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GRADE system AND meta-analysis

Adam Stenman, Jan Zedenius, Carl Christofer Juhlin
Pheochromocytomas (PCCs) and abdominal paragangliomas (PGLs), collectively abbreviated PPGLs, are neuroendocrine tumors of the adrenal medulla and paraganglia, respectively. These tumors exhibit malignant potential but seldom display evidence of metastatic spread, the latter being the only widely accepted evidence of malignancy. To counter this, pre-defined histological algorithms have been suggested to stratify the risk of malignancy: Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and the Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP)...
February 15, 2019: Cancers
M P Toniazzo, D Nodari, F W M G Muniz, P Weidlich
AIM: To evaluate the effectiveness of mobile applications and text messages, compared with conventional oral hygiene instructions, for improving oral health knowledge and/or reducing gingival inflammation, when delivered to adolescents, adults and mothers of young children. METHODS: Randomized clinical trials evaluating the use of mobile applications or text messages related to oral hygiene and/or oral health education were screened. A search was performed in the Medline-PubMed, Scopus and Embase databases and the gray literature...
February 13, 2019: Journal of Clinical Periodontology
Aron Downie, Mark Hancock, Hazel Jenkins, Rachelle Buchbinder, Ian Harris, Martin Underwood, Stacy Goergen, Chris G Maher
OBJECTIVES: To (1) estimate the proportion of patients seeking care for low back pain (LBP) who are imaged and (2) explore trends in the proportion of patients who received diagnostic imaging over time. We also examined the effect of study-level factors on estimates of imaging proportion. DATA SOURCES: Electronic searches of MEDLINE, Embase and CINAHL databases from January 1995 to December 2017. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Observational designs and controlled trials that reported imaging for patients presenting to primary care or emergency care for LBP...
February 13, 2019: British Journal of Sports Medicine
Joseph Alvin R Santos, Anthea Christoforou, Kathy Trieu, Briar L McKenzie, Shauna Downs, Laurent Billot, Jacqui Webster, Mu Li
BACKGROUND: Iodine deficiency disorders (IDD) affect close to 1.9 billion people worldwide, and are a major public health concern in many countries. Among children, iodine deficiency is the main cause of potentially preventable deficits of central nervous system development and impairment of cognitive function, as well as goitre and hypothyroidism in people of all ages. Salt iodisation is the preferred strategy for IDD prevention and control, however, in some instances where salt is not the major condiment, alternate vehicles for iodine fortification have been considered...
February 12, 2019: Cochrane Database of Systematic Reviews
Eleonora Papadimitriou, Ashleigh Filtness, Athanasios Theofilatos, Apostolos Ziakopoulos, Claire Quigley, George Yannis
The objective of this paper is the review and comparative assessment of infrastructure related crash risk factors, with the explicit purpose of ranking them based on how detrimental they are towards road safety (i.e. crash risk, frequency and severity). This analysis was carried out within the SafetyCube project, which aimed to identify and quantify the effects of risk factors and measures related to behaviour, infrastructure or vehicles, and integrate the results in an innovative road safety Decision Support System (DSS)...
February 5, 2019: Accident; Analysis and Prevention
C Dressler, L Eisert, P A Pham Thi, A Nast
Twenty percent of patients with plaque psoriasis also have psoriatic arthritis - a disease affecting joints and entheses. Different treatment options exist but currently no succinct systematic overview exists. A systematic review of approved systemic treatments for psoriatic arthritis was conducted. We systematically searched in 3 databases (last update 09/2017). Data was extracted for ACR 20/50, HAQ-DI, SF-36 and adverse/serious adverse events after 16-24 weeks. We assessed the quality of evidence using GRADE...
February 8, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Morgan Slater, Joanna Bielecki, Ana Carolina Alba, Lusine Abrahamyan, George Tomlinson, Susanna Mak, Jane MacIver, Shelley Zieroth, Douglas Lee, William Wong, Murray Krahn, Heather Ross, Valeria E Rac
BACKGROUND: Heart failure (HF) is a complex chronic condition, leading to frequent hospitalization, decreased quality of life, and increased mortality. Current guidelines recommend that multidisciplinary care be provided in specialized HF clinics. A number of studies have demonstrated the effectiveness of these clinics; however, there is a wide range in the services provided across different clinics. This network meta-analysis will aim to identify the aspects of HF clinic care that are associated with the best outcomes: a reduction in mortality, hospitalization, and visits to emergency department (ED) and improvements to quality of life...
