keyword
https://read.qxmd.com/read/37588624/dna-high-risk-hpv-mrna-hpv-and-p16-tests-for-diagnosis-of-anal-cancer-and-precursor-lesions-a-systematic-review-and-meta-analysis
#21
JOURNAL ARTICLE
Ana Cristina Macedo, Antônio José Grande, Tatiana Figueiredo, Tamy Colonetti, João Carlos Gonçalves, Eduardo Testoni, Maria Inês da Rosa
BACKGROUND: Anal cancer prevention has two critical points: the incidence rate is several fold higher for some groups, such as people living with human immunodeficiency virus (HIV) and men who have sex with men (MSM), and there is not a well-defined guideline for its screening. This systematic review evaluates the accuracy of DNA HRHPV (high-risk human papillomavirus), mRNA HPV, DNA HPV16 isolated and p16 staining biomarkers in anal canal smears for identifying anal intraepithelial neoplasia (AIN) 2 or 3, summarised as anal high-grade squamous intraepithelial lesions (aHSIL), and cancer...
August 2023: EClinicalMedicine
https://read.qxmd.com/read/37504676/succinyl-coa-and-cobalamin-are-biomarkers-that-improve-anal-cancer-screening
#22
COMMENT
(no author information available yet)
Elevated succinyl-CoA and cobalamin levels were associated with high-grade squamous intraepithelial lesions.
September 6, 2023: Cancer Discovery
https://read.qxmd.com/read/37464040/microbiome-derived-cobalamin-and-succinyl-coa-as-biomarkers-for-improved-screening-of-anal-cancer
#23
JOURNAL ARTICLE
Sergio Serrano-Villar, Camilla Tincati, Sajan C Raju, Johan S Sáenz, Elena Moreno, Rafael Bargiela, Alfonso Cabello-Ubeda, Elena Sendagorta, Alina Kurz, Jose A Perez Molina, Amparo de Benito, Johannes R Hov, Laura Fernandez-Lopez, Alfonso Muriel, Rosa Del Campo, Santiago Moreno, Marius Trøseid, Jana Seifert, Manuel Ferrer
Human papillomavirus can cause preinvasive, high-grade squamous intraepithelial lesions (HSILs) as precursors to cancer in the anogenital area, and the microbiome is suggested to be a contributing factor. Men who have sex with men (MSM) living with human immunodeficiency virus (HIV) have a high risk of anal cancer, but current screening strategies for HSIL detection lack specificity. Here, we investigated the anal microbiome to improve HSIL screening. We enrolled participants living with HIV, divided into a discovery (n = 167) and validation cohort (n = 46), and who were predominantly (93...
July 2023: Nature Medicine
https://read.qxmd.com/read/37399095/cumulative-incidence-of-anal-cancer-since-hiv-or-aids-diagnosis-in-the-united-states
#24
JOURNAL ARTICLE
Cameron B Haas, Eric A Engels, Marie-Josèphe Horner, Ruth Pfeiffer, Qianlai Luo, Aimée Kreimer, Joel M Palefsky, Meredith Shiels
Treatment of screen-detected anal high-grade squamous intraepithelial lesions has been shown to effectively reduce the incidence of invasive anal cancer in people with HIV (PWH). We provide population-based estimates of cumulative incidence of anal cancer by risk group and age at HIV and/or AIDS diagnosis. The 0-10-year cumulative incidence of anal cancer for men who have sex with men (MSM) aged <30 years at HIV diagnosis was 0.17% (95% CI = 0.13-0.20%) compared to 0.04% (0.02-0.06%) in other males and 0...
July 3, 2023: Journal of the National Cancer Institute
https://read.qxmd.com/read/37358055/evaluating-the-performance-of-anal-cytology-and-high-risk-hpv-genotyping-for-detecting-anal-hsil-in-a-clinic-based-sample-of-people-living-with-and-without-hiv-in-puerto-rico
#25
JOURNAL ARTICLE
Jeslie M Ramos-Cartagena, Kandyce Keller, Humberto M Guiot, Cristina Muñoz, Vivian Colón-López, Ashish A Deshmukh, Erick L Suárez, Maribel Tirado-Gómez, Ana P Ortiz
BACKGROUND: Given the disproportionately elevated anal cancer risk in high-risk populations, it is important to assess the performance of commonly used anal cancer screening tools to improve the effectiveness of detection and treatment methods. This study evaluates 1) the concordance between anal cytology and histology results and 2) the performance of cytology and high-risk human papillomavirus (HR-HPV) genotyping as screening tools for detecting histologically confirmed anal high-grade squamous intraepithelial lesions (HSIL)...
