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Santiago Fregoso, Brett E Dwyer, Santos J Franco
During neocortical development, neurons are produced by a diverse pool of neural progenitors. A subset of progenitors express the Cux2 gene and are fate-restricted to produce certain neuronal subtypes, but the upstream pathways that specify these progenitor fates remain unknown. To uncover the transcriptional networks that regulate Cux2 expression in the forebrain, we characterized a conserved Cux2 enhancer that recapitulates Cux2 expression specifically in the cortical hem. Using a bioinformatic approach, we identified putative transcription factor (TF) binding sites for cortical hem-patterning TFs...
February 15, 2019: Development
Padam P Acharya, Hem Raj Khatri, Sandip Janda, Jianglong Zhu
Total syntheses of aquayamycin (3) and a number of analogues of angucycline antitumor antibiotic derhodinosylurdamycin A bearing various 2-deoxy sugar subunits (4-7) have been achieved. These molecules (3-7) were synthesized based on a convergent strategy for the synthesis of derhodinosylurdamycin A (2) previously reported from our group. In particular, our recently developed mild cationic gold-catalyzed glycosylation with S-but-3-ynyl thioglycoside donors was employed for the synthesis of analogues (6 and 7) bearing disaccharide subunits containing α-l-olivoside and α-l-olioside moiety, respectively...
February 15, 2019: Organic & Biomolecular Chemistry
Jorge Ariel Rasmussen, Federico Landriel, Santiago Hem, Sebastián Kornfeld, Claudio Yampolsky
STUDY DESIGN: Systematic review and descriptive data meta-analysis. OBJECTIVE: The objective of this study was to appropriately establish the accuracy in the percutaneous transpedicular screws (PTS) placement using biplane radioscopy (Rx-2D). SUMMARY OF BACKGROUND DATA: The Rx-2D is a widely-used technique for PTS as it is practical, ubiquitous, and cost-effective. However, the reported "acceptable" accuracy attained by this method is widely variable ranging between 76% and 100%...
February 12, 2019: Clinical Spine Surgery
Michael J Campbell, Karla Hemming, Monica Taljaard
No abstract text is available yet for this article.
February 13, 2019: Medical Journal of Australia
Ilkka Pulkkinen, Jari Pirnes, Ari Rissanen, Päivi Laukkanen-Nevala
BACKGROUND: A high number of denied or cancelled HEMS missions are caused by poor weather conditions especially during winter season. Furthermore, many helicopter manufacturers have denied their helicopters to be operated in known icing conditions. Icing is a widely known phenomenon in aviation, but there is a lack of evidence about its influence on HEMS operations and patients. METHODS: A prospective observational study of HEMS missions in Northern Finland was conducted over a 1-year period in 2017...
February 12, 2019: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Ingvild Romstad Hem, Camilla Gjerstad, Ansgar Berg
BACKGROUND: A fall in recruitment of participants for research has been observed in recent years. In order to ensure a sufficient number of research participants, incentives such as remuneration and gift cards have been used. The number of Norwegian research groups that apply to use payment has not been previously studied. We have investigated the extent to which payment and other incentives are used in medical and health research in Norway. MATERIAL AND METHOD: Four of the seven Regional Committees for Medical and Health Research Ethics (REC) in Norway were selected to participate in the study...
February 12, 2019: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Songpu Ai, Antorweep Chakravorty, Chunming Rong
The progress of technology on energy and IoT fields has led to an increasingly complicated electric environment in low-voltage local microgrid, along with the extensions of electric vehicle, micro-generation, and local storage. It is required to establish a home energy management system (HEMS) to efficiently integrate and manage household energy micro-generation, consumption and storage, in order to realize decentralized local energy systems at the community level. Domestic power demand prediction is of great importance for establishing HEMS on realizing load balancing as well as other smart energy solutions with the support of IoT techniques...
