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https://read.qxmd.com/read/30781881/antioxidative-peptides-from-proteolytic-hydrolysates-of-false-abalone-volutharpa-ampullacea-perryi-characterization-identification-and-molecular-docking
#1
Shudong He, Yi Zhang, Hanju Sun, Ming Du, Jianlei Qiu, Mingming Tang, Xianbao Sun, Beiwei Zhu
Antioxidative peptides were produced from false abalone ( Volutharpa ampullacea perryi ) using enzymatic hydrolysis. Trypsin produced the most bioactive hydrolysates with the highest scavenging ABTS+• free radicals compared to pepsin, alcalase, neutrase, and flavourzyme. The response surface methodology studies on trypsin hydrolysis indicated that the hydrolysis temperature, time, and pH were interacted with each other ( p < 0.05), and the optimal conditions were hydrolysis at 51.8 °C for 4.1 h, pH 7...
February 13, 2019: Marine Drugs
https://read.qxmd.com/read/30781872/an-integrative-systems-perspective-on-plant-phosphate-research
#2
REVIEW
Ishan Ajmera, T Charlie Hodgman, Chungui Lu
The case for improving crop phosphorus-use-efficiency is widely recognized. Although much is known about the molecular and regulatory mechanisms, improvements have been hampered by the extreme complexity of phosphorus (P) dynamics, which involves soil chemistry; plant-soil interactions; uptake, transport, utilization and remobilization within plants; and agricultural practices. The urgency and direction of phosphate research is also dependent upon the finite sources of P, availability of stocks to farmers and reducing environmental hazards...
February 13, 2019: Genes
https://read.qxmd.com/read/30781836/roles-of-pi3k-akt-gsk3-pathway-involved-in-psychiatric-illnesses
#3
REVIEW
Satoru Matsuda, Yuka Ikeda, Mutsumi Murakami, Yukie Nakagawa, Ai Tsuji, Yasuko Kitagishi
Psychiatric illnesses may be qualified to the cellular impairments of the function for survival or death in neurons, which may consequently appear as abnormalities in the neuroplasticity. The molecular mechanism has not been well understood, however, it seems that PI3K, AKT, GSK3, and their downstream molecules have crucial roles in the pathogenesis. Through transducing cell surviving signal, the PI3K/AKT/GSK3 pathway may organize an intracellular central network for the action of the synaptic neuroplasticity...
February 13, 2019: Diseases (Basel)
https://read.qxmd.com/read/30781683/leukocyte%C3%A2-cancer-cell-fusion-genesis-of-a-deadly-journey
#4
REVIEW
Greggory S Laberge, Eric Duvall, Kay Haedicke, John Pawelek
According to estimates from the International Agency for Research on Cancer, by the year 2030 there will be 22 million new cancer cases and 13 million deaths per year. The main cause of cancer mortality is not the primary tumor itself but metastasis to distant organs and tissues, yet the mechanisms of this process remain poorly understood. Leukocyte⁻cancer cell fusion and hybrid formation as an initiator of metastasis was proposed more than a century ago by the German pathologist Prof. Otto Aichel. This proposal has since been confirmed in more than 50 animal models and more recently in one patient with renal cell carcinoma and two patients with malignant melanoma...
February 18, 2019: Cells
https://read.qxmd.com/read/30781578/microparticles-of-lamivudine-poly-%C3%AE%C2%B5-caprolactone-conjugate-for-drug-delivery-via-internalization-by-macrophages
#5
Tomasz Urbaniak, Daniela Machová, Olga Janoušková, Witold Musiał
The past decade may be considered as revolutionary in the research field focused on the physiological function of macrophages. Unknown subtypes of these cells involved in pathological mechanisms were described recently, and they are considered as potential drug delivery targets. The innate ability to internalize foreign bodies exhibited by macrophages can be employed as a therapeutic strategy. The efficiency of this uptake depends on the size, shape and surface physiochemical properties of the phagocyted objects...
