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https://read.qxmd.com/read/30759325/refining-initial-diagnosis-of-parkinson-s-disease-after-follow-up-a-4-year-prospective-clinical-and-magnetic-resonance-imaging-study
#1
Aldo Quattrone, Maurizio Morelli, Basilio Vescio, Salvatore Nigro, Emilio Le Piane, Umberto Sabatini, Manuela Caracciolo, Virginia Vescio, Andrea Quattrone, Gaetano Barbagallo, Carlo Stanà, Giuseppe Nicoletti, Gennarina Arabia, Rita Nisticò, Fabiana Novellino, Maria Salsone
BACKGROUND: No prospective study of patients with Parkinson's disease (PD) has investigated the appearance of vertical gaze abnormalities, a feature suggestive of progressive supranuclear palsy (PSP). OBJECTIVE: To identify, within a cohort of patients with an initial diagnosis of PD, those who developed vertical gaze abnormalities during a 4-year follow-up, and to investigate the performance of new imaging biomarkers in predicting vertical gaze abnormalities. METHODS: A total of 110 patients initially classified as PD and 74 controls were enrolled...
February 13, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30759320/striatal-spreading-depolarization-possible-implication-in-levodopa-induced-dyskinetic-like-behavior
#2
Antonio de Iure, Francesco Napolitano, Goichi Beck, Ana Quiroga Varela, Valentina Durante, Miriam Sciaccaluga, Petra Mazzocchetti, Alfredo Megaro, Michela Tantucci, Antonella Cardinale, Daniela Punzo, Andrea Mancini, Cinzia Costa, Veronica Ghiglieri, Alessandro Tozzi, Barbara Picconi, Stella M Papa, Alessandro Usiello, Paolo Calabresi
OBJECTIVE: Spreading depolarization (SD) is a transient self-propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson's disease (PD) pathophysiology, has been poorly investigated. METHODS: We characterized the participation of glutamatergic and dopaminergic transmission in the induction of striatal spreading depolarization by using a novel approach combining optical imaging, measurements of endogenous DA levels, and pharmacological and molecular analyses...
February 13, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30759124/evaluating-the-quality-of-antihypertensive-drugs-in-lagos-state-nigeria
#3
Elizabeth Thithi Ndichu, Kelechi Ohiri, Oluwafemi Sekoni, Olasunmbo Makinde, Kevin Schulman
BACKGROUND: As the burden of noncommunicable diseases grows, access to safe medical therapy is increasing in importance. The aim of this study was to develop a method for evaluating the quality of antihypertensive drugs and to examine whether this prevalence varies by socioeconomic variables. METHODS: We conducted a cross-sectional survey of registered pharmacies in 6 local government areas (LGAs) in Lagos State, Nigeria. In each LGA, we sampled 17 pharmacies from a list of all registered pharmacies derived from the Pharmacists Council of Nigeria...
2019: PloS One
https://read.qxmd.com/read/30758977/the-timing-of-corticosteroid-injections-after-arthroscopic-shoulder-procedures-affects-postoperative-infection-risk
#4
Michelle E Kew, Jourdan M Cancienne, James E Christensen, Brian C Werner
BACKGROUND: Corticosteroid injections are sometimes used in the postoperative period after shoulder arthroscopy; however, a well-defined safety profile has not been established. PURPOSE: To examine the association between the timing of postoperative corticosteroid injections and rates of infection after shoulder arthroscopy. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Private payer and Medicare national insurance databases were queried for patients who underwent arthroscopic rotator cuff repair, debridement, or subacromial decompression...
February 13, 2019: American Journal of Sports Medicine
https://read.qxmd.com/read/30758743/micronized-purified-flavonoid-fraction-mpff-for-patients-suffering-from-chronic-venous-disease-a-review-of-new-evidence
#5
REVIEW
Jorge H Ulloa
Chronic venous disease (CVD) is both prevalent and unavoidable in many people as a result of persistent or unalterable risk factors, the most important of which are advanced age, excess body weight, and family history. Given this inevitability, medical treatment is required to alleviate symptoms and slow disease progression. Venoactive drug therapy is emerging as a valuable treatment option for many CVD patients and micronized purified flavonoid fraction (MPFF) is the most widely prescribed and well-studied venoactive drug available...