February 10, 2019: Sensors
Lucy Bai, Brita Arver, Hemming Johansson, Kerstin Sandelin, Marie Wickman, Yvonne Brandberg
PURPOSE: To prospectively follow-up and investigate women's perceptions of the cosmetic outcome of their implant-based breast reconstruction, body image, sexuality, anxiety/depressive symptoms, and health-related quality of life (HRQoL) 6-20 years after bilateral risk-reducing mastectomy (RRM), or complementary RRM after breast cancer diagnosis, due to increased risk of hereditary breast cancer. PATIENTS AND METHODS: Women with and without previous breast cancer diagnosis that underwent RRM between March 1997 and September 2010 were invited (n = 200)...
February 1, 2019: Breast: Official Journal of the European Society of Mastology
Surasak Wichaiyo, Sian Lax, Samantha J Montague, Zhi Li, Beata Grygielska, Jeremy A Pike, Elizabeth J Haining, Alexander Brill, Steve P Watson, Julie Rayes
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induce platelet activation. GPVI and CLEC-2 support vascular integrity during inflammation in the skin through regulation of leukocyte migration and function, and by sealing sites of vascular damage. In this study, we have investigated the role of impaired vascular integrity due to GPVI and/or CLEC-2 deficiency in wound repair using a full-thickness excisional skin wound model in mice...
February 7, 2019: Haematologica
Ding Xu, Peng Luo, Sheng Li, Roman Pfeifer, Frank Hildebrand, Hans-Christoph Pape
BACKGROUND: After nearly 20 years of development, China has realized some achievements in helicopter emergency medical services (HEMS). The purpose of this article is to introduce and evaluate the development and characteristics of HEMS in China by collecting and analyzing relevant literature and, in so doing, help this vital service to further develop. METHOD: We conducted a Pubmed, Medline, Embase, ScienceDirect, Wanfang, CNKI, and VIP search of the literature on HEMS of China published between January 1950 and April 2017...
February 2019: Medicine (Baltimore)
Karla Yuritzi Amador-Rodríguez, Héctor Silos-Espino, Luis L Valera-Montero, Catarino Perales-Segovia, Silvia Flores-Benítez, Fernando Martínez-Bustos
High-energy milling (HEM) was used to produce nixtamalized corn flours, the traditional nixtamalization process was used as a control. Four creole grains were stone-milled, adjusted to an appropriate moisture content and calcium hydroxide concentration and milled using HEM. The physicochemical, thermal, and rheological characteristics of the flours and corn masas were affected by the HEM process. Negritas and Ahualulco creole grains nixtamalized by HEM showed similar viscosity profiles as a control. HEM reduced the gelatinization enthalpy compared to control and raw flours...
June 15, 2019: Food Chemistry
Madeline Rincheval, David R Cohen, Frank A Hemmings
Trace and major element composition of selected plant species and parts may be used to map geochemical dispersion from mineral deposits and contaminated areas. This study examines the application of field-portable X-ray fluorescence spectrometry (fpXRF) in obtaining real-time biogeochemical data. In situ analysis of parts of black and silver wattle (Acacia mearnsii De Wild. and Acacia dealbata Link) was conducted to map the extent of contamination surrounding the former Woodlawn base metal mine. High levels of ore-related elements were detected in the bark of these species in a zone extending up to 1 km down-drainage from the tailing ponds...
January 22, 2019: Science of the Total Environment
William D Jones, Sarah M Guadiana, Elizabeth A Grove
In the mouse, two telencephalic signaling centers orchestrate embryonic patterning of the cerebral cortex. From the rostral patterning center in the telencephalon (RPC), the Fibroblast Growth Factor, FGF8, disperses as a morphogen to establish the rostral to caudal (R/C) axis of the neocortical area map. FGF8 coordinates with Wnt3a from the cortical hem to regulate graded expression of transcription factors that position neocortical areas, and control hippocampal development. Whether similar signaling centers pattern the much larger cortices of carnivore and primate species, however, is unclear...
January 28, 2019: Journal of Comparative Neurology
J M Hunter, H C Hemmings
No abstract text is available yet for this article.