February 17, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30781484/opioid-use-in-pregnant-women-and-neonatal-abstinence-syndrome-a-review-of-the-literature
#6
REVIEW
Fábio Martins, David Oppolzer, Catarina Santos, Mário Barroso, Eugenia Gallardo
Opiate use during pregnancy has been an increasing problem over the last two decades, making it an important social and health concern. The use of such substances may have serious negative outcomes in the newborn, and clinical and cognitive conditions have been reported, including neonatal abstinence syndrome, developmental problems, and lower cognitive performance. These conditions are common when opiates are used during pregnancy, making the prescription of these kinds of drugs problematic. Moreover, the mother may develop opiate addiction, thus, increasing the likelihood of the infant being born with any of those conditions...
February 16, 2019: Toxics
https://read.qxmd.com/read/30780132/molecular-mechanisms-of-foxo1-in-adipocyte-differentiation
#7
REVIEW
Junye Chen, Yi Lu, Mengyuan Tian, Qiren Huang
Forkhead box-O1 (FOXO1) is a downstream target of AKT and plays crucial roles in cell cycle control, apoptosis, metabolism and adipocyte differentiation. It is thought that FOXO1 affects adipocyte differentiation by regulating lipogenesis and cell cycle. With the deepening in the understanding of this field, it is currently believed that FOXO1 translocation between nucleus and cytoplasm is involved in the regulation of FOXO1 activity, thus affecting adipocyte differentiation. Translocation of FOXO1 depends on its post-translational modifications and interactions with 14-3-3...
February 1, 2019: Journal of Molecular Endocrinology
https://read.qxmd.com/read/30780053/nudging-tourists-to-donate-for-conservation-experimental-evidence-on-soliciting-voluntary-contributions-for-coastal-management
#8
Katherine M Nelson, Stefan Partelow, Achim Schlüter
This research examines the donation behavior of tourists who are asked to donate to coastal conservation aimed at addressing a bundled mix of land and sea issues. Historically, the governance and financing of land and sea conservation have been separated; yet coastal tourism directly involves a mix of activities and development challenges which link land and sea together on the coast. Marine parks, and numerous studies examining their funding schemes, have typically focused on mandatory user fees targeting specific types of activities...
February 16, 2019: Journal of Environmental Management
https://read.qxmd.com/read/30780018/discovery-of-alkoxy-benzamide-derivatives-as-novel-bptf-bromodomain-inhibitors-via-structure-based-virtual-screening
#9
Dan Zhang, Jie Han, Wenchao Lu, Fulin Lian, Jun Wang, Tian Lu, Hongru Tao, Senhao Xiao, Fengcai Zhang, Yu-Chih Liu, Rongfeng Liu, Naixia Zhang, Hualiang Jiang, Kaixian Chen, Chunshen Zhao, Cheng Luo
Bromodomain PHD finger transcription factor (BPTF), a bromodomain-containing protein, plays a crucial role in the regulation of downstream gene expression through the specific recognition of lysine acetylation on bulk histones. The dysfunction of BPTF is closely involved with the development and progression of many human diseases, especially cancer. Therefore, BPTF bromodomain has become a promising drug target for epigenetic cancer therapy. However, unlike BET family inhibitors, few BPTF bromodomain inhibitors have been reported...
January 28, 2019: Bioorganic Chemistry
https://read.qxmd.com/read/30779960/does-outpatient-palliative-care-improve-patient-centered-outcomes-in-parkinson-s-disease-rationale-design-and-implementation-of-a-pragmatic-comparative-effectiveness-trial
#10
Benzi M Kluger, Maya Katz, Nicholas Galifianakis, Steven Z Pantilat, Jean S Kutner, Stefan Sillau, Mark Gritz, Jacqueline Jones, Diane Fairclough, Malenna Sumrall, Kirk Hall, Janis Miyasaki
Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better meet these needs. While PC has been shown to improve care and quality of life (QOL) for people with cancer and heart failure, few studies have evaluated the role of PC for people with PDRD. Well-designed clinical trials are needed to optimize the PC approach for PDRD and to influence policy and implementation efforts...
February 16, 2019: Contemporary Clinical Trials
https://read.qxmd.com/read/30779926/resting-respiratory-sinus-arrhythmia-and-posttraumatic-stress-disorder-a-meta-analysis
#11
Allison Campbell
Respiratory sinus arrhythmia (RSA) has been examined as a psychophysiological marker of stress vulnerability. Research indicates that low resting RSA is associated with physical and mental health problems, including posttraumatic stress disorder (PTSD). Some research suggests that people diagnosed with PTSD have lower RSA than people without PTSD, but findings have been mixed and the overall magnitude of this effect is unknown, indicating the need for a comprehensive meta-analysis. This meta-analysis examined the association between PTSD and baseline RSA in 55 studies, including 12 unpublished studies, with a total sample size of 6,689...
