesia. However, the current state is a historically high use of opioids for both appropriate and inappropriate reasons, and patients with chronic opioid use before their surgery represent a common, often difficult-to-manage population for the enhanced recovery providers and health care team at large...
February 12, 2019: Anesthesia and Analgesia
https://read.qxmd.com/read/30767504/long-term-effects-of-oxygen-therapy-on-death-or-hospitalization-for-heart-failure-in-patients-with-suspected-acute-myocardial-infarction
#13
Tomas Jernberg, Bertil Lindahl, Joakim Alfredsson, Ellinor Berglund, Olle Bergström, Anders Engström, David Erlinge, Johan Herlitz, Raluca Jumatate, Thomas Kellerth, Jorg Lauermann, Krister Lindmark, Markus Lingman, Lina Ljung, Carina Nilsson, Elmir Omerovic, J Pernow, Annica Ravn-Fischer, David Sparv, Troels Yndigegn, Ollie Östlund, Stefan K James, Robin Hofmann
Background: In the DETO2X-AMI trial (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction), we compared supplemental oxygen with ambient air in normoxemic patients presenting with suspected myocardial infarction and found no significant survival benefit at 1 year. However, important secondary end points were not yet available. We now report the prespecified secondary end points cardiovascular death and the composite of all-cause death and hospitalization for heart failure...
December 11, 2018: Circulation
https://read.qxmd.com/read/30766456/a-comprehensive-review-of-quality-of-life-surveys-for-trauma-affected-communities
#14
Kimberly A Peterson, Leming Zhou, Valerie J M Watzlaf
Research shows that exposure to community and domestic violence leads to psychological trauma from childhood through adulthood, which can lead to poor health and early death. A team of health information management (HIM) professionals reviewed existing surveys to determine their suitability for assessing the quality of life (QoL) of people in trauma-affected communities (TACs). Keywords were used to search for papers describing validated QoL surveys. The obtained papers were screened, reviewed, and summarized to determine if they include the aspects needed for assessing QoL in TACs...
2019: Perspectives in Health Information Management
https://read.qxmd.com/read/30766431/identifying-treatment-related-problems-and-associated-factors-among-hospitalized-post-stroke-patients-through-medication-management-review-a-multi-center-study
#15
Iman A Basheti, Shahnaz Mohammed Ayasrah, Muayyad Ahmad
Background: Stroke is a major cause of disability and one of the leading causes of death among the elderly. Treatment related problems can lead to undesirable consequences. The Medication Management Review (MMR) service is aimed at identifying, resolving and preventing TRPs, subsiding the undesirable outcomes associated with TRPs. Objectives: To explore the types, frequencies and severity of TRPs amongst post-stroke patients recruited through hospitals via conducting the MMR service by clinical pharmacists in Jordan...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30765944/prognostic-implications-of-minimal-covert-hepatic-encephalopathy-large-scale-validation-cohort-studies
#16
REVIEW
Christopher R Flud, Andres Duarte-Rojo
Minimal or Covert Hepatic Encephalopathy (MHE/CHE), the preclinical phase of Hepatic Encephalopathy (HE), is strongly associated with poorer Quality of Life (QOL), Overt HE (OHE), and death. Several diagnostic tests have been developed that have prognostic value in predicting clinical outcomes such as OHE, cirrhosis progression, and death. However, dispute among clinicians and HE researchers have kept its application largely underutilized. Current issues contributing to the confusion include: lack of a formal definition for CHE, uncertainty of which diagnostic tools to use, and whether one or two abnormal tests are required for a diagnosis...
January 2019: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/30765387/palliative-care-quality-measures-an-exploratory-study
#17
Alessandra Buja, Michele Rivera, Vincenzo Baldo, Marta Soattin, Ylenia Rizzolo, Giuseppe Zamengo, Sarah Boscolo, Maria Cristina Ghiotto, Gianfranco Damiani
OBJECTIVES: The aim of this study was to investigate how palliative care service structures and processes correlate with their outputs and outcomes, measuring the latter respectively in terms of intensity of care and death at home. METHODS: The Veneto Regional Health Authorities collected a set of 37 quality indicators for the year 2016, covering the following five dimensions: service integration, service structure, accessibility, professional processes and organisational processes...
February 14, 2019: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/30765305/quality-of-death-after-left-ventricular-assist-device-implantation-more-questions-than-answers
#18
EDITORIAL
Akshay S Desai, Kristen G Schaefer, James A Tulsky, Mandeep R Mehra
No abstract text is available yet for this article.
January 25, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30765289/a-better-understanding-of-the-concept-a-good-death-how-do-healthcare-providers-define-a-good-death
#19
Liesbeth Vanderveken, Birgitte Schoenmakers, Jan De Lepeleire
OBJECTIVE: The goal of palliative care is to improve quality of life when recovery is no longer possible. The study's objective was to widen our vision of potential (unspoken) needs at the end of life with patients, close relatives, nurses, and general practitioners to aim at more versatile but personal care. The question asked was how important patients, close relatives, and healthcare providers considered the 11 core themes in defining a good death, as described in the 2016 article "Defining a good death" by Meier et al...
December 18, 2018: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/30765151/defining-massive-transfusion-in-civilian-pediatric-trauma
#20
Eric Rosenfeld, Patricio Lau, Wei Zhang, Robert T Russell, Sohail R Shah, Bindi Naik-Mathuria, Adam M Vogel
PURPOSE: The purpose of this study was to identify an optimal definition of massive transfusion (MT) in civilian pediatric trauma. METHODS: Severely injured children (age ≤18 years, injury severity score ≥25) in the Trauma Quality Improvement Program research datasets 2014-2015 that received blood products were identified. Children with traumatic brain injury and non-survivable injuries were excluded. Early mortality was defined as death within 24 h and delayed mortality as death after 24 h from hospital admission...
January 31, 2019: Journal of Pediatric Surgery
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