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Reinald Pamplona, Consuelo Borras, Mariona Jové, Irene Pradas, Isidre Ferrer, Jose Viña
Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging. Yet the molecular mechanisms that sustain the preservation or deterioration of neurons and PFC functions are unknown. In this review, we focus on the role of lipids in human PFC aging. As the evolution of brain lipid concentrations is particularly accelerated in the human PFC, conferring a specific lipid profile, a brief approach to the lipidome of PFC was consider along with the relationship between lipids and lipoxidative damage, and the role of lipids in human PFC aging...
March 18, 2019: Free Radical Biology & Medicine
Marcos Fiuza de Carvalho, Thuliermes Lopes Pamplona, Márcio Alencar Barreira, Francisco Vagnaldo Jacuru Fechine, Lúcio Flávio Gonzaga-Silva, Ricardo Reges Maia de Oliveira
PURPOSE: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. METHODS: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to evaluate non-voiding contractions (NVC), threshold pressure (TP), baseline pressure (BP), frequency of micturition (FM) and threshold volume (TV)...
February 28, 2019: Acta Cirúrgica Brasileira
Daniela da Silva Garcia Regino, Juliana da Silva Garcia Nascimento, Cristina Maria Garcia de Lima Parada, Marli Teresinha Cassamassimo Duarte, Vera Lucia Pamplona Tonete
OBJECTIVE: To analyze the training and evaluation of professional competency to work in the area of pediatric nursing based on the conceptions and experiences of university professors. METHOD: A qualitative study conducted with pediatric nursing professors from six public undergraduate courses in the state of São Paulo, Brazil. The data were collected by semi-structured interview and analyzed by the Content Analysis method. RESULTS: Sixteen professors participated...
March 7, 2019: Revista da Escola de Enfermagem da U S P
Enric Sánchez, Àngels Betriu, Andree Yeramian, Elvira Fernández, Francesc Purroy, Manuel Sánchez-de-la-Torre, Reinald Pamplona, Eva Miquel, Mohsen Kerkeni, Cristina Hernández, Rafael Simó, Albert Lecube, Marta Hernández, Ferran Rius, Dinora Polanco, Ferran Barbé, Gerard Torres, Guillermo Suárez, Manuel Portero-Otin, Mariona Jové, Laura Colàs-Campàs, Ikram Benabdelhak, Cristina Farràs, Marta Ortega, José Manuel Valdivielso, Marcelino Bermúdez-López, Montse Martínez-Alonso
AIM: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in subjects with low to moderate vascular risk. METHODS: A cross-sectional study in which 2,568 non-diabetic subjects of both sexes without cardiovascular disease were included. Subcutaneous content of AGEs was assessed by skin autofluorescence (SAF) and subclinical atheromatous disease was measured by assessing the atheromatous plaque burden in carotid and femoral regions using ultrasonography...
March 6, 2019: Journal of Atherosclerosis and Thrombosis
Estelita Lima Cândido, Ulisses Mariano da Silva, Luciano Pamplona de Góes Cavalcanti
INTRODUCTION: Aedes fluviatilis(Lutz, 1904) is considered a potential vector of yellow fever and dengue viruses and is naturally infected by Wolbachia. METHODS: In March 2018, during a field activity in the municipality of Saboeiro, 163 mosquito larvae were collected in a dammed area of the Jaguaribe River. RESULTS: Of the larvae collected, 143 (87.7%) were identified asAe. fluviatilis. CONCLUSIONS: We report the first documentation of Ae...
February 21, 2019: Revista da Sociedade Brasileira de Medicina Tropical
Allan Henrique Depieri Cataneo, Diogo Kuczera, Ana Luiza Pamplona Mosimann, Emanuele Guimarães Silva, Álvaro Gil Araújo Ferreira, João Trindade Marques, Pryscilla Fanini Wowk, Claudia Nunes Duarte Dos Santos, Juliano Bordignon
BACKGROUND: The Zika virus (ZIKV) epidemics that affected South America in 2016 raised several research questions and prompted an increase in studies in the field. The transient and low viraemia observed in the course of ZIKV infection is a challenge for viral isolation from patient serum, which leads to many laboratories around the world sharing viral strains for their studies. C6/36 cells derived from Aedes albopictus larvae are commonly used for arbovirus isolation from clinical samples and for the preparation of viral stocks...
