Simona Bartimoccia, Michael Praktiknjo, Cristina Nocella, Robert Schierwagen, Vittoria Cammisotto, Christian Jansen, Luca Cristiano, Valentina Castellani, Johannes Chang, Roberto Carnevale, Sofia Maiucci, Frank Erhard Uschner, Pasquale Pignatelli, Maximilian Joseph Brol, Jonel Trebicka, Francesco Violi
Pathophysiology of portal vein thrombosis (PVT) in cirrhosis is still not entirely understood. Elevated levels of lipopolysaccharides (LPS) in portal circulation are significantly associated with hypercoagulation, increased platelet activation and endothelial dysfunction. The aim of the study was to investigate if LPS was associated with reduced portal venous flow, the third component of Virchow's triad, and the underlying mechanism. Serum nitrite/nitrate, as a marker of nitric oxide (NO) generation, and LPS were measured in the portal and systemic circulation of 20 patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS) procedure; portal venous flow velocity (PVV) was also measured in each patient and correlated with NO and LPS levels...
February 26, 2024: Internal and Emergency Medicine