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Gan Lin, Yang Zhang, Congqing Zhu, Chengchao Chu, Yesi Shi, Xin Pang, En Ren, Yayun Wu, Peng Mi, Haiping Xia, Xiaoyuan Chen, Gang Liu
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in cancer cells without toxicity to normal cells. However, the efficiency is greatly limited by its short half-life and wild resistance in various cancer cells. In this study, we reported a micellar hybrid nanoparticle to carry TRAIL ligand (denoted as IPN@TRAIL) for a novel photo-excited TRAIL therapy. These IPN@TRAIL offered increased TRAIL stability, prolonged half-life and enhanced tumor accumulation, monitored by dual mode imaging...
September 2018: Biomaterials
Yan Qu, Ying Wang, Yan Zhang, Chunyu Han, Dong Gao, Waishu Jin, Jinning Liang, Xiujuan Xia
BACKGROUND: Because of long-term exposure of skin, skin aging is an unavoidable natural law with age. Traditional Vitamin A and novel ablative fractional laser technique both have the effects of skin rejuvenation, and studies have demonstrated both of them have apparent clinical efficacy and histology-improving effects on photo-aging skin. MATERIALS AND METHODS: 45 female healthy Wistar rats were selected and the depilation areas of every rat were divided into four regions: control region(Region A), Vitamin A acid region(Region B), combination treatment region(Region C), and fractional laser region(Region D)...
March 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Oliver Faehnle, Rolf Rascher, Christian Vogt, Dae Wook Kim
This paper lays out the trail onto a closed-loop polishing process of optical elements enabling the application of the optimum polishing time needed. To that aim, an in-process testing method for monitoring an inclusive microsurface quality (e.g., comprising surface roughness and scratch-and-dig) within the polishing spot is analyzed, and its applicability to closed-loop polishing for classical loose-abrasive full-aperture polishing as well as for computer-controlled laser polishing is experimentally tested and verified...
February 1, 2018: Applied Optics
J Cowley, C Thornton, C Arran, R J Shalloo, L Corner, G Cheung, C D Gregory, S P D Mangles, N H Matlis, D R Symes, R Walczak, S M Hooker
We demonstrate experimentally the resonant excitation of plasma waves by trains of laser pulses. We also take an important first step to achieving an energy recovery plasma accelerator by showing that a plasma wave can be damped by an out-of-resonance trailing laser pulse. The measured laser wakefields are found to be in excellent agreement with analytical and numerical models of wakefield excitation in the linear regime. Our results indicate a promising direction for achieving highly controlled, GeV-scale laser-plasma accelerators operating at multikilohertz repetition rates...
July 28, 2017: Physical Review Letters
Jun-Yi Wu, Chao Zhang, Yang-Peng Xu, Ya-Yu Yu, Le Peng, Wei-Dong Leng, Yu-Ming Niu, Mo-Hong Deng
PURPOSE: The purpose of this study was to evaluate conventional acupuncture therapy in the management of clinical outcomes for temporomandibular disorders (TMD) in adults. METHODS: The electronic databases PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Clinical were searched for reports published until March 31, 2016. RESULTS: Nine eligible studies from 8 publications involving 231 patients were included in the meta-analysis...
March 2017: Medicine (Baltimore)
Guangzhi He, Chenhong Zheng, Ming-An Yu, Hongpeng Zhang
PURPOSE: To investigate and compare the relative efficacy, recurrence and complications of endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) for the treatment of varicose veins patients. METHODS: Searches were applied to the Cochrane Library as well as MEDLINE, EMBASE, BIOSIS databases. 12 articles published in English (10 randomized controlled trials and 2 cohort study) were identified from specialized trails. Fixed effect model and Random effect model were applied to compare the vein ablated length, pain scores (3days and 10days), quality of Life, occlusion, over all complication, thrombophlebitis, haematoma and recanalization between the EVLA and RFA group...
March 2017: International Journal of Surgery
Zhen Zhang, Ming Li, Feixue Chen, Lixiang Li, Jun Liu, Zhen Li, Rui Ji, Xiuli Zuo, Yanqing Li
INTRODUCTION: Mesenchymal stem cells (MSCs) can serve as vehicles for therapeutic genes. However, little is known about MSC behavior in vivo. Here, we demonstrated that probe-based confocal laser endomicroscopy (pCLE) can be used to track MSCs in vivo and individually monitor tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) gene expression within carcinomas. METHODS: Isolated BALB/c nu/nu mice MSCs (MSCs) were characterized and engineered to co-express the TRAIL and enhanced green fluorescent protein (EGFP) genes...
