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meta analysis or systematic reviews

Germain Honvo, Olivier Bruyère, Anton Geerinck, Nicola Veronese, Jean-Yves Reginster
INTRODUCTION: There are some controversies about treatment modalities in osteoarthritis (OA), including chondroitin sulfate (CS). The objective of this study was to determine whether CS is effective at alleviating pain and improving function in patients with knee OA and to identify the factors that explain inconsistencies in clinical trial results. METHODS: We conducted a systematic review of randomized, placebo-controlled trials, searching the databases Medline, Cochrane central register for controlled trials and Scopus...
March 16, 2019: Advances in Therapy
Victor M Lu, John P Welby, Anita Mahajan, Nadia N Laack, David J Daniels
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a pediatric brain tumor with dismal prognosis despite initial radiation therapy (RT). The clinical consequences of attempting reirradiation (reRT) in these patients to alleviate both symptomatology and improve prognosis are currently unclear. Thus, the aim of this systematic review and meta-analysis was to clarify the efficacy and safety of reRT in DIPG. METHODS: Searches of seven electronic databases from inception to January 2019 were conducted following the appropriate guidelines...
March 16, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2019: BMJ Open
Irene Gómez-Gómez, Emma Motrico, Patricia Moreno-Peral, Alina Rigabert, Sonia Conejo-Cerón, Manuel Ortega-Calvo, José-Ignacio Recio, Juan A Bellón
INTRODUCTION: Many studies have explored the impact of lifestyle interventions on depression. However, little is known about the effectiveness of complex multiple-risk lifestyle interventions in reducing symptoms of depression. Our objective is to assess the effectiveness of complex multiple-risk lifestyle interventions in reducing depressive symptoms in the adult population by the acquisition of at least two healthy habits-healthy diet, physical activity and/or smoking cessation. For such purpose, a systematic review and meta-analysis of randomised controlled trials will be conducted...
March 15, 2019: BMJ Open
Gonçalo Silva Duarte, Afonso Nunes-Ferreira, Filipe Brogueira Rodrigues, Fausto J Pinto, Joaquim J Ferreira, Joao Costa, Daniel Caldeira
OBJECTIVE: Morphine is frequently used in acute coronary syndrome (ACS) due to its analgesic effect, it being recommended in the main cardiology guidelines in Europe and the USA. However, controversy exists regarding its routine use due to potential safety concerns. We conducted a systematic review of randomised-controlled trials (RCTs) and observational studies to synthesise the available evidence. DESIGN: Systematic review and meta-analysis. DATA SOURCES: CENTRAL, MEDLINE, EMBASE and trial registries...
March 15, 2019: BMJ Open
Wei Zheng, Dong-Bin Cai, Qing-E Zhang, Jie He, Li-Yun Zhong, Kang Sim, Gabor S Ungvari, Yu-Ping Ning, Yu-Tao Xiang
The serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor has been implicated in the pathogenesis of schizophrenia. This meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of adjunctive ondansetron, a potent 5-HT3 receptor antagonist, in the treatment of schizophrenia. Only RCTs examining adjunctive ondansetron for schizophrenia were included. Standardized mean difference (SMD), risk ratio (RR) and their 95% confidence intervals (CIs) were analyzed using RevMan, Version 5...
March 5, 2019: Journal of Psychiatric Research
Linzhi Li, Zhimin Zhang, Zihan Yao, Hongjie Wang, Hebin Wang, Haishui An, Jun Yao
BACKGROUND: Increasing studies have shown that the use of laryngeal mask airways (LMAs) improved the perioperative respiratory adverse events (PRAEs) in children. However, the results of some of these studies still remained controversial as their sample sizes were small. A systematic review and meta-analysis was designed to evaluate the impact of LMAs in decreasing PRAEs in children. METHODS: We searched the Cochrane Library, PubMed, EMBASE and Web of Science up to May 29, 2018 to identify relevant randomized controlled trials (RCTs) which analyzed and evaluated the impact of LMAs in decreasing PRAEs in children...
March 13, 2019: International Journal of Surgery
Olympia Sideri, Konstantinos T Tsaousis, He J Li, Maria Viskadouraki, Ioannis T Tsinopoulos
Oxidative stress is one of the main mechanisms of lens opacification, and certain nutritional antioxidants are suspected to have a protective effect. To examine the role of these nutritional antioxidants in cataract prevention, we searched major databases and reviewed current evidence regarding the protective effect of nutritive antioxidants. We included observational studies that investigate the association between one or more of the following micronutrients and cataract: Vitamin A, Vitamin C, Vitamin E, lutein, zeaxanthin, α- and β-carotene...
