keyword
https://read.qxmd.com/read/38530931/imaging-markers-from-population-wide-mri-based-automated-kidney-segmentation-an-analysis-of-data-from-the-german-national-cohort-nako-gesundheitsstudie
#1
Elias Kellner, Peggy Sekula, Jan Lipovsek, Maximilian Russe, Harald Horbach, Christopher L Schlett, Matthias Nauck, Henry Völzke, Thomas Kroencke, Stefanie Bette, Hans-Ulrich Kauczor, Thomas Keil, Tobias Pischon, Iris M Heid, Annette Peters, Thoralf Niendorf, Wolfgang Lieb, Fabian Bamberg, Martin Büchert, Wilfried Reichardt, Marco Reisert, Anna Köttgen
BACKGROUND: Population-wide research on potential new imaging biomarkers of the kidney depends on accurate automated segmentation of the kidney and its compartments (cortex, medulla, and sinus). METHODS: We developed a robust deep-learning framework for kidney (sub-)segmentation based on a hierarchical, three-dimensional convolutional neural network (CNN) that was optimized for multi-scale problems of combined localization and segmentation. We applied the CNN to abdominal magnetic resonance images from the population-based German National Cohort (NAKO) study...
May 3, 2024: Deutsches Ärzteblatt International
https://read.qxmd.com/read/38530649/iatrogenic-hyperchloremia-an-overview-in-hospitalized-patients-for-pharmacists
#2
JOURNAL ARTICLE
Amoreena Most, Sarah Nordbeck, Nicholas Farina
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: The purpose of this therapeutic update is to provide pharmacists with a general overview of the pathophysiology of hyperchloremia and describe strategies to help prevent development of this electrolyte abnormality in hospitalized patients...
March 26, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38524020/an-investigation-of-contrast-induced-acute-kidney-injury-in-patients-undergoing-percutaneous-coronary-intervention-a-cross-sectional-study-from-pakistan
#3
JOURNAL ARTICLE
Zair Hassan, Usha Kumari, Umaima Wasim, Sanjana Kumari, Nikhil Reddy Daggula, Salim Surani, Hazir Ullah
Background and objective Contrast-induced acute kidney injury (CIAKI) is a complication observed among individuals undergoing primary percutaneous coronary intervention (PCI) and is associated with high morbidity and mortality rates. It is characterized by an elevation in serum creatinine (SCr) levels >0.5 mg/dl or a 50% relative increase in SCr from the baseline value following exposure to contrast within a 48- to 72-hour timeframe, in the absence of any alternative causes for acute kidney injury (AKI)...
February 2024: Curēus
https://read.qxmd.com/read/38519599/acute-kidney-injury-in-pediatric-burn-patients
#4
JOURNAL ARTICLE
Demet Kahramanlar, Sare Gülfem Özlü, Pervin Demirci, Elif Emel Erten, Emrah Şenel, Umut Selda Bayrakçi
BACKGROUND: Acute kidney injury (AKI) is a common and important complication of burn injury. Although there are numerous adult studies, data regarding AKI in pediatric burn patients are scarce. Here, we aimed to evaluate the frequency, clinical features, and prognosis of AKI among pediatric burn injury patients. METHODS: This is a retrospective cohort study. Patients aged between 1 month and 18 years who had been followed up between the years 2011 and 2017 were included, and patients with previous kidney disease were excluded...
March 22, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38514012/clinical-significance-of-the-cystic-phenotype-in-alport-syndrome
#5
JOURNAL ARTICLE
Letizia Zeni, Federica Mescia, Diego Toso, Chiara Dordoni, Cinzia Mazza, Gianfranco Savoldi, Laura Econimo, Roberta Cortinovis, Simona Fisogni, Federico Alberici, Francesco Scolari, Claudia Izzi
RATIONALE & OBJECTIVE: Alport Syndrome (AS) is the most common genetic glomerular disease caused by mutations that affect Type IV collagen. However, the clinical characteristics and significance of AS with kidney cysts are not well defined. This study investigated the prevalence and clinical significance of cystic kidney phenotype in AS. STUDY DESIGN: Retrospective cohort study. SETTING: & Participants: One hundred-eight patients with AS and a comparison cohort of 79 patients with IgA Nephropathy (IgAN)...