June 26, 2023: Cancer Cytopathology
https://read.qxmd.com/read/37276242/high-specificity-of-hpv-cell-free-dna-tests-in-persons-with-hiv-for-the-detection-of-hpv-related-cancer
#26
JOURNAL ARTICLE
Grant Ellsworth, Roger Shen, Kinge-Ann Marcelin, Rahul Majumdar, Maximillian Bazil, Grace Moore, Meredith Nelson, Isabel Alland, Gustavo Sepulveda, Timothy Wilkin, Daniel S Higginson
INTRODUCTION: Persons with HIV (PWH) experience high rates of human papillomavirus (HPV)-associated cancers compared with the general population. Plasma HPV cell-free DNA (cfDNA) tests are sensitive in patients with known HPV-associated cancers. It is not known whether these tests can screen for invasive cancers in populations with high burdens of nonmalignant HPV disease such as PWH. It was not known whether HPV infection and/or noninvasive anal high-grade squamous intraepithelial lesions (HSIL) alone in this population would result in detectable HPV cfDNA, which would result in a high number of false positives if HPV cfDNA is used to screen for invasive cancers...
September 1, 2023: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/37243256/hpv-infection-of-the-oropharyngeal-genital-and-anal-mucosa-and-associated-dysplasia-in-people-living-with-hiv
#27
JOURNAL ARTICLE
Carmen Hidalgo-Tenorio, Inmaculada Calle-Gómez, Raquel Moya-Megías, Javier Rodríguez-Granges, Mohamed Omar, Javier López Hidalgo, Carmen García-Martínez
BACKGROUND: The main objectives were to describe the prevalence of HPV, its genotypes and HPV-associated dysplastic lesions in the oropharyngeal mucosa of PLHIV and related factors. MATERIAL AND METHODS: This cross-sectional prospective study consecutively enrolled PLHIV attending our specialist outpatient units. At visit, HIV-related clinical and analytical variables were gathered, and oropharyngeal mucosa exudates were taken to detect HPV and other STIs by polymerase chain reaction...
May 15, 2023: Viruses
https://read.qxmd.com/read/37222693/current-monitoring-and-treatment-for-anal-intraepithelial-neoplasms
#28
REVIEW
Ray Ramirez, Kristen Donohue
Anal intraepithelial neoplasms (AIN) are precursors to anal cancer. To date, there is not a significant body of literature to support screening, monitoring, and treatment of these precursor lesions, particularly in high risk populations. This review will detail the current monitoring and indications for treatment of such lesions, with the goal of preventing progression to invasive cancer.
June 2023: Journal of Surgical Oncology
https://read.qxmd.com/read/37201549/demonstrating-a-statistically-significant-association-between-anal-high-grade-squamous-intraepithelial-lesion-and-positive-oncoe6-anal-test-in-men-who-have-sex-with-men-and-are-living-with-hiv
#29
JOURNAL ARTICLE
Jeanne A Jordan, Karina I Rivas, Annette Aldous, Kaleigh A Connors, Kamwing Jair, David A Klein, Elizabeth S Hoke, Stephen E Abbott
OBJECTIVES: The aim of the study is to determine whether a positive OncoE6 Anal Test result has statistically significant higher odds of being associated with high-grade squamous intraepithelial lesion (HSIL) and to calculate sensitivity and specificity of this test for predicting HSIL in adult men who have sex with men and are living with HIV (MSMLWH). MATERIALS AND METHODS: Men living with HIV 18 years or older having ≥atypical squamous cells of undetermined significance-grade anal cytology results were eligible to enroll in this cross-sectional study...
May 17, 2023: Journal of Lower Genital Tract Disease
https://read.qxmd.com/read/37195272/effectiveness-of-topical-cidofovir-for-treatment-of-refractory-anal-high-grade-squamous-intraepithelial-lesion-hsil
#30
JOURNAL ARTICLE
Joaquin Burgos, David Campany, Jorge Garcia, Stefania Landolfi, Vicenç Falcó, Adrià Curran
OBJECTIVES: Ablative electrocautery is effective treating anal high-grade squamous intraepithelial lesions (HSIL). However, persistence or recurrence of the HSIL despite ablative sessions is not uncommon. The aim of this study is to assess the feasibility of topical cidofovir as salvage therapy for the management of refractory HSIL. DESIGN: A prospective un-controlled unicenter study of men and transgender people who have sex with men with HIV who had a refractory intra-anal HSIL after ablative treatments and who received topical cidofovir (ointment at 1%, auto-applicated, three times a week, a total of 8 weeks) as salvage therapy...
