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https://read.qxmd.com/read/30900193/acute-and-subacute-effects-of-low-versus-high-doses-of-standardized-panax-ginseng-extract-on-the-heart-an-experimental-study
#1
Hakan Parlakpinar, Onural Ozhan, Necip Ermis, Nigar Vardi, Yilmaz Cigremis, Lokman H Tanriverdi, Cemil Colak, Ahmet Acet
Panax ginseng is commonly used in Chinese medicine and Western herbal preparations. However, it has also been recently noted to be associated with some cardiac pathologies-including cardiogenic shock due to acute anterior myocardial infarction, trans-ischemic attack, and stent thrombosis. This study was aimed to elucidate acute and subacute effects of the low and high doses of standardized Panax ginseng extract (sPGe) on cardiac functions. Rats were randomly assigned to control group, acute low-dose group (ALD), subacute low-dose group (SALD), acute high-dose group (AHD), and subacute high-dose group (SAHD)...
March 21, 2019: Cardiovascular Toxicology
https://read.qxmd.com/read/30871803/predictive-impact-of-previous-coronary-artery-bypass-grafting-on-mortality-after-mitraclip-implantation-for-ischemic-functional-mitral-regurgitation
#2
Mitsunobu Kitamura, Hidehiro Kaneko, Michael Schlüter, Dimitry Schewel, Tobias Schmidt, Hannes Alessandrini, Felix Kreidel, Maki Okamoto, Michael Neuss, Christian Butter, Karl-Heinz Kuck, Christian Frerker
BACKGROUND: Many candidates with ischaemic functional mitral regurgitation (FMR) have previously undergone coronary artery bypass grafting (CABG), in which transcatheter mitral valve repair can be reasonable for ameliorating the deteriorated hemodynamic and heart failure symptoms. We sought to elucidate the outcomes of MitraClip (MC) implantation in patients with symptomatic ischaemic FMR after CABG. METHODS: We investigated clinical characteristics, outcomes and predictive impact of previous CABG on mortality in ischaemic FMR patients who underwent MC implantation from two high-volume centres in Germany...
March 1, 2019: International Journal of Cardiology
https://read.qxmd.com/read/30871695/outcomes-of-direct-oral-anticoagulants-in-patients-with-mitral-stenosis
#3
Ju Youn Kim, Sung-Hwan Kim, Jun-Pyo Myong, Yoo Ri Kim, Tae-Seok Kim, Ji-Hoon Kim, Sung-Won Jang, Yong-Seog Oh, Man Young Lee, Tai-Ho Rho
BACKGROUND: Patients with mitral stenosis and atrial fibrillation (AF) require anticoagulation for stroke prevention. Thus far, all studies on direct oral anticoagulants (DOACs) have excluded patients with moderate to severe mitral stenosis. OBJECTIVES: The aim of this study was to validate the efficacy of DOACs in patients with mitral stenosis. METHODS: The study population was enrolled from the Health Insurance Review and Assessment Service (HIRA) database in the Republic of Korea, and it included patients who were diagnosed with mitral stenosis and AF and either were prescribed DOACs for off-label use or received conventional treatment with warfarin...
March 19, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30849464/mitral-valve-repair-rate-at-a-veterans-affairs-hospital-utilizing-a-multidisciplinary-heart-team
#4
Ernesto Jimenez, Darrell Wu, Shuab Omer, Lorraine Cornwell, Paulino Nunez, Todd K Rosengart, Joseph S Coselli
OBJECTIVE: Between 2000 and 2008, the mitral valve (MV) repair rate in patients with severe mitral regurgitation (MR) at our low-volume Veterans Affairs hospital was 21%. After instituting a multidisciplinary valve team in 2009, we determined whether this rate increased and characterized the outcomes of patients with degenerative disease. METHODS: We retrospectively reviewed data from 103 MV operations performed at our hospital between 1/2009 and 8/2016. Mitral valve pathology was categorized as degenerative, rheumatic, endocarditis, ischemic, hypertrophic cardiomyopathy, or failed prior MV repair...
March 5, 2019: Seminars in Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30847958/failure-of-annuloplasty-alone-to-correct-ischemic-mitral-regurgitation-what-we-learned-from-two-randomized-controlled-trials
#5
EDITORIAL
Antonio M Calafiore, Antonio Totaro, Cosimo Sacra, Massimiliano Foschi, Mario Gaudino, Michele Di Mauro
No abstract text is available yet for this article.
