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Heather Kornmehl, Farzam Gorouhi, Thomas Konia, Maxwell A Fung, Danielle M Tartar
Fixed drug eruption (FDE) is an adverse drug reaction characterized by the development of well-circumscribed, round, dusky erythematous macules and plaques on cutaneous or mucosal surfaces. The reaction occurs on the same mucosal or cutaneous site with subsequent exposures to the offending drug. Although FDE usually manifests as a single lesion, in rare instances, more than one lesion may arise and this is referred to as a generalized eruption. Herein, we present a 31year-old man with history of cystic fibrosis who developed a generalized fixed drug eruption to piperacillin/tazobactam (Zosyn, Pfizer)...
April 15, 2018: Dermatology Online Journal
S Patel, R Levin-Epstein, J Kobashigawa
BACKGROUND: The present study reports a case of piperacillin-induced thrombocytopenia in a dual heart and kidney transplant patient on January 28, 2016 (taking mycophenolate mofetil and tacrolimus). Before the transplant, the patient was treated with Zosyn twice, with no reports of thrombocytopenia or allergy. However, he was diagnosed with heparin-induced thrombocytopenia and vancomycin allergy during each of those hospitalizations, respectively. Eight months after the transplant, the patient presented with infectious symptoms and was started on Zosyn...
September 2017: Transplantation Proceedings
Shashank Kraleti, Nudrat Khatri, Diane Jarrett
OBJECTIVE: To describe a patient who developed acute interstitial nephritis, hepatitis and serum sickness-like syndrome after receiving piperacillin-tazobactam (zosyn) therapy. CASE SUMMARY: A 30-year-old woman received a 7-day course of piperacillin-tazobactam as empiric treatment for pneumonia. The patient's kidney function worsened and she turned anuric needing dialysis. She also developed fever and a rash. Laboratory analysis showed elevated liver function and leukocytosis...
June 2016: Journal of the Arkansas Medical Society
Latricia L Allen, Garrett Kalmar, Vickie R Driver
We report a case of calcaneal osteomyelitis that was surgically resected from a patient with diabetes and peripheral vascular disease. A 91-year-old male with history of type 2 diabetes, peripheral vascular disease, balloon angioplasty, and recent (2 months ago) stent of the superficial femoral artery presented to the emergency department with a left heel wound infection probed to bone. The patient reported having been on intravenous Zosyn for several months via an outside infectious disease provider for clinical suspicion of osteomyelitis, but noted no improvement...
June 2016: Techniques in Vascular and Interventional Radiology
J Nicholas O'Donnell, Natarajan Venkatesan, Malav Manek, Nathaniel J Rhodes, Marc H Scheetz
PURPOSE: The compatibility of vancomycin and piperacillin-tazobactam in concentrations typically used in extended-infusion dosing schemes was evaluated. METHODS: Piperacillin-tazobactam was reconstituted and diluted to concentrations of 33.75, 45, 50, 60, 67.5, 80, and 90 mg/mL. Vancomycin was diluted to concentrations of 4-8, 10, and 12 mg/mL. The resultant admixtures were visually observed after preparation against black and white backgrounds each hour between hours 1 through 4 and after 24 hours...
February 15, 2016: American Journal of Health-system Pharmacy: AJHP
Robert Ali, Candice Baldeo, Jesse Onenykwe, Cristian Landa
Miscellaneous Student/Resident Case Report Posters ISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Granulomatosis with Polyangitis (GPA) is an autoimmune disease of unknown etiology defined by necrotizing granulomatous inflammation and pauci-immune vasculitis in small and medium sized blood vessels. GPA falls under the category of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides and is associated with anti-proteinase 3 (PR3)-ANCA...
October 1, 2014: Chest
Narendra R Desai, Syed M Shah, Julianna Koczone, Maja Vencl-Joncic, Christopher Sisto, Stephen A Ludwig
During ongoing quality improvement efforts with two Wyeth parenteral products, Protonix and Zosyn, we noted that dosing solutions prepared from the products yielded inconsistent results on the United States Pharmacopeia Chapter 788 test for subvisible particulates. This manuscript discusses variables that have a direct impact on intravenous products meeting compendial monograph specifications under conditions that are encountered in the clinical setting. The rubber stoppers of vials used for parenteral products, different parts of commercial admixture bags, and the tubing of the administration sets and devices contain residual amounts of metal ions, plasticizers, and other additives incorparated for specific functions...
September 2007: International Journal of Pharmaceutical Compounding
Thanhtaik Kyaw, Rong Ji
SESSION TYPE: Infectious Disease Student/Resident Case Report Posters IIPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Infections with K. pneumoniae are usually hospital-acquired and occur primarily in patients with diminished resistance. Underlying diabetes was significantly more common with community-acquired infection. Compared with K. pneumoniae isolated from patients with primary bacteremia, abscess-forming organisms have a virulent hypermucoviscosity phenotype and may be associated with metastatic infection...
October 1, 2012: Chest
Ronald N Jones, Helio S Sader, Robert K Flamm, Amy A Watters
An ongoing program of international generic antimicrobial potency assays for piperacillin/tazobactam has been summarized here through December 2010, and the initial results for meropenem generic lots from the United States are also presented. Fifteen additional piperacillin/tazobactam generic lots revealed an average of -10% activity (range, +3 to -23%) compared to the branded product (Zosyn®; Wyeth-Pfizer), a finding consistent with prior reports (46 lots) of -16%. In contrast, meropenem branded and generic products had equivalent assay results (5 generic lots from 2 manufacturers [Hospira and Sandoz])...
