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degradable magnesium

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https://read.qxmd.com/read/30773016/interface-engineering-of-fully-metallic-stent-enabling-controllable-h2o2-generation-for-antirestenosis
#1
Jimin Park, Hyunseon Seo, Hae Won Hwang, Jonghoon Choi, Kyeongsoo Kim, Goeen Jeong, Eun Shil Kim, Hyung-Seop Han, Yeon-Wook Jung, Youngmin Seo, Hojeong Jeon, Hyun-Kwang Seok, Yu-Chan Kim, Myoung-Ryul Ok
Despite significant advances in the design of metallic materials for bare metal stents (BMSs), restenosis induced by the accumulation of smooth muscle cells (SMCs) has been a major constraint on improving the clinical efficacy of stent implantation. Here, a new strategy for avoiding this issue utilizing hydrogen peroxide (H2O2) generated by the galvanic coupling of nitinol (NiTi) stents and biodegradable magnesium-zinc (Mg-Zn) alloys is reported. The amount of H2O2 released is carefully optimized via the biodegradability engineering of the alloys and by controlling the immersion time to selectively inhibit the proliferation and function of SMCs without harming vascular endothelial cells (VECs)...
February 18, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/30771533/different-effects-of-single-protein-vs-protein-mixtures-on-magnesium-degradation-under-cell-culture-conditions
#2
Rui-Qing Hou, Nico Scharnagl, Regine Willumeit-Römer, Frank Feyerabend
Bovine serum albumin (BSA) or fetal bovine serum (FBS), as the protein component, is usually added into solution to study the influence of proteins on Mg degradation. However, the specific character of proteins used and the interaction between organic molecules in FBS do not draw enough attention. This study investigated the influence of BSA, fibrinogen (Fib) and FBS on Mg degradation in Hanks' balanced salt solution without (HBSS) or with calcium (HBSSCa) and Dulbecco's modified eagle medium Glutamax-I (DMEM)...
February 13, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30740241/a-portable-device-for-studying-the-effects-of-fluid-flow-on-degradation-properties-of-biomaterials-inside-cell-incubators
#3
Wensen Jiang, Jiajia Lin, Alex H Chen, Jianwei Pan, Huinan Liu
A portable device was designed and constructed for studying the properties of biomaterials in physiologically relevant fluids under controllable flow conditions that closely simulate fluid flow inside the body. The device can fit entirely inside a cell incubator; and, thus, it can be used directly under standard cell culture conditions. An impedance-driven pump was built in the sterile flow loop to control the flow rates of fluids, which made the device small and portable for easy deployment in the incubator...
February 2019: Regenerative Biomaterials
https://read.qxmd.com/read/30736270/doxorubicin-loaded-magnesium-oxide-nanoflakes-as-ph-dependent-carriers-for-simultaneous-treatment-of-cancer-and-hypomagnesemia
#4
Tharindu A Ranathunge, D G G P Karunaratne, R M G Rajapakse, Davita L Watkins
Doxorubicin (DOX) is an anticancer drug commonly used in treating cancer; however, it has severe cytotoxicity effects. To overcome both the adverse effects of the drug and mineral deficiency (i.e., hypomagnesemia) experienced by cancer patients, we have developed magnesium oxide (MgO) nanoflakes as drug carriers and loaded them with DOX for use as a targeted drug delivery (TDD) system for potential application in cancer therapy. The synthesis employed herein affords pure, highly porous MgO nanoparticles that are void of the potentially harmful metal contaminants often discussed in the literature...
February 6, 2019: Nanomaterials
https://read.qxmd.com/read/30733754/statistical-optimization-of-crude-oil-bio-degradation-by-a-local-marine-bacterium-isolate-pseudomonas-sp-sp48
#5
Soha Farag, Nadia A Soliman, Yasser R Abdel-Fattah
Pseudomonas sp. sp48, a marine bacterium isolated from Bahary area (Alexandria, Egypt), showed a high potency for oil degradation up to 1.5%. Additionally, it showed an ability to consume aromatic hydrocarbons (phenol & naphthalene) and aliphatic (pentadecane) reaching to 79; 73; 62%, respectively. In the current study, Plackett-Burman factorial design was applied to evaluate culture conditions affecting the degradation potency. Analysis of Plackett-Burman design results revealed that, the most significant variables affecting oil removal were magnesium sulfate, inoculum size, glucose and Triton X-100...
