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Erika Di Zazzo, Rita Polito, Silvia Bartollino, Ersilia Nigro, Carola Porcile, Andrea Bianco, Aurora Daniele, Bruno Moncharmont
Adipose tissue is a key regulator of energy balance playing an active role in lipid storage as well as in synthesizing several hormones directly involved in the pathogenesis of obesity. Obesity represents a peculiar risk factor for a growing list of cancers and is frequently associated to poor clinical outcome. The mechanism linking obesity and cancer is not completely understood, but, amongst the major players, there are both chronic low-grade inflammation and deregulation of adipokines secretion. In obesity, the adipose tissue is pervaded by an abnormal number of immune cells that create an inflammatory environment supporting tumor cell proliferation and invasion...
February 15, 2019: International Journal of Molecular Sciences
Siwen Liang, Hongwei Li, Xuhua Shen, Ruifeng Liu
BACKGROUND: Previous studies suggested that adiponectin (APN) could ameliorate ischemia/reperfusion injury and endothelial dysfunction in patients with acute myocardial infarction. However, the relationship between serum APN level and coronary flow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) is unclear. METHODS: A total of 144 patients with STEMI treated by PPCI were enrolled and divided into two groups based on the mean serum APN level on admission...
February 19, 2019: Journal of Clinical Laboratory Analysis
Fong Yeong Brigitte Woo, Wentao Zhou, Toon Wei Lim, Wai San Wilson Tam
AIMS: To provide an overview of the practice patterns of advanced practice nurses and to explore their perceptions of their role in Singapore. BACKGROUND: Role expansion of advanced practice nurses is increasingly popular in healthcare systems. However, their practice patterns remain variable, thereby introducing role ambiguity. Uncertainty revolves around how advanced practice nurses perceive their practice, competency, and readiness for role expansion. METHODS: A nationwide survey of advanced practice nurses was conducted in Singapore...
February 18, 2019: Journal of Nursing Management
Jing Wang, Ya-Yun Zuo, Ng-Li Li, Hui Wang, Shao-Yan Liu, Yi-Hua Yang, Yi-Dong Wu
Bacillus thuringiensis (Bt) insecticidal toxins have been globally utilized for control of agricultural insects through spraying or transgenic crops. Binding of Bt toxins to special receptors on midgut epithelial cells of target insects is a key step in the mode of action. Previous studies suggested aminopeptidase N1 (APN1) as a receptor or putative receptor in several lepidopteran insects including Helicoverpa armigera through evidence from RNAi-based gene silencing approaches. In the current study we tested the role of APNs in the mode of action of Bt toxins using CRISPR/Cas9-mediated gene knockout...
February 14, 2019: Insect Science
Jiangying Cao, Jie Zang, Xiujie Kong, Chunlong Zhao, Ting Chen, Yingying Ran, Hang Dong, Wenfang Xu, Yingjie Zhang
Aminopeptidase N (APN) has been proved to be deeply associated with cancer angiogenesis, metastasis and invasion. Therefore, APN gains increasing attention as a promising anti-tumor target. In the current study, we report the design, synthesis, biological evaluation and structure-activity relationship of one new series of leucine ureido derivatives containing the 1,2,3-triazole moiety. Among them, compound 31f was identified as the best APN inhibitor with IC50 value being two orders of magnitude lower than that of the positive control bestatin...
January 31, 2019: Bioorganic & Medicinal Chemistry
Pål Gunnes, Jacob Thalamus, Daniela Melichova, Slobodan Calic, Ole Johan Jakobsen, Tomas Larsen, Jarle Jortveit
BAKGRUNN: Takotsubosyndrom er en akutt hjertesykdom med symptomer som ved akutt hjerteinfarkt, men med åpne koronararterier og regionale funksjonsforstyrrelser i venstre ventrikkel. Vi har undersøkt forekomst av og forløp ved tilstanden hos pasienter i Agder og Telemark. MATERIALE OG METODE: Alle pasienter innlagt i Sørlandet sykehus Arendal fra 1. mars 2010 til 31. januar 2016 med diagnosen takotsubosyndrom ble inkludert og fulgt til 15. september 2016. RESULTATER: Totalt ble det inkludert 91 episoder med takotsubosyndrom fordelt på 90 pasienter, hvorav 93 % var kvinner og 88 % var over 60 år...
