Zhina Sadeghi, Yi Xi Wu, Amberly Vu, Liankun Song, William Phan, Jeffery Kim, Janet R Keast, Ulysses Balis, John DeLancey, S Armando Villalta, Xiaolin Zi
The decline of urethral function with advancing age plays a major role in urinary incontinence in women, impairing quality of life and economically burdening the health care system. However, none of the current urinary incontinence treatments address the declining urethral function with aging, and the mechanisms by which aging impacts urethra physiology remain little known or explored. Here, we have compared functional, morphometric, and global gene expression of urethral tissues between young and old female mice...
2023: American Journal of Clinical and Experimental Urology