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John R Shorter, Maya L Najarian, Timothy A Bell, Matthew Blanchard, Martin T Ferris, Pablo Hock, Anwica Kashfeen, Kathryn E Kirchoff, Colton L Linnertz, J Sebastian Sigmon, Darla R Miller, Leonard McMillan, Fernando Pardo-Manuel de Villena
Two key features of recombinant inbred panels are well-characterized genomes and reproducibility. Here we report on the sequenced genomes of six additional Collaborative Cross (CC) strains and on inbreeding progress of 72 CC strains. We have previously reported on the sequences of 69 CC strains that were publicly available, bringing the total of CC strains with whole genome sequence up to 75. The sequencing of these six CC strains updates the efforts towards inbreeding undertaken by the UNC Systems Genetics Core...
March 11, 2019: G3: Genes—Genomes—Genetics
Nicole S Kirchoff, Monique A R Udell, Thomas J Sharpton
Aggression is a serious behavioral disorder in domestic dogs that endangers both dogs and humans. The underlying causes of canine aggression are poorly resolved and require illumination to ensure effective therapy. Recent research links the compositional diversity of the gut microbiome to behavioral and psychological regulation in other mammals, such as mice and humans. Given these observations, we hypothesized that the composition of the canine gut microbiome could associate with aggression. We analyzed fecal microbiome samples collected from a small population of pit bull type dogs seized from a dogfighting organization...
2019: PeerJ
Cornelia Siegl, Marielle König-Schuster, Sabine Nakowitsch, Christiane Koller, Philipp Graf, Nicole Unger-Manhart, Yvonne Schindlegger, Norman Kirchoff, Christian Knecht, Eva Prieschl-Grassauer, Wolfgang Sipos
Corticosteroids and macrolide immunomodulators such as tacrolimus are effective drugs for the topical treatment of inflammatory eye diseases like allergic conjunctivitis or dry eye. However, tacrolimus is practically insoluble in aqueous solutions and is therefore currently formulated as dispersion. This leads to low bioavailability. Here, we present a novel pharmacologically acceptable, aqueous formulation of tacrolimus based on the "Marinosolv formulation platform". Marinosolv allows the solubilization and thereby improvement of the bioavailability of many otherwise practically insoluble drugs, since dissolved drugs permeate faster into tissues, including ocular tissues...
November 19, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Viqar Uddin Ahmad, Faryal Vali Mohammad, Rasool Bakhsh Tareen
Phytochemical investigation of the aerial parts of Astragalus tephrosioides Boiss. var. lacei (Ali) Kirchoff. (Family Fabaceae) resulted in the isolation of a new cycloartane glycoside laceioside (1). The structure of the previously undescribed compound 1 was established as 16β-acetyloxy-3-O-β-d-glucopyranosyloxy-cycloartan-11α,24ξ, 25-triol. The structure elucidation of compound 1 was based primarily on 1D and 2D-NMR techniques including 1 H and 13 CNMR spectra, DEPT and by 2D COSY, HSQC and HMBC experiments...
March 27, 2018: Natural Product Research
Kathryn F Kirchoff-Torres, Ekaterina Bakradze
PURPOSE OF REVIEW: Cerebral hyperperfusion syndrome (CHS) is a rare but significant complication after carotid revascularization and is increasingly recognized after acute stroke treatments. In this review, we discuss the epidemiology and pathophysiology of CHS, clinical presentation including ipsilateral headache, seizures, and focal neurological deficits, and radiographic presentation. We propose preventive therapies with emphasis on acute stroke post-thrombectomy hyperperfusion. RECENT FINDINGS: CHS was first described after carotid revascularization but is now also reported in patients with acute ischemic stroke...
March 19, 2018: Current Pain and Headache Reports
Barry Sinervo, Donald B Miles, Yayong Wu, Fausto R Méndez de la Cruz, Sebastian Kirchoff, Yin Qi
Determining the susceptibility of species to changing thermal niches is a major goal for biologists. In this paper we develop an eco-physiological model of extinction risk under climate change premised on behavioral thermoregulation. Our method downscales operative environmental temperatures, which restrict hours of activity of lizards, hr , for present-day climate (1975) and future climate scenarios (2070). We apply our model using occurrence records of 20 Phrynocephalus lizards (or taxa in species complexes) drawn from literature and museum records...
February 13, 2018: Integrative Zoology
Mary M Peacock, Evon R Hekkala, Veronica S Kirchoff, Lisa G Heki
Currently one small, native population of the culturally and ecologically important Lahontan cutthroat trout ( Oncorhynchus clarkii henshawi , LCT, Federally listed) remains in the Truckee River watershed of northwestern Nevada and northeastern California. The majority of populations in this watershed were extirpated in the 1940s due to invasive species, overharvest, anthropogenic water consumption and changing precipitation regimes. In 1977, a population of cutthroat trout discovered in the Pilot Peak Mountains in the Bonneville basin of Utah, was putatively identified as the extirpated LCT lacustrine lineage native to Pyramid Lake in the Truckee River basin based on morphological and meristic characters...
November 2017: Royal Society Open Science
Petr Pokorný, Filip Šmejkal, Pavel Kulmon, Pavel Novák, Jiří Novák, Antonín Mikš, Martin Horák, Milan Jirásek
This paper presents a complete model for analysis of the deformed shape of a prestressed circular axisymmetric membrane of a liquid lens. The governing equations are derived using the exact relation between displacements and the Green-Lagrange strains combined with the Saint Venant-Kirchhoff material law, which postulates a linear relation between the Green-Lagrange strains and the second Piola-Kirchoff stresses. A numerical solution based on minimization of potential energy is illustrated by an example, and the dependence of the maximum membrane deflection on material properties and initial prestress is analyzed...
December 1, 2017: Applied Optics
Jerome F Pierson, Matthew C Kirchoff, Susan M Orsega, Scott F Giberson, Betsey R Herpin, Travis W Ready, Michelle L Holshue, Grace G Kelly
The U.S. response to the Ebola epidemic resulted in many federal agencies assessing their ability to respond to global threats and improve the efficiency of humanitarian efforts.
August 2017: Federal Practitioner
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