keyword
https://read.qxmd.com/read/38297406/international-anal-neoplasia-society-s-consensus-guidelines-for-anal-cancer-screening
#1
JOURNAL ARTICLE
Elizabeth A Stier, Megan A Clarke, Ashish A Deshmukh, Nicolas Wentzensen, Yuxin Liu, I Mary Poynten, Eugenio Nelson Cavallari, Valeria Fink, Luis F Barroso, Gary M Clifford, Tamzin Cuming, Stephen E Goldstone, Richard J Hillman, Isabela Rosa-Cunha, Luciana La Rosa, Joel M Palefsky, Rosalyn Plotzker, Jennifer M Roberts, Naomi Jay
The International Anal Neoplasia Society (IANS) developed consensus guidelines to inform anal cancer screening use among various high-risk groups. Anal cancer incidence estimates by age among risk groups provided the basis to identify risk thresholds to recommend screening. Guided by risk thresholds, screening initiation at age 35 years was recommended for men who have sex with men (MSM) and transgender women (TW) with HIV. For other people with HIV and MSM and TW not with HIV, screening initiation at age 45 years was recommended...
January 31, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38280748/anal-and-perianal-preneoplastic-lesions
#2
REVIEW
Maurice B Loughrey, Neil A Shepherd
Anal cancer, mainly squamous cell carcinoma, is rare but increasing in prevalence, as is its precursor lesion, anal squamous dysplasia. They are both strongly associated with human papillomavirus infection. The 2-tiered Lower Anogenital Squamous Terminology classification, low-grade SIL and high-grade SIL, is preferred to the 3-tiered anal intraepithelial neoplasia classification because of better interobserver agreement and clearer management implications. Immunohistochemistry with p16 is helpful to corroborate the diagnosis of squamous dysplasia...
March 2024: Gastroenterology Clinics of North America
https://read.qxmd.com/read/38270249/deep-learning-in-high-resolution-anoscopy-assessing-the-impact-of-staining-and-therapeutic-manipulation-on-automated-detection-of-anal-cancer-precursors
#3
JOURNAL ARTICLE
Miguel Mascarenhas Saraiva, Lucas Spindler, Nadia Fathallah, Hélene Beaussier, Célia Mamma, Mathilde Quesnée, Tiago Ribeiro, João Afonso, Mariana Carvalho, Rita Moura, Patrícia Andrade, Hélder Cardoso, Julien Adam, João Ferreira, Guilherme Macedo, Vincent de Parades
INTRODUCTION: High-resolution anoscopy (HRA) is the gold standard for detecting anal squamous cell cancer (ASCC) precursors. Preliminary studies on the application of artificial intelligence (AI) models to this modality have revealed promising results. However, the impact of staining techniques and anal manipulation on the effectiveness of these algorithms has not been evaluated. We aimed to develop a deep learning system for automatic differentiation of high (HSIL) versus low-grade (LSIL) squamous intraepithelial lesions in HRA images in different subsets of patients (non-stained, acetic acid, lugol, and after manipulation)...
January 25, 2024: Clinical and Translational Gastroenterology
https://read.qxmd.com/read/38217494/effectiveness-of-trichloroacetic-acid-versus-electrocautery-for-the-treatment-of-anal-high-grade-squamous-intraepithelial-lesions-in-persons-with-hiv
#4
JOURNAL ARTICLE
Joaquin Burgos, Adrià Curran, Jorge Garcia, Stefania Landolfi, Javier Hernández-Losa, Paula Suanzes, Jordi Navarro, Vicenç Falcó
PURPOSE: This study aimed to compare trichloroacetic acid (TCA) versus electrocautery (ECA) for the treatment of anal high-grade squamous intraepithelial lesions (HSIL). METHODS: This is an observational, single-center study. All subjects with HIV who had anal HSIL treated with TCA or ECA from 2010 to 2022 were included. Effectiveness was evaluated by on-treatment analysis, defining response as the resolution of HSIL and recurrence as a new diagnosis of HSILs during follow-up...