May 2013: Diagnostic Microbiology and Infectious Disease
Ruud P M Dings, Judith R Haseman, Dan B Leslie, Mike Luong, David L Dunn, Kevin H Mayo
BACKGROUND: Dodecapeptide SC4 is a broad-spectrum bactericidal agent that functions by disintegrating bacterial membranes and neutralizing endotoxins. For insight into which SC4 amino acids are functionally important, we assessed Gram-negative bactericidal effects in structure-activity relationship experiments. Subsequently, SC4 was tested in a murine bacteremia model to combine and compare the efficacy with Zosyn, a first-line antibiotic against Pseudomonas aeruginosa (P. aeruginosa)...
June 2013: Biochimica et Biophysica Acta
Albert Y Yang, Vishal Khiatani, Yang Lu
We report an incidental finding of absent liver uptake of (99m)Tc leukocyte scan in an alcoholic patient with acute Zosyn (piperacillin and tazobactom)-related drug reaction with eosinophilia and systemic symptoms, persistent elevated white blood cell counts, and negative blood culture. Alcoholic steatohepatitis was confirmed in this patient through further clinical examination, blood test, and CT imaging.
February 2013: Clinical Nuclear Medicine
Peter Nagele, Swatilika Pal, Frank Brown, Jane Blood, J Philipp Miller, Joshua Johnston
BACKGROUND: Abnormal cardiac repolarization, indicated by a prolongation of the QT interval, increases the risk for torsades de pointes, a potentially life-threatening arrhythmia. Many perioperatively administered drugs and conditions prolong the QT interval. Despite several reports of perioperative torsades de pointes, systematic evidence regarding perioperative QT interval prolongation is limited. METHODS: Serial postoperative 12-lead electrocardiograms were obtained from 469 adult patients undergoing major noncardiac surgery under general anesthesia...
August 2012: Anesthesiology
Thomas G Pagano, Yumin Gong, Fangming Kong, Rushung Tsao, Mahdi Fawzi, Tianmin Zhu
Tobramycin is an aminoglycoside antibiotic that loses a significant amount of activity in the presence of Zosyn at pH 6. As part of our investigation into ways to improve the compatibility of tobramycin with Zosyn (which contains piperacillin and tazobactam in an 8:1 ratio buffered at pH 6 by sodium citrate) by lowering the pH, we identified the reaction product of tobramycin and piperacillin at pH 6.0 and the order of the pK(a) values of tobramycin. The structure of the main reaction product of tobramycin and piperacillin at pH 6...
October 2011: Journal of Antibiotics
Gary J Moet, Amy A Watters, Helio S Sader, Ronald N Jones
The experience with analyzing the potency of piperacillin/tazobactam generic formulations by a precise multiorganism in vitro assay was expanded to 46 lots (29 manufacturers, 17 countries). Across all generic lots, the range of activity compared with a reference branded lot (RLOT; Zosyn; Wyeth Pharmaceuticals, Philadelphia, PA) was +10% to -42% (average, -16%). Eight lots of Zosyn were also tested with a range of +7 to -19 (average, only -6%), and the reproducibility (13 replicates) of the RLOT assay was confirmed (+/-3%)...
November 2009: Diagnostic Microbiology and Infectious Disease
Tatsuya Uji, Yoshikazu Hashimoto
No abstract text is available yet for this article.
June 2009: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Sapan Talati, Moin Lala, Hiteshkumar Kapupara, Zeyar Thet
Acute generalized exanthematous pustulosis (AGEP) is a rare disorder characterized by an acute episode and sudden onset of erythematous and edematous eruptions of hundreds of sterile pustules. It is a self-limiting condition accompanied by fever and has a rapid course. It is mostly caused by drugs especially antibiotics. It is diagnosed by skin biopsy, which shows intracorneal pustules and neutrophilic infiltration in dermis and epidermis. We report a case of a patient who developed this rare skin condition with the use of piperacillin/tazobactam (Zosyn)...
November 2009: American Journal of Therapeutics
Narendra R Desai, Syed M Shah, Jonathan Cohen, Matthew McLaughlin, Hema R Dalal
Zosyn((R)) , also known as Tazocin((R)) for injection, contains piperacillin and tazobactam and was approved by the US Food and Drug Administration in 1993 for the treatment of indicated serious infections. In 1995, United States Pharmacopoeia and European Pharmacopoeias reduced the particulate limit for injectables by 40%, based on general safety concerns. Wyeth attempted to control sporadic batch failures (associated with increased particulate formation) by shortening product expiration dating from 36 to 24 months and optimizing the stopper siliconization process...
April 2008: Therapeutics and Clinical Risk Management
S M Culver, M G Martens
No abstract text is available yet for this article.
1996: Infectious Diseases in Obstetrics and Gynecology
Ronald N Jones, Thomas R Fritsche, Gary J Moet
Twenty-three generic intravenous piperacillin/tazobactam products were compared for in vitro activity to the branded formulation (Zosyn, Wyeth, Philadelphia, PA) by disk diffusion and incremental broth microdilution assay methods. All but 1 lot demonstrated significantly decreased activity (-5 to -35%), necessitating further investigations regarding the chemical purity, potency, and therapeutic equivalence of these products worldwide. The average -16% activity across all generic lots was equivalent to underdosing piperacillin/tazobactam by 2...
May 2008: Diagnostic Microbiology and Infectious Disease
Masau WaKabongo, Zachary N Stucki, Deborah Potym Torbert, Justine Olweny
No abstract text is available yet for this article.
January 2005: Journal of the American Osteopathic Association
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