Amélia Jordao, Damien Cléret, Mélanie Dhayer, Mégann Le Rest, Shengheng Cao, Alexandre Rech, Nathalie Azaroual, Anne-Sophie Drucbert, Patrice Maboudou, Salim Dekiouk, Nicolas Germain, Julien Payen, Pierre Guerreschi, Philippe Marchetti
Autologous fat grafting is the gold standard for treatment in patients with soft-tissue defects. However, the technique has a major limitation of unpredictable fat resorption due to insufficient blood supply in the initial phase after transplantation. To overcome this problem, we investigated the capability of a medical-grade poly L-lactide-co-poly ε-caprolactone (PLCL) scaffold to support adipose tissue and vascular regeneration. Deploying FDM 3D-printing, we produced a bioresorbable porous scaffold with interconnected pore networks to facilitate nutrient and oxygen diffusion...
December 18, 2023: Biomedicines