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radiotherapy cervical cancer review

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https://read.qxmd.com/read/30847178/short-term-outcomes-of-helical-tomotherapy-during-concurrent-chemoradiotherapy-for-advanced-cervical-cancer
#1
Yasushi Mabuchi, Yoshihiro Takiguchi, Tamaki Yahata, Mika Mizoguchi, Noriyuki Sasaki, Nami Ota, Sawako Minami, Kazuhiko Ino
The aim of the present study was to clarify the feasibility and efficacy of helical tomotherapy during concurrent chemoradiotherapy for treating cervical cancer. The medical records of 13 patients who underwent oncurrent chemoradiotherapy using helical tomotherapy for cervical cancer at Wakayama Medical University Hospital between 2013 and 2015 were retrospectively reviewed. A total of 15 patients who underwent oncurrent chemoradiotherapy using conventional radiotherapy (CRT) between 2008 and 2013 at our institution were also examined for comparison...
March 2019: Molecular and Clinical Oncology
https://read.qxmd.com/read/30844792/lack-of-survival-benefit-of-para-aortic-lymphadenectomy-in-advanced-cervical-cancer
#2
Cristina Gonzalez-Benitez, Patricia Salas, Jacek P Grabowski, Alicia Hernandez, Javier De Santiago, Ignacio Zapardiel
INTRODUCTION: The presence of positive para-aortic lymph nodes in advanced cervical cancer remains the most important prognostic factor for survival and also defines the treatment. Our aim was to define the influence of staging para-aortic lymphadenectomy in patients' survival. MATERIAL AND METHODS: The medical records of 74 patients with advanced cervical cancer (FIGO IIB-IVA) were reviewed. In 31 patients (41.9%), the assessment of lymph nodes was performed with imaging test (group 1) and in 43 (58...
March 7, 2019: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/30814150/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#3
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 2018: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30802615/neoadjuvant-chemoradiotherapy-followed-by-extrafascial-hysterectomy-in-locally-advanced-type-ii-endometrial-cancer-clinically-extending-to-cervix
#4
Uzoma K Iheagwara, John A Vargo, Katherine S Chen, Danielle Burton, Sarah E Taylor, Jessica L Berger, Michelle M Boisen, John T Comerci, Brian Orr, Paniti Sukumvanich, Alexander B Olawaiye, Joseph L Kelley, Robert P Edwards, Madeleine Courtney-Brooks, Sushil Beriwal
OBJECTIVE: The role of neoadjuvant chemoradiotherapy in locally-advanced type II endometrial cancer is controversial. We thus aimed to present our experience with the hypothesis that neoadjuvant chemoradiotherapy is associated with similarly high rates of downstaging and locoregional control for type II endometrial cancer as for type I endometrial cancer. METHODS: Thirty-four patients with type II endometrial cancer with clinical evidence of cervical ± parametrium involvement treated with neoadjuvant external beam radiotherapy (45-50...
February 22, 2019: Practical Radiation Oncology
https://read.qxmd.com/read/30771718/risk-factors-for-pelvic-and-distant-recurrence-in-locally-advanced-cervical-cancer
#5
Ana Carolina Matos Queiroz, Vanessa Fabri, Henrique Mantoan, Solange Moraes Sanches, Andréia Paiva Gadelha Guimarães, Adriana Regina Gonçalves Ribeiro, João Paulo da Nogueira Silveira Lima, Michael Jenwel Chen, Glauco Baiocchi, Alexandre André Balieiro Anastácio da Costa
OBJECTIVE: Despite the benefits of concomitant radiotherapy and cisplatin for locally advanced cervical cancer, recurrence rates remain high. New treatment strategies such as consolidation chemotherapy and different concomitant chemotherapy combinations have been tested in recent years. Identification of the best candidates for each treatment strategy could optimize results. STUDY DESIGN: A retrospective review of data from 127 patients with locally advanced cervical cancer (International Federation of Gynecology and Obstetrics Stages IIB-IVA), treated at a single institution from 2005 to 2014...