February 7, 2019: Memórias do Instituto Oswaldo Cruz
Jeniffer Carrillo, Cristhian Durán
The aim of this study was to develop and implement a methodology composed by a Static Head-Space-Sampler (SHS) coupled to a Sensory Perception System (SPS) for the extraction of Volatile Organic Compounds (VOC's) emitted by bacterial species in the water. The SPS was performed by means of a chamber of 16 Metal-Oxide-Semiconductor (MOS) gas sensors and a software with pattern recognition methods for the detection and identification of bacteria. At first, the tests were conducted from the sterile and polluted water with the Escherichia coli bacteria and modifying the incubation temperatures (50 °C, 70 °C and 90 °C), with the objective to obtain an optimal temperature for the distinguishing of species...
February 8, 2019: Biosensors
Liliana Gutiérrez-Carrasquilla, Enric Sánchez, Marta Hernández, Dinora Polanco, Jordi Salas-Salvadó, Àngels Betriu, Anna Michela Gaeta, Paola Carmona, Francesc Purroy, Reinald Pamplona, Cristina Farràs, Carolina López-Cano, Elvira Fernández, Albert Lecube
A few studies showed that both adherence to Mediterranean diet (MedDiet) and physical activity practice have a positive impact on pulmonary function in subjects with lung disease. These associations are not well studied in subjects free from lung disease. In a cross-sectional study conducted in 3020 middle-aged subjects free of lung disease, adherence to the MedDiet using the Mediterranean Diet Adherence Screener, and physical activity practice using the International Physical Activity Questionnaire short form were recorded...
February 3, 2019: Nutrients
A A Gasparin, N Pamplona Bueno de Andrade, V Hax, G Leví Tres, F J Veríssimo Veronese, O A Monticielo
Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predict disease activity and renal histology, but also lead to earlier treatment. In previous studies, the soluble vascular cell adhesion molecule-1 measured in urine showed a strong association with the presence of lupus nephritis, with clinical and histological activity indexes of the disease and with more severe renal lesions...
February 2, 2019: Lupus
I Pradas, M Jové, K Huynh, J Puig, M Ingles, C Borras, J Viña, P J Meikle, R Pamplona
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state...
February 2019: Redox Biology
Thiago Costa Pamplona da Silva, Marilda Guimarães Silva, Samuel Katsuyuki Shinjo
BACKGROUND: Until now, there are few studies evaluating serum levels of angiogenic cytokines in dermatomyositis (DM). Therefore, the aims of the present study were: (a) to analyze systematically and simultaneously serum levels of angiogenin (ANG), angiopoietin (ANGPT)-1, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-1 and - 2, platelet derived growth factor (PDGF)-AA and -BB in DM; (b) to correlate the serum level of these cytokines with the DM clinical and laboratory features...
July 31, 2018: Advances in Rheumatology
Penélope Esther Palominos, Andrese Aline Gasparin, Nicole Pamplona Bueno de Andrade, Ricardo Machado Xavier, Rafael Mendonça da Silva Chakr, Fernanda Igansi, Laure Gossec
OBJECTIVE: To assess the main fears and beliefs of people with rheumatoid arthritis (RA) and their effect on treatment outcomes; METHODS: A systematic literature review was conducted in Pubmed/Medline; original articles published up to May 2017, reporting fears and/or beliefs of adult patients with RA were analyzed. Fears and beliefs were collected by two independent researchers and grouped into categories. RESULTS: Among 474 references identified, 84 were analyzed, corresponding to 24,336 RA patients...
May 24, 2018: Advances in Rheumatology
Mônica Custódia do Couto Abreu Pamplona, Emanuele Cordeiro Chaves, Alôma Cecília Carvalho, Rúdrissa do Couto Abreu Pamplona, Antonio Carlos Rosário Vallinoto, Maria Alice Freitas Queiroz, Sandra Souza Lima, Ricardo Ishak
INTRODUCTION: Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services...
January 14, 2019: Revista da Sociedade Brasileira de Medicina Tropical
Mariona Jové, Irene Pradas, Mayelin Dominguez-Gonzalez, Isidro Ferrer, Reinald Pamplona
The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions are unknown. In this review, we focus attention on the role of lipids and the importance of the cross-regionally different vulnerabilities in human brain aging. In particular, we first consider a brief approach to the lipidomics of human brain, the relationship between lipids and lipoxidative damage, the role of lipids in human brain aging, and the specific targets of lipoxidative damage in human brain and during aging...
