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vascular restenosis

Shinn-Jong Jiang, Pei-I Tsai, Shih-Yi Peng, Chun-Chun Chang, Yi Chung, Hao-Hsiang Tsao, Hsin-Ting Huang, San-Yuan Chen, Hao-Jen Hsu
Chronic inflammation is a pivotal event in the pathogenesis of cardiovascular diseases, including atherosclerosis, restenosis, and coronary artery disease. The efficacy of current treatment or preventive strategies for such inflammation is still inadequate. Thus, new anti-inflammatory strategies are needed. In this study, based on molecular docking and structural analysis, a potential peptide KCF18 with amphiphilic properties (positively charged and hydrophobic residues) derived from the receptors of proinflammatory cytokines was designed to inhibit cytokine-induced inflammatory response...
February 19, 2019: Scientific Reports
Teppei Kitano, Soichiro Usui, Shin-Ichiro Takashima, Oto Inoue, Chiaki Goten, Ayano Nomura, Kazuaki Yoshioka, Masaki Okajima, Shuichi Kaneko, Yoh Takuwa, Masayuki Takamura
Vascular remodeling, resulting from proliferation and migration of vascular smooth muscle cells (VSMCs), is a major cause of atherosclerosis and restenosis. The lysophospholipid mediator sphingosine-1-phosphate (S1P) regulates proliferation and migration of VSMCs via S1P-specific G protein-coupled receptors, including S1P receptor 1 (S1PR1) to S1PR3. However, the role of S1PR1 in vascular remodeling is not well understood. Therefore, in this study, we aimed to investigate the effect of S1PR1 on neointimal hyperplasia in a carotid artery ligation mouse model using transgenic C57Bl/6 mice that overexpressed S1PR1 (Tg-S1PR1) under the control of α-smooth muscle actin promoter...
February 15, 2019: Biochemical and Biophysical Research Communications
Jimin Park, Hyunseon Seo, Hae Won Hwang, Jonghoon Choi, Kyeongsoo Kim, Goeen Jeong, Eun Shil Kim, Hyung-Seop Han, Yeon-Wook Jung, Youngmin Seo, Hojeong Jeon, Hyun-Kwang Seok, Yu-Chan Kim, Myoung-Ryul Ok
Despite significant advances in the design of metallic materials for bare metal stents (BMSs), restenosis induced by the accumulation of smooth muscle cells (SMCs) has been a major constraint on improving the clinical efficacy of stent implantation. Here, a new strategy for avoiding this issue utilizing hydrogen peroxide (H2O2) generated by the galvanic coupling of nitinol (NiTi) stents and biodegradable magnesium-zinc (Mg-Zn) alloys is reported. The amount of H2O2 released is carefully optimized via the biodegradability engineering of the alloys and by controlling the immersion time to selectively inhibit the proliferation and function of SMCs without harming vascular endothelial cells (VECs)...
February 18, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Barathi Rajaraman, Nirupama Ramadas, Sundar Krishnasamy, Vidya Ravi, Atima Pathak, C S Devasena, Krishnan Swaminathan, Arunkumar Ganeshprasad, Ashok Ayyappa Kuppuswamy, Srinivasan Vedantham
Hyperglycaemia during pregnancy is the main reason for developing diabetes mediated vascular complications. Advanced glycation end products (AGEs) are formed due to non-enzymatic glycation of proteins, lipids and nucleic acids during hyperglycaemia. It has the potential to damage vasculature by modifying the substrate or by means of AGEs and receptor of AGE (RAGE) interaction. It has been linked with the pathogenesis of various vascular diseases including coronary heart disease, atherosclerosis, restenosis etc...
