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https://read.qxmd.com/read/30778611/fermented-solids-and-their-application-in-the-production-of-organic-compounds-of-biotechnological-interest
#1
Nadia Krieger, Glauco Silva Dias, Robson Carlos Alnoch, David Alexander Mitchell
We review the application of dry fermented solids (DFS) containing naturally immobilized enzymes as catalysts in synthesis and in hydrolysis reactions. The most studied application is the use of DFS containing lipases in the synthesis of biodiesel esters, by transesterification of oils or by esterification of fatty acids with short-chain alcohols in solvent-free reaction media. Other applications of DFS that have been studied include the use of DFS containing pectinases to liberate D-galacturonic acid from pectin and the production of high-value compounds by DFS containing lipases, such as the synthesis of sugar esters and the production of pure enantiomers by resolution of racemic mixtures...
February 19, 2019: Advances in Biochemical Engineering/biotechnology
https://read.qxmd.com/read/30778277/addressing-the-dearth-of-critical-gender-analysis-in-public-health-and-medical-pedagogy-an-interdisciplinary-seminar-to-generate-student-created-teaching-examples
#2
Jerel P Calzo, Sabra L Katz-Wise, Brittany M Charlton, Allegra R Gordon, Nancy Krieger
Gender-based analysis in public health is a systematic examination of how population health is shaped by systems of gender relations, involving policies and laws, programs and services, research priorities, social norms and practices, and public discourse. To address the paucity of critical gender-based analysis training in most public health, medical, and health policy courses, we designed the capstone course in the Women, Gender, and Health (WGH) Interdisciplinary Concentration at the Harvard T.H. Chan School of Public Health...
2019: Critical Public Health
https://read.qxmd.com/read/30775265/efficacy-and-cost-effectiveness-of-guided-and-unguided-internet-and-mobile-based-indicated-transdiagnostic-prevention-of-depression-and-anxiety-icare-prevent-a-three-armed-randomized-controlled-trial-in-four-european-countries
#3
Kiona K Weisel, Anna-Carlotta Zarski, Thomas Berger, Tobias Krieger, Michael P Schaub, Christian T Moser, Matthias Berking, Michelle Dey, Cristina Botella, Rosa Baños, Rocio Herrero, Ernestina Etchemendy, Heleen Riper, Pim Cuijpers, Felix Bolinski, Annet Kleiboer, Dennis Görlich, Jennifer Beecham, Corinna Jacobi, David D Ebert
Background: Depression and anxiety are highly prevalent and often co-occur. Several studies indicate the potential of disorder-specific psychological interventions for the prevention of each of these disorders. To treat comorbidity, transdiagnostic treatment concepts seem to be a promising approach, however, evidence for transdiagnostic concepts of prevention remains inconclusive. Internet- and mobile-based interventions (IMIs) may be an effective means to deliver psychological interventions on a large scale for the prevention of common mental disorders (CMDs) such as depression and anxiety...
April 2019: Internet Interventions: the Application of Information Technology in Mental and Behavioural Health
https://read.qxmd.com/read/30770994/unusual-radiological-and-histological-presentation-of-a-diffuse-leptomeningeal-glioneuronal-tumor-dlgnt-in-a-13-year-old-girl
#4
Nishant Tiwari, Benita Tamrazi, Nathan Robison, Mark Krieger, Jianling Ji, Di Tian
Diffuse leptomeningeal glioneuronal tumors (DLGNTs) are newly recognized as an entity in the 2016 revision of the WHO Classification of tumors of the central nervous system. They typically present as diffuse leptomeningeal infiltrates along the neuraxis with focal and superficial involvement of the parenchyma. Here, we report a DLGNT with unusual radiological and histological features. A 13-year-old girl presented with scoliosis and back pain. Magnetic resonance imaging demonstrated a syrinx from C2 to T11 and an intramedullary mass from T6 to T9-10...
February 15, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30766863/does-male-circumcision-reduce-women-s-risk-of-sexually-transmitted-infections-cervical-cancer-and-associated-conditions
#5
Brian J Morris, Catherine A Hankins, Joya Banerjee, Eugenie R Lumbers, Adrian Mindel, Jeffrey D Klausner, John N Krieger
Background: Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Methods: Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Examination of bibliographies of these yielded 14 further publications...
