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Total Kidney Volume

Besma Nejim, Devin Zarkowsky, Caitlin W Hicks, Satinderjit Locham, Hanaa Dakour Aridi, Mahmoud Malas
BACKGROUND: Endovascular aneurysm repair (EVAR) offered outstanding survival benefit but at the expense of cost, periodic radiographic monitoring, and higher reinterventions rates. Perioperative complications, although rare, can occur after EVAR, contributing to longer hospitalization, higher cost, and significant comorbidity and mortality. Therefore, the aim of this study was to identify the predictors of in-hospital events (IHEs) after elective EVAR. METHODS: The Vascular Quality Initiative database was explored from 2003 to 2017...
February 15, 2019: Journal of Vascular Surgery
Hai-Feng Li, Guo-Qiang Hu, Wen-Wen Liu
OBJECTIVE: To observe the clinical therapeutic effect of acupuncture of Huatuo Jiaji (EX-B2) in the treatment of gastrointestinal dysfunction in sepsis patients, aiming at providing new clinical approach and evidence for improving septic gastrointestinal activity. METHODS: A total of 40 patients with septic gastrointestinal dysfunction who met our inclusive criteria were randomly divided into control group and treatment group ( n =20 cases in each). Patients in the control group received routine treatment of nasogastric mosapride citrate (5 mg/time, three times a day) and tifidobacterium triple viable capsules (420 mg, twice a day), intravenous infusion of omeprazole (40 mg, twice a day), rational dose of antibiotics, maintenance treatment of functions of the heart, lung, brain, kidney and other important organs and water electrolyte balance, as well as symptomatic treatment...
January 25, 2019: Zhen Ci Yan Jiu, Acupuncture Research
Min Zhang, Yan Chen, Mei-Ju Yang, Xin-Rong Fan, Hui Xie, Ling Zhang, Yu-Song Nie, Miao Yan
The purpose of this study was to investigate the renal protective effect of celastrol on diabetic rats. Furthermore, the mechanism of its action was discussed whether it was related to MAPK/NF-κB signaling pathway. There were a total of 36 rats. Six rats were randomly chosen as the control group. The remaining 30 rats were given 1% streptozotocin intraperitoneal injection (50 mg/kg) and were randomly divided into five groups: the model control group, the low-dose celastrol group, the high-dose celastrol group, the Tripterygium wilfordii polyglycosides group, and the MAPK/NF-κB inhibitor group...
February 15, 2019: Phytotherapy Research: PTR
Samuel N Heyman, Yuri Gorelik, Danny Zorbavel, Christian Rosenberger, Zaid Abassi, Seymour Rosen, Mogher Khamaisi
Concepts regarding hypoxic acute kidney injury (AKI) are derived from widely used warm ischemia-reflow (WIR) models, characterized by extensive proximal tubular injury and associated with profound inflammation. However, there is ample clinical and experimental data indicating that hypoxic AKI may develop without total cessation of renal blood flow, with a different injury pattern that principally affects medullary thick limbs in the outer medulla. This injury pattern likely reflects an imbalance between blood and oxygen supply and oxygen expenditure, principally for tubular transport...
February 14, 2019: Nephrology, Dialysis, Transplantation
Marie E Edwards, Jaime D Blais, Frank S Czerwiec, Bradley J Erickson, Vicente E Torres, Timothy L Kline
Background: The ability of unstandardized methods to track kidney growth in clinical trials for autosomal dominant polycystic kidney disease (ADPKD) has not been critically evaluated. Methods: The Tolvaptan Efficacy and Safety Management of ADPKD and its Outcomes (TEMPO) 3:4 study involved baseline and annual magnetic resonance follow-up imaging yearly for 3 years. Total kidney volume (TKV) measurements were performed on these four time points in addition to the baseline imaging in TEMPO 4:4, initially by Perceptive Informatics (Waltham, MA, USA) using planimetry (original dataset) and for this study by the Mayo Translational PKD Center using semiautomated and complementary automated methods (sequential dataset)...
February 2019: Clinical Kidney Journal
Yen-Ling Chiu, Hsiu-Hui Tsai, Yen-Jun Lai, Hsin-Yi Tseng, Yen-Wen Wu, Yu-Sen Peng, Cheng-Ming Chiu, Yi-Fang Chuang
BACKGROUND: Chronic kidney disease exhibits a prominent premature aging phenotype in many different organ systems, including the brain. Nevertheless, a comprehensive characterization of brain aging in non-demented patients with end-stage renal disease (ESRD) is lacking and it remains unclear if the collective changes of cognitive functions and brain structures in ESRD is compatible with aging. METHODS: We compared 56 non-demented, independently living dialysis patients (mean age 59...
