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ZnO NPs AND tumor

Morihiko Nakamura, Natsuko Watanabe
Successful development of safe and highly effective nanoprobes for targeted imaging of in vivo early cancer is a great challenge. Herein, we choose the visible-light emitting zinc oxide non-core/shell type nanoparticle (NP) fluorophores (ZHIE) as prototypical materials. We have reported on these materials previously. The results showed that the ZHIE NPs exhibited good water solubility and good biocompatibility. This study was conducted to investigate the toxicity of ZHIE NPs when intravenously administered to mice repeatedly at the dose required for successful tumor imaging in vivo...
December 31, 2018: Journal of Biochemical and Molecular Toxicology
Mona Navaei-Nigjeh, Mahdi Gholami, Maryam Sadat Fakhri-Bafghi, Maryam Baeeri, Mohammad Abdollahi
Chlorpyrifos (CP), an acetylcholinesterase (AChE) inhibitor, is used throughout the world as an insecticide in agriculture and an eradicating agent for termites around homes. In the present study, we examined the protective role of zinc oxide nanoparticles (ZnO NPs) in human CP-treated lymphocytes. Lymphocytes isolated by Ficoll and exposed to 75 µg/mL CP either alone or in combination with logarithmic doses of ZnO NPs (0/1, 1, 10, 100 µg/mL). After a 3-day incubation period, the viability and oxidative stress markers were determined...
2018: Iranian Journal of Pharmaceutical Research: IJPR
R Khoushika Raajshree, Durairaj Brindha
In the present study, we aimed to evaluate the anticancer effect of zinc oxide nanoparticles (ZnO-NPs) synthesized from Turbinaria conoides against a murine model of Dalton's lymphoma ascites (DLA). Nanoparticles were synthesized from the hydroethanolic extract of T. conoides (HETC). An ultraviolet-visible spectrophotometric analysis was performed to confirm the formation of ZnO-NPs. Size, morphology, and elemental composition of ZnO-NPs were also analyzed using scanning electron microscopy-energy dispersive X-ray diffraction (SEM-EDX)...
2018: Journal of Environmental Pathology, Toxicology and Oncology
Jianfeng Wang, Shutao Gao, Shuyu Wang, Zhaonan Xu, Limin Wei
Background: Tongue squamous cell carcinoma (tongue cancer) is one of the most common malignancies in the oral maxillofacial region. The tumor easily relapses after surgery, and the prognosis remains poor. Recently, zinc oxide nanoparticles (ZnO NPs) were shown to target multiple cancer cell types. In this study, we aimed to elucidate the anticancer effect of ZnO NPs on CAL 27 human tongue cancer cells and identify the role of PINK1/Parkin-mediated mitophagy in this effect. Materials and methods: We analyzed the dose-dependent cytotoxic effects of ZnO NPs on CAL 27 cells...
2018: International Journal of Nanomedicine
Yamei Qiao, Xiao Liang, Yingjie Yan, Yake Lu, Di Zhang, Wu Yao, Weidong Wu, Zhen Yan
It has been previously shown that inhaled zinc oxide nanoparticles (ZnO-NPs) can modulate inflammation. MicroRNAs (miRNAs) enclosed in exosomes have been identified as an important signature for inflammatory responses. However, the role of exosomal miRNAs during pathogenic inflammation has not been investigated. Healthy rats were exposed to ZnO-NPs (41.7 nm; 2, 4, and 8 mg/kg) or saline (control) via oropharyngeal aspiration. ZnO-NPs induced significant increases in the serum levels of interleukin 8 (IL-8), interleukin-1 beta (IL-1β), and tumor necrosis factor α (TNF-α), and elevated the number of cells and the percentage of neutrophils in the blood...
2018: Frontiers in Physiology
Bogdan Ştefan Vasile, Otilia Ruxandra Vasile, Daniela Cristina GhiŢulică, Florina Cristina Ilie, Irina Florentina Nicoară, Roxana Truşcă, Ovidiu Cristian Oprea, Vasile Adrian Surdu, Ionela Andreea Neacşu
In this work, several nanostructures (nanopowders and nanostars) of undoped and 1%, 3% and 5% europium (Eu3+)-doped ZnO have been synthesized via coprecipitation method using oxalic acid and sodium hydroxide as precipitation agents. Starting from zinc acetate and europium acetate, nanopowders were obtained by coprecipitation with oxalic acid. ZnO based nanostars were synthesized by coprecipitation of Zn2+ and Eu3+ with hydroxide ions (HO-), when zinc chloride and europium acetate were used as reagents. The structure and morphology of the as-prepared ZnO nanopowders and nanostars were investigated by X-ray diffraction and electron microscopy...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Helena Moratin, Agmal Scherzad, Thomas Gehrke, Pascal Ickrath, Katrin Radeloff, Norbert Kleinsasser, Stephan Hackenberg
The increasing usage of zinc oxide nanoparticles (ZnO-NPs) in industrial applications as well as in consumer products raises concern regarding their potential adverse effects to a greater extend. Numerous studies have demonstrated toxic properties of NPs, however there is still a lack of knowledge concerning the underlying mechanisms. This study was designed to systematically investigate cytotoxicity, apoptosis, cell cycle alterations, and genotoxicity induced by ZnO-NP. Moreover, it was an aim of the investigations to specify the diverse effects of nanoparticle exposure in malignant in comparison with non-malignant cells...
