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Joan Forns, Anton Pottegård, Tammo Reinders, Beatriz Poblador-Plou, Rosa Morros, Lena Brandt, Miguel Cainzos-Achirica, Maja Hellfritzsch, Tania Schink, Alexandra Prados-Torres, Maria Giner-Soriano, David Hägg, Jesper Hallas, Jordi Cortés, Emmanuelle Jacquot, Nicolas Deltour, Susana Perez-Gutthann, Manel Pladevall, Johan Reutfors
BACKGROUND: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009-2014 in Denmark, Germany, Spain, and Sweden. METHODS: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine...
February 6, 2019: Journal of Affective Disorders
Ferran Comas, Cristina Martínez, Mònica Sabater, Francisco Ortega, Jessica Latorre, Francisco Díaz-Sáez, Julian Aragonés, Marta Camps, Anna Gumà, Wifredo Ricart, José Manuel Fernández-Real, José María Moreno-Navarrete
Background: Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating NRG4 mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose tissue (SAT). We also studied the possible association of NRG4 with insulin action. Methods: SAT and VAT NRG4 and markers of brown/beige ( UCP1, UCP3, and TMEM26 )-related gene expression were analyzed in two independent cohorts ( n = 331 and n = 59)...
2019: Frontiers in Physiology
Alejandra Pérez-Pérez, Joaquín Guimbao Bescós, Ana Delia Cebollada Gracia, Carmen Malo Aznar, Silvia Martínez Cuenca, Amaya Aznar Brieba, María Ángeles Lázaro Belanche, Inmaculada Sanz Lacambra, Cecilia Compés Dea
OBJECTIVE: In Aragon, official veterinary controls to detect the presence of Trichinella in meat products have allowed trichinosis to be a low-incidence disease in the form of outbreaks associated with family consumption of meat products that are not sanitarily controlled. The aim of the work was to describe the epidemiological characteristics of the trichinosis outbreaks that occurred in Aragon during the study period and the action measures carried out, which served as a basis for redesigning and strengthening prevention and control measures...
February 15, 2019: Revista Española de Salud Pública
Ana E Gamiño-Arroyo, M Lourdes Guerrero, Sean McCarthy, Alejandra Ramírez-Venegas, Beatriz Llamosas-Gallardo, Arturo Galindo-Fraga, Sarbelio Moreno-Espinosa, Yuri Roldán-Aragón, Javier Araujo-Meléndez, Sally Hunsberger, Violeta Ibarra-González, Julia Martínez-López, Luis A García-Andrade, Heather Kapushoc, H Preston Holley, Mary C Smolskis, Guillermo M Ruiz-Palacios, John H Beigel
Background: Effective therapeutics for respiratory viruses are needed. Early data suggest Nitazoxanide (NTZ) may be beneficial for treating acute respiratory viral illness. Methods: From March 2014 through March 2017, a double-blind, placebo-controlled trial was conducted in 260 participants ≥ 1 year old hospitalized with influenza-like illness at six hospitals in Mexico. Participants were randomized 1:1 to NTZ (≥12 years old, 600 mg twice daily; 4-11 and 1-3 years old, 200 or 100 mg twice daily, respectively) or placebo for 5 days in addition to standard of care...
February 7, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Adoración Castro, Mª Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, Maria Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M Baños, Yolanda López-Del-Hoyo, Javier García-Campayo
BACKGROUND: The World Health Organization (WHO) has included comorbidity between depression and a chronic disease among the 10 leading global health priorities. Although there is a high prevalence of multimorbidity, health care systems are mainly designed for the management of individual diseases. Given the difficulty in delivering face-to-face psychological treatments, alternative models of treatment delivery have been proposed, emphasizing the role of technologies such as the Internet...
February 11, 2019: BMC Psychiatry
L Aragonés, J I Pagán, I López, F J Navarro-González, Y Villacampa
Coastal erosion and lack of sediment supply are a serious global problem. It is therefore necessary to determine the depth of closure (DoC) of a beach-key parameter in the calculation of the sand volume and the location of the beach protection elements-in a precise way. For this reason, this work generates a numerical model based on Galerkin's formulation of finite elements that provides sufficient precision for the determination of DoC with a minimum investment. Thus, after the generation of three models in which the difference was the dependent variables, the least complex has been chosen...
April 10, 2019: Science of the Total Environment
Renata Travassos da Rosa Moreira Bastos, Marco Nassar Blagitz, Mônica Lídia Santos de Castro Aragón, Lucianne Cople Maia, David Normando
OBJECTIVES: To identify the scientific evidence that demonstrates which of the transverse maxillary treatments has the least effect on periodontal tissues. MATERIALS AND METHODS: PubMed (MEDLINE), Cochrane Library, Scopus, Web of Science, Virtual Health Library, Google Scholar, and OpenGrey were searched without restrictions. A hand search was also carried out in the reference lists of the articles selected. The related articles tool in the PubMed database was checked for each article included...