2019: Frontiers in Public Health
https://read.qxmd.com/read/30762363/characterization-of-differential-dynamics-specificity-and-allostery-of-lipoxygenase-family-members
#6
Karolina Mikulska-Ruminska, Indira H Shrivastava, James Krieger, She Zhang, Hongchun Li, Hulya Bayir, Sally E Wenzel, Andrew P VanDemark, Valerian E Kagan, Ivet Bahar
Accurate modeling of structural dynamics of proteins and their differentiation across different species can help us understand generic mechanisms of function shared by family members and the molecular basis of the specificity of individual members. We focused here on the family of lipoxygenases, enzymes that catalyze lipid oxidation, the mammalian and bacterial structures of which have been elucidated. We present a systematic method of approach for characterizing the sequence, structure, dynamics and allosteric signaling properties of these enzymes using a combination of structure-based models and methods, and bioinformatics tools applied to a dataset of 88 structures...
February 14, 2019: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/30746432/improved-endoscopic-resection-of-large-flat-lesions-and-early-cancers-using-an-external-additional-working-channel-awc-a-case-series
#7
Benjamin Walter, Simone Schmidbaur, Yannick Krieger, Alexander Meining
Background  En-bloc resection of large, flat lesions or early stages of cancer is challenging. No bimanual tasks are possible using standard endoscopes. Dual-channel endoscopes are not available everywhere and have a small distance between the channels. Patients and methods  A new external additional working channel (AWC) (Ovesco, Tuebingen, Germany) was designed and developed potentially enabling bimanual tasks. Fixed to the tip of a standard gastroscope or pediatric colonoscope, a second endoscopic tool can be inserted through the AWC and used for tissue retraction during endoscopic resection...
February 2019: Endoscopy International Open
https://read.qxmd.com/read/30717394/temporal-change-of-extracellular-matrix-during-vein-arterialization-remodeling-in-rats
#8
Ayumi Aurea Miyakawa, Vinícius Bassaneze, Nubia Esteban Duarte, Thais Girão-Silva, Monica Nunes Bizerra, Julliana Carvalho Campos, Jose Eduardo Krieger
The global expression profile of the arterialized rat jugular vein was established to identify candidate genes and cellular pathways underlying the remodeling process. The arterialized jugular vein was analyzed on days 3 and 28 post-surgery and compared with the normal jugular vein and carotid artery. A gene array platform detected 9846 genes in all samples. A heatmap analysis uncovered patterns of gene expression showing that the arterialized vein underwent a partial transition from vein to artery from day 3 to 28 post-surgery...
February 2, 2019: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/30713086/endogenously-expressed-antigens-bind-mammalian-rna-via-cationic-domains-that-enhance-priming-of-effector-cd8-t-cells-by-dna-vaccination
#9
Jana Krieger, Petra Riedl, Katja Stifter, Gleyder Roman-Sosa, Thomas Seufferlein, Martin Wagner, Reinhold Schirmbeck
Hepatitis B virus (HBV) core (HBV-C) antigens with homologous or heterologous HIV-tat48-57-like (HBV-C149tat) cationic domains non-specifically bind cellular RNA in vector-transfected cells. Here, we investigated whether RNA-binding to cationic domains influences the immunogenicity of endogenously expressed antigens delivered by DNA vaccination. We initially evaluated induction of HBV-C (Kb /C93)-specific CD8+ T cell responses in C57BL/6J (B6) and 1.4HBV-Smut transgenic (tg) mice that harbor a replicating HBV genome in hepatocytes by DNA immunization...
January 22, 2019: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://read.qxmd.com/read/30713027/structural-and-functional-characterization-of-ubiquitin-variant-inhibitors-of-usp15
#10
Joan Teyra, Alex U Singer, Frank W Schmitges, Patrick Jaynes, Sarah Kit Leng Lui, Maria J Polyak, Nassima Fodil, Jonathan R Krieger, Jiefei Tong, Carsten Schwerdtfeger, Bradley B Brasher, Derek F J Ceccarelli, Jason Moffat, Frank Sicheri, Michael F Moran, Philippe Gros, Pieter J A Eichhorn, Martin Lenter, Guido Boehmelt, Sachdev S Sidhu
The multi-domain deubiquitinase USP15 regulates diverse eukaryotic processes and has been implicated in numerous diseases. We developed ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three adaptor domains in USP15, including the N-terminal DUSP domain. We also designed a linear dimer (diUbV), which targeted the DUSP and catalytic domains, and exhibited enhanced specificity and more potent inhibition of catalytic activity than either UbV alone. In cells, the UbVs inhibited the deubiquitination of two USP15 substrates, SMURF2 and TRIM25, and the diUbV inhibited the effects of USP15 on the transforming growth factor β pathway...