March 13, 2019: Survey of Ophthalmology
Rui Zhou, Dihan Lu, Wenda Li, Wenliang Tan, Sicong Zhu, Xianqing Chen, Jun Min, Changzhen Shang, Yajin Chen
BACKGROUND: The objective of this meta-analysis was to evaluate the effectiveness and safety of lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC). METHODS: A literature search with a date range of January 2000 to January 2018 was performed to identify studies comparing lymph node dissection (LND+) with non-lymph node dissection (LND-) for patients with ICC. The LND + group was further divided into positive (LND + N+) and negative (LND + N-) lymph node status groups based on pathological analysis...
March 13, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Chrysanthos Grigoratos, Andrea Barison, Alexander Ivanov, Daniele Andreini, Mihaela-Silvia Amzulescu, Lukasz Mazurkiewicz, Antonio De Luca, Jacek Grzybowski, Pier Giorgio Masci, Magdalena Marczak, John F Heitner, Juerg Schwitter, Bernhard L Gerber, Michele Emdin, Giovanni Donato Aquaro
OBJECTIVES: The objective of this meta-analysis was to assess the predictive value of late gadolinium enhancement (LGE) and global systolic impairment for future major adverse cardiovascular events in left ventricular noncompaction (LVNC). BACKGROUND: The prognosis of patients with LVNC, with and without left ventricular dysfunction and LGE, is still unclear. METHODS: A systematic review of published research and a meta-analysis reporting a combined endpoint of hard (cardiac death, sudden cardiac death, appropriate defibrillator firing, resuscitated cardiac arrest, cardiac transplantation, assist device implantation) and minor (heart failure hospitalization and thromboembolic events) events was performed...
March 8, 2019: JACC. Cardiovascular Imaging
Sun Hwa Lee, Seong Jong Yun
AIMS: We evaluated the diagnostic performance of optic nerve sheath diameter (ONSD) for prediction of neurologic outcome in post-cardiac arrest patients and relative prediction performance according to ONSD measurement modality. DATA SOURCES: PubMed and EMBASE databases were searched for diagnostic accuracy studies that used ocular ultrasound or brain computed tomography (CT) for prediction of neurologic outcome. Bivariate modelling and hierarchical-summary and receiver-operating-characteristic modelling were performed to evaluate diagnostic performance...
March 13, 2019: Resuscitation
Maud J M Geerkens, Hoda H M Al-Itejawi, Jakko A Nieuwenhuijzen, Eric J M Meuleman, Birgit I Lissenberg-Witte, R J A van Moorselaar, André N Vis
CONTEXT: Therapies initiated by urologists, medical as well as surgical, may cause adverse effects in different sexual domains. Sexual domains that are often affected are sexual interest, sexual activity, and erectile functioning. As many elderly men undergo these therapies, it is important to know the prevalence of sexual dysfunction (SD) in these domains and its impact in the healthy elderly male population. This may help healthcare providers counsel their patients properly on possible adverse effects...
March 13, 2019: European Urology Focus
Ajay Shah, Jeffrey Kay, Muzammil Memon, Ryan P Coughlin, Nicole Simunovic, Shane J Nho, Olufemi R Ayeni
PURPOSE: To perform a systematic review that assesses the current literature on suture anchor placement for the purpose of identifying factors that lead to suture anchor perforation and techniques that reduce the likelihood of complications. It was hypothesized that suture anchor placement in hip arthroscopy would generally be safe, with the exception of the complications of articular cartilage violation and psoas tunnel perforation. Perioperative factors, related to patient, surgeon, and technical variables, may influence the safety of suture anchor insertion...
March 13, 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Linzhen Xie, Yingying Zhang, Chunhui Chen, Wenhao Zheng, Hua Chen, Leyi Cai
PURPOSE: To investigate the evidence of deltoid-split approach (DS) versus deltopectoral approach (DP) in treatment of proximal humerus fractures from current RCT and prospective literatures. METHODS: The electronic literature database of Pubmed, Embase, and Cochrane library was searched at December 2017. The data complications (including implant failure, humeral head necrosis, infection, radiological adverse events, nonunion rate, subacromial impingement, and damage of the axillary nerve), functional outcomes (including Constant, NEER, DASH, ADL, VAS score), operation time, hospital stay and intraoperative blood loss were extracted and analyzed by STATA 11...