May 4, 2023: AIDS
https://read.qxmd.com/read/37181349/case-report-a-precancerous-lesion-associated-with-hpv-in-the-anal-canal-diagnosed-by-magnifying-endoscopy-with-narrow-band-imaging-and-resected-by-endoscopic-submucosal-dissection
#31
Hengcun Li, Xiujing Sun, Ling Yang, Rui Xu, Peng Li
Although anal cancer remains rarely diagnosed in the world, its frequency is rising, especially in high-risk groups. The prognosis of advanced anal cancer is poor. However, there are still few reports on the endoscopic diagnosis and treatment of early anal cancer and its precancerous lesions. A 60-year-old woman was referred to our hospital for endoscopic treatment of a flat precancerous lesion in the anal canal, which was identified by narrow-band imaging (NBI) and confirmed by pathological examination in another hospital...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37020153/construct-validity-and-responsiveness-of-a-health-related-symptom-index-for-persons-either-treated-or-monitored-for-anal-high-grade-squamous-intraepithelial-lesions-hsil-amc-a01-a03
#32
RANDOMIZED CONTROLLED TRIAL
Thomas M Atkinson, Shelly Lensing, Jeannette Y Lee, Di Chang, Soo Young Kim, Yuelin Li, Kathleen A Lynch, Andrew Webb, Susan M Holland, Erica I Lubetkin, Stephen Goldstone, Mark H Einstein, Elizabeth A Stier, Dorothy J Wiley, Ronald Mitsuyasu, Isabella Rosa-Cunha, David M Aboulafia, Shireesha Dhanireddy, Jeffrey T Schouten, Rebecca Levine, Edward Gardner, Jeffrey Logan, Hillary Dunleavy, Luis F Barroso, Gary Bucher, Jessica Korman, Benjamin Stearn, Timothy J Wilkin, Grant Ellsworth, Julia C Pugliese, Abigail Arons, Jack E Burkhalter, David Cella, J Michael Berry-Lawhorn, Joel M Palefsky
PURPOSE: To determine whether treatment of anal high-grade squamous intraepithelial lesions (HSIL), vs active monitoring, is effective in reducing incidence of anal cancer in persons living with HIV, the US National Cancer Institute funded the Phase III ANal Cancer/HSIL Outcomes Research (ANCHOR) clinical trial. As no established patient-reported outcomes (PRO) tool exists for persons with anal HSIL, we sought to estimate the construct validity and responsiveness of the ANCHOR Health-Related Symptom Index (A-HRSI)...
August 2023: Quality of Life Research
https://read.qxmd.com/read/36982714/role-of-low-risk-hpv-pcr-monoinfection-in-screening-for-hsil-and-anal-cancer-in-men-who-have-sex-with-men-living-with-hiv
#33
JOURNAL ARTICLE
Carmen María García-Martínez, Inmaculada Calle-Gómez, Javier López-Hidalgo, Patricia Gómez-Ronquillo, Mohamed Omar-Mohamed Balgahata, Carmen Hidalgo-Tenorio
To determine the value of low-risk human papillomavirus (HPV) PCR to screen for "high-grade anal squamous intraepithelial lesion and anal cancer" (HSIL-plus), rate of patients with low-grade anal squamous intraepithelial lesion (LSIL) progressing to HSIL-plus, and progression-related factors. Prospective, longitudinal study of consecutive MSM-LHIV attended between May 2010 and December 2021 and followed for 43 months (IQR: 12-76). HIV-related variables were gathered at baseline, performing anal cytology for HPV detection/genotyping, thin-layer cytological study, and high-resolution anoscopy (HRA)...
March 15, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36896618/-not-available
#34
JOURNAL ARTICLE
Helle Kiellberg Larsen, Merete Hædersdal, Susanne Krüger Kjær
Anal cancer risk is increased in certain risk groups including people living with HIV (PLWH), especially in men who have sex with men, but also in organ transplant recipients and women with a history of cervical or vulva dysplasia or cancer. High-resolution anoscopy (HRA) is a tool to diagnose anal high-grade squamous intraepithelial lesions (HSIL), and HRA-guided treatment of anal HSIL has been shown to reduce the risk of anal cancer in PLWH. The purpose of this review is to increase the awareness of HRA but also of tertiary prevention by digital anal rectal examination...
February 27, 2023: Ugeskrift for Laeger
https://read.qxmd.com/read/36869915/duration-of-time-cd4-cd8-ratio-is-below-0-5-is-associated-with-progression-to-anal-cancer-in-patients-with-hiv-and-high-grade-dysplasia
#35
JOURNAL ARTICLE
Aos Karim, Matthew J Freeman, Qiuyu Yang, Glen Leverson, Linda Cherney-Stafford, Rob Striker, Cristina B Sanger
BACKGROUND: A CD4/CD8 ratio < 0.5 is associated with increased risk of advanced anal disease (AAD) but it is unknown if duration below 0.5 matters. The purpose of this study was to determine if duration of a CD4/CD8 ratio < 0.5 is associated with increased risk of invasive anal cancer (IC) in people living with HIV and high-grade dysplasia (HSIL). METHODS: This single institution, retrospective study used the University of Wisconsin Hospital and Clinics Anal Dysplasia and Anal Cancer Database...