January 17, 2019: Structure
https://read.qxmd.com/read/30712339/insight-into-the-effects-of-plasmodium-chabaudi-on-platelets-using-carbon-fiber-microelectrode-amperometry
#11
Kang Xiong-Hang, Kaila Kemnetz-Ness, Anna Krieger, Christy L Haynes
Platelets are anuclear circulating cell bodies within the bloodstream commonly known for their roles in clot formation during vascular injury to prevent blood loss. They also have significant impact in a range of diseases, including malaria. However, the role of platelets in malaria is controversial, with contradicting evidence suggesting either that they assist in destruction of malarial parasites or facilitate a severe form of malaria. Precedent work suggests that the timing of infection is critical in determining whether platelets switch roles from being protective to deleterious...
February 3, 2019: ACS Infectious Diseases
https://read.qxmd.com/read/30698716/multi-ancestry-genome-wide-association-study-of-lipid-levels-incorporating-gene-alcohol-interactions
#12
Paul S de Vries, Michael R Brown, Amy R Bentley, Yun J Sung, Thomas W Winkler, Ioanna Ntalla, Karen Schwander, Aldi T Kraja, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jennifer E Huffman, Solomon K Musani, Changwei Li, Mary F Feitosa, Melissa A Richard, Raymond Noordam, Hugues Aschard, Traci M Bartz, Lawrence F Bielak, Xuan Deng, Rajkumar Dorajoo, Kurt K Lohman, Alisa K Manning, Tuomo Rankinen, Albert V Smith, Salman M Tajuddin, Evangelos Evangelou, Mariaelisa Graff, Maris Alver, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Ilaria Gandin, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E Harris, Fernando P Hartwig, Meian He, Andrea R V R Horimoto, Fang-Chi Hsu, Anne U Jackson, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Federica Laguzzi, Joseph H Lee, Jian'an Luan, Leo-Pekka Lyytikäinen, Nana Matoba, Ilja M Nolte, Maik Pietzner, Muhammad Riaz, M Abdullah Said, Robert A Scott, Tamar Sofer, Alena Stancáková, Fumihiko Takeuchi, Bamidele O Tayo, Peter J van der Most, Tibor V Varga, Yajuan Wang, Erin B Ware, Wanqing Wen, Lisa R Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Najaf Amin, Marzyeh Amini, Dan E Arking, Tin Aung, Christie Ballantyne, Eric Boerwinkle, Ulrich Broeckel, Archie Campbell, Mickaël Canouil, Sabanayagam Charumathi, Yii-Der Ida Chen, John M Connell, Ulf de Faire, Lisa de Las Fuentes, Renée de Mutsert, H Janaka de Silva, Jingzhong Ding, Anna F Dominiczak, Qing Duan, Charles B Eaton, Ruben N Eppinga, Jessica D Faul, Virginia Fisher, Terrence Forrester, Oscar H Franco, Yechiel Friedlander, Mohsen Ghanbari, Franco Giulianini, Hans J Grabe, Megan L Grove, C Charles Gu, Tamara B Harris, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, James E Hixson, Barbara V Howard, M Arfan Ikram, David R Jacobs, Craig Johnson, Jost Bruno Jonas, Candace M Kammerer, Tomohiro Katsuya, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Heikki A Koistinen, Ivana Kolcic, Charles Kooperberg, Jose E Krieger, Steve B Kritchevsky, Michiaki Kubo, Johanna Kuusisto, Timo A Lakka, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Benjamin Lehne, Rozenn N Lemaitre, Yize Li, Jingjing Liang, Jianjun Liu, Kiang Liu, Marie Loh, Tin Louie, Reedik Mägi, Ani W Manichaikul, Colin A McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Karen L Mohlke, Thomas H Mosley, Kenneth J Mukamal, Mike A Nalls, Matthias Nauck, Christopher