February 6, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/30765489/international-radical-trachelectomy-assessment-irta-study
#6
Gloria Salvo, Pedro T Ramirez, Mario Leitao, David Cibula, Christina Fotopoulou, Ali Kucukmetin, Gabriel Rendon, Myriam Perrotta, Reitan Ribeiro, Marcelo Vieira, Glauco Baiocchi, Henrik Falconer, Jan Persson, Xiaohua Wu, Mihai Emil Căpilna, Nicolae Ioanid, Berit Jul Mosgaard, Igor Berlev, Dilyara Kaidarova, Alexander Babatunde Olawaiye, Kaijiang Liu, Silvana Pedra Nobre, Roman Kocian, Srdjan Saso, Stuart Rundle, Florencia Noll, Audrey Tieko Tsunoda, Kolbrun Palsdottir, Xiaoqi Li, Elena Ulrikh, Zhijun Hu, Rene Pareja
BACKGROUND: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy. PRIMARY OBJECTIVE: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy...
February 13, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30740961/asian-society-of-gynecologic-oncology-international-workshop-2018
#7
REVIEW
Tae Wook Kong, Hee Sug Ryu, Seung Cheol Kim, Takayuki Enomoto, Jin Li, Kenneth H Kim, Seung Hyuk Shim, Peng Hui Wang, Suwanit Therasakvichya, Yusuke Kobayashi, Maria Lee, Tingyan Shi, Shin Wha Lee, Mikio Mikami, Satoru Nagase, Myong Cheol Lim, Jianliu Wang, Sarikapan Wilailak, Sang Wun Kim, Sook Hee Hong, David Sp Tan, Masaki Mandai, Suk Joon Chang, Ruby Yun Ju Huang, Kimio Ushijima, Jung Yun Lee, Xiaojun Chen, Kazunori Ochiai, Taek Sang Lee, Bingyi Yang, Farhana Kalam, Qiaoying Lv, Mohd Faizal Ahmad, Muhammad Rizki Yaznil, Kanika Batra Modi, Manatsawee Manopunya, Dae Hoon Jeong, Arb Aroon Lertkhachonsuk, Hyun Hoon Chung, Hidemichi Watari, Seob Jeon
The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts...
January 14, 2019: Journal of Gynecologic Oncology
https://read.qxmd.com/read/30712019/magnetic-resonance-imaging-after-external-beam-radiotherapy-and-concurrent-chemotherapy-for-locally-advanced-cervical-cancer-helps-to-identify-patients-at-risk-of-recurrence
#8
Martina Aida Angeles, Pauline Baissas, Eric Leblanc, Amélie Lusque, Gwénaël Ferron, Anne Ducassou, Carlos Martínez-Gómez, Denis Querleu, Alejandra Martinez
OBJECTIVE: Tumor volume and regression after external beam radiotherapy have been shown to be accurate parameters to assess treatment response via magnetic resonance imaging (MRI). The aim of the study was to evaluate the prognostic value of tumor size reduction rate after external beam radiotherapy and chemotherapy prior to brachytherapy. METHODS: Patients with locally advanced cervical cancer treated at two French comprehensive cancer centers between 1998 and 2010 were included...
February 1, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30711972/radiation-therapy-for-extrapelvic-lymph-node-recurrence-after-curative-treatment-for-cervical-cancer
#9
Takashi Uno, Aki Kanazawa, Miho Watanabe Nemoto, Rintaro Harada, Hiroki Kobayashi, Makoto Saito, Yuma Iwai, Hirokazu Usui, Akira Mitsuhashi, Makio Shozu
BACKGROUND/AIM: To investigate outcomes of patients with cervical cancer who received radiation therapy for extrapelvic lymph node recurrence after initial pelvic radiotherapy. PATIENTS AND METHODS: The treatment charts of 20 patients were retrospectively reviewed, and factors influencing patient's prognosis were statistically analyzed. RESULTS: The three-year in-field tumor control rate was 55% and overall survival (OS) at 2, 3, and 5 years was 55%, 45%, and 37...
February 2019: Anticancer Research
https://read.qxmd.com/read/30659133/role-of-immunotherapy-in-the-management-of-locally-advanced-and-recurrent-metastatic-cervical-cancer
#10
REVIEW
Brandon A Dyer, Dmitriy Zamarin, Ramez N Eskandar, Jyoti M Mayadev
Despite combined therapeutic approaches, there is an unmet clinical need to identify effective strategies for improved patient outcomes in treating locally advanced and metastatic cervical cancer (CC). Immunotherapy is emerging as a novel therapeutic approach in this disease for which the causative agent, human papillomavirus (HPV), has dynamic, complex immunomodulatory effects. This review explores the biologic rational of immuno-oncology in the treatment of CC and discusses the initial clinical efficacy, ongoing clinical trials, and rationale for combined multimodal treatment approaches for locally advanced and recurrent/metastatic CC...