December 2018: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/30732513/corrosion-and-bone-healing-of-mg-y-zn-zr-ca-alloy-implants-comparative-in-vivo-study-in-a-non-immobilized-rat-femoral-fracture-model
#6
Da-Tren Chou, Daeho Hong, Sinan Oksuz, Riccardo Schweizer, Abhijit Roy, Boeun Lee, Puneeth Shridhar, Vijay Gorantla, Prashant N Kumta
Biodegradable magnesium (Mg) alloys exhibit improved mechanical properties compared to degradable polymers while degrading in vivo circumventing the complications of permanent metals, obviating the need for surgical removal. This study investigated the safety and efficacy of Mg-Y-Zn-Zr-Ca (WZ42) alloy compared to non-degradable Ti6Al4V over a 14-week follow-up implanted as pins to fix a full osteotomy in rat femurs and as wires wrapped around the outside of the femurs as a cerclage. We used a fully load bearing model allowing implants to intentionally experience realistic loads without immobilization...
February 7, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30732512/degradation-and-interaction-with-bone-of-magnesium-alloy-we43-implants-a-long-term-follow-up-in-vivo-rat-tibia-study
#7
Narumi Oshibe, Eriko Marukawa, Tetsuya Yoda, Hiroyuki Harada
The aim of this in vivo study was to examine the degradation and biocompatibility of the WE43 magnesium alloy containing magnesium yttrium, rare earth elements, and zirconium over a one-year long-term follow-up period. Additionally, we compared anodized WE43 implants with monolithic ones and clarified the effect of the anodization. WE43 cylindrical implants with and without anodization (length, 10 mm; diameter, 0.3 mm) were transplanted into the rat tibia. In both groups, the development of corrosion and the change in implant volume were evaluated by in vivo micro-computed tomography until 12 months, and the bone tissue reaction was observed histologically...
February 7, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30732147/successful-rescue-of-antepartum-eclampsia-in-a-chinese-patient-case-report
#8
Weiping Cao, Xinzhi Wang, Tingmei Chen, Mingmei Qin, Zuxian Wang, Qin Wang, Bing Xie, Wenlin Xu
RATIONALE: Eclampsia is a life-threatening complication of pregnancy. Eclampsia is a leading cause of maternal and neonatal morbidity and mortality with most injury being associated with the seizures that mark the onset of the disease. It is vital that medical worker managing eclampsia have an understanding of the disease process. PATIENT CONCERNS: A 28-year-old female, G4P1, with history of caesarean section was admitted at GA34+6, in addition to headache and severe hypertension (180/120 mm Hg) and proteinuria (+++)...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30723682/use-of-a-three-dimensional-printed-polylactide-coglycolide-tricalcium-phosphate-composite-scaffold-incorporating-magnesium-powder-to-enhance-bone-defect-repair-in-rabbits
#9
Wen Yu, Rui Li, Jing Long, Peng Chen, Angyang Hou, Long Li, Xun Sun, Guoquan Zheng, Haoye Meng, Yu Wang, Aiyuan Wang, Xiang Sui, Quanyi Guo, Sheng Tao, Jiang Peng, Ling Qin, Shibi Lu, Yuxiao Lai
Background: The repair of large bone defects remains challenging for orthopaedic surgeons. Bone grafting remains the method of choice; such grafts fill spaces and enhance bone repair. Therapeutic agents also aid bone healing. The objective of this study is to develop a composite bioactive scaffold composed of polylactide-coglycolide (PLGA) and tricalcium phosphate (TCP) (the basic carrier) incorporating osteogenic, bioactive magnesium metal powder (Mg). Method: Porous PLGA/TCP scaffolds incorporating Mg were fabricated using a low-temperature rapid-prototyping process...
January 2019: Journal of Orthopaedic Translation
https://read.qxmd.com/read/30723676/hybrid-fracture-fixation-systems-developed-for-orthopaedic-applications-a-general-review
#10
REVIEW
Li Tian, Ning Tang, To Ngai, Chi Wu, Yechun Ruan, Le Huang, Ling Qin
Orthopaedic implants are applied daily in our orthopaedic clinics for treatment of musculoskeletal injuries, especially for bone fracture fixation. To realise the multiple functions of orthopaedic implants, hybrid system that contains several different materials or parts have also been designed for application, such as prosthesis for total hip arthroplasty. Fixation of osteoporotic fracture is challenging as the current metal implants made of stainless steel or titanium that are rather rigid and bioinert, which are not favourable for enhancing fracture healing and subsequent remodelling...
