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anal HSIL

Pompeyo Viciana, Yusnelkis Milanés-Guisado, María Fontillón, Ana Domínguez Castaño, César Sotomayor, Nuria Espinosa, Luis F López-Cortés, Karin Neukam
BACKGROUND: Screening methods for anal intraepithelial neoplasia (AIN) are suboptimal. This study aimed to determine the diagnostic performance of a composite endpoint comprising anal liquid-based cytology (aLBC) and high-risk human papillomavirus (HR-HPV) testing to predict histological high-grade squamous intraepithelial lesions (HSIL). METHODS: From a cohort of HIV-infected men who have sex with men (MSM) seen at a Spanish University hospital, all individuals who had an aLBC with concomitant HR-HPV testing were included...
February 16, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Thomas M Atkinson, Joel Palefsky, Yuelin Li, Andrew Webb, J Michael Berry, Stephen Goldstone, Rebecca Levine, Timothy J Wilkin, Gary Bucher, David Cella, Jack E Burkhalter
PURPOSE: The Anal Cancer HSIL Outcomes Research (ANCHOR) trial aims to determine whether treating precancerous anal high-grade squamous intraepithelial lesions (HSIL), versus active surveillance, is effective in reducing anal cancer incidence in HIV-infected individuals. We evaluated the reliability (i.e., internal consistency, test-retest) and between-group stability of a 25-item ANCHOR Health-Related Symptom Index (A-HRSI). METHODS: ANCHOR participants at least 1-month post-randomization to treatment or active surveillance completed the A-HRSI via telephone...
January 7, 2019: Quality of Life Research
Abhilasha Gautam, Jaya Chakravarty, Vijay Kumar Singh, Amrita Ghosh, Shashi Bhushan Chauhan, Madhukar Rai, Shyam Sundar
BACKGROUND: Oncogenic Human papillomavirus (HPV) infections are closely associated with anal cancer which is high among human immunodeficiency virus (HIV) infected males. There are no data regarding anal HPV infection and cytological abnormalities in HIV positive males receiving free therapy in the national program. Thus, this cross-sectional study was performed to assess the prevalence and risk factors of anal HPV infection and cytological abnormalities in HIV positive males. METHODS: We screened 126 HIV-positive male patients attending the antiretroviral treatment center (ART) between 2014 and 2015 with anal papanicolaou smear cytology and HPV-DNA testing...
December 27, 2018: BMC Infectious Diseases
Takaaki Kobayashi, Keith Sigel, Tamara Kalir, Iain J MacLeod, Yuxin Liu, Michael Gaisa
BACKGROUND: Data on tissue distribution of human papillomavirus types in anal high-grade squamous intraepithelial lesions are limited and the impact on treatment outcomes poorly understood. OBJECTIVE: We aimed to investigate potential predictors of treatment failure after electrocautery ablation, including human papillomavirus type(s) isolated from index lesions. DESIGN: This was a retrospective cohort study. SETTINGS: The study was conducted at a tertiary academic referral center in New York City...
December 17, 2018: Diseases of the Colon and Rectum
Chia-Ching J Wang, Joel M Palefsky
The prevalence of anal human papillomavirus (HPV) infection and anal high-grade squamous intraepithelial lesion (HSIL) remain high among HIV-infected individuals on effective antiretroviral therapy (ART). The incidence of HPV-related anal cancers has continued to increase since the introduction of ART. Therefore, ART may confer only limited benefit with respect to reducing the risk of anal HSIL and cancer. Efforts are in progress to define the efficacy of secondary prevention programs for prevention of anal cancer...
2019: Cancer Treatment and Research
Maryam Sadat Hosseini, Donya Khosravi, Farah Farzaneh, Abdalali Ebrahimi, Maliheh Arab, Tahereh Ashraf Ganjoie, Farzane Jamdar, Atefeh Moridi, Mohammad Chehrazi
Background: Anal cancer is uncommon. Although uncommon, the incidence of anal cancer has increased among the general population of the United States and other countries over the past 30 years. We evaluated anal cytology in women with the history of abnormal pap smear, cervical intraepithelial neoplasia, cervical cancer and high risk HPV for anogenital dysplasia. Methods: In this cross-sectional study, 153 patients over the age of 21 years, referred to Imam Hossein Hospital in 1395-1396 who were being monitored due to abnormal pap smear, cervical cancer, CIN and high risk HPV, were evaluated with anal cytology for anogenital dysplasia...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
S L Goddard, D J Templeton, K Petoumenos, F Jin, R J Hillman, C Law, J M Roberts, C K Fairley, S M Garland, A E Grulich, I M Poynten
BACKGROUND: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated. METHODS: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Anal cytology and high-resolution anoscopy were undertaken. Using baseline visit data, men negative for squamous intra-epithelial lesion (SIL) were compared with men diagnosed with composite-HSIL (cytology and/or histology)...