P Nelson, Nona Sotoodehnia, Jeff R O'Connell, Nicholette D Palmer, Raha Pazoki, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Ozren Polasek, Neil Poulter, Leslie J Raffel, Olli T Raitakari, Alex P Reiner, Treva K Rice, Stephen S Rich, Antonietta Robino, Jennifer G Robinson, Lynda M Rose, Igor Rudan, Carsten O Schmidt, Pamela J Schreiner, William R Scott, Peter Sever, Yuan Shi, Stephen Sidney, Mario Sims, Blair H Smith, Jennifer A Smith, Harold Snieder, John M Starr, Konstantin Strauch, Nicholas Tan, Kent D Taylor, Yik Ying Teo, Yih Chung Tham, André G Uitterlinden, Diana van Heemst, Dragana Vuckovic, Melanie Waldenberger, Lihua Wang, Yujie Wang, Zhe Wang, Wen Bin Wei, Christine Williams, Gregory Wilson, Mary K Wojczynski, Jie Yao, Bing Yu, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, John C Chambers, Ian J Deary, Tõnu Esko, Martin Farrall, Paul W Franks, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo L Horta, Yoichiro Kamatani, Norihiro Kato, Jaspal S Kooner, Markku Laakso, Karin Leander, Terho Lehtimäki, Patrik K E Magnusson, Brenda Penninx, Alexandre C Pereira, Rainer Rauramaa, Nilesh J Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E Wagenknecht, Ya Xing Wang, Nicholas J Wareham, Hugh Watkins, David R Weir, Ananda R Wickremasinghe, Wei Zheng, Paul Elliott, Kari E North, Claude Bouchard, Michele K Evans, Vilmundur Gudnason, Ching-Ti Liu, Yongmei Liu, Bruce M Psaty, Paul M Ridker, Rob M van Dam, Sharon L R Kardia, Xiaofeng Zhu, Charles N Rotimi, Dennis O Mook-Kanamori, Myriam Fornage, Tanika N Kelly, Ervin R Fox, Caroline Hayward, Cornelia M van Duijn, E Shyong Tai, Tien Yin Wong, Jingmin Liu, Jerome I Rotter, W James Gauderman, Michael A Province, Patricia B Munroe, Kenneth Rice, Daniel I Chasman, L Adrienne Cupples, Dabeeru C Rao, Alanna C Morrison
An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups...
January 29, 2019: American Journal of Epidemiology
https://read.qxmd.com/read/30677764/dynamic-mri-in-the-evaluation-of-atlantoaxial-stability-in-pediatric-down-syndrome-patients
#13
Albert Tu, Edward Melamed, Mark D Krieger
BACKGROUND/AIMS: Down syndrome is the most common inherited disorder. Some patients develop atlantoaxial instability. Existing screening guidelines were developed prior to availability of MRI. We present predictors for deficit using dynamic MRI of the craniocervical junction. METHODS: A retrospective review of Down syndrome patients from 2001 to 2015 was carried out. Patients were considered symptomatic if they had clinical deficits or signal change on MRI. Measurements were taken at the atlantoaxial junction and structural abnormalities noted...
January 24, 2019: Pediatric Neurosurgery
https://read.qxmd.com/read/30676802/police-related-deaths-and-neighborhood-economic-and-racial-ethnic-polarization-united-states-2015-2016
#14
Justin M Feldman, Sofia Gruskin, Brent A Coull, Nancy Krieger
OBJECTIVES: To estimate the association between rates of police-related deaths and neighborhood residential segregation (by income, race/ethnicity, or both combined) in the United States. METHODS: We identified police-related deaths that occurred in the United States (2015-2016) using a data set from the Guardian newspaper. We used census data to estimate expected police-related death counts for all US census tracts and to calculate the Index of Concentration at the Extremes as a segregation measure...