January 13, 2024: Infectious Diseases
https://read.qxmd.com/read/38198036/screening-for-precancerous-anal-lesions-linked-to-human-papillomaviruses-french-recommendations-for-clinical-practice
#5
REVIEW
L Spindler, I Etienney, L Abramowitz, V de Parades, F Pigot, L Siproudhis, J Adam, V Balzano, D Bouchard, N Bouta, M Bucau, A Carlo, J Chanal, C Charpentier, G Clifford, M Draullette, N Fathallah, V Ferré, J-F Fléjou, S Fouéré, T Higuero, L Kassouri, S Kurt, A Laurain, E Leclerc, Q Lepiller, A-C Lesage, D Mège, A Ménard, P Merle, P Mortreux, C Noël, H Péré, J-L Prétet, D Roland, G Staumont, L Tracanelli, L Vuitton, S Wylomanski, O Zaegel-Faucher
In France, about 2000 new cases of anal cancer are diagnosed annually. Squamous cell carcinoma is the most common histological type, mostly occurring secondary to persistent HPV16 infection. Invasive cancer is preceded by precancerous lesions. In addition to patients with a personal history of precancerous lesions and anal cancer, three groups are at very high risk of anal cancer: (i) men who have sex with men and are living with HIV, (ii) women with a history of high-grade squamous intraepithelial lesions (HSILs) or vulvar HPV cancer, and (iii) women who received a solid organ transplant more than 10 years ago...
January 10, 2024: Techniques in Coloproctology
https://read.qxmd.com/read/38186663/association-of-tobacco-use-and-the-presence-of-anal-warts-in-people-who-attend-the-anal-neoplasia-clinic-in-puerto-rico
#6
JOURNAL ARTICLE
Tanialy Rivera-Santiago, Jeslie M Ramos-Cartagena, Claudia Amaya-Ardila, Cristina Muñoz, Humberto M Guiot, Vivian Colón-López, Miriam Matos, Maribel Tirado-Gómez, Ana Patricia Ortiz
BACKGROUND: Limited research exists regarding the association between smoking and anal warts. In this study, we evaluated this association among a clinic-based Hispanic population in Puerto Rico. METHODS: Cross-sectional study among eligible patients seen at the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Cancer Center (2016-2023) (n = 920). Sociodemographic and clinical variables were collected from medical records. Patients underwent a high-resolution anoscopy (HRA) during the clinical visit; physicians assessed anal condylomas on HRA...
January 2024: Preventive Medicine Reports
https://read.qxmd.com/read/38117576/anal-dysplasia-screening-in-people-living-with-hiv-long-term-follow-up-in-a-large-cohort-from-northwest-spain
#7
JOURNAL ARTICLE
Alexandre Pérez-González, Silvia Rodríguez-Rivero, Pilar Fernández-Veiga, Erene Flores, Eva Poveda, Joaquín González-Carreró, Sonia Pérez-Castro, Laura Labajo-Leal, Celia Miralles, Antonio Ocampo
Anal squamous cell carcinoma (SCC) is not a common disease in the general population, although its incidence is higher in people living with human immunodeficiency virus (PLWH). Anal SCC is caused by human papillomavirus (HPV) infection and arises from premalignant lesions termed squamous intraepithelial lesions (SILs). SIL surveillance programs are based on the early detection and treatment of SILs, especially those with a higher risk of transforming into cancer. An anal surveillance program has been under development in our institution since 2011...
January 2024: AIDS Patient Care and STDs
https://read.qxmd.com/read/38100463/a-phase-i-study-of-intra-anal-artesunate-suppositories-to-treat-anal-high-grade-squamous-intraepithelial-lesions
#8
JOURNAL ARTICLE
Sandy Hwang Fang, Mihaela Plesa, Evie H Carchman, Nicole A Cowell, Emily Staudt, Kyleigh Ann Twaroski, Ulrike K Buchwald, Cornelia L Trimble
BACKGROUND: Ablation or surgical excision is the typical treatment of anal high-grade squamous intraepithelial lesions (HSIL). Recurrences are common due to the persistence of underlying human papillomavirus (HPV) infection. Additional well-tolerated and effective non-surgical options for HPV-associated anal disease are needed. METHODS: This 3+3 dose escalation Phase I clinical trial evaluated the safety and tolerability of artesunate suppositories in the treatment of patients with biopsy-proven HSIL...