February 13, 2019: Advances in Therapy
https://read.qxmd.com/read/30758738/the-seriousness-of-chronic-venous-disease-a-review-of-real-world-evidence
#6
REVIEW
Alun H Davies
Chronic venous disease (CVD) is a prevalent condition that tends to worsen with age. Patients initially seek treatment to relieve symptoms of leg pain, discomfort, heaviness and swelling, all of which impact their quality of life. As the disease increases in severity to include varicose veins, skin changes, and venous ulcer, the demand for treatment increases while the quality of life further diminishes. The prevalence of CVD is highest in Western countries where it already consumes up to 2% of healthcare budgets...
February 13, 2019: Advances in Therapy
https://read.qxmd.com/read/30758737/fibrous-dysplasia-with-secondary-aneurysmal-bone-cyst-a-rare-case-report-and-literature-review
#7
Levy Hermes Rau, Angélica Reinheimer, Maria Inês Meurer, Aline Luiza Marodin, Catherine Schmitz Espezim, Leandro Eduardo Klüppel, Paula Cristina Dos Santos Vaz Fernandes, Elena Riet Correa Rivero
INTRODUCTION: Fibrous dysplasia (FD) and aneurysmal bone cyst (ABC) are uncommon non-neoplastic intraosseous lesions, and the occurrence of concomitant FD and ABC is extremely rare. CASE REPORT: An 11-year-old boy presented with gradual progressive enlargement of his right zygomatic bone over 4 years prior to presentation. Computed tomography revealed a lesion with a central bony area showing a ground-glass appearance surrounded by a well-defined expansile lesion with internal septations...
February 13, 2019: Oral and Maxillofacial Surgery
https://read.qxmd.com/read/30758678/role-of-mri-in-staging-and-follow-up-of-endometrial-and-cervical-cancer-pitfalls-and-mimickers
#8
REVIEW
María Milagros Otero-García, Alicia Mesa-Álvarez, Olivera Nikolic, Patricia Blanco-Lobato, Marijana Basta-Nikolic, Rafael Menéndez de Llano-Ortega, Laura Paredes-Velázquez, Nikola Nikolic, Magda Szewczyk-Bieda
MRI plays important roles in endometrial and cervical cancer assessment, from detection to recurrent disease evaluation. Endometrial cancer (EC) is the most common malignant tumor of the female genital tract in Western countries. EC patients are divided into risk categories based on histopathological tumor type, grade, and myometrial invasion depth. EC is surgically staged using the International Federation of Gynecology and Obstetrics (FIGO) system. Since FIGO (2009) stage correlates with prognosis, preoperative staging is essential for tailored treatment...
February 13, 2019: Insights Into Imaging
https://read.qxmd.com/read/30758637/-breakthrough-in-understanding-the-molecular-causes-of-psychiatric-disorders
#9
REVIEW
Markus M Nöthen, Franziska Degenhardt, Andreas J Forstner
A long-established hypothesis is that genetic factors contribute to the development of psychiatric diseases, including common illnesses such as schizophrenia and the affective disorders; however, reliable molecular identification of these factors represents a far more recent innovation. This has been rendered possible by technological advances in the individual characterization of the human genome and the combining of large genetic datasets at the international level. For the first time, the results of genome-wide analyses provide researchers with systematic insights into disease-relevant biological mechanisms...
February 2019: Der Nervenarzt
https://read.qxmd.com/read/30758529/a-hierarchical-cobalt-carbon-nanotube-hybrid-nanocomplex-based-ratiometric-fluorescent-nanosensor-for-ultrasensitive-detection-of-hydrogen-peroxide-and-glucose-in-human-serum
#10
Pengcheng Qian, Yingnan Qin, Yanlong Lyu, Yunfei Li, Lei Wang, Shuo Wang, Yaqing Liu
Highly sensitive detection of H2 O2 and glucose is critical for fundamental research and disease diagnosis. A ratiometric sensor can simultaneously afford two readout signals that provide an internally normalized response to change, thereby reducing false results and improving detection accuracy. A novel ratiometric fluorescent nanosensor for ultrasensitive detection of hydrogen peroxide and glucose was constructed on the basis of the peroxidase-like properties of a hierarchical cobalt/carbon nanotube hybrid nanocomplex (Co-CNT)...