January 24, 2019: American Journal of Public Health
https://read.qxmd.com/read/30673091/active-learning-outcomes-on-nclex-rn-or-standardized-predictor-examinations-an-integrative-review
#15
Bobbi Shatto, Anne Shagavah, Mary Krieger, Lauren Lutz, Cori E Duncan, Emma K Wagner
BACKGROUND: Despite research indicating that active learning pedagogies that allow more student interaction in the classroom are the most effective way of teaching for comprehension and retention of material, lecture methods are still the most prominent method of teaching in schools of nursing. Although an abundance of research has explored student satisfaction and active learning methods, few studies have examined these methods to determine how they may affect scores on the NCLEX-RN and standardized predictor examinations such as Health Education Systems, Inc...
January 1, 2019: Journal of Nursing Education
https://read.qxmd.com/read/30670697/multi-ancestry-study-of-blood-lipid-levels-identifies-four-loci-interacting-with-physical-activity
#16
Tuomas O Kilpeläinen, Amy R Bentley, Raymond Noordam, Yun Ju Sung, Karen Schwander, Thomas W Winkler, Hermina Jakupović, Daniel I Chasman, Alisa Manning, Ioanna Ntalla, Hugues Aschard, Michael R Brown, Lisa de Las Fuentes, Nora Franceschini, Xiuqing Guo, Dina Vojinovic, Stella Aslibekyan, Mary F Feitosa, Minjung Kho, Solomon K Musani, Melissa Richard, Heming Wang, Zhe Wang, Traci M Bartz, Lawrence F Bielak, Archie Campbell, Rajkumar Dorajoo, Virginia Fisher, Fernando P Hartwig, Andrea R V R Horimoto, Changwei Li, Kurt K Lohman, Jonathan Marten, Xueling Sim, Albert V Smith, Salman M Tajuddin, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Mariaelisa Graff, Sarah E Harris, Meian He, Fang-Chi Hsu, Anne U Jackson, Jing Hua Zhao, Aldi T Kraja, Brigitte Kühnel, Federica Laguzzi, Leo-Pekka Lyytikäinen, Ilja M Nolte, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Rico Rueedi, Heather M Stringham, Fumihiko Takeuchi, Peter J van der Most, Tibor V Varga, Niek Verweij, Erin B Ware, Wanqing Wen, Xiaoyin Li, Lisa R Yanek, Najaf Amin, Donna K Arnett, Eric Boerwinkle, Marco Brumat, Brian Cade, Mickaël Canouil, Yii-Der Ida Chen, Maria Pina Concas, John Connell, Renée de Mutsert, H Janaka de Silva, Paul S de Vries, Ayşe Demirkan, Jingzhong Ding, Charles B Eaton, Jessica D Faul, Yechiel Friedlander, Kelley P Gabriel, Mohsen Ghanbari, Franco Giulianini, Chi Charles Gu, Dongfeng Gu, Tamara B Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Steven C Hunt, M Arfan Ikram, Jost B Jonas, Woon-Puay Koh, Pirjo Komulainen, Jose E Krieger, Stephen B Kritchevsky, Zoltán Kutalik, Johanna Kuusisto, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Karin Leander, Rozenn N Lemaitre, Cora E Lewis, Jingjing Liang, Jianjun Liu, Reedik Mägi, Ani Manichaikul, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Karen L Mohlke, Thomas H Mosley, Alison D Murray, Mike A Nalls, Ei-Ei Khaing Nang, Christopher P Nelson, Sotoodehnia Nona, Jill M Norris, Chiamaka Vivian Nwuba, Jeff O'Connell, Nicholette D Palmer, George J Papanicolau, Raha Pazoki, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Ozren Polasek, David J Porteous, Alaitz Poveda, Olli T Raitakari, Stephen S Rich, Neil Risch, Jennifer G Robinson, Lynda M Rose, Igor Rudan, Pamela J Schreiner, Robert A Scott, Stephen S Sidney, Mario Sims, Jennifer A Smith, Harold Snieder, Tamar Sofer, John M Starr, Barbara Sternfeld, Konstantin Strauch, Hua Tang, Kent D Taylor, Michael Y Tsai, Jaakko Tuomilehto, André G Uitterlinden, M Yldau van der Ende, Diana van Heemst, Trudy Voortman, Melanie Waldenberger, Patrik Wennberg, Gregory Wilson, Yong-Bing Xiang, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, Ulf de Faire, Ian J Deary, Paul Elliott, Tõnu Esko, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Norihiro Kato, Markku Laakso, Timo A Lakka, Terho Lehtimäki, Patrik K E Magnusson, Albertine J Oldehinkel, Brenda W J H Penninx, Nilesh J Samani, Xiao-Ou Shu, Pim van der Harst, Jana V Van Vliet-Ostaptchouk, Peter Vollenweider, Lynne E Wagenknecht, Ya X Wang, Nicholas J Wareham, David R Weir, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Michele K Evans, Paul W Franks, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Tanika N Kelly, Yongmei Liu, Kari E North, Alexandre C Pereira, Paul M Ridker, E Shyong Tai, Rob M van Dam, Ervin R Fox, Sharon L R Kardia, Ching-Ti Liu, Dennis O Mook-Kanamori, Michael A Province, Susan Redline, Cornelia M van Duijn, Jerome I Rotter, Charles B Kooperberg, W James Gauderman, Bruce M Psaty, Kenneth Rice, Patricia B Munroe, Myriam Fornage, L Adrienne Cupples, Charles N Rotimi, Alanna C Morrison, Dabeeru C Rao, Ruth J F Loos
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus...