February 14, 2019: Molecular and Cellular Biochemistry
Jiankun Li, Hairong Wang, Xiaowei Shi, Lili Zhao, Tao Lv, Qi Yuan, Wenyang Hao, Jing Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: The abnormal increase in vascular smooth muscle cell (VSMC) proliferation and migration are critical events in the pathogenesis of cardiovascular diseases (CVDs) including restenosis and atherosclerosis. The dried roots of Scutellaria baicalensis Georgi (common name: Huangqin in China) have been confirmed to possess beneficial effects on CVD by clinical and modern pharmacological studies. Flavonoids in Huangqin exert anti-proliferative and anti-migratory effects...
February 11, 2019: Journal of Ethnopharmacology
Ken Ling, Ancong Xu, Yunfei Chen, Xueyin Chen, Yiqing Li, Weici Wang
Restenosis is liable to occur following treatment with endovascular interventional therapy. Increasing evidence indicates that hydrogen sulfide (H2S) exhibits numerous physiological properties, including antioxidative and cardioprotective disease properties. Thus, the present study aimed to investigate the anti‑restenosis effects of H2S and its protective mechanisms. A balloon dilatation restenosis model was used, in which model Sprague‑Dawley rats were treated with sodium hydrosulfide (NaHS: A donor of H2S, 30 µmol/kg) by intraperitoneal injection for 4 weeks...
January 23, 2019: International Journal of Molecular Medicine
Yu Zhou, Xuyu He, Ruiming Liu, Yuansen Qin, Shenming Wang, Xi Yao, Chunying Li, Zuojun Hu
Restenosis after angioplasty or stent is a major clinical problem. While long noncoding RNAs (lncRNAs) are implicated in a variety of diseases, their role in restenosis is not well understood. This study aims to investigate how dysregulated lncRNAs and messenger RNAs (mRNAs) contribute to restenosis. By microarray analysis, we identified 202 lncRNAs and 625 mRNAs (fold change > 2.0, p < 0.05) differentially expressed between the balloon-injured carotid artery and uninjured carotid artery in the rats...
February 10, 2019: Journal of Cellular Physiology
Roman Marchenko, Salik Nazir, Shelina Malla, Anthony Donato
Revascularization of chronic total occlusions (CTO) with percutaneous coronary intervention is associated with favorable long-term clinical and echocardiographic outcomes. Whether bioresorbable vascular scaffolds (BVS) would be advantageous in the treatment of CTO is unknown as patients with these lesions were generally excluded from large BVS randomized trials. We performed a systematic review, which sought to summarize known data on mid- to long-term clinical outcomes for BVS in CTO. We searched MEDLINE, EMBASE, clinicaltrials...
November 28, 2018: Curēus
Florah Tshepo Moshapa, Kirsten Riches-Suman, Timothy Martin Palmer
Type 2 diabetes mellitus (T2DM) is increasing worldwide, and it is associated with increased risk of coronary artery disease (CAD). For T2DM patients, the main surgical intervention for CAD is autologous saphenous vein grafting. However, T2DM patients have increased risk of saphenous vein graft failure (SVGF). While the mechanisms underlying increased risk of vascular disease in T2DM are not fully understood, hyperglycaemia, insulin resistance, and hyperinsulinaemia have been shown to contribute to microvascular damage, whereas clinical trials have reported limited effects of intensive glycaemic control in the management of macrovascular complications...
2019: Cardiology Research and Practice
Jih-Shyong Lin, Chia-Jung Wang, Wen-Tyng Li
Background: Vascular smooth muscle cells play a critical role in the intimal hyperplasia of restenosis. A previous study of a rat balloon injury model demonstrated that photodynamic therapy (PDT) using indocyanine green (ICG) and near-infrared (NIR) light irradiation reduced intimal hyperplasia in carotid arteries. However, the effect of ICG-PDT on smooth muscle cells remains unclear. This study aimed to evaluate the effects of PDT with ICG and NIR irradiation on the viability of vascular smooth muscle (A-10) cells...