January 2019: Journal of Orthopaedic Translation
https://read.qxmd.com/read/30717611/a-feasibility-study-of-biodegradable-magnesium-aluminum-zinc-calcium-manganese-azxm-alloys-for-tracheal-stent-application
#11
Jingyao Wu, Boeun Lee, Partha Saha, Prashant N Kumta
Airway obstruction conditions are relatively rarely observed in clinical settings but nevertheless, extremely challenging to handle, especially when observed in pediatric patients. Several surgical procedures, including tracheal resection, end-to-end tracheal anastomosis, and tracheoplasty, have been developed and practised of late, to treat airway obstruction. However, the clinical outcome is typically not satisfactory due to airway restenosis conditions that develop following surgery. Various types of stents are currently available for airway stenting ranging from non-degradable silicone tubes and bio-inert metallic stents (bare or coated with polymer matrix) to hybrid silicone tubes strengthened by metallic cores, but none of the stents provides the satisfactory long-term effectiveness...
February 4, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30716604/enhancing-delignification-and-subsequent-enzymatic-hydrolysis-of-corn-stover-by-magnesium-oxide-ethanol-pretreatment
#12
Jun Li, Meng Zhang, Donghai Wang
Corn stover pretreatment by MgO-ethanol was investigated to improve sugar recovery by reducing sugar degradation and enhance enzymatic hydrolysis by improving delignification and reducing inhibitor formation. Results showed MgO as an effective additive and Lewis base, functioned to neutralize the acids released from hemicellulose during pretreatment, reduce monosaccharide degradation and inhibitor formation, and enhance delignification. The optimal pretreatment conditions were 50% ethanol, 0.08 mol/L MgO, and 10% solid loading at 190 °C for 40 min...
January 26, 2019: Bioresource Technology
https://read.qxmd.com/read/30715842/electrophoretic-deposition-of-bio-adaptive-drug-delivery-coatings-on-magnesium-alloy-for-bone-repair
#13
Hongfei Qi, Svenja Heise, Juncen Zhou, Katharina Schuhladen, Yuyun Yang, Ning Cui, Rongxin Dong, Sannakaisa Virtanen, Qiang Chen, Aldo R Boccaccini, Tingli Lu
Biodegradable polymer coatings on magnesium alloys are attractive, as they can provide corrosion resistance as well as additional functions for biomedical applications, e.g. drug delivery. A gelatin nanospheres/chitosan (GNs/CTS) composite coating on WE43 substrate was fabricated by electrophoretic deposition (EPD) with simvastatin (SIM) loaded into the GNs. Apart from a sustained drug release over 28 days, the anti-corrosion behavior of the coated WE43 substrates was investigated by electrochemical tests. Both the degradation and corrosion rates of the coated substrate were significantly minimized in contrast with bare WE43...
February 4, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30712470/evaluation-of-magnesium-based-medical-devices-in-preclinical-studies-challenges-and-points-to-consider
#14
Madeleine Chagnon, Louis-Georges Guy, Nicolette Jackson
Absorbable metallic implants have been under investigation for more than a century. Animal and human studies have shown that magnesium (Mg) alloys can be safely used in bioresorbable scaffolds. Several cardiovascular and orthopedic biodegradable metallic devices have recently been approved for use in humans. Bioresorbable Mg implants present many advantages when compared to bioabsorbable polymer or nonabsorbable metallic implants, including similar strength and mechanical properties as existing implant-grade metals without the drawbacks of permanence or need for implant removal...
February 3, 2019: Toxicologic Pathology
https://read.qxmd.com/read/30708153/degradation-kinetics-of-hexachlorobenzene-over-zero-valent-magnesium-graphite-in-protic-solvent-system-and-modeling-of-degradation-pathways-using-density-functional-theory
#15
Amel M Garbou, Muqiong Liu, Shengli Zou, Cherie L Yestrebsky
Hexachlorobenzene (HCB), like many chlorinated organic compounds, has accumulated in the environment from agricultural and industrial activity. Because of its health risks and adverse impact on various ecosystems, remediation of this contaminant is of vital concern. The objective of this study is to evaluate the proficiency of activated magnesium metal in a protic solvent system to accomplish reductive dechlorination of HCB. Experimental results were compared with those predicted by quantum chemical calculations based on Density Functional Theory (DFT)...
