Sania Ashrafi, Safaet Alam, Arifa Sultana, Asef Raj, Nazim Uddin Emon, Fahmida Tasnim Richi, Tasnuva Sharmin, Myunghan Moon, Moon Nyeo Park, Bonglee Kim
The pharmacological actions of benzylisoquinoline alkaloids are quite substantial, and have recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been found in the unripe seed capsules of Papaver somniferum L. Although it lacks analgesic effects and is unrelated to the compounds in the morphine class, it is a peripheral vasodilator and has a direct effect on vessels. It is reported to inhibit the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) phosphodiesterase in smooth muscles, and it has been observed to increase intracellular levels of cAMP and cGMP...
March 31, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry