keyword
https://read.qxmd.com/read/38512795/surveillance-for-coccidioidomycosis-histoplasmosis-and-blastomycosis-during-the-covid-19-pandemic-united-states-2019-2021
#1
JOURNAL ARTICLE
Samantha L Williams, Dallas J Smith, Kaitlin Benedict, Jamie R Ahlers, Connie Austin, Rachael Birn, Angel M Carter, Natalie N Christophe, Katie Cibulskas, Paul R Cieslak, Suzanne N Gibbons-Burgener, Michael Gosciminski, Malia J Ireland, Katelyn V Lazenby, Tom Loftus, Kristy Lunquest, Abby A Mathewson, Alyssa D Nguyen, Hanna N Oltean, BreAnne Osborn, Erin M Petro, Danny J Power, Rebecca R Reik, Levi Schlosser, Judi Sedivy, Chad B Smelser, Tom Chiller, Mitsuru Toda
Coccidioidomycosis, histoplasmosis, and blastomycosis are lower respiratory tract fungal infections whose signs and symptoms can resemble those of other respiratory illnesses, including pneumonia caused by bacterial or viral etiologies; this overlap in clinical presentation might lead to missed or delayed diagnoses. The causative fungi live in the environment, often in soil or plant matter. To describe the epidemiologic characteristics of cases of coccidioidomycosis, histoplasmosis, and blastomycosis during the COVID-19 pandemic, CDC analyzed case surveillance data for 2019-2021...
March 21, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38495772/esophageal-candidiasis-associated-hospitalizations-declining-rates-and-changes-in-underlying-conditions-united-states-2010-2020
#2
JOURNAL ARTICLE
Jeremy A W Gold, Kaitlin Benedict
In a nationally representative hospital discharge database, esophageal candidiasis-associated hospitalization rates per 100 000 population steadily declined from 17.0 (n = 52 698, 2010) to 12.9 (n = 42 355, 2020). During this period, a decreasing percentage of EC-associated hospitalizations involved HIV and an increasing percentage involved gastroesophageal reflux disease, diabetes, and long-term steroid use.
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38462134/low-incidence-of-invasive-fungal-infections-in-a-large-observational-cohort-of-patients-initiating-il-17-or-il-23-inhibitor-therapy-united-states-2016-2022
#3
JOURNAL ARTICLE
Nathan C Bahr, Kaitlin Benedict, Mitsuru Toda, Jeremy A W Gold, Shari R Lipner
No abstract text is available yet for this article.
March 8, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38462071/healthcare-use-and-health-disparities-associated-with-mold-exposure-diagnosis-codes
#4
JOURNAL ARTICLE
Kaitlin Benedict, Ginger L Chew, Joy Hsu, Mitsuru Toda, Jeremy A W Gold
Medicaid and commercial health insurance claims databases revealed disparities in patients assigned the ICD-10 code "Contact with and (suspected) exposure to mold (toxic)" by insurance type, age, and sex. Allergic rhinitis was the most common concomitant diagnosis.
March 8, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38379572/epidemiology-clinical-characteristics-and-diagnostic-testing-practices-for-pneumocystis-pneumonia-associated-hospitalizations-united-states-2019-2022
#5
JOURNAL ARTICLE
Kaitlin Benedict, James Baggs, Jeremy A W Gold
Among 9196 hospitalizations involving Pneumocystis pneumonia, those without HIV had higher in-hospital mortality (24.3% vs 10.5%, P < .001) when compared with those with HIV. These findings underscore the continued importance of Pneumocystis pneumonia clinical awareness and the need for comprehensive prophylaxis guidance, particularly for certain patients without HIV who are immunosuppressed.
February 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38358752/prevalence-and-features-of-fungal-keratitis-among-us-patients-with-commercial-health-insurance
#6
JOURNAL ARTICLE
Kaitlin Benedict, Jeremy A W Gold, Dallas J Smith
No abstract text is available yet for this article.
February 15, 2024: JAMA Ophthalmology
https://read.qxmd.com/read/38206854/-topical-antifungal-prescribing-for-medicare-part-d-beneficiaries-united-states-2021
#7
JOURNAL ARTICLE
Kaitlin Benedict, Dallas J Smith, Tom Chiller, Shari R Lipner, Jeremy A W Gold
Incorrect use of topical antifungals and antifungal-corticosteroid combinations is likely contributing to the global emergence and spread of severe antimicrobial-resistant superficial fungal infections, which have recently been detected in the United States. Understanding prescribing patterns is an initial step in establishing and promoting recommended use of these medications. Using 2021 Medicare Part D data, CDC examined prescription volumes, rates, and costs for topical antifungals (including topical combination antifungal-corticosteroid medications)...
January 11, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38028688/concerning-rates-of-laboratory-confirmed-antifungal-resistant-onychomycosis-and-tinea-pedis-an-online-survey-of-podiatrists-united-states
#8
JOURNAL ARTICLE
Kaitlin Benedict, Jeremy A W Gold, Carolynn T Jones, Lisa A Tushla, Shari R Lipner, Warren S Joseph, Dyane E Tower, Boni Elewski, Peter G Pappas
No abstract text is available yet for this article.
November 2023: Health Science Reports
https://read.qxmd.com/read/37802909/clinical-testing-guidance-for-coccidioidomycosis-histoplasmosis-and-blastomycosis-in-patients-with-community-acquired-pneumonia-for-primary-and-urgent-care-providers
#9
JOURNAL ARTICLE
Dallas J Smith, Rebecca J Free, George R Thompson Iii, John W Baddley, Peter G Pappas, Kaitlin Benedict, Jeremy A W Gold, Lisa A Tushla, Tom Chiller, Brendan R Jackson, Mitsuru Toda
Coccidioidomycosis, histoplasmosis, and blastomycosis are underrecognized and frequently misdiagnosed fungal infections that can clinically resemble bacterial and viral community-acquired pneumonia (CAP). This guidance is intended to help clinicians in outpatient settings test for these fungal diseases in patients with CAP to reduce misdiagnoses, unnecessary antibacterial use, and poor outcomes.
October 6, 2023: Clinical Infectious Diseases
https://read.qxmd.com/read/37771852/antifungal-therapeutic-drug-monitoring-practices-results-of-an-emerging-infections-network-survey
#10
JOURNAL ARTICLE
Kaitlin Benedict, Jeremy A W Gold, Susan E Beekmann, Philip M Polgreen, Mitsuru Toda, Dallas J Smith
In a survey of 523 infectious disease specialists, a moderate to high percentage reported using any antifungal therapeutic drug monitoring (TDM) during itraconazole (72%), posaconazole (72%), and voriconazole (90%) treatment, and a low to moderate percentage reported using any antifungal TDM during prophylaxis (32%, 55%, and 65%, respectively). Long turnaround times for send-out TDM testing and logistical difficulties were frequent barriers.
September 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37754992/a-phylogeographic-description-of-histoplasma-capsulatum-in-the-united-states
#11
JOURNAL ARTICLE
Ujwal R Bagal, Lalitha Gade, Kaitlin Benedict, Victoria Howell, Natalie Christophe, Suzanne Gibbons-Burgener, Sara Hallyburton, Malia Ireland, Stephanie McCracken, Alison Keyser Metobo, Kimberly Signs, Kimberly A Warren, Anastasia P Litvintseva, Nancy A Chow
Histoplasmosis is one of the most under-diagnosed and under-reported endemic mycoses in the United States. Histoplasma capsulatum is the causative agent of this disease. To date, molecular epidemiologic studies detailing the phylogeographic structure of H. capsulatum in the United States have been limited. We conducted genomic sequencing using isolates from histoplasmosis cases reported in the United States. We identified North American Clade 2 (NAm2) as the most prevalent clade in the country. Despite high intra-clade diversity, isolates from Minnesota and Michigan cases were predominately clustered by state...
August 29, 2023: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/37754975/blastomycosis-associated-hospitalizations-united-states-2010-2020
#12
JOURNAL ARTICLE
Kaitlin Benedict, Ian Hennessee, Jeremy A W Gold, Dallas J Smith, Samantha Williams, Mitsuru Toda
BACKGROUND: Blastomycosis is an environmentally acquired fungal disease that can cause severe illness, with approximately 65% of reported cases requiring hospitalization. Recent trends in blastomycosis-associated hospitalizations in the United States have not been described. METHODS: We analyzed hospital discharge data from the Healthcare Cost and Utilization Project (HCUP) National (Nationwide) Inpatient Sample. We calculated hospitalization rates per 100,000 population using U...
August 22, 2023: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/37640556/a-cost-effectiveness-analysis-of-avelumab-plus-best-supportive-care-versus-best-supportive-care-alone-as-first-line-maintenance-treatment-for-patients-with-locally-advanced-or-metastatic-urothelial-carcinoma-in-taiwan
#13
JOURNAL ARTICLE
Po-Jung Su, Ying Xiao, Amy Y Lin, Connie Goh, Ethan Wu, Kevin Liu, Patrick Chou, Kaitlin Kuo, Roberto Palencia, Jane Chang, Mairead Kearney, Venediktos Kapetanakis, Agnes Benedict
BACKGROUND: Patients with locally advanced or metastatic urothelial carcinoma have limited treatment options and a poor prognosis. The JAVELIN Bladder 100 trial showed that avelumab as first-line maintenance plus best supportive care significantly prolonged overall survival and progression-free survival versus best supportive care alone in patients with locally advanced or metastatic urothelial carcinoma that had not progressed with first-line platinum-containing chemotherapy. AIMS: We assessed whether avelumab plus best supportive care is a cost-effective treatment option versus best supportive care alone in this patient group in Taiwan...
