Iset M Vera, Anne Kessler, Visopo Harawa, Ajisa Ahmadu, Thomas E Keller, Stephen Tj Ray, Terrie E Taylor, Stephen J Rogerson, Wilson L Mandala, Morayma Reyes Gil, Karl B Seydel, Kami Kim
BACKGROUND: Features of consumptive coagulopathy and thromboinflammation are prominent in cerebral malaria (CM). We hypothesized that thrombogenic autoantibodies contribute to a procoagulant state in CM. METHODS: Plasma from children with uncomplicated malaria (UM, n = 124) and CM (n = 136) was analyzed by ELISA for a panel of 8 autoantibodies including anti-Platelet Factor 4/polyanion (anti-PF4/P), anti-Phospholipid, anti-Phosphatidylserine, anti-Myeloperoxidase, anti-Proteinase 3, anti-dsDNA, anti-Beta-2-Glycoprotein I (β2GPI), and anti-Cardiolipin...
April 23, 2024: Journal of Clinical Investigation