February 16, 2019: Biological Psychology
https://read.qxmd.com/read/30779921/mir-29c-regulates-resistance-to-paclitaxel-in-nasopharyngeal-cancer-by-targeting-itgb1
#12
Limin Huang, Chaoquan Hu, Hui Chao, Xiaoliang Wu, Rongpin Wang, He Lu, Hong Li, Hui Chen
Paclitaxel (Taxol) is an anticancer taxane drug commonly used in the treatment of nasopharyngeal carcinoma (NPC). However, resistance to paclitaxel is a major difficulty in developing an effective therapy against NPC. MicroRNAs (miRNAs) are known to regulate genes that are involved in drug resistance. We assessed the effects of miR-29c, an miRNA identified in a genome-wide study of Taxol resistance, on genes associated with resistance in NPC cells. We established Taxol resistance in two human NPC cell lines, SUNE-1 and C666-1 (SUNE-1-Taxol and C666-1-Taxol) and found that miR-29c was downregulated and integrin beta-1 (ITGB1) was upregulated in Taxol-resistant NPC cells compared with parental NPC cells...
February 16, 2019: Experimental Cell Research
https://read.qxmd.com/read/30779909/aryl-hydrocarbon-receptor-ahr-functions-in-nad-metabolism-myelopoiesis-and-obesity
#13
REVIEW
Karl Walter Bock
Diverse physiologic functions of AHR, a transcription factor discovered in studies of dioxin toxicity, are currently elucidated in many laboratories including chemical and microbial defense, immunity and myelopoiesis. Accumulating evidence suggests that AHR may also be involved in obesity and TCDD-mediated lethality in sensitive species. Underlying mechanisms include NAD+ - and sirtuin-mediated deregulation of lipid, glucose and NAD+ homeostasis. Progress in NAD metabolome research suggests large consumption of NAD+ by NAD glycohydrolases (NADases) and NAD-dependent sirtuins...
February 16, 2019: Biochemical Pharmacology
https://read.qxmd.com/read/30779882/taking-the-pulse-of-the-health-services-research-community-a-cross-sectional-survey-of-research-impact-barriers-and-support
#14
Elizabeth A Fradgley, Jon Karnon, Della Roach, Katherine Harding, Laura Wilkinson-Meyers, Catherine Chojenta, Megan Campbell, Melissa L Harris, Jacqueline Cumming, Kim Dalziel, Janet McDonald, Tilley Pain, Kirsten Smiler, Christine L Paul
Objective This study reports on the characteristics of individuals conducting health service research (HSR) in Australia and New Zealand, the perceived accessibility of resources for HSR, the self-reported impact of HSR projects and perceived barriers to conducting HSR. Methods A sampling frame was compiled from funding announcements, trial registers and HSR organisation membership. Listed researchers were invited to complete online surveys. Close-ended survey items were analysed using basic descriptive statistics...
February 20, 2019: Australian Health Review: a Publication of the Australian Hospital Association
https://read.qxmd.com/read/30779813/pixelating-crop-production-consequences-of-methodological-choices
#15
Alison K B Joglekar, Ulrike Wood-Sichra, Philip G Pardey
Worldwide, crop production is intrinsically intertwined with biological, environmental and economic systems, all of which involve complex, inter-related and spatially-sensitive phenomena. Thus knowing the location of agriculture matters much for a host of reasons. There are several widely cited attempts to model the spatial pattern of crop production worldwide, not least by pixilating crop production statistics originally reported on an areal (administrative boundary) basis. However, these modeled measures have had little scrutiny regarding the robustness of their results to alternative data and modeling choices...