February 13, 2019: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/30758506/association-of-statin-adherence-with-mortality-in-patients-with-atherosclerotic-cardiovascular-disease
#11
Fatima Rodriguez, David J Maron, Joshua W Knowles, Salim S Virani, Shoutzu Lin, Paul A Heidenreich
Importance: Statins decrease mortality in those with atherosclerotic cardiovascular disease (ASCVD), but statin adherence remains suboptimal. Objective: To determine the association between statin adherence and mortality in patients with ASCVD who have stable statin prescriptions. Design, Setting, and Participants: This retrospective cohort analysis included patients who were between ages 21 and 85 years and had 1 or more International Classification of Diseases, Ninth Revision, Clinical Modification codes for ASCVD on 2 or more dates in the previous 2 years without intensity changes to their statin prescription who were treated within the Veterans Affairs Health System between January 1, 2013, and April 2014...
February 13, 2019: JAMA Cardiology
https://read.qxmd.com/read/30758425/management-of-copd-within-the-brazilian-unified-health-care-system-in-the-state-of-bahia-an-analysis-of-real-life-medication-use-patterns
#12
Charleston Ribeiro Pinto, Antônio Carlos Moreira Lemos, Lindemberg Assunção-Costa, Aramis Tupiná de Alcântara, Laira Lorena Lima Yamamura, Gisélia Santana Souza, Eduardo Martins Netto
OBJECTIVE: To describe COPD pharmacological treatment patterns in the state of Bahia, Brazil, and to evaluate the extent to which these patterns conform to clinical guidelines for the management of COPD. METHODS: This was a cross-sectional study of 441 patients referred from the Public Health Care Network of the state of Bahia to a public referral outpatient clinic of a COPD management program of the Brazilian Unified Health Care System. Individuals with a spirometry-confirmed diagnosis of moderate to very severe COPD were included in the study...
February 11, 2019: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/30757902/polyelectrolyte-coatings-can-control-charged-fluorocarbon-nanodroplet-stability-and-their-interaction-with-macrophage-cells
#13
Amanda L Martin, Christa M Homenick, Yun Xiang, Elizabeth R Gillies, Naomi Matsuura
Fluorocarbon nanodroplets, ~100 to ~400 nm in diameter, are of immense interest in a variety of medical applications including the imaging and therapy of cancer and inflammatory diseases. However, fluorocarbon molecules are both hydrophobic and lipophobic, so it is challenging to synthesize fluorocarbon nanodroplets with the optimal stability and surface properties without the use of highly specialized surfactants. Here, we hypothesize that we can decouple the control of fluorocarbon nanodroplet size and stability from its surface properties...
February 13, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/30756413/ectopic-spinal-calcification-associated-with-diffuse-idiopathic-skeletal-hyperostosis-dish-a-quantitative-micro-ct-analysis
#14
Dale E Fournier, Chris J D Norley, Steven I Pollmann, Christopher S Bailey, Fahad Al Helal, Katherine E Willmore, David W Holdsworth, Jeffrey Dixon, Cheryle A Séguin
Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory spondyloarthropathy identified radiographically by calcification of the ligaments and/or entheses along the anterolateral aspect of the vertebral column. The etiology and pathogenesis of calcifications are unknown, and the diagnosis of DISH is currently based on radiographic criteria associated with advanced disease. To characterize the features of calcifications associated with DISH, we used micro-computed tomographic imaging to evaluate a cohort of 19 human cadaveric vertebral columns...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30756367/the-impact-of-low-volume-lymph-node-metastases-and-stage-migration-after-pathologic-ultrastaging-of-non-sentinel-lymph-nodes-in-early-stage-cervical-cancer-a-study-of-54-patients-with-4-2-years-of-follow-up
#15
Marcin Sniadecki, Dariusz Grzegorz Wydra, Szymon Wojtylak, Ewa Wycinka, Marcin Liro, Nikola Sniadecka, Agnieszka Mrozinska, Sambor Sawicki
OBJECTIVES: To assess the significance of pathologic ultrastaging (PU) of sentinel (SLN) and non-sentinel (nSLN) lymph nodes (LNs) and the influence on cancer staging in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA2-IB1 cervical cancer. MATERIAL AND METHODS: A retrospective study was conducted with 54 patients divided into two equal-sized groups. In test group (n1), at least one SLN/patient was detected with blue dye. All excised LNs in this group were subjected to PU (4 μm slices/150 μm intervals) with hematoxylin-eosin staining and immunohistochemistry (AE1-AE3 antibodies)...
