Bingchen Lv, Ping Fu, Miao Wang, Likun Cui, Lei Bao, Xingzhi Wang, Lu Yu, Chao Zhou, Mengxin Zhu, Fei Wang, Ye Pang, Suhua Qi, Zuohui Zhang, Guiyun Cui
OBJECTIVE: Neuronal precursor cells expressed developmentally down-regulated 4 (Nedd4) are believed to play a critical role in promoting the degradation of substrate proteins and are involved in numerous biological processes. However, the role of Nedd4 in intracerebral hemorrhage (ICH) remains unknown. This study aims to investigate the regulatory role of Nedd4 in the ICH model. METHODS: Male C57BL/6J mice were induced with ICH. Subsequently, the levels of glutathione peroxidase 4 (GPX4), malondialdehyde (MDA) concentration, iron content, mitochondrial morphology, as well as the expression of divalent metal transporter 1 (DMT1) and Nedd4 were assessed after ICH...
April 2024: CNS Neuroscience & Therapeutics