August 28, 2023: Cancer reports
https://read.qxmd.com/read/37623591/public-health-research-priorities-for-fungal-diseases-a-multidisciplinary-approach-to-save-lives
#14
REVIEW
Dallas J Smith, Jeremy A W Gold, Kaitlin Benedict, Karen Wu, Meghan Lyman, Alexander Jordan, Narda Medina, Shawn R Lockhart, D Joseph Sexton, Nancy A Chow, Brendan R Jackson, Anastasia P Litvintseva, Mitsuru Toda, Tom Chiller
Fungal infections can cause severe disease and death and impose a substantial economic burden on healthcare systems. Public health research requires a multidisciplinary approach and is essential to help save lives and prevent disability from fungal diseases. In this manuscript, we outline the main public health research priorities for fungal diseases, including the measurement of the fungal disease burden and distribution and the need for improved diagnostics, therapeutics, and vaccines. Characterizing the public health, economic, health system, and individual burden caused by fungal diseases can provide critical insights to promote better prevention and treatment...
August 3, 2023: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/37549790/racial-disparities-risk-factors-and-clinical-management-practices-for-tinea-capitis-an-observational-cohort-study-among-u-s-children-with-medicaid
#15
JOURNAL ARTICLE
Ian P Hennessee, Kaitlin Benedict, Theresa M Dulski, Shari R Lipner, Jeremy A W Gold
No abstract text is available yet for this article.
August 5, 2023: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/37539059/low-rates-of-antifungal-therapeutic-drug-monitoring-among-inpatients-who-received-itraconazole-posaconazole-or-voriconazole-united-states-2019-2021
#16
JOURNAL ARTICLE
Kaitlin Benedict, Jeremy A W Gold, Mitsuru Toda, George R Thompson, Nathan P Wiederhold, Dallas J Smith
Antifungal therapeutic drug monitoring (TDM) is recommended for hospitalized patients receiving itraconazole, posaconazole, or voriconazole for treatment or prophylaxis. In this analysis of hospital-based data, TDM was uncommonly performed (15.8%) in a large cohort of eligible patients, suggesting missed opportunities to avoid subtherapeutic drug levels and minimize toxicity.
August 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37347923/candida-auris%C3%A2-associated-hospitalizations-united-states-2017-2022
#17
JOURNAL ARTICLE
Kaitlin Benedict, Kaitlin Forsberg, Jeremy A W Gold, James Baggs, Meghan Lyman
Using a large US hospital database, we describe 192 Candida auris‒associated hospitalizations during 2017-2022, including 38 (20%) C. auris bloodstream infections. Hospitalizations involved extensive concurrent conditions and healthcare use; estimated crude mortality rate was 34%. These findings underscore the continued need for public health surveillance and C. auris containment efforts.
July 2023: Emerging Infectious Diseases
https://read.qxmd.com/read/37347805/increased-hospitalizations-involving-fungal-infections-during-covid-19-pandemic-united-states-january-2020-december-2021
#18
JOURNAL ARTICLE
Jeremy A W Gold, Stacey Adjei, Adi V Gundlapalli, Ya-Lin A Huang, Tom Chiller, Kaitlin Benedict, Mitsuru Toda
Hospitalizations involving fungal infections increased 8.5% each year in the United States during 2019-2021. During 2020-2021, patients hospitalized with COVID-19-associated fungal infections had higher (48.5%) in-hospital mortality rates than those with non-COVID-19-associated fungal infections (12.3%). Improved fungal disease surveillance is needed, particularly during respiratory virus pandemics.
July 2023: Emerging Infectious Diseases
https://read.qxmd.com/read/37274390/low-positivity-rate-and-high-percentage-of-nondermatophyte-molds-in-an-analysis-of-35-257-fungal-nail-culture-results-from-a-united-states-national-commercial-laboratory-2019-2022
#19
JOURNAL ARTICLE
Kaitlin Benedict, Shari R Lipner, Shawn R Lockhart, Jeremy A W Gold
No abstract text is available yet for this article.
September 2023: JAAD international
https://read.qxmd.com/read/37142095/epidemiology-of-implantation-mycoses-in-the-united-states-an-analysis-of-commercial-insurance-claims-data-2017-2021
#20
JOURNAL ARTICLE
Jeremy A W Gold, Dallas J Smith, Kaitlin Benedict, Shawn R Lockhart, Shari R Lipner
No abstract text is available yet for this article.
May 2, 2023: Journal of the American Academy of Dermatology
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