February 7, 2019: Journal of the Formosan Medical Association, Taiwan Yi Zhi
M N Ansari, R I Aloliet, M A Ganaie, T H Khan, Najeeb-Ur-Rehman, F Imam, A M Hamad
OBJECTIVE: In the present study, the protective effect of Roflumilast (ROF, a selective phosphodiesterase (PDE-4) inhibitor) was investigated against cadmium (Cd)-induced nephrotoxicity in rats. METHODS: A total of 24 rats were selected and randomly divided into four groups ( n = 6). Group 1 served as the control; groups 2-4 administered with CdCl2 (3 mg/kg, i.p.) for 7 days; groups 3 and 4 were co-administered with ROF in doses of 0.5 and 1.5 mg/kg, orally for 7 consecutive days...
February 11, 2019: Human & Experimental Toxicology
J Dong, H Fan, X Y Zhao, S Y Chang, J Mi
Objective: To estimate the dietary salt and potassium intake by two 24 hour urine salt and potassium excretion in primary and secondary school students. Methods: The boarders from Grade 5 to 6 in a rural primary school and Grade 1 to 3 in a rural middle school in Changde City, Hunan Province were recruited from October to December in 2017. Subjects who had 2 and more urinary incontinence episodes or a history of kidney disease or diarrhea and girls in menstruation were excluded. The final analysis included 284 subjects...
February 6, 2019: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Wanjun Ren, Yuejuan Du, Huili Jiang, Dongmei Xu
BACKGROUND:  Chronic kidney disease has become a serious public health problem in China. Our study is to explore effect of hydraulic expansion on arteriovenous fistula (AVF) of hemodialysis patients. METHODS:  A total of 190 patients with end-stage renal disease (ESRD) were randomly divided into hydraulic expansion group ( n  = 117) and conventional surgery group ( n  = 73). Age, sex, the cause of ESRD, height, weight, body mass index (BMI), blood pressure, and diameter of artery and vein from ultrasonography before surgery from patients were recorded...
February 9, 2019: Thoracic and Cardiovascular Surgeon
Andrew Yu Li, Nikki Elliot
INTRODUCTION: Natural language processing (NLP) is an emerging tool which has the ability to automate data extraction from large volumes of unstructured text. One of the main described uses of NLP in radiology is cohort building for epidemiological studies. This study aims to assess the accuracy of NLP in identifying a group of patients positive for ureteric stones on Computed Tomography - Kidneys, Ureter, Bladder (CT KUB) reports. METHODS: Retrospective review of all CT KUB reports in a single calendar year...
February 5, 2019: Journal of Medical Imaging and Radiation Oncology
Xiao-Jun Fu, Shuang-Yan Hu
BACKGROUND: Systemic oxidative stress has been reported to play a central role in the pathogenesis of kidney function decline. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is one of the important endogenous antioxidant stress pathways in cells. This study aims to investigate whether shenduning granule can ameliorate oxidative stress in kidney tissues by activating the Nrf2/ARE pathway, and explores the detailed underlying mechanism...
January 30, 2019: Pharmacology
Hannah A Blair
Tolvaptan [Jynarque® (USA); Jinarc® (EU, Canada); Samsca® (Japan)] is a highly selective vasopressin V2 receptor antagonist approved for the treatment of autosomal dominant polycystic kidney disease (ADPKD). In the phase III TEMPO 3:4 trial, 3 years' treatment with tolvaptan slowed the increase in total kidney volume (TKV) and the decline in renal function relative to placebo. The composite secondary endpoint of time to investigator-assessed clinical progression also favoured tolvaptan over placebo. Although tolvaptan did not demonstrate a sustained disease-modifying effect on TKV over the longer term in the TEMPO 4:4 extension trial, the effect of tolvaptan in slowing renal function decline was maintained for a further 2 years...
January 28, 2019: Drugs
Li Yuan, Ping-Ping Liao, Hai-Cheng Song, Jia-Hui Zhou, Hai-Chen Chu, Lin Lyu
AIMS: Hyperbilirubinemia is associated with postoperative acute kidney injury in patients undergoing cardiac surgeries. A high concentration of bilirubin could induce oxidative stress and cell apoptosis. The aim of this study was to investigate whether hyperbilirubinemia aggravated the renal tubule cells injury and the pro-apoptotic potential of bilirubin on renal ischemia reperfusion injury (RIRI). METHODS: The human proximal tubular epithelial cell line HK-2 cells were challenged with a gradient concentration of bilirubin for 24 h...
January 23, 2019: Nephron
Md Monirujjaman, Harold M Aukema
BACKGROUND: Increased levels of cyclooxygenase (COX) derived oxylipins is the earliest and most consistent alteration in the renal oxylipin profile in diverse models of cystic kidney diseases. Therefore, we examined whether a COX2 inhibitor would reduce disease progression in the Pkd2WS25/- mouse model of autosomal dominant polycystic kidney disease (ADPKD). METHODS: Weanling normal and diseased male Pkd2 mice were provided diets that provided 0 or 50 mg celecoxib/kg body weight/day, for 13 weeks...