January 22, 2019: Nature Communications
https://read.qxmd.com/read/30668103/biased-agonist-trv027-determinants-in-at1r-by-molecular-dynamics-simulations
#17
Silvestre Modestia, Matheus Malta de Sa, Eric Auger, Gustavo Henrique Goulart Trossini, José Eduardo Krieger, Carlota Oliviera Rangel-Yagui
Functional selectivity is a phenomenon observed in G protein coupled-receptors (GPCR) in which intermediate active states conformations are stabilized by mutations or ligand binding, resulting in different sets of signaling pathways. Peptides capable of selectively activating β-arrestin, known as biased agonists, have already been characterized in vivo, and could correspond to a new therapeutic approach for cardiovascular diseases treatment. Despite biased agonism potential, the mechanism involved in selective signaling remains unclear...
January 22, 2019: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/30665700/a-review-of-guidelines-to-distinguish-between-gastric-and-pulmonary-placement-of-nasogastric-tubes
#18
REVIEW
Norma A Metheny, Mary M Krieger, Frances Healey, Kathleen L Meert
The purpose of this review was to (1) identify areas of agreement and disagreement in guidelines/recommendations to distinguish between gastric and pulmonary placement of nasogastric tube and (2) summarize factors that affect choices made by clinicians regarding which method(s) to use in specific situations. Systematic searches were conducted in the PubMed, Scopus, and CINAHL Plus databases using a combination of keywords and data-specific subject headings. Searches were limited to guidelines/recommendations from national level specialty groups and governmental sources published in the English language between January 1, 2015 and September 20, 2018...
January 18, 2019: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/30665343/sexual-risk-behavior-and-substance-use-among-young-diverse-women-seeking-care-at-a-reproductive-health-clinic
#19
Alyssa L Norris, Carla Rich, Naomi Krieger, Kate M Guthrie, Clair Kaplan, Kate B Carey, Michael P Carey
BACKGROUND: To describe sexual risk behavior, alcohol (and other substance) use, and perceived health promotion needs among young adult women seeking care from an urban reproductive health care clinic in the Northeastern United States, and to examine if these needs differ by race and ethnicity. METHODS: Women 18-29 years old presenting for a routine medical visit were invited to participate. Of 486 eligible women, 466 (96%) agreed to participate and completed a brief survey on a tablet computer...
January 21, 2019: BMC Women's Health
https://read.qxmd.com/read/30634520/cultural-differences-in-diet-and-determinants-of-diet-quality-in-switzerland-results-from-the-national-nutrition-survey-menuch
#20
Giulia Pestoni, Jean-Philippe Krieger, Janice Marie Sych, David Faeh, Sabine Rohrmann
Sociodemographic differences in dietary consumption were observed in different populations. The current study aimed to identify sociodemographic and lifestyle determinants of diet quality and to investigate the differences in diet quality between the three main language regions of Switzerland. Using data of the Swiss National Nutrition Survey menuCH ( n = 2057), two diet quality scores-Alternate Healthy Eating Index and Mediterranean Diet Score-were computed. Linear regression models were used to investigate the determinants of diet quality and chi-square tests were used to test for differences in single score components between language regions...
January 9, 2019: Nutrients
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