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Diabetes And Endocrine And Internal Medicine

Nidheesh Dadheech, A M James Shapiro
The successful landmark discovery of mouse and human inducible pluripotential stem cells (iPSC's) by Takahashi and Yamanaka in 2006 and 2007 has triggered a revolution in the potential generation of self-compatible cells for regenerative medicine, and further opened up a new avenue for "disease in dish" drug screening of self-target cells (Neofytou et al. 2015). The introduction of four 'Yamanaka' transcription factors through viral or other transfection of mature cells can induce pluripotency and acquired plasticity...
December 21, 2018: Advances in Experimental Medicine and Biology
Andrea Peloso, Antonio Citro, Tamara Zoro, Lorenzo Cobianchi, Arianna Kahler-Quesada, Carlo M Bianchi, Axel Andres, Ekaterine Berishvili, Lorenzo Piemonti, Thierry Berney, Christian Toso, Graziano Oldani
According to the Juvenile Diabetes Research Foundation (JDRF), almost 1. 25 million people in the United States (US) have type 1 diabetes, which makes them dependent on insulin injections. Nationwide, type 2 diabetes rates have nearly doubled in the past 20 years resulting in more than 29 million American adults with diabetes and another 86 million in a pre-diabetic state. The International Diabetes Ferderation (IDF) has estimated that there will be almost 650 million adult diabetic patients worldwide at the end of the next 20 years (excluding patients over the age of 80)...
2018: Frontiers in Endocrinology
José L Mansur
The main source of vitamin D is produced by the exposure of sunlight on the skin. It has been proven that the deficit is frequent and also occurs in pregnant women. Possible consequences may be preeclampsia and others. The level of vitamin D in breast milk depends on the level of the mother, so that deficient mothers produce milk with low concentration. Possible consequences for the baby are rickets and seizures, but also lower respiratory tract infections or risk of type 1 diabetes. Various suggestions have been published...
August 1, 2018: Archivos Argentinos de Pediatría
Kyeong Jin Kim, Shin Ha, Yo Han Lee, Jung Hyun Noh, Sin Gon Kim
BACKGROUND: Past decades of division have led to substantial differences in medical environments between South and North Korea. However, little is known about North Korea's medical status and research field, especially regarding endocrinology. In this study, we report the characteristics of North Korea's articles regarding endocrine-related diseases. METHODS: Among the nine medical journals, articles published in Internal Medicine between 2006 and 2015 were reviewed...
June 2018: Endocrinology and Metabolism
Rossella Messina, Paola Rucci, Jackie Sturt, Tatiana Mancini, Maria Pia Fantini
BACKGROUND: Being highly self-efficacious is a key factor in successful chronic disease self-management. In the context of measuring self-efficacy in type 2 diabetes management, the Diabetes Management Self-Efficacy Scale (DMSES) is the most widely used scale. The aim of this study was to adapt the English version of the scale to Italian and to evaluate the psychometric properties of the Italian version of DMSES in type 2 diabetes (IT-DMSES). METHODS: We conducted a cross-sectional study of people with type 2 diabetes attending the Endocrine-Metabolic Disease Care Unit of the Internal Medicine Department of San Marino State Hospital between October 2016 and February 2017...
April 23, 2018: Health and Quality of Life Outcomes
Imam Subekti, Laurentius Aswin Pramono, Esthika Dewiasty, Dante Saksono Harbuwono
BACKGROUND: thyroid dysfunction is more likely to occur in diabetes mellitus patients than general population. Until now, no study has been done to find prevalence of hypothyroidism and hyperthyroidism in Indonesian diabetics. This study aimed to find the proportion and characteristics of thyroid dysfunction in Indonesian type 2 diabetes mellitus patients. METHODS: a cross-sectional study was conducted in Endocrine and Diabetes Polyclinic, Department of Internal Medicine, Cipto Mangunkusumo Hospital from July to September 2015...
October 2017: Acta Medica Indonesiana
G J Kahaly, J Zimmermann, M P Hansen, F Gundling, F Popp, M Welcker
Polyglandular autoimmune syndromes encompass several endocrine and nonendocrine autoimmune disorders with variable onset and phenotype. Rheumatoid and gastroenterological symptoms in patients with autoimmune polyglandular syndromes are suggestive of additional rheumatoid gastrointestinal and hepatological autoimmune diseases. Autoimmune gastritis, celiac disease, autoimmune hepatitis, rheumatoid arthritis, Sjögren syndrome, and systemic Lupus erythematodus are of particular clinical relevance. In addition, unspecific rheumatoid and gastrointestinal attendant symptoms of the existing autoimmune endocrinopathy must be considered...