February 11, 2019: Angle Orthodontist
Carmen M Martínez-Caballero, Eva Sierra Quintana
INTRODUCTION: Cardiac events are one of the leading causes of death in the Spanish population. Given the increase in the nontraumatic medical conditions found in mountain rescues, the objective of this study was to report on the heart conditions of patients rescued in the mountains of Aragón in the Spanish Pyrenees. METHODS: We conducted a retrospective observational study based on data collected from patients' medical histories for rescues undertaken in from 2010 to 2016 (at altitudes between 500 m [1640 ft] and 3404 m [11,168 ft])...
February 5, 2019: Wilderness & Environmental Medicine
Ajmeeta Sangtani, Eleonora Petryayeva, Kimihiro Susumu, Eunkeu Oh, Alan L Huston, Guillermo Lasarte-Aragones, Igor L Medintz, W Russ Algar, James B Delehanty
Multidrug resistance (MDR) is a significant challenge in the treatment of many types of cancers as membrane-associated transporters actively pump drugs out of the cell, limiting therapeutic efficacy. While nanoparticle (NP)-based therapeutics have emerged as a mechanism for overcoming MDR, they often rely on the delivery of multiple anticancer drugs, nucleic acid hybrids, or MDR pump inhibitors. The effectiveness of these strategies, however, can be limited by their off-target toxicity or the need for genetic transfection...
February 8, 2019: Bioconjugate Chemistry
Gemma Aragonès, Sergio González-García, Carmen Aguilar, Cristóbal Richart, Teresa Auguet
Nonalcoholic fatty liver disease (NAFLD) is a common, multifactorial, and poorly understood liver disease whose incidence is globally rising. During the past decade, several lines of evidence suggest that dysbiosis of intestinal microbiome represents an important factor contributing to NAFLD occurrence and its progression into NASH. The mechanisms that associate dysbiosis with NAFLD include changes in microbiota-derived mediators, deregulation of the gut endothelial barrier, translocation of mediators of dysbiosis, and hepatic inflammation...
2019: BioMed Research International
Manuel Castellá, Dipak Kotecha, Charlotte van Laar, Lisette Wintgens, Yakir Castillo, Johannes Kelder, David Aragon, María Nuñez, Elena Sandoval, Aina Casellas, Lluís Mont, Wim Jan van Boven, Lucas V A Boersma, Bart P van Putte
Aims: Our objectives were to compare effectiveness and long-term prognosis after epicardial thoracoscopic atrial fibrillation (AF) ablation vs. endocardial catheter ablation, in patients with prior failed catheter ablation or high risk of failure. Methods and results: Patients were randomized to thoracoscopic or catheter ablation, consisting of pulmonary vein isolation with optional additional lines (2007-2010). Patients were reassessed in 2016/2017, and those without documented AF recurrence underwent 7-day ambulatory electrocardiography...
January 30, 2019: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Octavio Sánchez-García, Laura G Hernández-Aragón, Kenia López-García, Margarita Juárez, Margarita Martínez-Gómez, Francisco Castelán
INTRODUCTION AND HYPOTHESIS: Temporary effects to pelvic floor muscles are linked to impairments in micturition, particularly stress urinary incontinence (SUI), during pregnancy. We hypothesize that bulbospongiosus (Bsm) and pubococcygeus (Pcm) are differently damaged in primigravid and primiparous rabbits. METHODS: Twenty-four rabbits allocated evenly (n = 6) into nulliparous, pregnant, and primiparous groups on postpartum days 3 (P3) and 20 (P20) were used to evaluate the myofiber cross-sectional area (CSA), β-glucuronidase activity, and anti-3-nitrotyrosine (anti-3-NTyr) immunoreactivity in Bsm and Pcm muscles...
February 1, 2019: International Urogynecology Journal
Juan D Cañete, Antonio Naranjo, Javier Calvo, Carmen Ordás, Belén Aragón, Gonzalo Nocea, Montse Roset, Antonio Fernández-Nebro
OBJECTIVES: To describe the therapeutic management of Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA) and Ankylosing Spondylitis (AS) in patients initiating treatment with biological agents. MATERIALS AND METHODS: Observational, retrospective, longitudinal study in 33 Spanish hospitals. Patients with RA, PsA and AS starting treatment with biological agents between September 2009 and August 2010 and a follow-up longer than 3 years were included. Clinical-demographic characteristics, drugs, biological therapy survival, and reasons for discontinuation or switching were analyzed...
January 28, 2019: Reumatología Clinica
Brad Jon Schoenfeld, Alan Albert Aragon
Nutrient timing is a popular strategy for enhancing muscular adaptations and athletic performance. From the standpoint of muscle hypertrophy, the concept of a "postworkout anabolic window of opportunity" has been proposed, whereby a limited time exists after training to optimize accretion of muscle proteins. Some researchers have gone so far as to claim that the timing of nutritional consumption is even more critical to muscle development than the absolute daily consumption of nutrients. Thus, the purpose of this paper is to review the current literature as to the relevance of the anabolic window of opportunity, and draw evidence-based conclusions for application into practice...