2023: PloS One
https://read.qxmd.com/read/38094635/the-vulvar-microbiome-in-lichen-sclerosus-and-high-grade-intraepithelial-lesions
#9
JOURNAL ARTICLE
Lisa Pagan, Bertine W Huisman, Michelle van der Wurff, Rosanne G C Naafs, Frank H J Schuren, Ingrid M J G Sanders, Wiep Klass Smits, Romy D Zwittink, Jacobus Burggraaf, Robert Rissmann, Jurgen M J Piek, Jannie G E Henderickx, Mariëtte I E van Poelgeest
BACKGROUND: The role of the vulvar microbiome in the development of (pre)malignant vulvar disease is scarcely investigated. The aim of this exploratory study was to analyze vulvar microbiome composition in lichen sclerosus (LS) and vulvar high-grade squamous intraepithelial lesions (HSIL) compared to healthy controls. METHODS: Women with vulvar lichen sclerosus ( n  = 10), HSIL ( n  = 5) and healthy controls ( n  = 10) were included...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37970975/cumulative-detection-of-anal-high-grade-squamous-intraepithelial-lesions-over-two-year-follow-up-in-men-who-have-sex-with-men-living-with-hiv-in-france
#10
JOURNAL ARTICLE
Jean-Damien Combes, Jean-Michel Didelot, Sylvie Radenne, Olivia Zaegel-Faucher, Anne-Carole Lesage, Laurent Siproudhis, Lionel Piroth, Lucie Marchand, Isabelle Heard, Nadia Hoyeau, Sébastien Henno, Teresa M Darragh, Catharina J Alberts, Gary M Clifford, Isabelle Etienney
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSIL) in men who have sex with men living with HIV who underwent three visits over two years, with cytology and high-resolution anoscopy (HRA), within the ANRS-EP57-APACHES study. Cumulative HSIL detection was 33% (134/410), of which 48% were detected at baseline. HSIL detection varied considerably by center (13-51%). Strongest HSIL determinants were baseline HPV16 (adjusted odds ratio [aOR] 8.2; 95% confidence interval [95%CI] 3...
November 16, 2023: Journal of Infectious Diseases
https://read.qxmd.com/read/37951596/inflammatory-bowel-disease-and-the-risk-of-anal-squamous-intraepithelial-lesions-and-anal-cancer-in-men-who-have-sex-with-men
#11
JOURNAL ARTICLE
Justin Field, Cynthia Fenton, Li Zhang, Cristina Brickman, Uma Mahadevan
BACKGROUND: The risk of anal cancer is increased in patients with human immunodeficiency virus (HIV), inflammatory bowel disease (IBD), and among men who have sex with men (MSM). High grade squamous intraepithelial lesions (HSILs) are precursor lesions to anal squamous cell carcinoma (SCC), and treatment of these lesions can decrease progression to anal SCC. This study aims to determine the prevalence of HSIL and anal cancer among MSM patients with and without IBD referred for anal cancer screening...
November 10, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37889583/the-microbiome-as-a-biomarker-of-anal-precancerous-lesions-in-people-with-hiv
#12
JOURNAL ARTICLE
Raquel Ron, Elena Moreno, Marta Rosas Cancio-Suárez, Sergio Serrano-Villar
PURPOSE OF REVIEW: Early detection and treatment of human papillomavirus (HPV)-related anal dysplasia in some high-risk groups can help anal cancer prevention, but new tools to improve diagnostic and risk assessment are needed. Here, we aim to discuss the evidence on the role of the microbiome as a potential biomarker for anal high-grade squamous intraepithelial lesions (HSILs) in people with HIV (PWH). RECENT FINDINGS: This review covers relevant studies on the links between the microbiome and HPV infection, cervical dysplasia/cancer, and anal HPV disease...