March 8, 2019: Journal of Cardiac Surgery
https://read.qxmd.com/read/30847218/ventricular-septal-rupture-following-myocardial-infarction-a-potentially-fatal-complication
#6
Athanasios Saplaouras, Antigoni Sakellaropoulou, Panagiotis Mililis, George Bazoukis, Angelos-Michail Kolokathis, Eleni Konstantinidou, Aikaterini Anagnostou, Niki Panagopoulou, Konstantinos Vlachos, Ioannis Lakoumentas, Antonios Sideris
Mechanical complications of acute myocardial infarction include ventricular septal rupture (VSR), free wall rupture, and ischemic mitral regurgitation. Postinfarction VSR is a rare but serious complication of myocardial infarction. VSR has a lower incidence in the era of new reperfusion therapies. However, clinicians should be aware of this potentially fatal complication as the mortality remains extremely high. Early diagnosis and treatment are the cornerstones of achieving a better outcome.
February 2019: Clinical Case Reports
https://read.qxmd.com/read/30820393/risk-factors-of-atrial-fibrillation-in-patients-with-heart-failure
#7
Alam Sarfraz, Parveen Akhtar, Syed N Hassan Rizvi, Musa Karim
Introduction Coexistence of atrial fibrillation (AF) in patients with heart failure (HF) is a common phenomenon associated with poor prognosis. Therefore, this study was designed with an aim to estimate the different risk factors of atrial fibrillation (AF) in patients with HF. Methods In this study, patients of either gender, 18 to 80 years of age, and with echocardiographic confirmation of HF presenting at the adult cardiology department of the National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan were consecutively included...
December 24, 2018: Curēus
https://read.qxmd.com/read/30803776/do-annuloplasty-rings-designed-to-treat-ischemic-functional-mitral-regurgitation-alter-left-ventricular-dimensions-in-the-acutely-ischemic-ovine-heart
#8
Wolfgang Bothe, John-Peder Escobar Kvitting, Manuel K Rausch, Tomasz A Timek, Julia C Swanson, David H Liang, Mario Walther, Ellen Kuhl, Neil B Ingels, D Craig Miller
OBJECTIVE: To quantify the effects of annuloplasty rings designed to treat ischemic/functional mitral regurgitation on left ventricular septal-lateral (S-L) and commissure-commissure (C-C) dimensions. METHODS: Radiopaque markers were placed as opposing pairs on the S-L and C-C aspects of the mitral annulus and the basal, equatorial, and apical level of the left ventricle (LV) in 30 sheep. Ten true-sized Carpentier-Edwards Physio (PHY), Edwards IMR ETlogix (ETL), and GeoForm (GEO; all from Edwards Lifesciences, Irvine, Calif) annuloplasty rings were inserted in a releasable fashion...
January 11, 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30800149/clinical-sonographic-characteristics-and-long-term-prognosis-of-valvular-heart-disease-in-elderly-patients
#9
Feier Song, Fang-Zhou Liu, Yuan-Feng Liang, Gary Tse, Xin Li, Hong-Tao Liao, Ji-Yan Chen
Background: Valvular heart disease (VHD) is expected to become more prevail as the population ages and disproportionately affects older adults. However, direct comparison of clinical characteristics, sonographic diagnosis, and outcomes in VHD patients aged over 65 years is scarce. The objective of this study was to evaluate the differences in clinical characteristics and prognosis in two age-groups of geriatric patients with VHD. Methods: We retrospectively enrolled consecutive individuals aged ≥ 65 years from Guangdong Provincial People's Hospital and screened for VHD using transthoracic echocardiography (TTE) or transesophageal echocardiography (TEE)...
January 2019: Journal of Geriatric Cardiology: JGC
https://read.qxmd.com/read/30785252/cost-effectiveness-of-mitral-valve-repair-versus-replacement-for-severe-ischemic-mitral-regurgitation-a-randomized-clinical-trial-from-the-cardiothoracic-surgical-trials-network
#10
Bart S. Ferket, Gorav Ailawadi, Annetine C. Gelijns, Michael Acker, Samuel F. Hohmann, Helena L. Chang, Denis Bouchard,, David O. Meltzer, Robert E. Michler, Ellen G. Moquete, Pierre Voisine, John C. Mullen, Anuradha Lala, Michael J. Mack, A. Marc Gillinov, Vinod H. Thourani, Marissa A. Miller, James S. Gammie, Michael K. Parides, Emilia Bagiella, Robert L. Smith, Peter K. Smith, Judy W. Hung, Lopa N. Gupta, Eric A. Rose, Patrick T. O'Gara, Alan J. Moskowitz, Cardiothoracic Surgical Trials Network (CTSN) Investigators
BACKGROUND: The CTSN (Cardiothoracic Surgical Trials Network) recently reported no difference in left ventricular end-systolic volume index or in survival at 2 years between patients with severe ischemic mitral regurgitation (MR) randomized to mitral valve repair or replacement. However, replacement provided more durable correction of MR and fewer cardiovascular readmissions. Yet, costeffectiveness outcomes have not been addressed. METHODS AND RESULTS: We conducted a cost-effectiveness analysis of the surgical treatment of ischemic MR based on the CTSN trial (n=126 for repair; n=125 for replacement)...