March 13, 2019: Orthopaedics & Traumatology, Surgery & Research: OTSR
Thiago Farias Rocha Lima, Samara Luize Dos Santos, Tatiana Kelly da Silva Fidalgo, Emmanuel João Nogueira Leal Silva
INTRODUCTION: The objective of this systematic review was to evaluate the efficacy of vitality tests (pulse oximetry and flowmetry) in the pulpal diagnosis of traumatized teeth in comparison with sensibility tests. METHODS: This review was registered in the PROSPERO database (CRD42018097361) and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. An electronic systematic search of the literature was performed in the PubMed (Medline), Scopus, Web of Science, Cochrane Library, Lilacs, and Gray Literature databases and the reference lists of articles published until May 2018...
March 13, 2019: Journal of Endodontics
Wafaa M Rashed, Ali M Hammad, Anas M Saad, Kyrillus S Shohdy
Several studies detected abnormal mi-RNAs expression levels in childhood Acute Lymphoblastic Leukemia (ALL) with potential diagnostic value. We conducted a systematic search on certain microRNAs in childhood ALL. We included 17 studies with a total of 928 ALL children and 307 controls. Ten studies provided miRNAs expression levels and seven provided frequency data. Sensitivity and specificity of a single miRNA ranged from 46.55% to 100% and from 71.8% to 100%, respectively. The highest diagnostic odds ratio (DOR) was for the diagnostic panel (miR-128a and miR-223) reaching 546 [95% CI: 73...
April 2019: Critical Reviews in Oncology/hematology
Claudia Marchetti, Francesca De Felice, Giorgia Perniola, Innocenza Palaia, Angela Musella, Violante Di Donato, Gianluca Cascialli, Ludovico Muzii, Vincenzo Tombolini, Pierluigi Benedetti Panici
PURPOSE: Intravenous (IV) chemotherapy has been compared with intraperitoneal (IP) chemotherapy in randomized clinical trials in advanced ovarian cancer (OC). The aim of this meta-analysis was to evaluate efficacy and toxicity of IV and IP and identify differences in outcomes. METHODS: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement was applied. Random-effects models were used. Primary endpoint was progression-free survival (PFS)...
April 2019: Critical Reviews in Oncology/hematology
Rama Jayaraj, Chellan Kumarasamy, Luke Norbury, David Piedrafita, Peter Smooker
The immunogenicity and efficacy of Fasciola DNA vaccines have not yet been comprehensively summarised in the form of a systematic review and meta-analysis. Though multiple vaccine studies with respect to Fasciola vaccines exist, the variance in the experimental parameters has made comparison difficult. We conducted a bibliographic database search in Scopus, PubMed, Science Direct, Cochrane Library, EMBASE and Web of Science databases, limited to publications from 1998 to 2017. The key words: Liver fluke, Fasciola hepatica, Fasciola gigantica, DNA vaccination, and immunogenicity were used in combination to form search strings...
March 2019: Veterinary Parasitology
Wendelin Moser, Christian Schindler, Jennifer Keiser
The soil-transmitted helminths (STHs), Ascaris lumbricoides, hookworm and Trichuris trichiura are common in areas with warm and moist climates with little access to adequate water, sanitation, and hygiene affecting the poorest populations. The current control strategy of the World Health Organization is preventive chemotherapy (PC), i.e., the administration of the two benzimidazoles (albendazole and mebendazole) using single, oral doses to at risk populations without prior diagnosis. The recent success of PC is threatened by anthelmintic drug resistance and the low efficacy of the drugs against hookworm (mebendazole) and T...
2019: Advances in Parasitology
Frank Doyle, Kenneth Freedland, Robert Carney, Peter de Jonge, Chris Dickens, Susanne Pedersen, Jan Sorensen, Martin Dempster
BACKGROUND: Depression is common in patients with coronary artery disease (CAD) and is associated with poorer outcomes and higher costs. Several randomised controlled trials (RCTs) targeting depression, of various modalities (including pharmacological, psychotherapeutic and other approaches), have been conducted and summarised in pairwise meta-analytic reviews. However, no study has considered the cumulative evidence within a network, which can provide valuable indirect comparisons and information about the relative efficacy of interventions...
March 16, 2019: Systematic Reviews
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