January 29, 2019: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Karthikka Palanisamy, Rajiv Raman, Konerirajapuram Natarajan Sulochana, Subbulakshmi Chidambaram
Fibrosis in ocular tissues causes severe visual deterioration and blindness in patients with glaucoma, cataract, age related macular degeneration (AMD) and diabetic retinopathy (DR). Currently available anti-fibrotic agents exhibit undesirous cytotoxic effects and thus prove ineffective to treat post-surgical fibrosis. Accordingly, there is a need to develop efficient and novel anti-fibrotic agents. Adiponectin (APN), an adipokine from adipocytes is increased in the aqueous and vitreous humor of the patients with micro-angiopathy and chronic inflammation...
February 2019: Medical Hypotheses
Xiaofeng Zhang, Lijun Rui, Beili Lv, Fangfang Chen, Liming Cai
BACKGROUND Obstructive sleep apnea (OSA) is associated with many cardiovascular disorders. Intermittent hypoxia (IH) is a key pathological hallmark of OSA. This study was conducted to evaluate the potential therapeutic effects and the associated mechanisms of adiponectin (APN) on IH induced human adult cardiac myocytes (HACMs) injury. MATERIAL AND METHODS HACMs were exposed to normoxia or IH (1% to 21% O₂) using a novel cell culture bio-reactor with gas-permeable membranes. Cell viability was detected by Cell Counting Kit-8 assay...
January 27, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jianyun He, Zhiyan Wang, Sihai Zhang
Changes in expression levels of serum interleukin-4 (IL-4), IL-10 and adiponectin (APN) in patients with postoperative infection of colorectal cancer were studied. The clinical data of 159 patients receiving radical surgery for colorectal cancer in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from January 2014 to December 2017, were retrospectively analyzed. A total of 67 patients with postoperative infection were enrolled into the infection group, while the remaining 92 patients without infection were enrolled into the non-infection group...
February 2019: Oncology Letters
Manijeh Kahbazi, Mojtaba Sharafkhah, Parsa Yousefichaijan, Hassan Taherahmadi, Mohammad Rafiei, Parisa Kaviani, Sahand Abaszadeh, Ali Massoudifar, Abolfazl Mohammadbeigi
INTRODUCTION: It is believed that tubulointerstitial inflammation plays a role in the formation of renal scarring secondary to acute pyelonephritis (APN). Vitamin A is an anti-inflammatory agent that is involved in the re-epithelialization of damaged mucosal surfaces. OBJECTIVE: The aim of this study was to evaluate the efficacy of vitamin A supplementation in combination with antibiotics for improving urinary tract infections (UTIs) symptoms and preventing renal scarring in girls with APN...
February 2019: Complementary Therapies in Medicine
Qingmei Yang, Chensheng Fu, Xiaoli Zhang, Zhenxing Zhang, Jianan Zou, Jing Xiao, Zhibin Ye
Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation in proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. In the present study, human PTECs were incubated with 100 µg/ml soluble (S) UA in the presence or absence of globular (g) APN, APN receptor 1 (AdipoR1)‑short hairpin RNA lentivirus or compound C. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) assays were performed to assess APN mRNA expression...
January 21, 2019: International Journal of Molecular Medicine
Bannakij Lojanapiwat, Sireethorn Nimitvilai, Manit Bamroongya, SupunNee Jirajariyavej, Chirawat Tiradechavat, Aumnat Malithong, Chagkrapan Predanon, Dan Tanphaichitra, Boonlert Lertsupphakul
Background: The conventional antibiotic regimen for community-acquired upper urinary tract infections with moderate severity in Thailand is parenteral ceftriaxone (CTRX) for several days followed by oral cephalosporin for 7-14 days. The aim of this study was to compare the efficacy and safety of oral sitafloxacin (STFX) with that of intravenous CTRX followed by oral cefdinir (CFDN) for the therapy of acute pyelonephritis (APN) and complicated urinary tract infection (cUTI). Methods: This open-label, randomized, controlled, noninferiority clinical trial included patients from nine centers across Thailand...
2019: Infection and Drug Resistance
L Umesha, S M Shivaprasad, E N Rajiv, M M Satish Kumar, V Leelavathy, C G Sreedhara, M R Niranjan
Acute pyelonephritis (APN), although a common clinical entity, still not much is known about the clinical profile in the Indian scenario. We prospectively collected clinical, biochemical, and radiological data of patients hospitalized with a diagnosis of APN from March 2014 to June 2016. A total of 296 cases were included in the study. Mean age was 53.85 ± 9.78 years. Male to females ratio was 1.93:1. Among the risk factors recognized for complicated pyelonephritis (PN), diabetes mellitus (DM) (54.4%) was the most common factor followed by renal calculi (14...