April 2017: Der Internist
Shelley Ehrlich, Donna Lambers, Andrea Baccarelli, Jane Khoury, Maurizio Macaluso, Shuk-Mei Ho
Gestational diabetes mellitus (GDM) has increased dramatically in the past 20 years together with the obesity epidemic. Mirroring the increase in incidence of GDM is increasing use of endocrine disrupting chemicals (EDCs). EDCs are structurally similar to endogenous hormones and interfere with synthesis, secretion, activity, or elimination of natural hormones, resulting in adverse health effects, including diabetes, obesity, developmental disorders, etc. Although the association between bisphenol A (BPA), a well-studied EDC, and type 2 diabetes has been repeatedly investigated in epidemiological and animal studies, there is a dearth of studies examining EDCs and GDM...
November 2016: American Journal of Perinatology
J Feldkamp, M Schott, M Gogol, M Quinkler, M Blüher, S Diederich, M Reincke
POSITIVE RECOMMENDATIONS: A. After osteoporotic fractures in the elderly, as a rule specific antiosteoporotic therapy should be initiated. a. Osteoporosis as a disease of the elderly should be diagnosed and treated (recommendation of the German Society for Geriatrics). B. All patients with diabetes mellitus should complete a specific diabetes training program when antidiabetic drug medication is initiated. C. In Germany, all pregnant women should be advised to undertake iodine supplementation...
June 2016: Der Internist
Roisin Worsley, Nanette Santoro, Karen K Miller, Sharon J Parish, Susan R Davis
INTRODUCTION: In recent years, multiple hormones have been investigated in relation to female sexual function. Because consumers can easily purchase products claiming to contain these hormones, a clear statement regarding the current state of knowledge is required. AIM: To review the contribution of hormones, other than estrogens and androgens, to female sexual functioning and the evidence that specific endocrinopathies in women are associated with female sexual dysfunction (FSD) and to update the previously published International Society of Sexual Medicine Consensus on this topic...
March 2016: Journal of Sexual Medicine
Sándor Gődény, Orsolya Karola Csenteri
Polycystic ovary syndrome is the most common hormonal and metabolic disorder likely to affect women. The syndrome is often associated with obesity, hyperinsulinemia and adversely affects endocrine, metabolic, and cardiovascular health. The complex feature of the syndrome requires an interdisciplinary approach to treatment, where cooperation of paediatrician, internist, gynaecologist, endocrinologist, dermatologist, psychologist and oncologist is essential. The prevention and the treatment should be based on the best available evidence...
December 13, 2015: Orvosi Hetilap
Celeste C L Quianzon, Pamela R Schroeder
OBJECTIVE: The article studied the knowledge and practice patterns of primary care providers and internal medicine residents in their initial evaluation of thyroid nodules and determined whether their practice is in accordance with published guidelines by the American Thyroid Association and American Association of Clinical Endocrinologists. METHOD: A survey was distributed to primary care physicians (PCPs) and internal medicine residents at a community hospital in Baltimore and a chart review was conducted at the Diabetes and Endocrine Center in the same hospital...
2015: Journal of Community Hospital Internal Medicine Perspectives
Joseph I Wolfsdorf
The current version of the International Society of Pediatric and Adolescent Diabetes (ISPAD) guidelines for management of diabetic ketoacidosis (DKA) is largely based on the Lawson Wilkins Pediatric Endocrine Society/European Society of Pediatric Endocrinology (LWPES/ESPE) consensus statement on DKA in children and adolescents published in 2004. This article critically reviews and presents the most pertinent new data published in the past decade, which have implications for diagnosis and management. Four elements of the guidelines warrant modification: (i) The definition of DKA; (ii) insulin therapy; (iii) water and salt replacement; and (iv) blood ß-hydroxybutyrate measurements for the management of DKA...
June 2014: Pediatric Diabetes
Rebecca D Wilson, Marilyn Bailey, Mary E Boyle, Karen M Seifert, Karla Y Cortez, Leslie J Baker, Michael J Hovan, Jan Stepanek, Curtiss B Cook
BACKGROUND: We aim to provide data on a diabetes technology simulation course (DTSC) that instructs internal medicine residents in the use of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring system (CGMS) devices. METHODS: The DTSC was implemented during calendar year 2012 and conducted in the institution's simulation center. It consisted of a set of prerequisites, a practicum, and completion of a web-based inpatient CSII-ordering simulation...
