Mingxin Ci, Gaichao Zhao, Chongyang Li, Ruochen Liu, Xiaosong Hu, Jun Pan, Yang Shen, Guanghui Zhang, Yongsen Li, Li Zhang, Ping Liang, Hongjuan Cui
Glioblastoma, IDH-Wild type (GBM, CNS WHO Grade 4) is a highly heterogeneous and aggressive primary malignant brain tumor with high morbidity, high mortality, and poor patient prognosis. The global burden of GBM is increasing notably due to limited treatment options, drug delivery problems, and the lack of characteristic molecular targets. OTU deubiquitinase 4 (OTUD4) is a potential predictive factor for several cancers such as breast cancer, liver cancer, and lung cancer. However, its function in GBM remains unknown...
March 1, 2024: Cell Death & Disease