November 2018: Indian Journal of Nephrology
Kassiani Skouloudaki, Dimitrios K Papadopoulos, Pavel Tomancak, Elisabeth Knust
Most organs of multicellular organisms are built from epithelial tubes. To exert their functions, tubes rely on apico-basal polarity, on junctions, which form a barrier to separate the inside from the outside, and on a proper lumen, required for gas or liquid transport. Here we identify apnoia (apn), a novel Drosophila gene required for tracheal tube elongation and lumen stability at larval stages. Larvae lacking Apn show abnormal tracheal inflation and twisted airway tubes, but no obvious defects in early steps of tracheal maturation...
January 2019: PLoS Genetics
Si-Ho Kim, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck
To investigate factors for the recurrence of acute pyelonephritis (APN) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBL-PE), a retrospective cohort study was performed at a tertiary-care hospital from 2014 through 2016. Among 135 patients who had recovered from APN caused by ESBL-PE, the 1-year cumulative recurrence rates of APN caused by any pathogen or by ESBL-PE specifically were 35.6% and 22.1%, respectively. In a multivariate analysis, infectious disease (ID) consultation was associated with decreased recurrence (95% confidence interval [CI] = 0...
November 29, 2018: Diagnostic Microbiology and Infectious Disease
X Wu, W Qiu, Z Hu, J Lian, Y Liu, X Zhu, M Tu, F Fang, Y Yu, P Valverde, Q Tu, Y Yu, J Chen
Periodontitis is twice as prevalent in diabetics as in nondiabetics, and type 2 diabetes (T2D)-associated periodontitis is severe in many cases due to the altered and aberrant functions of bone cells in hyperglycemic conditions. Therefore, developing an effective method to halt the disease process, as well as restore and regenerate lost alveolar bone to reserve the natural teeth in diabetics, is critically important. In the current study, we applied a newly discovered adiponectin receptor agonist AdipoRon (APR) in experimental periodontitis in diabetic animal models and demonstrated the underlying molecular mechanisms...
March 2019: Journal of Dental Research
Katarzyna B Miska, Raymond H Fetterer
Within the last 60 yr genetics of broilers have changed to produce rapid growing birds that achieve market weight in 6 wk or less. To investigate the differences in factors that play a role in nutrient processing and uptake between modern fast growing (Ross) and slow growing broilers not selected for growth (ACRBC), a study was carried comparing the expression of 13 genes that encode amino acid transporters (ASCT1, ATBo,+, BoAT, bo, +AT, CAT1, CAT2, EAAT3, γ+LAT1, and LAT1) and sugar transporters (GLUT2 and GLUT5), as well as aminopeptidase (APN) and the di- and tri-peptide transporter PepT1...
January 9, 2019: Poultry Science
Guozhu Yin, Hanghang Liu, Jiayang Li, Yao Liu, Xian Liu, En Luo
BACKGROUND: Adiponectin (APN) has been reported to promote bone formation. However, it is difficult to utilize conventional method to administer sufficient APN to the implant site. This study investigated the efficacy of APN transgene to accelerate the implant osseointegration in ovariectomized (OVX) rats. METHODS: In vitro, bone marrow stromal cells (BMSCs) were transduced with reconstructed adenovirus (Ad-APN-EGFP) and osteoclast precursor RAW264.7 cells were co-cultured with the conditioned medium secreted by transduced BMSCs...
January 3, 2019: Journal of Gene Medicine
Guillermo J Hönig
Schizophrenia presents a high predisposition to present metabolic alterations. This is evidenced in patients never treated with antipsychotics (naïve) and first-degree relatives who do not have the disease, both groups have alterations in the glucose tolerance curve, increase in basal insulin, inflammatory factors and adiponectin (APN). In schizophrenics, antipsychotics increase the frequency of appearance of obesity and metabolic syndrome. These changes are accompanied by a decrease in APN and increase in leptin...
March 2018: Vertex: Revista Argentina de Psiquiatriá
Shengnan Wang, Yuanyi Yang, Yunfei Li, Jiacheng Shi, Jianshu Zhou, Li Zhang, Yi Deng, Weizhong Yang
Polyetheretherketone (PEEK)-based implants have become popular in hard tissue orthopedic and dental field. However, its inherent bio-inertness limited its applications for bone repair/substitution of osteoporosis patients, with poor osteogenesis capability. In order to ameliorate their bioactivity, the 3D porous PEEK substrate was created by sulfonate processing, and the substrate was subsequently incorporated with strontium (Sr) through a hydrothermal reaction in Sr(OH)2 solutions. The adiponectin (APN) protein membrane was deposited on the substrate via polydopamine-assisted deposition...
December 20, 2018: Colloids and Surfaces. B, Biointerfaces
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