April 2018: Environmental and Molecular Mutagenesis
Jiao Wang, Jung Seok Lee, Dongin Kim, Lin Zhu
Because of the complexity of cancer, an ideal anticancer strategy is better to target both cancer cells and the tumor microenvironment. In this study, for the first time, we demonstrated that zinc oxide nanoparticles (ZnO NPs) were able to target multiple cell types of cancer, including cancer cells, cancer stem cells (CSCs), and macrophages, and simultaneously perform several key functions, including inhibition of cancer proliferation, sensitization of drug-resistant cancer, prevention of cancer recurrence and metastasis, and resuscitation of cancer immunosurveillance...
November 22, 2017: ACS Applied Materials & Interfaces
Hala M Abdelkarem, Laila H Fadda, Eman M El-Sayed, Omyma K Radwan
The purpose of this study was to illustrate the effects of zinc oxide nanoparticles (ZnO-NPs) administration on bone turnover and bone resorbing agents in rats and how L-arginine (L-arg) or vitamin E (vit E) co-administrations might affect them. Fasting rats were randomly divided into four groups (n = 10): G1-normal healthy animals; G2-ZnO-NPs-exposed rats (600 mg/kg- 1/day-1 ); G3-ZnO-NPs-exposed rats co-administrated L-arg (200 mg/kg- 1/day-1 ); G4-ZnO-NPs-exposed rats co-administrated vit E (200 mg/kg- 1/day-1 )...
May 4, 2018: Journal of Dietary Supplements
Zhen Yan, Wenjun Wang, Yongjun Wu, Wei Wang, Bing Li, Ning Liang, Weidong Wu
Engineered zinc oxide nanoparticles (ZnO-NPs) are currently being produced in high tonnage. Exposure to ZnO-NPs presents potential risks to cardiovascular system. Thus far, the toxicological effects of ZnO-NPs on cardiovascular system have not been well characterized. In this study, human coronary artery endothelial cells (HCAECs) were exposed to ZnO-NPs directly or indirectly using a transwell coculture system with human alveolar epithelial cell line A549 to mimic the lung/circulation interaction. It was shown that levels of proinflammatory mediators (interleukin-8 [IL-8] and tumor necrosis factor-α [TNF-α]) and biomarkers of atherosclerogenesis (heme oxygenase-1 [HO-1] and platelet endothelial cell adhesion molecules-1 [PECAM-1]) in the supernatants of culture media were significantly increased...
2017: International Journal of Nanomedicine
Marwa A Abass, Sally A Selim, Assmaa O Selim, Amal S El-Shal, Zienab A Gouda
This study aimed to evaluate the toxicological effects of oral intake of Zinc oxide nanoparticles (ZnO NPs) on the structure of thymus and spleen. Twenty-four young male Wistar albino rats were assigned into two groups: group I (control) and group II (ZnO NPs treated group).The thymus and spleen were analyzed biochemically, histopathologically and immunohistochemically. After ZnO NPs intake, hematologically, the total leucocytic count was significantly increased while the RBCs and platelets counts and Hb % were significantly decreased...
July 2017: IUBMB Life
Thomas Gehrke, Agmal Scherzad, Pascal Ickrath, Philipp Schendzielorz, Rudolf Hagen, Norbert Kleinsasser, Stephan Hackenberg
Zinc oxide nanoparticles (ZnO-NPs) are being used in many cosmetic products and have been shown to induce tumor-selective cell death in human head and neck squamous cell carcinoma (HNSCC) in vitro. Cetuximab is a monoclonal antibody directed against the epidermal growth factor receptor (EGFR), whose effectiveness for HNSCC, alone or in combination with cytostatic drugs, has been demonstrated intensively in the last decades. Nanoparticles are known to interact with protein structures and thus may influence their functionality...
July 3, 2017: Cancer Biology & Therapy
Gui Chen, Yuexin Shen, Xiyue Li, Qin Jiang, Shanshan Cheng, Yuxiu Gu, Liangliang Liu, Yi Cao
It was recently shown that exposure to ZnO nanoparticles (NPs) could induce endoplasmic reticulum (ER) stress both in vivo and in vitro, but the role of ER stress in ZnO NP induced toxicity remains unclear. Because macrophages are sensitive to ER stress, we hypothesized that stressing macrophages with ER stress inducer could enhance the toxicity of ZnO NPs. In this study, the effects of ER stress inducer thapsigargin (TG) on the toxicity of ZnO NPs to THP-1 macrophages were investigated. The results showed that TG enhanced ZnO NP induced cytotoxicity as revealed by water soluble tetrazolium-1 (WST-1) and neutral red uptake assays, but not lactate dehydrogenase (LDH) assay...
