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anogenital neoplasia

Eduardo Lazcano-Ponce, Staci L Sudenga, B Nelson Torres, Mark Stoler, Leith León-Maldonado, Betania Allen-Leigh, Héctor Posso, Manuel Quiterio, María Del Pilar Hernández-Nevarez, Jorge Salmerón, Anna R Giuliano
OBJECTIVE: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs. MATERIALS AND METHODS: Participants (healthy males 18- 74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months;including excision biopsy on suspicious EGL with histological confirmation.Linear array assay PCR characterized 37 high/low-risk HPV-DNA types...
November 2018: Salud Pública de México
Lunthita M Duthely, Jose A Carugno, Cayla Y Suthumphong, Erica B Feldman, JoNell E Potter
Background: Vaginal cancer is a rare disease with poor clinical outcomes and limited therapeutic options. In the United States (US), minority women and older women are disproportionately diagnosed with late-stage vaginal cancer. Sociodemographic characteristics, risk behaviors, and cooccurring conditions are linked to vaginal intraepithelial neoplasia (VaIN). The diagnosis of VaIN is more prevalent among older women and women living with HIV (WLWH). The Caribbean basin has one of the highest rates of anogenital cancers in the Western Hemisphere...
2019: Interdisciplinary Perspectives on Infectious Diseases
Xuelian Wang, Xiumin Huang, Youzhong Zhang
Human papillomaviruses (HPV) are the first viruses to have been acknowledged to prompt carcinogenesis, and they are linked with cancers of the uterine cervix, anogenital tumors, and head and neck malignancies. This paper examines the structure and primary genomic attributes of HPV and highlights the clinical participation of the primary HPV serotypes, focusing on the roles that HPV-16 and 18 play in carcinogenesis. The mechanisms that take place in the progression of cervical neoplasia are described. The oncogenic proteins E6 and E7 disrupt control of the cell cycle by their communication with p53 and retinoblastoma protein...
2018: Frontiers in Microbiology
Daniel Grace, Mark Gaspar, Rachelle Paquette, Ron Rosenes, Ann N Burchell, Troy Grennan, Irving E Salit
The human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Gay, bisexual, and other men who have sex with men (GBM) living with HIV are disproportionately impacted by HPV-associated anal cancer, with rates about 100-fold that of the general population. Fortunately, HPV vaccination has proven efficacy in preventing both anogenital warts (condyloma) in males and anal pre-cancers (anal intraepithelial neoplasia; AIN) in GBM up to the age of 26. We conducted in-depth, semi-structured interviews with 25 HIV-positive gay men in Toronto to gain an understanding of their knowledge and experiences related to HPV and the HPV vaccine...
2018: PloS One
Maryam Sadat Hosseini, Donya Khosravi, Farah Farzaneh, Abdalali Ebrahimi, Maliheh Arab, Tahereh Ashraf Ganjoie, Farzane Jamdar, Atefeh Moridi, Mohammad Chehrazi
Background: Anal cancer is uncommon. Although uncommon, the incidence of anal cancer has increased among the general population of the United States and other countries over the past 30 years. We evaluated anal cytology in women with the history of abnormal pap smear, cervical intraepithelial neoplasia, cervical cancer and high risk HPV for anogenital dysplasia. Methods: In this cross-sectional study, 153 patients over the age of 21 years, referred to Imam Hossein Hospital in 1395-1396 who were being monitored due to abnormal pap smear, cervical cancer, CIN and high risk HPV, were evaluated with anal cytology for anogenital dysplasia...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Kurt G Davis, Guy R Orangio
Despite the progress made in the reduction of squamous cell carcinoma of the cervix, the incidence of anal squamous cell carcinoma (ASCC) has been increasing since 1992. While it remains an uncommon disease, the prevalence is climbing steadily. Among human immunodeficiency virus (HIV)-infected adults, especially men who have sex with men, ASCC is one of the more common non-AIDS-defining malignancies. The precursor lesion, anal intraepithelial neoplasia (AIN), is prevalent in the HIV-infected population. More than 90% of ASCCs are related to human papilloma virus (HPV), oncogenic types (HPV 16, 18)...
November 2018: Clinics in Colon and Rectal Surgery
Keegan M Lyons, Samantha L Butler
Anal squamous cell carcinoma is a relatively rare diagnosis, but its incidence has continued to rise. Anal squamous cell carcinoma and its precursor lesion, anal intraepithelial neoplasia (AIN), are human papillomavirus (HPV)-associated squamous neoplasias. High-risk HPV subtypes cause cellular proliferation in the anal transformation zone mucosa leading to similar dysplastic changes as seen in the cervix. Unified cytologic and histologic classification systems have emerged for all HPV-associated squamous lesions of the lower anogenital tract due to recent advancements in the understanding of these lesions...