December 19, 2018: Redox Biology
Mónica Enguita, Nerea Razquin, Reinald Pamplona, Jorge Quiroga, Jesús Prieto, Puri Fortes
Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive hepatic insufficiency associated with high mortality unless liver transplantation is performed. We have hypothesized that the deficiency of critical nutrients such as essential omega-3 fatty acids might play a role in the progression of liver cirrhosis. Here we evaluated by LC-MS/MS the liver content of omega-3 docosahexaenoic fatty acid (DHA) in cirrhotic patients and investigated the effect of DHA in a murine model of liver injury and in the response of hepatic stellate cells (HSCs) (the main producers of collagen in the liver) to pro-fibrogenic stimuli...
January 8, 2019: Cell Death & Disease
Tiago Machado-de-Souza, Ricardo Pamplona Campos, Mariano Devoto, Isabela Galarda Varassin
One of the major challenges in ecology is to understand the relative importance of neutral- and niche-based processes structuring species interactions within communities. The concept of neutral-based processes posits that network structure is a result of interactions between species based on their abundance. On the other hand, niche-based processes presume that network structure is shaped by constraints to interactions. Here, we evaluated the relative importance of neutral-based process, represented by species' abundance (A) and fruit production (F) models, and niche-based process, represented by spatial overlap (S), temporal overlap (T) and morphological barrier (M) models, in shaping the structure of a bird-seed dispersal network from the Brazilian Atlantic Forest...
January 5, 2019: Oecologia
E Robledo Martín, C Goñi Murillo, R Elcuaz Viscarret, S Muro Arbizu, E Aranguren Erdozain, J M Zalbide Galé
OBJECTIVES: The demand in the extra-hospital emergency department of Pamplona has increased considerably in 2015 and 2016. The objective of the study is to determine the profile of the patients, the reasons why they come, Primary Care centres of origin, and if they have requested an appointment in them. MATERIAL AND METHODS: A multicentre, descriptive study using a self-completed questionnaire by patients was conducted during one week per month, between August 2016 and January 2017...
December 18, 2018: Semergen
Manoela Fantinel Ferreira, Charles Lubianca Kohem, Ricardo Machado Xavier, Everton Abegg, Otavio Silveira Martins, Marcus Barg Resmini, Ariele Lima de Mello, Franciele de Almeida Menegat, Vanessa Hax, Andrese Aline Gasparin, Claiton Viegas Brenol, Nicole Pamplona Bueno de Andrade, Daniela Viecceli, João Carlos Tavares Brenol, Penélope Esther Palominos
The treat-to-target strategy (T2T) was associated with better outcomes in psoriatic arthritis (PsA) compared to standard care in clinical trials. This study aimed to analyze factors precluding treatment optimization in a T2T strategy conducted in a real-world cohort of PsA patients. A retrospective cross-sectional study nested in a cohort was conducted. Medical records of patients ≥ 18 years old, fulfilling CASPAR criteria and with at least one visit in the PsA clinic, were reviewed. Demographic data, current medication, and minimal disease activity (MDA) criteria were recorded...
December 3, 2018: Clinical Rheumatology
Rebeka Ferreira Pequeno Leite, Marinisi Sales Aragão Santos, Erlane Marques Ribeiro, André Luiz Santos Pessoa, Doris Ruthy Lewis, Célia Maria Giacheti, Luciano Pamplona de Góes Cavalcanti
OBJECTIVE: to describe the results of hearing screening performed in children with Congenital Zika Virus Syndrome (CZS) in Fortaleza, Ceará, Brazil. METHODS: this was a descriptive cross-sectional study involving children with CZS receiving health care in Fortaleza, 2016; the hearing screening tests performed were immittance audiometry, transient otoacoustic emissions (TOAE), acoustic reflexes, and cochleopalpebral reflex (CPR). RESULTS: The study included 45 children with an average age of 10 months...
November 8, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Izabel Letícia Cavalcante Ramalho, Fernanda Montenegro de Carvalho Araújo, Luciano Pamplona de Góes Cavalcanti, Deborah Nunes Melo Braga, Anne Carolinne Bezerra Perdigão, Flavia Barreto Dos Santos, Fernanda de Bruycker Nogueira, Kiliana Nogueira Farias da Escóssia, Maria Izabel Florindo Guedes
BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012...
October 18, 2018: Memórias do Instituto Oswaldo Cruz
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