2019: Ginekologia Polska
https://read.qxmd.com/read/30756117/shift-in-hospitalizations-for-alzheimer-s-disease-to-related-dementias-in-france-between-2007-and-2017
#16
M Rochoy, E Chazard, S Gautier, R Bordet
INTRODUCTION: Alzheimer's disease (AD) is the first cause of dementia. Diagnostic criteria have evolved: proposals to revise the NINCDS-ADRDA criteria were published in 2007. Our aim was to analyze the evolution in the coding of AD in the French nationwide exhaustive hospital discharge database (PMSI) between 2007 and 2017. METHODS: We analyzed evolution of International Classification of Diseases and Related Health Problems, 10th edition (ICD-10) coding for AD and AD dementia in the PMSI database from 2008 to 2017 (285,748,938 inpatient stays)...
2019: Journal of Prevention of Alzheimer's Disease
https://read.qxmd.com/read/30755724/variation-in-collagenase-clostridium-histolyticum-practice-patterns-a-survey-of-issm-members
#17
T A Masterson, A Galante, M Butaney, A Pastuszak, H Sadeghi-Nejad, R Ramasamy
Collagenase clostridium histolyticum (CCH, Xiaflex, Xiapex) is the only FDA-approved medication for treatment of Peyronie's disease. It is unclear how practitioners actually use CCH in their own practices. The objectives of the study were: (1) to identify variability in practice patterns for CCH among practitioners, (2) to assess adherence to the package insert instructions, and (3) to evaluate whether provider satisfaction was associated with adherence to instructions. A 30-question online survey was distributed to 1270 members of the International Society for Sexual Medicine (ISSM) from the EU, USA, Canada and Australia...
February 12, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30755551/variations-in-the-position-of-vermiform-appendix-in-bangladeshi-people
#18
S A Sumi, S Z Sultana, S Mannan, U K Paul, M S Khan, M O Faruque, M Rahman, N Sultana, N J Khan, L Jabeen, T Jannat, S K Bose
This cross sectional descriptive study was performed on 70 postmortem vermiform appendices (male 34 and female 36) to find out the various positions of vermiform appendix of Bangladeshi people. The specimens were collected from autopsy laboratory of the Department of Forensic Medicine, Mymensingh Medical College, Mymensingh, Bangladesh by purposive sampling technique from October 2016 to March 2017. The collected samples were divided into four age groups. They were Group A (upto 20 years), Group B (21 to 40 years), Group C (41 to 60 years) and Group D (above 60 years)...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30755511/-cryptococcus-deuterogattii-vgiia-infection-associated-with-travel-to-the-pacific-northwest-outbreak-region-in-an-anti-granulocyte-macrophage-colony-stimulating-factor-autoantibody-positive-patient-in-the-united-states
#19
Shelly Applen Clancey, Emily J Ciccone, Marco A Coelho, Joie Davis, Li Ding, Renee Betancourt, Samuel Glaubiger, Yueh Lee, Steven M Holland, Peter Gilligan, Julia Sung, Joseph Heitman
The region encompassing the Pacific Northwest (PNW), Vancouver Island, Oregon, and Washington has been the location of an ongoing Cryptococcus gattii outbreak since the 1990s, and there is evidence that the outbreak is expanding along the West Coast into California. Here we report a clinical case of a 69-year-old, HIV-negative man from North Carolina who was diagnosed with a fungal brain mass by magnetic resonance imaging (MRI) and pathology. He had traveled to Seattle and Vancouver 3 years earlier and to Costa Rica 4 months prior to presentation...
February 12, 2019: MBio
https://read.qxmd.com/read/30755288/re-emerging-foci-of-visceral-leishmaniasis-in-armenia-first-molecular-diagnosis-of-clinical-samples
#20
Anna Sukiasyan, Ara Keshishyan, Dezdemonia Manukyan, Gayane Melik-Andreasyan, Liana Atshemyan, Hripsime Apresyan, Margarita Strelkova, Marcus Frohme, Sofia Cortes, Katrin Kuhls
Visceral leishmaniasis (VL) was firstly reported in Armenia in 1913. Following a considerable increase of the number of cases until the mid 1950s, the disease disappeared after 1969 and re-emerged in 1999. Scientific literature about VL in Armenia is available only in Russian or Armenian. This paper presents a historical overview about leishmaniasis in Armenia based on this literature as well as an epidemiological update since the re-emergence of the disease. In 1999-2016, 116 indigenous VL cases were recorded mainly in children in 8 of the 11 districts, however, VL is underreported because of lack of trained medical personal and diagnostic facilities...
February 13, 2019: Parasitology
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