October 30, 2023: Current Opinion in Infectious Diseases
https://read.qxmd.com/read/37854673/case-report-resolution-of-high-grade-anal-squamous-intraepithelial-lesion-with-antibiotics-proposes-a-new-role-for-syphilitic-infection-in-potentiation-of-hpv-associated-ascc
#13
A Ranabhotu, N Habibian, B Patel, E Farrell, J Do, S Sedghi, L Sedghi
INTRODUCTION: Human Papillomavirus (HPV) is the primary risk factor for the development of anal intraepithelial neoplasia (AIN) and is a leading risk factor for anogenital squamous cell carcinoma (ASCC). Despite common shared risk factors for both HPV and syphilis, co-infection is not well documented, and the role of syphilitic infection in HPV-associated AIN and ASCC potentiation is not defined. CASE DESCRIPTION/METHODS: A 72-year-old single male presented with complaints of mild rectal pain and intermittent rectal bleeding...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37842856/endoscopic-underwater-detection-and-resection-of-anal-squamous-intraepithelial-lesions-in-non-anesthetized-patients-a-feasibility-study-and-comparison-with-standard-surgical-treatment
#14
JOURNAL ARTICLE
Peter Borch-Johnsen, Jonas Nygren, Peter T Schmidt
BACKGROUND: Anal squamous intraepithelial lesions (ASILs) correspond to premalignant changes preceding the development of anal squamous cell carcinoma. OBJECTIVE: To describe a new endoscopic technique to detect and remove ASILs in non-anesthetized patients and compare it with standard surgical treatment. METHODS: For endoscopic treatment, high resolution (HR) flexible endoscopes with a distal attachment were used. Underwater inspection of the anal canal was performed in near-focus mode with white light and narrow-band imaging...
October 16, 2023: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/37805952/two-year-incidence-and-cumulative-risk-and-predictors-of-anal-high-grade-squamous-intraepithelial-lesions-anal-precancer-among-women-with-hiv
#15
JOURNAL ARTICLE
Elizabeth A Stier, Mayuri Jain, Himanshu Joshi, Teresa M Darragh, Ashish A Deshmukh, Jeannette Lee, Mark H Einstein, Naomi Jay, J Michael Berry-Lawhorn, Joel M Palefsky, Timothy Wilkin, Grant Ellsworth, Audrey L French, Luis F Barroso, Rebecca Levine, Humberto M Guiot, M Katayoon Rezaei, Elizabeth Chiao
BACKGROUND: Detection and treatment of anal histologic high-grade squamous intraepithelial lesions (hHSIL) prevents anal cancer. However, anal hHSIL incidence among women with HIV (WHIV) remains unknown. Performance of anal high-risk (hr)HPV, anal cytology (anal-cyt), and both for hHSIL detection longitudinally over 2 years also remains undetermined. METHODS: We determined 2-year incidence and cumulative risk estimates (2-y-CR) of anal hHSIL among WHIV using prevalence and incidence (per 100 person years (py) observations stratified by baseline hrHPV and/or anal-cyt results...
October 8, 2023: Clinical Infectious Diseases
https://read.qxmd.com/read/37728489/anal-cancer-screening-results-from-18-to-34-year-old-men-who-have-sex-with-men-living-with-hiv
#16
JOURNAL ARTICLE
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M Gaisa
Men who have sex with men living with HIV (MSM LWH) are at highest risk for human papillomavirus (HPV)-associated anal cancer. There is no consensus on the optimal screening initiation age. This study aimed to assess the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, which is a currently proposed screening age threshold. Between 2014 and 2020, 1255 18-to-34-year-old MSM LWH underwent anal cytology screening. 916 were co-tested for high-risk HPV (HR-HPV). 467 underwent high-resolution anoscopy (HRA) and biopsy...