November 12, 2018: Cancer Epidemiology
Megan A Clarke, Li C Cheung, Thomas Lorey, Brad Hare, Rebecca Landy, Diane Tokugawa, Julia C Gage, Teresa M Darragh, Philip E Castle, Nicolas Wentzensen
Background: Human papillomavirus (HPV)-related biomarkers have shown good cross-sectional performance for anal precancer detection in HIV-positive (HIV+) men who have sex with men (MSM). However, the long-term performance and risk stratification of these biomarkers are unknown. Here, we prospectively evaluated high-risk (HR) HPV DNA, HPV16/18 genotyping, HPV E6/E7 mRNA, and p16/Ki-67 dual stain in a population of HIV+ MSM. Methods: We enrolled 363 HIV+ MSM between 2009-2010 with passive follow-up through 2015...
November 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Martina Z Liu, Yin P Hung, Eric C Huang, Brooke E Howitt, Marisa R Nucci, Christopher P Crum
Human papillomavirus (HPV) type 6 is historically classified as low-risk HPV type and associates with low-grade squamous intraepithelial lesions of the anogenital tract. Rare squamous carcinomas have been reported in association with these HPV types but the mechanism(s) behind this carcinogenic sequence have been unclear. We report 4 cases of low risk anogenital HPV infections-3 cervical (immature low-grade squamous intraepithelial lesion with metaplastic phenotype) and one anal (exophytic condyloma) lesion-that manifested with high-grade squamous intraepithelial lesion/squamous cell carcinoma...
October 11, 2018: International Journal of Gynecological Pathology
J Burgos, M Martin-Castillo, S Landolfi, Mªc Dinares, J Villar, J Navarro, E Ribera, V Falcó, A Curran
Trichloroacetic acid (TCA) and Electrocautery (ECA) are two of the main treatment options for anal high-grade squamous intraepithelial lesion (HSIL). Our aim was to compare the efficacy and tolerance of TCA vs. ECA for HSIL METHODS:: Retrospective un-controlled study of HIV-infected men who have sex with men (MSM) who had an anal HSIL treated with TCA or ECA. On-treatment effectiveness was evaluated at 6-8 weeks after treatment. A complete response was defined as resolution of HSIL, a partial response as regression to low-grade lesion and recurrence as biopsy-proven HSIL during follow-up...
August 28, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Elske Marra, Matthijs L Siegenbeek van Heukelom, Annemiek Leeman, Tim Waterboer, Chris J L M Meijer, Peter J F Snijders, Audrey J King, Irina Cairo, Arne van Eeden, Wilma Brokking, Pascal van der Weele, Wim Quint, Jan M Prins, Henry J C de Vries, Maarten F Schim van der Loeff
Background: Our objective was to identify virological and serological predictors of anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men-who-have-sex-with-men (MSM). Methods: HIV-positive MSM were recruited from a longitudinal study (2010-2013), during which anal self-swabs and serum were collected at up to five bi-annual visits. Swabs were HPV genotyped, and type-specific HPV viral load in anal swabs was determined. Serum antibodies to E6, E7, E1, E2 and L1 proteins of 7 hrHPV-types and HPV6 and 11 were analyzed...
August 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Jack E Burkhalter, Thomas M Atkinson, J Berry-Lawhorn, Stephen Goldstone, Mark H Einstein, Timothy J Wilkin, Jeannette Lee, David Cella, Joel M Palefsky
BACKGROUND: Anal cancer, caused by oncogenic types of human papillomavirus, is a growing problem in the United States. A key focus of anal cancer prevention has been screening for and treating precancerous high-grade squamous intraepithelial anal lesions (HSILs). OBJECTIVES: To develop a health-related symptom index for HSIL using qualitative techniques because anal HSIL and its treatment may have a negative impact on health-related quality of life (HRQOL), and no HRQOL measure specific to this condition and treatment currently exists...
August 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Stephen E Goldstone, Shelly Y Lensing, Elizabeth A Stier, Teresa Darragh, Jeannette Y Lee, Annemieke van Zante, Naomi Jay, J Michael Berry-Lawhorn, Ross D Cranston, Ronald Mitsuyasu, David Aboulafia, Joel M Palefsky, Timothy Wilkin
Background: Anal high-grade dysplasia (HSIL) ablation may reduce the incidence of invasive cancer, but few data exist on HSIL treatment efficacy and natural regression without treatment. Methods: An open-label, randomized, multi-site clinical trial of HIV-infected adults age 27 or older with 1-3 biopsy-proven anal HSIL (index HSIL) without prior history of HSIL treatment with infrared coagulation. Participants were randomized 1:1 to ablation of anal HSIL with infrared coagulation (treatment group) or no HSIL treatment (active monitoring)...