January 25, 2019: Chemosphere
https://read.qxmd.com/read/30707487/degradation-behaviors-and-cytocompatibility-of-mg-%C3%AE-tricalcium-phosphate-composites-produced-by-spark-plasma-sintering
#16
Kai Narita, Qiaomu Tian, Ian Johnson, Chaoxing Zhang, Equo Kobayashi, Huinan Liu
Magnesium (Mg)-based materials have shown great potentials for bioresorbable implant applications. Previous studies showed that Mg with 10 and 20 vol % β-tricalcium phosphate (β-TCP) composites produced by spark plasma sintering, improved mechanical properties when compared with pure Mg. The objectives of this study were to evaluate the degradation behaviors of Mg/10% β-TCP and Mg/20% β-TCP composites in revised stimulated body fluid (rSBF), and to determine their cytocompatibility with bone marrow derived mesenchymal stem cells (BMSCs) using the direct culture method...
February 1, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30701665/effect-of-magnesium-on-reducing-the-uv-induced-oxidative-damage-in-marrow-mesenchymal-stem-cells
#17
Yangmei Chen, Shibing Xiong, Fenghua Zhao, Xugang Lu, Boyao Wu, Bangcheng Yang
Oxidative stress could cause damage to lipids, proteins and DNA, which is induced by the imbalance between the production of reactive oxygen species (ROS) and the biological system ability to counteract or detoxify their harmful effects. The oxidative stress damage significantly contributes to a number of diseases. Magnesium (Mg) is endowed with a novel function of removing excess ROS by releasing H2 during the degradation. In this study, in order to explore the property of anti-oxidative damage of Mg metal, rat bone marrow mesenchymal stem cells (MSCs) oxidative damaged by UV radiation was employed to co-culture with Mg metal...
January 30, 2019: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/30692582/nano-to-submicron-hydroxyapatite-coatings-for-magnesium-based-bioresorbable-implants-deposition-characterization-degradation-mechanical-properties-and-cytocompatibility
#18
Qiaomu Tian, Jiajia Lin, Laura Rivera-Castaneda, Amit Tsanhani, Zachary S Dunn, Alexis Rodriguez, Arash Aslani, Huinan Liu
Magnesium (Mg) and its alloys have shown attractive biocompatibility and mechanical strength for medical applications, but low corrosion resistance of Mg in physiological environment limits its broad clinical translation. Hydroxyapatite (HA) nanoparticles (nHA) are promising coating materials for decreasing degradation rates and prolonging mechanical strength of Mg-based implants while enhancing bone healing due to their osteoconductivity and osteoinductivity. Conformal HA coatings with nano-to-submicron structures, namely nHA and mHA coatings, were deposited successfully on Mg plates and rods using a transonic particle acceleration (TPA) process under two different conditions, characterized, and investigated for their effects on Mg degradation in vitro...
January 28, 2019: Scientific Reports
https://read.qxmd.com/read/30682664/effect-of-phosphate-amendments-on-improving-the-fertilizer-efficiency-and-reducing-the-mobility-of-heavy-metals-during-sewage-sludge-composting
#19
Xiankai Wang, Guodi Zheng, Tongbin Chen, Xiaoxiao Shi, Yuewei Wang, Erqi Nie, Junwan Liu
Composting has been globally applied as an effective and cost-efficient process to manage and reuse sewage sludge. In the present study, four different phosphates as well as a mixture of ferrous sulfate and monopotassium phosphate were used in sewage sludge composting. The results showed that these phosphate amendments promoted an increase in temperature and the degradation of organic matter as well as reduction on nitrogen loss during 18 days of composting. In addition, ferrous sulfate and phosphate had a synergistic effect on reducing nitrogen loss...
January 22, 2019: Journal of Environmental Management
https://read.qxmd.com/read/30678910/the-design-strategy-of-intelligent-biomedical-magnesium-with-controlled-release-platform
#20
Yanze Bi, Xinyun Zhu, Jianliang Zhao, Hanrui Cui, Zhenguo Wang, Yan Li, Cai-Qi Wang
Magnesium has a very promising adhibition in biomedical field for its excellent mechanical and biodegradable properties, however, the intelligent applications of biomedical magnesium developed difficultly due to its characteristic degradation. A intelligent biomedical magnesium was constructed on magnesium (Mg) surface by incorporating polydopamine (PD) and mechanized hollow mesoporous silica nanoparticles (HMSs) as smart delivery platform nanocontainers. The supramolecular nanovalves of mechanized HMSs consisted of alginate/chitosan multilayers by self-assembly, which are capable of entrapping rhodamine 6G in the mesopores and can release the cargo under the chemical environment of alkali or Mg iron stimuli that correspond to the degradation of biomedical Mg...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
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