November 2018: Clinics in Colon and Rectal Surgery
Marc Steben, Mattea Tan Thompson, Caroline Rodier, Nathalie Mallette, Voica Racovitan, Fern DeAngelis, Melissa Stutz, Emmanouil Rampakakis
Publicly funded administration of the quadrivalent HPV (qHPV) vaccine in school-aged girls was implemented for all Canadian provinces and territories between 2007 and 2009. However, the impact of female qHPV vaccination in Canada has yet to be evaluated. This systematic literature review of studies published between September 1, 2006 and September 1, 2016 looked at real-world evidence related to the effects of qHPV vaccination on prevalence of HPV infection and disease in Canada over the past decade. PubMed was searched for studies published between September 1, 2006 and September 1, 2016...
October 16, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
C Rossi, C Vanhomwegen, F Laurent
High-risk oncogenic HPVs (HR-HPV) are associated in men with pre-cancerous anal dysplasia, oropharyngeal, anal and penile cancer. Anogenital warts are induced by low-risk HPVs. These manifestations are increasing among men, and especially in some high-risk groups as men who have sex with men (MSM). This review targets HPV-associated disease epidemiology as well as safety, immunogenicity, and efficacy level of HPV vaccine in men. Obstacle and cost-effectiveness analysis of HPV vaccination are discussed. Three HPV vaccines are currently available in Belgium with the 9-valent (" 9HPV " - 6/11/16/18/31/33/45/52/58) offering protection against most of HPVassociated diseases...
2018: Revue Médicale de Bruxelles
Martina Z Liu, Yin P Hung, Eric C Huang, Brooke E Howitt, Marisa R Nucci, Christopher P Crum
Human papillomavirus (HPV) type 6 is historically classified as low-risk HPV type and associates with low-grade squamous intraepithelial lesions of the anogenital tract. Rare squamous carcinomas have been reported in association with these HPV types but the mechanism(s) behind this carcinogenic sequence have been unclear. We report 4 cases of low risk anogenital HPV infections-3 cervical (immature low-grade squamous intraepithelial lesion with metaplastic phenotype) and one anal (exophytic condyloma) lesion-that manifested with high-grade squamous intraepithelial lesion/squamous cell carcinoma...
October 11, 2018: International Journal of Gynecological Pathology
Alexandre Harlé, Julie Guillet, Jacques Thomas, Xavier Sastre-Garau, Marie Rouyer, Carole Ramacci, Pauline Gilson, Cindy Dubois, Gilles Dolivet, Agnès Leroux, Julia Salleron, Jean-Louis Merlin
Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and compare the results with conventional PCR. Repeatability, reproducibility and limit of detection of Cobas assay were estimated for oral cytobrush and FFPE samples of patients with HNC. 53 samples of patients with a HNC were then used for assay comparison with conventional PCR...
July 27, 2018: Scientific Reports
Thomas Harder, Ole Wichmann, Stefanie J Klug, Marianne A B van der Sande, Miriam Wiese-Posselt
BACKGROUND: Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also advocated, but systematic reviews on efficacy and safety in males are lacking. METHODS: We performed a systematic review on the efficacy, effectiveness and safety of HPV vaccination in males of any age. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and ClinicalTrials...
July 18, 2018: BMC Medicine
Suzanne M Garland, Elmar A Joura, Kevin A Ault, F Xavier Bosch, Darron R Brown, Xavier Castellsagué, Alex Ferenczy, Daron G Ferris, Anna R Giuliano, Mauricio Hernandez-Avila, Warner K Huh, Ole-Erik Iversen, Susanne K Kjaer, Robert J Kurman, Joaquin Luna, Joseph Monsonego, Nubia Muñoz, Jorma Paavonen, Punnee Pitisuttihum, Brigitte M Ronnett, Marc Steben, Mark H Stoler, Cosette M Wheeler, Dorothy J Wiley, Gonzalo Perez, Alfred J Saah, Alain Luxembourg, Se Li, Mark J DiNubile, Monika Wagner, Christine Velicer
OBJECTIVE: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). METHODS: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay...