September 20, 2023: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/37718496/hpv-vaccination-and-anal-high-grade-precancerous-lesions-and-cancer-a-real-world-effectiveness-study
#17
JOURNAL ARTICLE
Louise Baandrup, Thomas Maltesen, Christian Dehlendorff, Susanne K Kjaer
BACKGROUND: Human papillomavirus (HPV) vaccination has shown high efficacy against anal HPV infection and lesions in clinical trials, and the HPV prevalence and type distribution in anal precancers and cancer predict a high preventable potential for HPV vaccination. However, the real-world effectiveness of HPV vaccination against anal high-grade lesions and cancer is yet to be shown. METHODS: We investigated HPV vaccine effectiveness against anal high-grade squamous intraepithelial lesion or worse (HSIL+) in a nationwide cohort including all Danish women aged (17-32 years) during October 2006-December 2021 (N = 968,881)...
September 18, 2023: Journal of the National Cancer Institute
https://read.qxmd.com/read/37674762/is-the-anal-component-of-the-anogenital-hpv-related-disease-overlooked-during-the-surveillance-of-patients-treated-for-cervical-intraepithelial-neoplasia
#18
JOURNAL ARTICLE
Utku Ozgen, Tolga Guler, Derya Kilic, Ali Gokakin, Muhammed Aykota, Ilknur Kaleli, Yeliz Arman Karakaya, Ugur Sungurtekin
AIM: To investigate the anal component of the anogenital Human Papillomavirus (HPV) related disease during surveillance of patients treated for cervical intraepithelial neoplasia (CIN). METHODS: Patients were analyzed within two groups according to the histopathological examination of the cervical biopsies: Low-Grade Squamous Intraepithelial Lesion (LSIL) and High-Grade Squamous Intraepithelial Lesion (HSIL) groups. Anal specimens were also collected in the first-year follow-up visit...
September 2023: Curēus
https://read.qxmd.com/read/37637161/evaluation-of-the-validity-of-the-hpv-viral-load-compared-to-conventional-techniques-for-the-detection-of-high-grade-anal-intraepithelial-lesions-in-men-with-hiv-who-have-sex-with-men
#19
JOURNAL ARTICLE
Marcos Díez-Martínez, Juana Perpiñá-Galvañ, Joaquín Ferri, Maripaz Ventero, Joaquin Portilla, María José Cabañero-Martínez
BACKGROUND: The incidence of high-grade anal intraepithelial lesions (HSILs) has increased in recent years among men who have sex with men with human immunodeficiency virus (HIV). This work evaluated the validity of the human papilloma virus viral load (HPV-VL) versus cytological and qualitative HPV results to detect HSILs. METHODS: From May 2017 to January 2020, 93 men who have sex with men and HIV were included in an anal cancer screening program from the Infectious Diseases Unit at a tertiary-care hospital in Alicante (Spain)...
2023: PeerJ
https://read.qxmd.com/read/37588624/dna-high-risk-hpv-mrna-hpv-and-p16-tests-for-diagnosis-of-anal-cancer-and-precursor-lesions-a-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Ana Cristina Macedo, Antônio José Grande, Tatiana Figueiredo, Tamy Colonetti, João Carlos Gonçalves, Eduardo Testoni, Maria Inês da Rosa
BACKGROUND: Anal cancer prevention has two critical points: the incidence rate is several fold higher for some groups, such as people living with human immunodeficiency virus (HIV) and men who have sex with men (MSM), and there is not a well-defined guideline for its screening. This systematic review evaluates the accuracy of DNA HRHPV (high-risk human papillomavirus), mRNA HPV, DNA HPV16 isolated and p16 staining biomarkers in anal canal smears for identifying anal intraepithelial neoplasia (AIN) 2 or 3, summarised as anal high-grade squamous intraepithelial lesions (aHSIL), and cancer...
August 2023: EClinicalMedicine
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