March 19, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38512284/choroidal-vascularity-index-and-choroidal-structural-changes-in-children-with-nephrotic-syndrome
#6
JOURNAL ARTICLE
Wenbo Zhang, Junmeng Li, Lei Zhu, Shuang Zeng, Yanye Lu, Yadi Zhang, Xiaopeng Gu, Hailong Wu, Liu Yang
PURPOSE: To investigate the choroidal vascularity index (CVI) and choroidal structural changes in children with nephrotic syndrome. METHODS: This was a cross-sectional study involving 45 children with primary nephrotic syndrome and 40 normal controls. All participants underwent enhanced depth imaging-optical coherence tomography examinations. An automatic segmentation method based on deep learning was used to segment the choroidal vessels and stroma, and the choroidal volume (CV), vascular volume (VV), and CVI within a 4...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38511865/renal-hemodynamic-and-functional-changes-in-adpkd-patients
#7
JOURNAL ARTICLE
Ryota Ishii, Hirayasu Kai, Kentaro Nakajima, Takuya Harada, Tomoki Akiyama, Eri Okada, Ryoya Tsunoda, Toshiaki Usui, Kaori Mase, Naoki Morito, Chie Saito, Joichi Usui, Kunihiro Yamagata
BACKGROUND: Although the mechanisms underlying cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) are becoming clearer, those of renal dysfunction are not fully understood. In particular, total kidney volume (TKV) and renal function do not always correspond. To elucidate this discrepancy, we studied in detail glomerular hemodynamic changes during ADPKD progression. METHODS: Sixty-one ADPKD patients with baseline height-adjusted TKV (Ht-TKV) of 933±537 ml/m and serum creatinine of 1...
March 21, 2024: Kidney360
https://read.qxmd.com/read/38511221/-cardioprotective-effect-of-intradialytic-exercise-on-left-atrial-mechanics
#8
JOURNAL ARTICLE
Claire Maufrais, Matthieu Josse, Laure Patrier, Antoine Grandperrin, Myriam Isnard, Cécile Turc-Baron, Stéphane Nottin, Stéphane Mandigout, Jean-Paul Cristol, Philippe Obert
INTRODUCTION: The left atrial (LA) function plays a pivotal role in cardiac performance by modulating left ventricular (LV) function. Impairments in LV function are commonly reported during hemodialysis, but available data describing changes in LA function are limited. There is growing evidence of the cardioprotective effect of intradialytic exercise (IDE) on the LV function but studies analyzing its effect on LA function are scarce. Our aim was to evaluate whether IDE can limit the severity of hemodialysis-induced impairment in LA myocardial function...
March 21, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38507156/application-value-of-extreme-flexion-and-abduction-hip-combined-with-stirrup-shaped-multifunctional-leg-frame-in-blocking-obturator-nerve-reflex-in-transurethral-resection-of-bladder-tumor
#9
JOURNAL ARTICLE
Yongjiang Xiong, Tao Zhao, Changlong Li
OBJECTIVE: To explore the effectiveness and safety of the extreme flexion and abduction hip combined with a stirrup-shaped multifunctional leg frame position in preventing obturator nerve reflex during plasma resection of bladder tumors (TUR-BT). METHODS: A total of 112 patients with bladder tumors were included in the study. The control group was placed in a lithotomy position, while the experimental group was placed in an extreme flexion and abduction hip combined with a stirrup-shaped multifunctional leg frame position...
March 20, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38499048/effect-of-a-hispanic-outreach-program-on-referral-and-liver-transplantation-volume-at-a-single-center
#10
JOURNAL ARTICLE
Sudha Kodali, Constance M Mobley, Elizabeth W Brombosz, Analisa Lopez, Riki Graves, John Ontiveros, Marcela Velazquez, Ashish Saharia, Yee Lee Cheah, Caroline J Simon, Christian Valverde, Alphonse Brown, Julie Corkrean, Linda W Moore, Edward A Graviss, David W Victor, Kelly Maresh, Mark J Hobeika, Chukwuma Egwim, R Mark Ghobrial
BACKGROUND: Although Hispanic patients have high rates of end-stage liver disease and liver cancer, for which liver transplantation (LT) offers the best long-term outcomes, they are less likely to receive LT. Studies of end-stage renal disease patients and kidney transplant candidates have shown that targeted, culturally relevant interventions can increase the likelihood of Hispanic patients receiving kidney transplant. However, similar interventions remain largely unstudied in potential LT candidates...
