John L Hopper, Shuai Li, Robert J MacInnis, James G Dowty, Tuong L Nguyen, Minh Bui, Gillian S Dite, Vivienne F C Esser, Zhoufeng Ye, Enes Makalic, Daniel F Schmidt, Benjamin Goudey, Karen Alpen, Miroslaw Kapuscinski, Aung Ko Win, Pierre-Antoine Dugué, Roger L Milne, Harindra Jayasekara, Jennifer D Brooks, Sue Malta, Lucas Calais-Ferreira, Alexander C Campbell, Jesse T Young, Tu Nguyen-Dumont, Joohon Sung, Graham G Giles, Daniel Buchanan, Ingrid Winship, Mary Beth Terry, Melissa C Southey, Mark A Jenkins
Young breast and bowel cancers (e.g., those diagnosed before age 40 or 50 years) have far greater morbidity and mortality in terms of years of life lost, and are increasing in incidence, but have been less studied. For breast and bowel cancers, the familial relative risks, and therefore the familial variances in age-specific log(incidence), are much greater at younger ages, but little of these familial variances has been explained. Studies of families and twins can address questions not easily answered by studies of unrelated individuals alone...
March 19, 2024: Genetic Epidemiology