August 2018: Obstetrics and Gynecology
Mehenaz Hanbazazh, Kymberly A Gyure
CONTEXT: - Human papillomavirus (HPV) has a well-known role in the pathogenesis of squamous cell carcinoma and precursor lesions of the cervix, anogenital region, and head and neck, but its role in the development of squamous neoplasms of the eye, particularly the conjunctiva, remains unclear. OBJECTIVE: - To review recent evidence implicating HPV in the pathophysiology of ocular lesions. DATA SOURCES: - Published articles obtained from a PubMed search of the English literature were the primary sources for this review...
June 2018: Archives of Pathology & Laboratory Medicine
Racheal S Dube Mandishora, Kristina S Gjøtterud, Sonja Lagström, Babill Stray-Pedersen, Kerina Duri, Nyasha Chin'ombe, Mari Nygård, Irene Kraus Christiansen, Ole Herman Ambur, Mike Z Chirenje, Trine B Rounge
Human papillomaviruses (HPVs) co-evolve slowly with the human host and each HPV genotype displays epithelial tropisms. We assessed the evolution of intra HPV genotype variants within samples, and their association to anogenital site, cervical cytology and HIV status. Variability in the L1 gene of 35 HPV genotypes was characterized phylogenetically using maximum likelihood, and portrayed by phenotype. Up to a thousand unique variants were identified within individual samples. In-depth analyses of the most prevalent genotypes, HPV16, HPV18 and HPV52, revealed that the high diversity was dominated by a few abundant variants...
June 2018: Papillomavirus Research
Andreia Albuquerque, Michael Sheaff, Oliver Stirrup, Carmelina Cappello, Julie Bowring, Tamzin Cuming, Anke De Masi, Adam N Rosenthal, Mayura Nathan
Background: Information on the performance of anal cytology in women who are high risk for human papillomavirus-related lesions and the factors that might influence cytology are largely lacking. Methods: Retrospective study including all new referrals of women with a previous history of anogenital neoplasia from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies. Results: Six hundred and thirty six anal cytology samples and 323 biopsies obtained from 278 women were included...
September 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Leonora Maciel de Souza Vianna, Fabiana Pirani Carneiro, Rivadavio Amorim, Eliete Neves da Silva Guerra, Florêncio Figueiredo Cavalcanti Neto, Valdenize Tiziani, Andrea Barretto Motoyama, Anamélia Lorenzetti Bocca
Background: The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is not clear. The aim of the present study was to detect HPV infection, and clinical and cytological changes in the oropharynx of HIV-positive patients. Methods: Samples collected from the oropharynx of 100 HIV-positive patients were subjected to hybrid capture (HC), conventional and liquid-based cytology...
2018: PeerJ
Lulu Sun, Lingxin Zhang, Hannah R Krigman, Ian S Hagemann
OBJECTIVES: Preinvasive squamous neoplasms of the lower genital tract are currently classified using a two-tier system (high- or low-grade squamous intraepithelial lesion) as directed by the Lower Anogenital Squamous Terminology (LAST) guidelines but may also be subclassified as intraepithelial neoplasia grade 1 (-IN1), -IN2, or -IN3. The LAST recommended that all diagnoses of -IN2 be supported by immunohistochemistry (IHC) for p16. We examined whether p16 and Ki-67 IHC are necessary to diagnose -IN2 when the lesion has obvious high-grade histology...
April 2018: Journal of Lower Genital Tract Disease
Andreia Albuquerque, Elisabete Rios, Claudia Camila Dias, Mayura Nathan
p16 is the most widely studied biomarker in lower anogenital tract squamous intraepithelial lesions and, currently the only recommended biomarker for histological grade assessment. The aim of this systematic review and meta-analysis was to evaluate p16-positive rates according to anal squamous intraepithelial lesions/anal intraepithelial neoplasia (AIN) grade. Two investigators independently searched four electronic databases: PubMed, Web of Sciences, Scopus, and Embase from inception until August 2017. Studies that evaluated p16 immunostaining in histological samples of anal and/or perianal squamous intraepithelial lesions and defined a p16-positive result as diffuse block staining with nuclear or nuclear plus cytoplasmic staining were included...
July 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Elizabeth A Stier, Elizabeth Y Chiao
The epidemiology of anal cancer in the U.S. has changed over the past 3 decades. During this period the incidence of anal cancer has increased among both men and women. Of note, women with a history of anogenital HPV infection are at higher risk than the general population for anal cancer. The increased risk ranged from increased incidence rate ratios ranging from 1.82 to 6.3 in women with a history of cervical cancer, to 4.2-16.4 in women with a history of prior cervical intraepithelial neoplasia 3 (CIN 3)...
June 2017: Seminars in Colon & Rectal Surgery
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