March 16, 2024: Transplant Immunology
https://read.qxmd.com/read/38497685/incidence-and-risk-factors-of-acute-kidney-injury-after-transcatheter-aortic%C3%A2-valve-replacement
#11
JOURNAL ARTICLE
Zhenjian Xu, Xin Zhou, Hui Yang, Qiuju Chen, Guangxuan Luo, Shichun Cai, Anping Xu
PURPOSE: Acute kidney injury (AKI) is a common early complication secondary to transcatheter aortic valve replacement (TAVR). Studies on the incidence and risk factors for AKI after TAVR surgery are limited to date. Here, we retrospectively analyzed the incidence and risk factors for AKI after TAVR surgery in our hospital. MATERIALS AND METHODS: Patients who underwent TAVR surgery at our hospital from November 2017 to February 2023 were selected. AKI was defined using the 2012 KDIGO definition and staging criteria...
March 18, 2024: Clinical Nephrology
https://read.qxmd.com/read/38483544/pharmacokinetics-of-polymyxin-b-in-different-populations-a-systematic-review
#12
REVIEW
Xing Wang, Wenqiang Xiong, Maolian Zhong, Yan Liu, Yuqing Xiong, Xiaoyi Yi, Xiaosong Wang, Hong Zhang
BACKGROUND AND OBJECTIVES: Despite being clinically utilized for the treatment of infections, the limited therapeutic range of polymyxin B (PMB), along with considerable interpatient variability in its pharmacokinetics and frequent occurrence of acute kidney injury, has significantly hindered its widespread utilization. Recent research on the population pharmacokinetics of PMB has provided valuable insights. This study aims to review relevant literature to establish a theoretical foundation for individualized clinical management...
March 14, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38478092/comparison-of-metabolic-parameters-between-pure-uric-acid-and-mixed-uric-acid-kidney-stone-formers
#13
JOURNAL ARTICLE
Anna Ricapito, Kavita Gupta, Jacob Zipkin, Samuel Yim, Christopher Connors, Raymond Khargi, Alan J Yaghoubian, Johnathan A Khusid, William M Atallah, Mantu Gupta
PURPOSE: We seek to compare clinical and 24-h urine parameters between pure-uric acid (UA) and UA-CaOx stone formers in our practice and explore how any differences in metabolic profiles could suggest different prevention strategies between the two groups. METHODS: We retrospectively reviewed patients with either pure- or mixed-UA nephrolithiasis from 2020 to 2023 at a tertiary care center. We included patients with a 24-h urine collection and a stone analysis detecting any amount of UA...
March 13, 2024: World Journal of Urology
https://read.qxmd.com/read/38464892/magnetic-resonance-imaging-based-kidney-volume-assessment-for-risk-stratification-in-pediatric-autosomal-dominant-polycystic-kidney-disease
#14
JOURNAL ARTICLE
Kubra Yilmaz, Seha Saygili, Nur Canpolat, Ozlem Akgun-Dogan, Zeynep Nagehan Yuruk Yildirim, Rumeysa Yasemin Cicek-Oksuz, Huseyin Adil Oner, Bagdagul Aksu, Nazli Gulsum Akyel, Ozge Oguzhan-Hamis, Hasan Dursun, Sevgi Yavuz, Neslihan Cicek, Nurver Akinci, Esra Karabag Yilmaz, Ayse Agbas, Ahmet Nevzat Nayir, Dildar Konukoglu, Sebuh Kurugoglu, Lale Sever, Salim Caliskan
INTRODUCTION: In the pediatric context, most children with autosomal dominant polycystic kidney disease (ADPKD) maintain a normal glomerular filtration rate (GFR) despite underlying structural kidney damage, highlighting the critical need for early intervention and predictive markers. Due to the inverse relationship between kidney volume and kidney function, risk assessments have been presented on the basis of kidney volume. The aim of this study was to use magnetic resonance imaging (MRI)-based kidney volume assessment for risk stratification in pediatric ADPKD and to investigate clinical and genetic differences among risk groups...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38462235/the-screening-diagnosis-and-management-of-patients-with-autosomal-dominant-polycystic-kidney-disease-a-national-consensus-statement-from-taiwan
#15
REVIEW
Pao-Wen Yen, Yung-An Chen, Wei Wang, Fang-Sheng Mao, Chia-Ter Chao, Chih-Kang Chiang, Shih-Hua Lin, Der-Cherng Tarng, Yi-Wen Chiu, Ming-Ju Wu, Yung-Chang Chen, Juliana Tze-Wah Kao, Mai-Szu Wu, Chun-Liang Lin, Jenq-Wen Huang, Kuan-Yu Hung
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of end-stage kidney disease (ESKD) worldwide. Guidelines for the diagnosis and management of ADPKD in Taiwan remains unavailable. In this consensus statement, we summarize updated information on clinical features of international and domestic patients with ADPKD, followed by suggestions for optimal diagnosis and care in Taiwan. Specifically, counselling for at-risk minors and reproductive issues can be important, including ethical dilemmas surrounding prenatal diagnosis and pre-implantation genetic diagnosis...