January 2019: Acta Cardiologica Sinica
Long Bai, Yanlian Liu, Xiangyu Zhang, Xiaobo Huang, Xiaohong Yao, Ruiqiang Hang, Bin Tang, Yin Xiao
Inflammatory reactions and the functionality of endothelial cells (ECs) on the surfaces of coronary stents are critical in the prevention of in-stent restenosis and subsequent neoatherosclerosis. However, the interactions between immune cells and ECs on modified coronary stent surfaces have long been underestimated. In the present study, silicon (Si)-doped titania nanotube arrays (TNA-Sis) were obtained via the facile anodization of magnetron-sputtered Ti-Si coatings. The synergetic effects of titania nanotube arrays (TNAs) and chemical cues (Si) on the functionality of macrophages (MΦs)/ECs and their cross-talk were investigated...
January 29, 2019: Nanoscale
Ahmed Kayssi, Wissam Al-Jundi, Giuseppe Papia, Daryl S Kucey, Thomas Forbes, Dheeraj K Rajan, Richard Neville, Andrew D Dueck
BACKGROUND: Stents are placed in the femoropopliteal arteries for numerous reasons, such as atherosclerotic disease, the need for dissection, and perforation of the arteries, and can become stenosed with the passage of time. When a stent develops a flow-limiting stenosis, this process is known as "in-stent stenosis." It is thought that in-stent restenosis is caused by a process known as "intimal hyperplasia" rather than by the progression of atherosclerotic disease...
January 26, 2019: Cochrane Database of Systematic Reviews
Hangqi Luo, Changzuan Zhou, Jufang Chi, Sunlei Pan, Hui Lin, Feidan Gao, Tingjuan Ni, Liping Meng, Jie Zhang, Chengjian Jiang, Zheng Ji, Haitao Lv, Hangyuan Guo
PURPOSE: The role of endoplasmic reticulum (ER) stress in cardiovascular disease is now recognized. Tauroursodeoxycholic acid (TUDCA) is known to have cardiovascular protective effects by decreasing ER stress. This study aimed to assess the ability of TUDCA to decrease ER stress, inhibit dedifferentiation of vascular smooth muscle cells (VSMCs), and reduce in-stent restenosis. METHODS: The effect of TUDCA on dedifferentiation of VSMCs and ER stress was investigated in vitro using wound-healing assays, MTT assays, and western blotting...
January 21, 2019: Cardiovascular Drugs and Therapy
Ramon L Varcoe, Sharath Paravastu, Shannon D Thomas, Michael H Bennet
BACKGROUND: Endovascular treatment below-the-knee is safe and effective but limited by poor potency. Coronary DES may play a role in providing mechanical scaffolding and deliver anti-proliferative drug to the site of vascular barotrauma to reduce the incidence of restenosis. Our aim was to evaluate and compare the use of contemporary drug-eluting stents (DES) with standard endovascular-therapies for atherosclerotic disease of infrapopliteal arteries. METHODS: We performed a meta-analysis of randomised controlled trials comparing DES with conventional treatment for symptomatic peripheral artery disease (search date 30 August 2017)...
January 16, 2019: International Angiology: a Journal of the International Union of Angiology
Mengxue Zhang, Go Urabe, Christopher Little, Bowen Wang, Alycia M Kent, Yitao Huang, K Craig Kent, Lian-Wang Guo
Cellular plasticity is fundamental in biology and disease. Vascular smooth muscle cell (SMC) dedifferentiation (loss of contractile proteins) initiates and perpetrates vascular pathologies such as restenosis. Contractile gene expression is governed by the master transcription factor, serum response factor (SRF). Unlike other histone deacetylases, histone deacetylase 6 (HDAC6) primarily resides in the cytosol. Whether HDAC6 regulates SRF nuclear activity was previously unknown in any cell type. This study found that selective inhibition of HDAC6 with tubastatin A preserved the contractile protein (alpha-smooth muscle actin) that was otherwise diminished by platelet-derived growth factor-BB...