March 4, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36839524/human-papillomavirus-genotypes-infecting-the-anal-canal-and-cervix-in-hiv-men-and-women-anal-cytology-and-risk-factors-for-anal-infection
#36
JOURNAL ARTICLE
Laura Conde-Ferráez, Alberto Chan-Mezeta, Jesús Gilberto Gómez-Carballo, Guadalupe Ayora-Talavera, María Del Refugio González-Losa
The incidence of anal intraepithelial neoplasias associated with HPV is rising worldwide. In the general population, this pathology is rare, but individuals living with HIV/AIDS are at a significantly higher risk. We aimed to study HPV infection and performed cytological screening to study the epidemiological and behavioral determinants in a group of men and women living with HIV from a region in Mexico with high HIV incidence. This was a cross-sectional study including adults living with HIV/AIDS performed in Merida (Mexico)...
February 4, 2023: Pathogens
https://read.qxmd.com/read/36831490/natural-history-of-anal-hpv-infection-in-women-treated-for-cervical-intraepithelial-neoplasia
#37
JOURNAL ARTICLE
Marta Del Pino, Isabel Matas, Pilar Carrillo, Cristina Martí, Ariel Glickman, Núria Carreras-Dieguez, Lorena Marimon, Adela Saco, Natalia Rakislova, Aureli Torné, Jaume Ordi
Women with high-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (HSIL/CIN) are at high risk of anal human papillomavirus HPV infection, and it has also been suggested that self-inoculation of the virus from the anal canal to the cervix could explain HPV recurrence in the cervix after treatment of HSIL/CIN. We aimed to evaluate the bidirectional interactions of HPV infection between these two anatomical sites. We evaluated 68 immunocompetent women undergoing excisional treatment for HSIL/CIN...
February 10, 2023: Cancers
https://read.qxmd.com/read/36821789/comorbidity-of-urogynecological-and-gastrointestinal-disorders-in-female-patients-with-lichen-sclerosus
#38
JOURNAL ARTICLE
Jenni M Söderlund, Niina K Hieta, Samu H Kurki, Katri J Orte, Päivi Polo-Kantola, Sakari H Hietanen, Marjut Am Haataja
OBJECTIVE: Lichen sclerosus (LS) is a chronic inflammatory disease with a significant impact on quality of life. The aim of this cross-sectional case-control study was to characterize concomitant urogynecological and gastrointestinal disorders in female patients with LS. METHODS: A medical records search between 2004 and 2012 yielded 455 women and girls (mean age 64 years) with LS. The study cohort was compared with a 10-fold age- and sex-matched control cohort...
February 23, 2023: Journal of Lower Genital Tract Disease
https://read.qxmd.com/read/36785857/cost-effectiveness-of-screening-and-treating-anal-pre-cancerous-lesions-among-gay-bisexual-and-other-men%C3%A2-who%C3%A2-have-sex-with-men-living-with-hiv
#39
JOURNAL ARTICLE
Qinglu Cheng, I Mary Poynten, Fengyi Jin, Andrew Grulich, Jason J Ong, Richard J Hillman, George Hruby, Kirsten Howard, Anthony Newall, David C Boettiger
BACKGROUND: Gay, bisexual and other men who have sex with men (GBM) living with HIV have a substantially elevated risk of anal cancer (85 cases per 100,000 person-years vs 1-2 cases per 100,000 person-years in the general population). The precursor to anal cancer is high-grade squamous intraepithelial lesion (HSIL). Findings regarding the cost-effectiveness of HSIL screening and treatment in GBM are conflicting. Using recent data on HSIL natural history and treatment effectiveness, we aimed to improve upon earlier models...
March 2023: The Lancet Regional Health. Western Pacific
https://read.qxmd.com/read/36765617/hpv-type-distribution-in-benign-high-grade-squamous-intraepithelial-lesions-and-squamous-cell-cancers-of-the-anus-by-hiv-status
#40
JOURNAL ARTICLE
Sona Chowdhury, Teresa M Darragh, J Michael Berry-Lawhorn, Maria G Isaguliants, Maxim S Vonsky, Joan F Hilton, Ann A Lazar, Joel M Palefsky
The incidence of anal cancer is increasing, especially in high-risk groups, such as PLWH. HPV 16, a high-risk (HR) HPV genotype, is the most common genotype in anal high-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) in the general population. However, few studies have described the distribution of HR HPV genotypes other than HPV 16 in the anus of PLWH. HPV genotyping was performed by DNA amplification followed by dot-blot hybridization to identify the HR and low-risk (LR) genotypes in benign anal lesions (n = 34), HSIL (n = 30), and SCC (n = 51) of PLWH and HIV-negative individuals...
January 20, 2023: Cancers
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