July 27, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Yuxin Liu, Keith Sigel, Michael M Gaisa
Background: High-risk human papillomavirus (hrHPV)-induced anal low-grade squamous intraepithelial lesions (LSILs) have the potential to progress to high-grade squamous intraepithelial lesions (HSILs). We investigated whether anal hrHPV infections, particularly types 16 and 18, predict LSIL-to-HSIL progression. Methods: One hundred forty-six human immunodeficiency virus (HIV)-infected and 22 HIV-uninfected patients with anal LSILs underwent cytology, HPV genotyping (16, 18, and pooled 12 hrHPV types), and high-resolution anoscopy-guided biopsy at baseline and surveillance...
October 20, 2018: Journal of Infectious Diseases
Lucas Tadeu Bidinotto, Carlos A R Véo, Edgar Aleman Loaiza, Guilherme G Ribeiro, Adriana T Lorenzi, Luciana Albina Reis Rosa, Cristina Mendes De Oliveira, José Eduardo Levi, Cristovam Scapulatempo-Neto, Adhemar Longatto-Filho, Rui Manuel Reis
There has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high-risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of the loss of RKIP expression in several gastrointestinal tumors. Therefore, the present study aimed to evaluate the clinical implications of RKIP expression in a series of neoplastic lesions of the anal canal...
August 2018: Oncology Letters
Yuxin Liu, Morgan Blakely, Keith Sigel, Tin Htwe Thin, Pei Hui, Michael Donovan, Michael M Gaisa
OBJECTIVES: The aim of this study was to determine whether biomarker P16 predicts progression risk for anal low-grade squamous intraepithelial lesions (LSILs). DESIGN: A retrospective study. METHODS: One hundred and nine HIV-infected and 18 HIV-uninfected patients with biopsy-proven anal LSIL at initial screening underwent surveillance high-resolution anoscopy and biopsy within 2 years of diagnosis. P16 immunohistochemistry was performed on index lesions and evaluated using a semi-quantitative scoring system...
October 23, 2018: AIDS
Gary M Clifford, Laurent Siproudhis, Lionel Piroth, Isabelle Poizot-Martin, Sylvie Radenne, Jacques Reynes, Anne Lesage, Isabelle Heard, Sébastien Henno, Jean-François Fléjou, Lucie Marchand, Jean-Damien Combes, Isabelle Etienney
OBJECTIVE: To assess determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive men who have sex with men (MSM), a population at high-risk of HPV-related anal cancer. DESIGN: APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged at least 35 years in six centres across France. METHODS: At baseline, participants underwent high-resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA...
October 23, 2018: AIDS
Diana T Medina-Laabes, Erick L Suarez-Perez, Humberto M Guiot, Cristina Muñoz, Vivian Colón-López, Maribel Tirado-Gómez, Ana Patricia Ortiz
OBJECTIVE: To estimate the magnitude of association between anal infection with high-risk human papilloma virus (HR-HPV) types and severity of biopsy-confirmed histopathological anal squamous intraepithelial lesions (SILs) among a clinic-based sample of HIV-infected adults in Puerto Rico. METHODS: This cross-sectional study analyzed data from medical records of adult patients who visited a specialized anal neoplasia clinic from June 2015 to December 2017 (n = 239); sociodemographics, behavioral risk factors, medical history, clinical data, and pathology reports were collected...
October 2018: Journal of Lower Genital Tract Disease
Kaan Z Apaydin, Andy Nguyen, Christina P C Borba, Derri L Shtasel, Sharon Ulery, Kenneth H Mayer, Alex S Keuroghlian
OBJECTIVES: High-resolution anoscopy (HRA) is a potential screening method for detection of anal cancer precursors. We evaluated factors associated with adherence to recommended HRA follow-up time intervals among men who have sex with men (MSM). METHODS: We employed a retrospective, observational cohort study with 155 MSM screened by HRA between 1 April 2011 and 31 March 2016 at a Federally Qualified Health Centre in Boston, Massachusetts. RESULTS: The sample was 80% white, with a median age of 48 (non-normal distribution, IQR 15)...
June 22, 2018: Sexually Transmitted Infections
Isobel M Poynten, Tim Waterboer, Fengyi Jin, David J Templeton, Richard J Hillman, Carmella Law, Alyssa Cornall, Sepehr Tabrizi, Jennifer M Roberts, Suzanne M Garland, Christopher K Fairley, Andrew E Grulich
Background: Gay and bisexual men (GBM) are at disproportionately high risk of anal cancer. The precursor lesions, high-grade squamous intraepithelial lesions (HSIL), are very common and it is evident that not all HSIL progresses to cancer. The serologic response to anal human papillomavirus (HPV) in GBM has not been well characterized. Methods: The Study of the Prevention of Anal Cancer is an ongoing cohort study of GBM ages 35 years and older. At six visits over three years, anal samples are collected for cytology, HPV DNA testing, and histology...
July 2018: Cancer Epidemiology, Biomarkers & Prevention
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