February 2019: British Journal of Anaesthesia
Thorsteinn Astradsson, Göran Laurell, Alexander Ahlberg, Polymnia Nikolaidis, Hemming Johansson, Ylva Tiblom Ehrsson
BACKGROUND: Trismus is a common complication of radiotherapy for head and neck cancer but its impact on survival is unknown. AIMS/OBJECTIVES: This prospective study evaluates the incidence of trismus in patients with head and neck cancer receiving radiotherapy and the impact of trismus on 5-year overall survival. MATERIAL AND METHODS: Two hundred forty-four patients with head and neck cancer were included. All patients received instructions on jaw exercises and were evaluated before initiation of radiotherapy and at 2, 6, and 12 months after termination of radiotherapy...
December 2018: Acta Oto-laryngologica
Christina L Torturo, Zhen-Yu Zhou, Timothy A Ryan, Hugh C Hemmings
Volatile anesthetics affect neuronal signaling by poorly understood mechanisms. Activation of central dopaminergic pathways has been implicated in emergence from general anesthesia. The volatile anesthetic isoflurane differentially inhibits glutamatergic and GABAergic synaptic vesicle (SV) exocytosis by reducing presynaptic Ca2+ influx without affecting the Ca2+ -exocytosis relationship, but its effects on dopaminergic exocytosis are unclear. We tested the hypothesis that isoflurane inhibits exocytosis in dopaminergic neurons...
January 2019: ENeuro
Paras Bikram Singh, Pradip Saud, Douglas Cram, Kumar Mainali, Arjun Thapa, Nar Bahadur Chhetri, Laxman Prasad Poudyal, Hem Sagar Baral, Zhigang Jiang
Himalayan musk deer ( Moschus leucogaster ; hereafter musk deer) are endangered as a result of poaching and habitat loss. The species is nocturnal, crepuscular, and elusive, making direct observation of habitat use and behavior difficult. However, musk deer establish and repeatedly use the same latrines for defecation. To quantify musk deer habitat correlates, we used observational spatial data based on presence-absence of musk deer latrines, as well as a range of fine spatial-scale ecological covariates. To determine presence-absence of musk deer, we exhaustively searched randomly selected forest trails using a 20-m belt transect in different study sites within the Neshyang Valley in the Annapurna Conservation Area...
January 2019: Ecology and Evolution
Patrick Schober, Tessa Biesheuvel, Marcel A de Leeuw, Stephan A Loer, Lothar A Schwarte
BACKGROUND: Creating a patent airway by cricothyrotomy is the ultimate maneuver to allow oxygenation (and ventilation) of the patient. Given the rarity of airway management catastrophes necessitating cricothyrotomy, sufficiently sized prospective randomized trials are difficult to perform. Our Helicopter Emergency Medical Service (HEMS) documents all cases electronically, allowing a retrospective analysis of a larger database for all cases of prehospital cricothyrotomy. METHODS: We analyzed all 19,382 dispatches of our HEMS 'Lifeliner 1', since set-up of a searchable digital database...
January 23, 2019: BMC Emergency Medicine
Arash Rashed, Nora Olsen, Christopher M Wallis, Li Paetzold, Lynn Woodell, Mahnaz Rashidi, Fekede Workneh, Charles M Rush
Zebra chip (ZC) disease of potato is associated with the putative pathogen 'Candidatus Liberibacter solanacearum', which is transmitted by the potato psyllid Bactericera cockerelli (Hem., Triozidae). The present study was initiated to investigate 'Ca. L. solanacearum' development during and following typical commercial storage practices. Using bacteriliferous psyllids, Russet Norkotah potato tubers were infested in field cages 14, 10, and 4 days before harvest. Changes in 'Ca. L. solanacearum' detection rate, 'Ca...
March 2018: Plant Disease
A Kiesewetter, C Cursiefen, S A Eming, D Hos
Macrophages are critical mediators of injury-associated corneal hemangiogenesis (HA) and lymphangiogenesis (LA). Yet, molecular regulators of the hem- and lymphangiogenic potential of corneal wound macrophages are poorly understood. Using two different mouse models of acute (perforating corneal incision injury) and chronic (corneal suture placement model) corneal injury, here we identified distinct functions of early- versus late-phase corneal wound macrophages in corneal HA and LA. Whereas early-phase wound macrophages are essential for initiation and progression of injury-mediated corneal HA and LA, late-phase wound macrophages control maintenance of established corneal lymphatic vessels, but not blood vessels...
January 22, 2019: Scientific Reports
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