December 2018: Journal of Orthopaedic and Sports Physical Therapy
Carlos B Manjarrez-Domínguez, Jesús A Prieto-Amparán, M Cecilia Valles-Aragón, M Del Rosario Delgado-Caballero, M Teresa Alarcón-Herrera, Myrna C Nevarez-Rodríguez, Griselda Vázquez-Quintero, Cesar A Berzoza-Gaytan
Mining is a major source for metals and metalloids pollution, which could pose a risk for human health. In San Guillermo, Chihuahua, Mexico mining wastes are found adjacent to a residential area. A soil-surface sampling was performed, collecting 88 samples for arsenic determination by atomic absorption. Arsenic concentration data set was interpolated using the ArcGis models: inverse distance weighting (IDW), ordinary kriging (OK), and radial basis function (RBF). For method validation purposes, a set of the data was selected and two tests were performed (P1 and P2)...
January 29, 2019: International Journal of Environmental Research and Public Health
Lisard Iglesias-Carres, Anna Mas-Capdevila, Francisca I Bravo, Gerard Aragonès, Begoña Muguerza, Anna Arola-Arnal
The consumption of sweet oranges has been linked to several health benefits, many of which are attributed to hesperidin, a flavanone that is present in high amounts in these fruits. However, other phenolic compounds can contribute to the bioactivity of sweet orange. To link those effects to their phenolic profile, the complete characterization of the phenolic profile is mandatory. Although many studies have profiled the phenolic composition of orange juices, their pulps, which retain phenolic compounds, are overlooked...
2019: PloS One
Manuel Ibarra, Teresa Dalla Costa, Paula Schaiquevich, Rodrigo Cristofoletti, Ignacio Hernández González, Nicte S Fajardo-Robledo, Marcela Aragón Novoa, Marisín Pecchio, Ignacio Cortinez, Iñaki F Trocóniz, Elba M Romero-Tejeda
This report provides a brief description of the 2018 RedIF Congress that took place in Guadalajara (Mexico), on November 7-9. The meeting aimed to foster modeling & simulation approaches for drug development, regulatory sciences and clinical application in Latin America. Organizations that cosponsored the meeting were: University of Guadalajara, International Society of Pharmacometrics (ISoP), International Pharmaceutical Federation (FIP), Clinic of Chronic Diseases and Special Procedures (CECyPE), Zurich Pharma, Pharmet (Pharmometrica), Lixoft and ICON...
January 25, 2019: CPT: Pharmacometrics & Systems Pharmacology
Anna Mas-Capdevila, Lisard Iglesias-Carres, Anna Arola-Arnal, Gerard Aragonès, Amaya Aleixandre, Francisca I Bravo, Begoña Muguerza
AVFQHNCQE is an antihypertensive nonapeptide obtained from a chicken foot protein hydrolysate. The present study aims to investigate the mechanisms involved in its blood pressure (BP)-lowering effect. Male (17⁻20 weeks old) spontaneously hypertensive rats (SHR) were used in this study. Rats were divided into two groups and orally administered water or 10 mg/kg body weight (bw) AVFQHNCQE. One hour post-administration, animals of both groups were intra-peritoneally treated with 1 mL of saline or with 1 mL of saline containing 30 mg/kg bw Nω-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, or with 1 mL of saline containing 5 mg/kg bw indomethacin, which is an inhibitor of prostacyclin synthesis ( n = 6 per group)...
January 22, 2019: Nutrients
Laura R Arriaga, Yuting Huang, Shin-Hyun Kim, Juan L Aragones, Roy Ziblat, Stephan A Koehler, David A Weitz
Asymmetric vesicles are membranes in which amphiphiles are asymmetrically distributed between each membrane leaflet. This asymmetry dictates chemical and physical properties of these vesicles, enabling their use as more realistic models of biological cell membranes, which also are asymmetric, and improves their potential for drug delivery and cosmetic applications. However, their fabrication is difficult as the self-assembly of amphiphiles always leads to symmetric vesicles. Here, we report the use of water-in-oil-in-oil-in-water triple emulsion drops to direct the assembly of the two leaflets to form asymmetric vesicles...
January 23, 2019: Lab on a Chip
Rubén Vázquez-Medina, Aldo Ledesma-Durán, José Luis Aragón
A three-species population system under a facultative mutualistic relationship of one of the species is studied. The considered interactions are as follows: facultative between the first species and the second species, obligatory mutualism between the second species and the first one, and the third species is a predator of the first species. For this purpose, we extend the model proposed by Morozov et al., originally used to describe obligatory mutualism, to consider obligatory and facultative mutualism and prove that under adequately selected parameters this system produces a spatial patchy spread of populations or continuous wave fronts...
January 16, 2019: Bio Systems
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