January 22, 2019: Journal of Nephrology
B Kaleeswaran, S Ramadevi, R Murugesan, S Srigopalram, T Suman, T Balasubramanian
Pedalium murex (L.) is a traditional herb, commonly used for the treatment of kidney stone related problems. Struvite stone can swiftly grow and become 'staghorn calculi' in kidney and its associated areas, which is the most aching urological disorder. The present study investigated the anti-urolithiasis activities of ethyl acetate extract of P. murex L. (EAEP) against struvite crystal. The antibacterial activity of EAEP examined against several urease producing bacteria. It showed the minimum bactericidal concentration (MBC) against Escherichia coli and Staphylococcus aureus (>125)...
January 2019: Journal of Traditional and Complementary Medicine
Ercan Malkoç, Matthew J Maurice, Önder Kara, Daniel Ramirez, Ryan J Nelson, Julien Dagenais, Khaled Fareed, Amr Fergany, Robert J Stein, Pascal Mouracade, Jihad H Kaouk
OBJECTIVE: To identify preoperative factors that predict positive surgical margins in partial nephrectomy. MATERIAL AND METHODS: Using our institutional partial nephrectomy database, we investigated the patients who underwent partial nephrectomy for malignant tumors between January 2011 and December 2015. Patient, tumor, surgeon characteristics were compared by surgical margin status. Multivariable logistic regression was used to identify independent predictors of positive surgical margins...
January 1, 2019: Turkish Journal of Urology
Sung-Hye You, Deuk Jae Sung, Kyung-Sook Yang, Myung-Gyu Kim, Na Yeon Han, Beom Jin Park, Min Ju Kim
OBJECTIVE: The purpose of this study was to predict the probability of surgically induced chronic kidney disease (CKD) developing in patients who underwent total nephrectomy by measuring the body surface area (BSA)-adjusted renal cortical volume (RCV) with preoperative CT angiography (CTA). MATERIALS AND METHODS: A total of 105 patients with a normal preoperative estimated glomerular filtration rate (eGFR) who underwent preoperative CTA and subsequent total nephrectomy for kidney donation (n = 67) or a renal tumor (n = 38) were included in this retrospective study...
February 2019: AJR. American Journal of Roentgenology
Roslyn J Simms, Trushali Doshi, Peter Metherall, Desmond Ryan, Peter Wright, Nicolas Gruel, Maatje D A van Gastel, Ron T Gansevoort, Wendy Tindale, Albert C M Ong
OBJECTIVES: To develop a high-performance, rapid semi-automated method (Sheffield TKV Tool) for measuring total kidney volume (TKV) from magnetic resonance images (MRI) in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS: TKV was initially measured in 61 patients with ADPKD using the Sheffield TKV Tool and its performance compared to manual segmentation and other published methods (ellipsoidal, mid-slice, MIROS). It was then validated using an external dataset of MRI scans from 65 patients with ADPKD...
January 21, 2019: European Radiology
Davood Nasiry, Ali Reza Khalatbary, Hassan Ahmadvand, Fereshteh Talebpour Amiri
Background: There is accumulating evidence that Juglans regia L. (GRL) leaf extract has hypoglycemic and antioxidative properties. The present study aimed to investigate the protective effects of GRL leaf extract against diabetic nephropathy (DN). Methods: In total, 28 male adult Sprague-Dawley rats were used. The DN rat model was generated by intraperitoneal injection of a single 55 mg/kg dose of streptozotocin (STZ). A subset of the STZ-induced diabetic rats received intragastric administration of GRL leaf extract (200 mg/kg/day) starting 1 week (preventive group) and 4 weeks (curative group) after the onset of hyperglycemia up to the end of the 8th week, whereas other diabetic rats received only isotonic saline (diabetic group) as the same volume of GRL leaf extract...
January 2019: Iranian Journal of Medical Sciences
Per Eckerbom, Peter Hansell, Eleanor F Cox, Charlotte Buchanan, Jan Weis, Fredrik Palm, Susan T Francis, Per Liss
Non-invasive methods of magnetic resonance imaging (MRI) can quantify parameters of kidney function. The main purpose of this study was to determine baseline values of such parameters in healthy volunteers. In 28 healthy volunteers (15 females, 13 males), Arterial Spin Labeling (ASL) to estimate regional renal perfusion, Blood Oxygen Level Dependent (BOLD) transverse relaxation rate (R2 *) to estimate oxygenation, and Apparent Diffusion Coefficient (ADC), true diffusion (D) and longitudinal relaxation time (T1 ) to estimate tissue properties were determined bilaterally in the cortex, outer and inner medulla...
January 16, 2019: American Journal of Physiology. Renal Physiology
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