2016: PloS One
Alexis Ghanem, Sandeep Pasumarthy, Vinisha Ranna, Sergio Varela Kellesarian, Tariq Abduljabbar, Fahim Vohra, Hans Malmstrom
BACKGROUND: The aim of the present study was to review the pertinent literature on the effects of mechanical curettage (MC) with and without adjunct photodynamic therapy (PDT) for the management of peri-implantitis. METHODS: The addressed focused question was "Is PDT effective in the treatment of peri-implantitis?" A search without language or time restrictions up to March 2016 was conducted using various key words. The exclusion criteria included; review papers, in vitro Studies, case reports, commentaries, interviews, and letters to the editors...
September 2016: Photodiagnosis and Photodynamic Therapy
Ming Sang, Jiaxin Zhang, Bin Li, Yuqing Chen
A TRAIL-CM4 fusion protein in soluble form with tumor selective apoptosis and antibacterial functions was expressed in the Escherichia coli expression system and isolated through dialysis refolding and histidine-tag Nickel-affinity purification. Fresh Jurkat cells were treated with the TRAIL-CM4 fusion protein. Trypan blue staining and MTT analyses showed that, similar to a TRAIL positive control, Jurkat cell proliferation was significantly inhibited. Flow cytometry analyses using Annexin V-fluorescein revealed that Jurkat cells treated with the TRAIL-CM4 fusion protein exhibited increased apoptosis...
June 2016: Protein Expression and Purification
Yi Hu, Amirhossein Tehranchi, Stefan Wabnitz, Raman Kashyap, Zhigang Chen, Roberto Morandotti
We experimentally demonstrate the possibility of tuning the frequency of a laser pulse via the use of an Airy pulse-seeded soliton self-frequency shift. The intrinsically asymmetric nature of Airy pulses, typically featured by either leading or trailing oscillatory tails (relatively to the main lobe), is revealed through the nonlinear generation of both a primary and a secondary Raman soliton self-frequency shift, a phenomenon which is driven by the soliton fission processes. The resulting frequency shift can be carefully controlled by using time-reversed Airy pulses or, alternatively, by applying an offset to the cubic phase modulation used to generate the pulses...
February 20, 2015: Physical Review Letters
Elizabeth A Strychalski, Christopher Konek, Erica L R Butts, Peter M Vallone, Alyssa C Henry, David Ross
Gradient elution isotachophoresis (GEITP) was demonstrated for DNA purification, concentration, and quantification from crude samples, represented here by soiled buccal swabs, with minimal sample preparation prior to human identification using STR analysis. During GEITP, an electric field applied across leading and trailing electrolyte solutions resulted in isotachophoretic focusing of DNA at the interface between these solutions, while a pressure-driven counterflow controlled the movement of the interface from the sample reservoir into a microfluidic capillary...
September 2013: Electrophoresis
Yi Zheng, Hongbo Chen, Xiaowei Zeng, Zhigang Liu, Xiaojun Xiao, Yongqiang Zhu, Dayong Gu, Lin Mei
The efficient delivery of therapeutic genes into cells of interest is a critical challenge to broad application of non-viral vector systems. In this research, a novel TPGS-b-(PCL-ran-PGA) nanoparticle modified with polyethyleneimine was applied to be a vector of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and endostatin for cervical cancer gene therapy. Firstly, a novel biodegradable copolymer, TPGS-b-(PCL-ran-PGA), was synthesized and characterized. The nanoparticles were fabricated by an emulsion/solvent evaporation method and then further modified with polyethyleneimine (PEI) carrying TRAIL and/or endostatin genes...
2013: Nanoscale Research Letters
Xu Wang, Yuan-Hao Du, Jun Xiong
OBJECTIVE: To evaluate the clinical effect of acupuncture therapy for fibromyalgia syndrome (FMS) by analyzing the available studies so as to provide clinical decision-making reference. METHODS: The published papers on clinical trails for acupuncture treatment of FMS were widely retrieved from Chinese Biomedical Databases (1979 - 2010), www. cnki. net (1979-2010), VIP China Scientific Journal Database (1989- 2010), Digital Periodicals on Wanfang Data (1998 - 2010), PubMed (1966-2010), etc...
June 2011: Zhen Ci Yan Jiu, Acupuncture Research
Usama Fares, Hanif Suleman, Mouhamed Ali Al-Aqaba, Ahamd Muneer Otri, Dalia G Said, Harminder S Dua
PURPOSE: To compare the efficacy, predictability, safety, and induced higher-order aberrations (HOAs) between wavefront-guided and non-wavefront-guided ablations. SETTING: Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, United Kingdom. DESIGN: Metaanalysis. METHODS: The Cochrane Central Register of Controlled Trials, PubMED, and EMBASE were searched for randomized controlled trails...