January 2019: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/30605752/single-institution-experience-in-3d-mri-based-brachytherapy-for-cervical-cancer-for-239-women-can-dose-overcome-poor-response
#11
Zachary D Horne, Pooja Karukonda, Ronny Kalash, Robert P Edwards, Joseph L Kelley, John T Comerci, Alexander B Olawaiye, Madelaine Courtney-Brooks, Michelle M Bochmeier, Jessica L Berger, Sarah E Taylor, Paniti Sukumvanich, Sushil Beriwal
INTRODUCTION: Recent GEC-ESTRO guidelines recommend that the dose to 90% (D90) of the high-risk clinical target volume (HRCTV) in cervical cancer be at least 85Gy with higher doses for poor response to radiotherapy. METHODS AND MATERIALS: A retrospective review of brachytherapy delivered at a single institution were evaluated for dosimetry and outcomes. Significance of tumor parameters on local control was evaluated with Kaplan-Meier and uni- and multivariable Cox regression analysis...
December 31, 2018: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30580379/a-multi-institutional-observational-study-on-the-effects-of-three-dimensional-radiotherapy-and-weekly-40-mg-m-2-cisplatin-on-postoperative-uterine-cervical-cancer-patients-with-high-risk-prognostic-factors
#12
Fumiaki Isohashi, Tadao Takano, Mamiko Onuki, Takahide Arimoto, Naoki Kawamura, Ryusuke Hara, Yoshiaki Kawano, Yukinobu Ota, Haruo Inokuchi, Hidenori Shinjo, Toshiaki Saito, Satoe Fujiwara, Takashi Sawasaki, Ken Ando, Koji Horie, Hiroyuki Okamoto, Naoya Murakami, Yoko Hasumi, Takahiro Kasamatsu, Takafumi Toita
BACKGROUND: The aim of this study was to evaluate the effects of treatment with both three-dimensional radiotherapy (3DRT) and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors. METHODS: We conducted a retrospective multi-institutional chart review of postoperative uterine cervical cancer patients with high-risk prognostic factors who had been treated with both 3DRT and weekly 40-mg/m2 cisplatin from 2007 to 2012...
December 22, 2018: International Journal of Clinical Oncology
https://read.qxmd.com/read/30567074/bladder-cavernous-hemangioma-after-pelvic-radiotherapy-in-a-female-patient-a-case-report-and-literature-review
#13
Xinming Hu, Kangli Deng
INTRODUCTION: Hemangiomas are benign tumor formations of capillaries and blood vessels which are commonly found in various organs. However they are extremely rare in urinary bladder accounting for only 0.6% of all urinary bladder tumors. The differentiating of these benign tumors from malignant neoplasms are important since they have extremely different prognostic features as well as therapeutic strategies. Here we reported a female patient diagnosed with bladder cavernous hemangioma (BCH) after recent pelvic radiotherapy for the cervical cancer and reviewed relevant literatures...
2018: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30558636/comparison-of-treatment-outcomes-between-squamous-cell-carcinoma-and-adenocarcinoma-of-cervix-after-definitive-radiotherapy-or-concurrent-chemoradiotherapy
#14
COMPARATIVE STUDY
Ke Hu, Weiping Wang, Xiaoliang Liu, Qingyu Meng, Fuquan Zhang
BACKGROUND: Concurrent chemoradiotherapy (CCRT) is effective in the treatment of locally advanced cervical squamous cell carcinoma (SCC). However, whether treatment outcomes of cervical adenocarcinoma are equivalent to SCC after CCRT has been a topic of debate. METHODS: Medical records of cervical cancer patients treated with definitive radiotherapy or CCRT in our institute from January 2011 to December 2014 were reviewed. Patients were treated with intensity modulated radiation therapy combined with intracavitary brachytherapy...
December 17, 2018: Radiation Oncology
https://read.qxmd.com/read/30548508/high-dose-versus-standard-dose-radiation-therapy-for-cervical-esophageal-cancer-a-retrospective-single-institution-study
#15
Tae Hyung Kim, Ik Jae Lee, Ji-Hyun Kim, Chang Geol Lee, Yong Chan Lee, Jun Won Kim
BACKGROUND: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). METHODS: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. RESULTS: The median follow-up was 35 months for surviving patients...