November 14, 2018: Circulation. Cardiovascular Quality and Outcomes
https://read.qxmd.com/read/30770116/commentary-repair-for-ischemic-mitral-valve-regurgitation-does-the-type-of-ring-matter
#11
EDITORIAL
Manuel J Antunes
No abstract text is available yet for this article.
January 23, 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30766003/left-circumflex-artery-injury-postmitral-valve-surgery-single-center-experience
#12
Aysha Husain, Aly Alsanei, Mohammed Tahir, Ziad Dahdouh, Zohair AlHalees, Ali AlMasood
The left circumflex (LCX) artery is located close to the mitral valve (MV), making it susceptible to injury during MV surgery. We are reporting our experience in the diagnosis and management of this complication. We retrospectively reviewed our surgical and coronary angiography databases for patients with documented LCX artery injury during MV surgery between January 2000 and December 2016. The complication was associated with MV replacement (9/1313, 0.7%) but not MV repair (0/393, 0.0%). Eight patients (88...
April 2019: Journal of the Saudi Heart Association
https://read.qxmd.com/read/30764533/the-correlation-between-severity-of-neurological-impairment-and-left-ventricular-function-in-patients-after-acute-ischemic-stroke
#13
Pei-Hsun Sung, Kuan-Hung Chen, Hung-Sheng Lin, Chi-Hsiang Chu, John Y Chiang, Hon-Kan Yip
Despite left ventricular (LV) dysfunction increases the risk of incidental acute ischemic stroke (AIS), the association between LV function and severity of neurological deficits after AIS remains unclear. Between November 2015 and October 1017, a total of 99 AIS patients were prospectively enrolled and categorized into two groups based on National Institute of Health Stroke Scale (NIHSS). The AIS patients with NIHSS <6 were allocated into Group 1 ( n = 50) and those with NIHSS ≥6 were into Group 2 ( n = 49)...
February 5, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30747925/-treatment-of-secondary-ischemic-mitral-regurgitation-controversial-issues
#14
Donato Mele, Giovanni Andrea Luisi, Gabriele Pestelli, Vittorio Smarrazzo, Filippo Trevisan, Carlo Savini, Roberto Ferrari
The presence of secondary mitral regurgitation is an unfavorable prognostic factor in patients with chronic ischemic heart disease. This type of regurgitation can be treated with medical therapy, cardiac resynchronization therapy, surgically or percutaneously but each strategy has controversial aspects. The purpose of this review is to discuss the most debated issues relative to the various modalities available to treat ischemic secondary mitral regurgitation, highlighting also future perspectives.
February 2019: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/30746243/clinical-manifestations-diagnosis-and-treatment-of-ischemic-mitral-regurgitation-a-review
#15
REVIEW
Néstor Báez-Ferrer, María Manuela Izquierdo-Gómez, Belén Marí-López, Javier Montoto-López, Amelia Duque-Gómez, Javier García-Niebla, Julio Miranda-Bacallado, Alejandro de la Rosa Hernández, Ignacio Laynez-Cerdeña, Juan Lacalzada-Almeida
Ischemic mitral regurgitation (IMR) is a frequent complication after acute myocardial infarction (AMI) associated with a worse prognosis. The pathophysiological mechanisms of IMR are not fully understood, but it is known to be a complex process in which ventricular remodelling is the main causal factor. The various imaging techniques in cardiology and echocardiography fundamentally have contributed significantly to clarify the mechanisms that cause and progressively aggravate IMR. At present, different therapeutic options, the most important of which are cardio-surgical, address this problem...