August 2011: Journal of Cataract and Refractive Surgery
Gloria Juan, Stephen J Zoog, John Ferbas
Quantitation of activated caspases in xenograft models by laser scanning cytometry has demonstrated mechanism-specific biological activity of Anti-Trail Receptor immunoglobulin therapies in situ. These preclinical data confirmed that caspase activation is an early event that precedes tumor regression. To apply this platform for clinical monitoring of caspase activation using fine needle aspirate (FNA) biopsies, additional assay feasibility and validation experiments need be addressed. Furthermore, important instrument parameters should be considered including the maintenance and operation of the cytometer in a controlled state to ensure aspects like data traceability, reliability, and integrity...
2011: Methods in Cell Biology
Mario R Romano, Xavier Valldeperas, Paolo Vinciguerra, David Wong
PURPOSE: This review summarizes the data reported in peer-reviewed literature on the effects of submacular surgery for age-related macular degeneration (AMD) associated with choriodal neovascularization (CNV). METHODS: A review of the MEDLINE database has been performed in order to examine the therapeutic effects of submacular surgical treatments in patients affected by AMD. RESULTS: The multicenter studies conducted by the Submacular Surgery Trials Research Group compare the removal of the CNV complex, both with (336) and without blood (454), with observation in patients affected by AMD...
February 2011: Current Drug Targets
Karolin Kamel Abdul-Aziz, M J Tuorkey
The ionizing radiations could be taken in considerate as an integral part in our life, since, living organisms are actually exposed to a constant shower of ionizing radiations whether from the natural or artificial resources. The radio-protective efficiency of several chemicals has been confirmed in animal trails, whereas, due to their accumulative toxicity, their clinical utility is limited. Therefore, we aimed in the present work to investigate the possibility of using argon laser to recuperate the damaged tissues due to exposing to the ionizing radiation...
April 2, 2010: Journal of Photochemistry and Photobiology. B, Biology
Tyler B Coplen, Haiping Qi
New isotope laboratories can achieve the goal of reporting the same isotopic composition within analytical uncertainty for the same material analysed decades apart by (1) writing their own acceptance testing procedures and putting them into their mass spectrometric or laser-based isotope-ratio equipment procurement contract, (2) requiring a manufacturer to demonstrate acceptable performance using all sample ports provided with the instrumentation, (3) for each medium to be analysed, prepare two local reference materials substantially different in isotopic composition to encompass the range in isotopic composition expected in the laboratory and calibrated them with isotopic reference materials available from the International Atomic Energy Agency (IAEA) or the US National Institute of Standards and Technology (NIST), (4) using the optimum storage containers (for water samples, sealing in glass ampoules that are sterilised after sealing is satisfactory), (5) interspersing among sample unknowns local laboratory isotopic reference materials daily (internationally distributed isotopic reference materials can be ordered at three-year intervals, and can be used for elemental analyser analyses and other analyses that consume less than 1 mg of material) - this process applies to H, C, N, O, and S isotope ratios, (6) calculating isotopic compositions of unknowns by normalising isotopic data to that of local reference materials, which have been calibrated to internationally distributed isotopic reference materials, (7) reporting results on scales normalised to internationally distributed isotopic reference materials (where they are available) and providing to sample submitters the isotopic compositions of internationally distributed isotopic reference materials of the same substance had they been analysed with unknowns, (8) providing an audit trail in the laboratory for analytical results - this trail commonly will be in electronic format and might include a laboratory information management system, (9) making at regular intervals a complete backup of laboratory analytical data (both of samples logged into the laboratory and of mass spectrometric analyses), being sure to store one copy of this backup offsite, and (10) participating in interlaboratory comparison exercises sponsored by the IAEA and other agencies at regular intervals...
June 2009: Isotopes in Environmental and Health Studies
Edward J Q Li, Cecilia W P Li-Tsang, C S Lam, Karen Y L Hui, Chetwyn C H Chan
BACKGROUND: This is a clinical randomized trail (RCT) to investigate the effects of a three-week training program on work readiness designed for musculoskeletal injured workers with long-term sick leave who had difficulties resuming their work role. The program was planned to help injured workers overcome the psychological and psychosocial problems and to facilitate their Work Readiness on Return to Work (RTW) based on the Employment readiness model. METHODOLOGY: A total of 64 injured workers were recruited and randomly assigned into the training (T) and control (C) groups...
December 2006: Journal of Occupational Rehabilitation
Wolf Hanke, Horst Bleckmann
The hydrodynamic trails of fish belonging to the families Centrarchidae, Tetraodontidae and Cichlidae were investigated. Water movements were measured in six horizontal planes, spaced 10-12 mm apart, for up to 5 min after the passage of a fish, using a computer controlled array of modulated laser diodes. We measured continuously and non-continuously swimming fish. Water velocities decayed rapidly in the leading seconds after the passage of a fish, but could still be measured for a period considerably longer than that...
April 2004: Journal of Experimental Biology
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