Liangge He, Yaosi Liang, Xue Yu, Yulin Zhao, Zhenjiang Zou, Qinxi Dai, Jinhui Wu, Songyong Gan, Haoran Lin, Yong Zhang, Danqi Lu
Toll-like receptor 5 (TLR5), serving as a sensor of bacterial flagellin, mediates the innate immune response to actively engage in the host's immune processes against pathogen invasion. However, the mechanism underlying TLR5-mediated immune response in fish remains unclear. Despite the presumed cell surface expression of TLR5 member form TLR5M, its trafficking dynamics remain elusive. Here, we have identified Epinephelus coioides TLR5M as a crucial mediator of Vibrio flagellin-induced cytokine expression in grouper cells...
December 10, 2023: International Journal of Biological Macromolecules