March 10, 2024: Nephrology
https://read.qxmd.com/read/38458044/association-between-echocardiographic-indexes-and-urinary-neutrophil-gelatinase-associated-lipocalin-ungal-in-dogs-with-myxomatous-mitral-valve-disease
#16
JOURNAL ARTICLE
Serena Crosara, Francesca Fidanzio, Stefano Oricco, Francesco Dondi, Chiara Mazzoldi, Erika Monari, Giovanni Romito, Maria Chiara Sabetti, Roberta Troìa, Cecilia Quintavalla
Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of tubular damage, and its elevation has been described in human and canine cardiorenal syndrome. The aim was to evaluate the association between echocardiographic indexes and urine NGAL (uNGAL) and uNGAL normalized to urine creatinine (uNGALC) in dogs with MMVD. This is a multicentric prospective cross-sectional study. A total of 77 dogs with MMVD at different ACVIM stages were included. All dogs underwent echocardiography, serum chemistry, and urinalysis...
March 5, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38456308/impact-of-advanced-therapy-centers-on-characteristics-and-outcomes-of-heart-failure-admissions
#17
JOURNAL ARTICLE
Daniel Y Lu, Jaya Kanduri, Ilhwan Yeo, Parag Goyal, Udhay Krishnan, Evelyn M Horn, Maria G Karas, Irina Sobol, David T Majure, Yoshifumi Naka, Robert M Minutello, Jim W Cheung, Nir Uriel, Luke K Kim
BACKGROUND: Although much attention has been paid to admission and transfer patterns for cardiogenic shock, contemporary data are lacking on decompensated heart failure (HF) admissions and transfers and the impact of advanced therapy centers (ATCs) on outcomes. METHODS: HF hospitalizations were obtained from the Nationwide Readmissions Database 2016 to 2019. Centers performing at least 1 heart transplant or left ventricular assist device were classified as ATCs...
March 8, 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38443863/forgotten-ureteral-stents-a-systematic-review-of-literature
#18
JOURNAL ARTICLE
Xiaochuan Wang, Zhengguo Ji, Peiqian Yang, Jun Li, Ye Tian
BACKGROUND: The forgotten ureteral stents (FUS) is one of the late complications of stent placement. This systematic review summarized different aspects of FUS and focused on the problems and solutions related to FUS. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. PubMed® and Embase® were searched from inception until October 1st, 2022. Eligible studies were those defining FUS as a stent unintentionally left in situ longer than at least 2 months...
March 5, 2024: BMC Urology
https://read.qxmd.com/read/38441868/blunted-cerebral-hemodynamic-responses-to-incremental-exercise-in-patients-with-end-stage-renal-disease
#19
JOURNAL ARTICLE
Amal Machfer, Mohamed Amine Bouzid, Nadia Fekih, Hayfa Ben Haj Hassen, Hassen Ibn Hadj Amor, Sèmah Tagougui, Hamdi Chtourou
PURPOSE: The aims of this study were to compare cerebral hemodynamics and maximal oxygen uptake (VO2peak ) in patients with end-stage renal disease (ESRD) vs. age-matched healthy controls during maximal exercise. METHODS: Twelve patients with ESRD and twelve healthy adults (CTR group) performed exhaustive incremental exercise test. Throughout the exercise test, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2 Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the prefrontal cortex...
March 5, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38435071/cardiac-surgery-outcomes-in-patients-receiving-hemodialysis-versus-peritoneal-dialysis
#20
JOURNAL ARTICLE
Elias Bassil, Milad Matta, Haytham El Gharably, Serge Harb, Juan Calle, Susana Arrigain, Jesse Schold, Jonathan Taliercio, Ali Mehdi, Georges Nakhoul
RATIONALE & OBJECTIVE: We sought to compare outcomes of patients receiving dialysis after cardiothoracic surgery on the basis of dialysis modality (intermittent hemodialysis [HD] vs peritoneal dialysis [PD]). STUDY DESIGN: This was a retrospective analysis. SETTING & PARTICIPANTS: In total, 590 patients with kidney failure receiving intermittent HD or PD undergoing coronary artery bypass graft and/or valvular cardiac surgery at Cleveland Clinic were included...
March 2024: Kidney medicine
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