2019: PloS One
https://read.qxmd.com/read/30779809/use-of-medicine-pricing-and-reimbursement-policies-for-universal-health-coverage-in-indonesia
#16
Riswandy Wasir, Sylvi Irawati, Amr Makady, Maarten Postma, Wim Goettsch, Erik Buskens, Talitha Feenstra
OBJECTIVES: This study aimed to define the problems of the current use of the e-Catalogue and the national formulary (NF)-two elements of medicine pricing and reimbursement policies in Indonesia for achieving universal health coverage (UHC)-by examining the knowledge and attitudes of stakeholders. Specifically, to investigate (1) the perceived challenges involved in the further implementation of the e-Catalogue and the NF, (2) reasons of prescribing medicines not listed in the NF, and (3) possible improvements in the acceptance and use of the e-Catalogue and the NF...
2019: PloS One
https://read.qxmd.com/read/30779798/technology-enabled-non-physician-health-workers-extending-telemedicine-to-rural-homes-to-control-hypertension-and-diabetes-tetra-a-pre-post-demonstration-project-in-telangana-india
#17
Shailendra Dandge, Panniyammakal Jeemon, P S Reddy
OBJECTIVES: We aimed to determine the feasibility and effectiveness of an intervention anchored on mHealth and task sharing strategy of involving non-physician health workers (NPHW) on population level detection, treatment and control of hypertension and diabetes in India. METHODS: Non-physician health workers (NPHWs) equipped with tablet computers that were linked with point-of-care devices for blood pressure (BP) and blood sugar measurements visited households, screened adult individuals for hypertension and diabetes from two randomly selected villages in the Medchal district, Telangana, India...
2019: PloS One
https://read.qxmd.com/read/30779787/integrative-systematic-review-of-psychodrama-psychotherapy-research-trends-and-methodological-implications
#18
Hod Orkibi, Rinat Feniger-Schaal
BACKGROUND: Psychodrama is an experiential psychotherapy in which guided role-play is used to gain insights and work on personal and interpersonal problems and possible solutions. Despite the wealth of literature describing clinical work, psychodrama intervention research is relatively scarce compared to other psychotherapies and psychological interventions. OBJECTIVE: For this reason we implemented the integrative approach to systematic review that authorizes the combination of publications with diverse methodologies and all types of participants, interventions, comparisons, and outcomes...
2019: PloS One
https://read.qxmd.com/read/30779522/competencies-for-global-mental-health-developing-training-objectives-for-a-post-graduate-fellowship-for-psychiatrists
#19
Colin Buzza, Anna Fiskin, Jorien Campbell, Jennifer Guo, Jacob Izenberg, Barbara Kamholz, Erick Hung, Bibhav Acharya
Despite an increase in psychiatry trainees' interest in global mental health (GMH), there is a lack of relevant training competencies developed using educational frameworks that incorporate viewpoints from high- and low-income countries. Objective: The aim of this study was to determine competencies for a two-year post-graduate GMH fellowship for psychiatrists utilizing Kern's six-step process as a theoretical framework for curriculum development. Methods: We conducted a targeted needs assessment via key informant interviews with a purposive sample of stakeholders (n = 19), including psychiatry trainees, generalist clinicians, medical directors, psychiatrists, researchers, and GMH educators from high- and low-resource settings in the United States and abroad...
November 5, 2018: Annals of Global Health
https://read.qxmd.com/read/30779484/-the-israeli-inherited-retinal-diseases-consortium-iirdc-clinical-genetic-mapping-and-future-perspectives
#20
Dror Sharon, Tamar Ben-Yosef, Eran Pras, Nitza Goldenberg-Cohen, Libe Gradstein, Noam Shomron, Ohad Birk, Miriam Ehrenberg, Jaime Levy, Eedy Mezer, Shiri Soudry, Ygal Rotenstreich, Hadas Newman, Rina Leibu, Eyal Banin, Ido Perlman
INTRODUCTION: The sense of vision is highly important for humans and its loss markedly affects function and quality of life. Many inherited retinal diseases (IRDs) cause visual loss due to dysfunction or progressive degeneration of photoreceptor cells. These diseases show clinical and genetic heterogeneity. AIMS: The Israeli IRD consortium (IIRDC) was established with the goal of performing clinical and genetic mapping of IRDs in the Israeli population. METHODS: Clinical evaluation is carried out at electroretinography (ERG) centers and ophthalmology departments, where the patients undergo a comprehensive eye exam, including testing of visual acuity, refractive error, imaging techniques and ERG tests...
February 2019: Harefuah
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