March 2017: Environmental Toxicology and Pharmacology
Meghana Ramani, Miranda C Mudge, R Tyler Morris, Yuntao Zhang, Stanislaw A Warcholek, Miranda N Hurst, Jim E Riviere, Robert K DeLong
There is current interest in harnessing the combined anticancer and immunological effect of nanoparticles (NPs) and RNA. Here, we evaluate the bioactivity of poly I:C (pIC) RNA, bound to anticancer zinc oxide NP (ZnO-NP) against melanoma. Direct RNA association to unfunctionalized ZnO-NP is shown by observing change in size, zeta potential, and absorption/fluorescence spectra upon complexation. RNA corona was visualized by transmission electron microscopy (TEM) for the first time. Binding constant (Kb = 1.6-2...
March 6, 2017: Molecular Pharmaceutics
Balasubramanian Malaikozhundan, Baskaralingam Vaseeharan, Sekar Vijayakumar, Karuppiah Pandiselvi, Mohamed Ali Rajamohamed Kalanjiam, Kadarkarai Murugan, Giovanni Benelli
The overuse of antimicrobics and drugs has led to the development of resistance in a number of pathogens and parasites, which leads to great concerns for human health and the environment. Furthermore, breast cancer is the second most common cause of cancer death in women. MCF-7 is a widely used epithelial cancer cell line, derived from breast adenocarcinoma for in vitro breast cancer studies, since the cell line has retained several ideal characteristics particular to the mammary epithelium. In this scenario, the development of novel and eco-friendly drugs are of timely importance...
March 2017: Microbial Pathogenesis
Yuxiu Gu, Shanshan Cheng, Gui Chen, Yuexin Shen, Xiyue Li, Qin Jiang, Juan Li, Yi Cao
It was recently shown that ZnO nanoparticles (NPs) could induce endoplasmic reticulum (ER) stress in human umbilical vein endothelial cells (HUVECs). If ER stress is associated the toxicity of ZnO NPs, the presence of ER stress inducer thapsigargin (TG) should alter the response of HUVECs to ZnO NP exposure. In this study, we addressed this issue by assessing cytotoxicity, oxidative stress and inflammatory responses in ZnO NP exposed HUVECs with or without the presence of TG. Moreover, TiO2 NPs were used to compare the effects...
March 2017: Toxicology Mechanisms and Methods
Zhongyan Zhang, Fengbin Zhang, Hua Zhang
In this study, three engineered metal oxide nanoparticles (NPs) with similar size but significantly different solubility were used to study the cellular uptake, toxicity and immune activation of Raw 264.7 cells. Commercially available TiO2, Fe2O3 and ZnO NPs were used in this study. Although the size of three pristine NPs are different, all three NPs showed similar aggregation state (250-300 nm) and surface zeta potential (-10 mV) in serum containing cell culture medium due to the surface adsorption of proteins...
June 2016: Journal of Nanoscience and Nanotechnology
Basmah A Othman, Christina Greenwood, Ayman F Abuelela, Anil A Bharath, Shu Chen, Ioannis Theodorou, Trevor Douglas, Maskai Uchida, Mary Ryan, Jasmeen S Merzaban, Alexandra E Porter
On page 1310 J. S. Merzaban, A. E. Porter, and co-workers present fluorescently labeled RGD-targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light-electron microscopy shows that NPs dissolve into ionic Zn(2+) (blue) upon uptake and cause apoptosis (red) with intra-tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. Cover design by Ivan Gromicho...
June 2016: Advanced Healthcare Materials
Li Li, Yan Zhang, Lina Zhang, Shenguang Ge, Haiyun Liu, Na Ren, Mei Yan, Jinghua Yu
In this work, a novel dual photoelectrochemical/colorimetric cyto-analysis format was first introduced into a microfluidic paper-based analytical device (μ-PAD) for synchronous sensitive and visual detection of H2O2 released from tumor cells based on an in situ hydroxyl radicals ((•)OH) cleaving DNA approach. The resulted μ-PAD offered an excellent platform for high-performance biosensing applications, which was constructed by a layer-by-layer modification of concanavalin A, graphene quantum dots (GQDs) labeled flower-like Au@Pd alloy nanoparticles (NPs) probe, and tumor cells on the surface of the vertically aligned bamboo like ZnO, which grows on a pyknotic Pt NPs modified paper working electrode (ZnO/Pt-PWE)...
May 17, 2016: Analytical Chemistry
Ahmed Salem, Eman Noaman, Eman Kandil, Abdelfattah Badawi, Nihal Mostafa
The objective of this study was to investigate the antitumor efficacy of a novel synthesized compound, betaine gallium-tetrachloride (BTG), alone or combined with ZnO-nanoparticles (BTG + ZnO-NPs) on the incidence of 7, 12-dimethylbenz-anthrathene-induced mammary tumor in female rats. Crystal and molecular structure of the prepared BTG were identified using X-ray crystallography. In vitro study revealed BTG more cytotoxic than BTG + ZnO-NPs on human breast cancer (MCF-7) cell line. In vivo study demonstrated that the blood antioxidant status of tumor-bearing rats (DMBA group) was significantly lower than normal noticeable by a significant decrease in GSH content, GPx, SOD, and CAT activities associated with a significantly high MDA content...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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