Reza Bahar, Shahram Darabi, Mohsen Norouzian, Susan Roustaei, Shayesteh Torkamani-Dordshahikh, Maral Hasanzadeh, Kimia Vakili, Mobina Fathi, Fariba Khodagholi, Neda Kaveh, Shima Jahanbaz, Meysam Hassani Moghaddam, Hojjat-Allah Abbaszadeh, Abbas Aliaghaei
Huntington's disease (HD) is a hereditary condition characterized by the gradual deterioration of nerve cells in the striatum. Recent scientific investigations have revealed the promising potential of Extracellular vesicles (EVs) as a therapy to mitigate inflammation and enhance motor function. This study aimed to examine the impact of administering EVs derived from human umbilical cord blood (HUCB) on the motor abilities and inflammation levels in a rat model of HD. After ultracentrifugation to prepare EVs from HUCB to determine the nature of the obtained contents, the expression of CD markers 81 and 9, the average size and also the morphology of its particles were investigated by DLS and scanning electron microscope (SEM)...
April 10, 2024: Journal of Chemical Neuroanatomy