December 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/30745489/extended-posterior-leaflet-augmentation-for-ischemic-mitral-regurgitation-augmented-posterior-leaflet-snuggling-up-to-anterior-leaflet
#16
Naoko Ikeda, Hiroki Yamaguchi, Masami Takagaki, Shinichi Mitsuyama, Mio Ebato, Kaoru Tanno, Hiromasa Nakamura, Tasuku Kadowaki, Yosuke Ueno, Hiroshi Kataoka, Takaki Uchida, Tomoyuki Aoki
BACKGROUND: The ideal surgical technique for ischemic mitral regurgitation (MR) is controversial. We introduced an extended posterior mitral leaflet (PML) augmentation technique for functional MR with severe tethering, which detached the PML from the annulus almost completely and augmented it with a large 3×6-cm oval pericardial patch. Methods and Results: A total of 17 mitral repairs using the new technique were performed for ischemic MR with no 30-day mortality and 2 hospital deaths...
February 9, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30713755/acute-myocardial-infarction-and-concomitant-ischemic-stroke-as-an-unusual-presentation-of-native-mitral-valve-endocarditis
#17
Osman Karaarslan, Macit Kalçık, Volkan Çamkıran, Sinan Eliaçık, Çağlar Alp, Yusuf Karavelioğlu
ST-elevation myocardial infarction (STEMI) due to septic coronary embolism is a rare complication of infective endocarditis (IE) and is associated with high mortality rates. When common signs of IE are often overlooked on admission, the diagnosis may be established through complications, which may cause prominent symptoms. Here, we report a case of native mitral valve endocarditis with an unusual presentation with STEMI and concomitant ischemic stroke, which was due to multiple coronary and cerebral septic embolisms...
September 2018: Interventional Medicine & Applied Science
https://read.qxmd.com/read/30684477/risk-of-ischemic-mitral-regurgitation-recurrence-after-combined-valvular-and-subvalvular-repair
#18
Francesco Nappi, Mario Lusini, Sanjeet Singh Avtaar Singh, Orlando Santana, Massimo Chello, Christos G Mihos
BACKGROUND: Mitral valve repair combined with papillary muscle approximation (MVr+PMA) may improve repair durability in severe ischemic mitral regurgitation (MR), when compared with MVr alone. We sought to identify preoperative transthoracic echocardiographic markers associated with MR recurrence after MVr+PMA. METHODS: A post-hoc analysis was performed on patients with severe ischemic MR who underwent coronary artery bypass grafting with MVr+PMA, in the Papillary Muscle Approximation Randomized Trial...
January 23, 2019: Annals of Thoracic Surgery
https://read.qxmd.com/read/30674593/associations-of-echocardiographic-features-with-stroke-in-those-without-atrial-fibrillation
#19
Michelle C Johansen, Michelle Lin, Saman Nazarian, Rebecca F Gottesman
OBJECTIVE: To determine the associations between transthoracic echocardiogram (TTE) cardiac structure/function measures and cardioembolic stroke (CES) and new-onset atrial fibrillation (AF) in patients without known AF. METHODS: Inpatients at a single institution (2013-2015) with imaging-confirmed ischemic stroke, no AF, and TTE within the 1st week were included. TTE structure/function variables were abstracted. Stroke subtype (CES vs other) was defined according to Trial of Org 10172 in Acute Stroke Treatment, blinded to TTE results...
February 26, 2019: Neurology
https://read.qxmd.com/read/30659508/transfer-of-a-minimally-invasive-mitral-valve-repair-program-from-a-high-volume-center-to-a-very-low-volume-center-how-many-cases-are-necessary-to-maintain-acceptable-results
#20
Hiroyuki Kamiya, Hiroto Kitahara, Hirotsugu Kanda, Hayato Ise, Sentaro Nakanishi, Natsuya Ishikawa, Takayuki Kunisawa, Jan-Philipp Minol, Artur Lichtenberg, Payam Akhyari
OBJECTIVE: To investigate whether minimally invasive mitral valve repair (MIMVR) can be transferred from a high-volume center into a very small volume center and to clarify how many cases are necessary for maintenance of this program, early outcomes of MIMVR in Asahikawa Medical University were compared with those results in patients operated by a single surgeon in Duesseldorf University Hospital. METHODS: Sixty-five patients who underwent MIMVR in Asahikawa Medical University (group A) between May 2014 and July 2018 and 134 patients who underwent MIMVR in Duesseldorf University Hospital (group D) between September 2009 and January 2014 by a surgeon who started MIMVS later in Asahikawa were retrospectively analyzed...
January 18, 2019: General Thoracic and Cardiovascular Surgery
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