November 1, 2013: Journal of Diabetes Science and Technology
Z Merhi
STUDY QUESTION: Do advanced glycation end products (AGEs) and their receptors play a role in female reproduction? SUMMARY ANSWER: AGEs might contribute to the etiology of polycystic ovary syndrome (PCOS) and infertility. WHAT IS KNOWN ALREADY: The endogenous AGEs are produced in the body by chemical reactions. Exogenous sources of AGEs are diet and smoking. AGEs have been proposed to be among the main intermediaries involved in several diseases, such as metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease, ovarian aging, inflammation, neurodegenerative disorders and PCOS...
January 2014: Human Reproduction
S Shubeska Stratrova
The Clinic of Endocrinology, diabetes and metabolic disorders was founded in 1975 by Prof d-r Alexandar Plashevski. Healthcare, educational and scientific activities in the Clinic of Endocrinology are performed in its departments. The Department for hospitalized diabetic and endocrine patients consists of the metabolic and endocrine intensive care unit, the department for diagnosis and treatment of diabetics and endocrine patients, day hospital, the department for education of diabetic patients, and the national center for insulin pump therapy...
2013: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Christoph Henzen, Marius Kraenzlin, Christian Meier
Endocrine disorders are common in internal medicine. Diagnosis of endocrine diseases are usually based on patient history, clinical assessment and laboratory investigations. Thereby, biochemical analyses are used to confirm clinical diagnosis, to assess the need for treatment and to monitor disease progression, in particular to ascertain treatment efficacy. This article will focus on frequently used laboratory investigations for endocrine diseases such as diabetes, thyroid dysfunction, male hypogonadism and adrenal insufficiency...
August 2013: Therapeutische Umschau. Revue Thérapeutique
Boris Draznin, Janice Gilden, Sherita H Golden, Silvio E Inzucchi, David Baldwin, Bruce W Bode, Jeffrey B Boord, Susan S Braithwaite, Enrico Cagliero, Kathleen M Dungan, Mercedes Falciglia, M Kathleen Figaro, Irl B Hirsch, David Klonoff, Mary T Korytkowski, Mikhail Kosiborod, Lillian F Lien, Michelle F Magee, Umesh Masharani, Gregory Maynard, Marie E McDonnell, Eti S Moghissi, Neda Rasouli, Daniel J Rubin, Robert J Rushakoff, Archana R Sadhu, Stanley Schwartz, Jane Jeffrie Seley, Guillermo E Umpierrez, Robert A Vigersky, Cecilia C Low, Deborah J Wexler
Currently patients with diabetes comprise up to 25-30% of the census of adult wards and critical care units in our hospitals. Although evidence suggests that avoidance of hyperglycemia (>180 mg/dL) and hypoglycemia (<70 mg/dL) is beneficial for positive outcomes in the hospitalized patient, much of this evidence remains controversial and at times somewhat contradictory. We have recently formed a consortium for Planning Research in Inpatient Diabetes (PRIDE) with the goal of promoting clinical research in the area of management of hyperglycemia and diabetes in the hospital...
July 2013: Diabetes Care
M Thomas, P Arlet, O Aumaitre, J Cosserat, B Grosbois, L Guillevin, A Kettaneh, C Le Jeunne, C Massot, P Morlat
PURPOSE: Up to 4600 drugs in about 15,000 pharmaceutical forms are available in France which may be a source of misuse with increased occurrence of side effects and costs. While the World Health Organization is encouraging each developed country to work out its own list of essential drugs. The list provided in 2008 by the French Office for the safety of health products has had so far limited impact on practice, so it became obvious to a group of internists to work out a "wise list" of 100 essential medicines covering 95% of the disorders observed in France...
August 2013: La Revue de Médecine Interne
Zdravko A Kamenov, Latchezar D Traykov
Diabetic autonomic neuropathy (DAN) affects each tissue, organ, system and the whole body, and presents with a diverse clinical picture. Originating from endocrine factors, this neurological disease may cause symptoms, whose differential diagnosis needs a good knowledge of the whole internal medicine. DAN is strongly involved in the development of diabetic foot, ulceration and amputation. The life threatening consequences of cardiac and patient-frustrating sequels of other types of DAN is more difficult to estimate...
2012: Advances in Experimental Medicine and Biology
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