December 12, 2018: Head & Neck
https://read.qxmd.com/read/30534024/hyperthermia-in-cervical-cancer-current-status
#16
REVIEW
Ewa Burchardt, Andrzej Roszak
Background: This article reviews the salient features of recent results of clinical studies. It puts a special emphasis on technical aspects, mechanisms of action together with radiotherapy and chemotherapy and points out areas for additional investigation. Aim: To present the current state of knowledge on hyperthermia (HT) and to highlight its role in the treatment of cervical cancer. Materials and methods: The literature on the clinical use of combined hyperthermia for cervical cancer was analyzed...
November 2018: Reports of Practical Oncology and Radiotherapy
https://read.qxmd.com/read/30534018/the-role-of-para-aortic-nodal-irradiation-in-cervical-cancer
#17
REVIEW
Adela Poitevin Chacón, Jessica Chavez-Nogueda, Rubí Ramos-Prudencio, Michelle Aline Villavicencio-Queijeiro, Francisco Lozano-Ruiz
The current standard of care for locally advanced cervical cancer is whole pelvis and para-aortic radiation when indicated, delivered concomitantly with chemotherapy and brachytherapy. Para-aortic node involvement is a predictor of survival in locally advanced disease but presence of metastases is difficult to determine because the currently available imaging methods lack enough sensitivity to be able to detect accurately para-aortic metastases when surgical staging is not feasible. The objective of this review is to describe the current status of para-aortic lymph node irradiation in locally advanced cervical cancer...
November 2018: Reports of Practical Oncology and Radiotherapy
https://read.qxmd.com/read/30534015/problems-and-solutions-in-igrt-for-cervical-cancer
#18
REVIEW
Iván Ríos, Ilse Vásquez, Elsa Cuervo, Óscar Garzón, Johnny Burbano
The contribution of Image-guided Radiotherapy (IGRT) to modern radiotherapy is undeniable, being the way to bring into daily practice the dosimetric benefits of Intensity-Modulated Radiotherapy (IMRT). Organ and target motion is constant and unpredictable at the pelvis, thus posing a challenge to the safe execution of IMRT. There are potential benefits of IMRT in the radical treatment of cervical cancer patients, both in terms of dose escalation and decrease of toxicity. But it is essential to find IGRT solutions to control the aspects that can lead to geographic miss targeting or organs at risk (OAR) overdose...
November 2018: Reports of Practical Oncology and Radiotherapy
https://read.qxmd.com/read/30534012/present-status-of-sentinel-lymph-node-biopsy-in-cervical-cancer
#19
REVIEW
Ariel Gustavo Glickman, Sergio Valdes, Blanca Gil-Ibañez, Pilar Paredes, Karen Sttephannía Cortés, Aureli Angel Torné Blade
Cervical cancer is the fourth most common cancer in women, and seventh overall. This disease represents a medical, economic and social burden. In early FIGO stage patients (IA, IB1 and IIA1), nodal involvement is the most important prognostic factor. Imaging evaluation of nodal metastasis is of limited value. In order to determine lymph node involvement, allow loco-regional control of the disease, define the need for adjuvant radiotherapy and improve survival, standard surgery for early disease is radical hysterectomy with systematic pelvic lymphadenectomy...
November 2018: Reports of Practical Oncology and Radiotherapy
https://read.qxmd.com/read/30530009/proton-therapy-for-treatment-of-intracranial-benign-tumors-in-adults-a-systematic-review
#20
REVIEW
Paul Lesueur, Valentin Calugaru, Catherine Nauraye, Dinu Stefan, Kim Cao, Evelyne Emery, Yves Reznik, Jean Louis Habrand, Thomas Tessonnier, Abdulhamid Chaikh, Jacques Balosso, Juliette Thariat
INTRODUCTION: The depth-dose distribution of a proton beam, materialized by the Bragg peak makes it an attractive radiation modality as it reduces exposure of healthy tissues to radiations, compared with photon therapy Prominent indications, based on a long-standing experience are: intraocular melanomas, low-grade skull-base and spinal canal malignancies. However, many others potential indications are under investigations such as the benign morbid conditions that are compatible with an extended life-expectancy: low grade meningiomas, paragangliomas, pituitary adenomas, neurinomas craniopharyngioma or recurrent pleomorphic adenomas...
January 2019: Cancer Treatment Reviews
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