December 2018: JACC. Basic to Translational Science
Muhammad Rizwan, Hanaa Dakour Aridi, Tru Dang, Widian Alshwaily, Besma Nejim, Mahmoud B Malas
OBJECTIVES: Carotid artery endarterectomy (CEA) and carotid artery stenting (CAS) are 2 effective treatment options for carotid revascularization and stroke prevention. The long-term outcomes of Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) reported similar stroke and death rate between the 2 procedures. This study presents the short- and long-term outcomes of CEA and CAS of all risk patients performed by a single vascular surgeon in a real-world setting. METHODS: We retrospectively reviewed all patients who underwent CEA and CAS from September 2005 to June 2017 at our institute...
January 6, 2019: Vascular and Endovascular Surgery
Marinos Kosmopoulos, Dimitrios Drekolias, Phaedon D Zavras, Christina Piperi, Athanasios G Papavassiliou
Coronary artery disease remains the leading cause of mortality in adult diabetic population with however, a high predominance also in non-diabetic subjects. In search of common molecular mechanisms and metabolic by-products with potential pathogenic role, increased advanced glycation end products (AGEs) present a critical biomarker for CAD development in both cases. Interaction of AGEs with their transmembrane cell receptor, RAGE in endothelial and smooth muscle cells as well as in platelets, activates intracellular signaling that leads to endothelial injury, modulation of vascular smooth muscle cell function and altered platelet activity...
January 3, 2019: Biochimica et biophysica acta. Molecular basis of disease
Christoph Hehrlein, Björn Schorch, Nadia Kress, Amina Arab, Constantin von Zur Mühlen, Christoph Bode, Thomas Epting, Jörg Haberstroh, Lilly Mey, Hans Schwarzbach, Ralf Kinscherf, Vitus Stachniss, Stefanie Schiestel, Adalbert Kovacs, Harald Fischer, Ernst Nennig
Metallic Zn alloys have recently gained interest as potential candidates for developing platforms of bioresorbable vascular stents (BVS). Previous studies revealed that Mg alloys used for BVS can degrade too early, whereas PLLA materials may fail to provide effective scaffolding properties. Here we report on results of a new bioresorbable, metallic stent made from a Zn-Ag alloy studied in a porcine animal model of thrombosis and restenosis. While the tensile strength (MPa) of Zn-3Ag was higher than that of PLLA and resembled Mg's (WE43), fracture elongation (%) of Zn-3Ag was much greater (18-fold) than the PLLA's or Mg alloy's (WE43)...
2019: PloS One
Siyu Li, Guiquan Yu, Fuyu Jing, Hui Chen, Aoyi Liu, Minghao Luo, Wei Huang, Peng Pu, Ming Chen
Vascular smooth muscle cell (VSMC) hyperproliferation is the main pathological process in various cardiovascular diseases, such as vascular restenosis. This process may be repressed by RING finger protein 10 (RNF10) in metabolic syndrome (MetS) rats. The aim of this study is to evaluate the inhibitory effects and molecular mechanisms of RNF10 on VSMC hyperproliferation. Neointimal hyperplasia in MetS and high-glucose-induced VSMC hyperproliferation were measured after infection with adenoviruses encoding RNF10 (Ad-RNF10), short hairpin RNF10 (Ad-shRNF10), or green fluorescent protein (Ad-GFP)...
December 30, 2018: IUBMB Life
Shibo Li, Long Lei, Ying Hu, Yanfang Zhang, Shijia Zhao, Jianwei Zhang
Finite element analysis (FEA) can be implemented along with Agent-based model (ABM) to investigate the biomechanical and mechanobiological mechanisms of pathophysiological processes. However, traditional ABM-FEA approaches are often partially coupled and lack the feedback responses from biological analysis. To overcome this problem, a fully coupled ABM-FEA framework is developed in this paper by linking the macro-scale and cell-scale modules bi-directionally. Numerical studies of the in-stent restenosis process are conducted using the proposed approach and comparisons are made between the two types of frameworks...
December 31, 2018: Computer Methods in Biomechanics and Biomedical Engineering
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