February 2, 2019: Systematic Reviews
M Maagaard, E E Nielsen, C Gluud, J C Jakobsen
BACKGROUND: Coronary artery disease and heart failure are both highly prevalent diseases with a global prevalence of 93 million and 40 million. These patients are at increased risk of morbidity and mortality. The management of these patients involves medical therapy, and both diseases can be treated using the heart rate-lowering drug ivabradine. However, the evidence regarding the use of ivabradine in the treatment of coronary artery disease and/or heart failure is unclear. Our objective is to assess the beneficial and harmful effects of ivabradine in the treatment of coronary artery disease and/or heart failure...
February 1, 2019: Systematic Reviews
Mathias Maagaard, Marija Barbateskovic, Anders Perner, Janus C Jakobsen, Jørn Wetterslev
BACKGROUND: Delirium is a common complication in critically ill patients and carries an increased risk of mortality and morbidity. Dexmedetomidine can potentially treat delirium by diminishing predisposing factors. The evidence regarding the use of dexmedetomidine in the management of delirium is conflicting. This protocol aims to identify the beneficial and harmful effects of dexmedetomidine in the management of delirium. METHODS: This protocol uses the recommendations of the Cochrane Collaboration, the Preferred Report Items of Systematic reviews with Meta-Analysis Protocols, and the eight-step assessment procedure suggested by Jakobsen and colleagues...
January 31, 2019: Acta Anaesthesiologica Scandinavica
Monika Becker, Stefanie Bühn, Jessica Breuing, Catherine A Firanek, Simone Hess, Hisanori Nariai, Mark R Marshall, James A Sloand, Qiang Yao, Käthe Goossen, Dawid Pieper
BACKGROUND: Previous meta-analyses have found several advantages of icodextrin compared with glucose in the application of peritoneal dialysis (PD), such as an improvement of peritoneal ultrafiltration during the long dwell and a reduction in episodes of uncontrolled fluid overload. However, the effect of icodextrin on patient-relevant outcomes remains unclear. This review aims to evaluate the benefits and harms of icodextrin in comparison with conventional glucose PD solution in patients with end-stage kidney disease receiving PD...
January 30, 2019: Systematic Reviews
Yu Cui, Jinbo Chen, Feng Zeng, Peihua Liu, Jiao Hu, Huihuang Li, Chao Li, Xu Cheng, Minfeng Chen, Yangle Li, Yang Li, Zhongqing Yang, Zhiyong Chen, Harripersaud Chand, Hequn Chen, Xiongbing Zu
PURPOSE: Tamsulosin is widely administered as a medical expulsive therapy to facilitate stone passage in patients with ureteral calculi. Recently several large, multicenter, randomized controlled trials revealed conflicting results, which led to considerable uncertainty about the efficacy of tamsulosin in the management of ureteral stones. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of tamsulosin in the management of ureteral stones...
January 29, 2019: Journal of Urology
Komodo Matta, Stéphane Ploteau, Xavier Coumoul, Meriem Koual, Bruno Le Bizec, Jean-Philippe Antignac, German Cano-Sancho
BACKGROUND: Endometriosis is a hormone-dependent gynaecological disease characterised by the presence and growth of endometrial tissues outside of the uterus. There is growing experimental evidence that suggests environmental endocrine disrupting chemicals, specifically organochlorine chemicals (OCCs), may play a role in the pathogenesis of endometriosis, but to date, there are no studies attempting to gather and synthesise the published literature systematically. OBJECTIVES: The main objective of this SR is to evaluate the associations between the exposure to OCCs and endometriosis in experimental models (in vivo and in vitro)...
January 22, 2019: Environment International
Jing Zhang, Lanfang Mao, Longde Wang, Cuncun Lu, Xiaojuan Du, Qiankun Liang, Bo Yang, Hongli Wu
BACKGROUND: Pain is very common and its management with a huge burden for patients and the healthcare system. And the network meta-analysis was designed to provide reference for the clinical practice. METHODS: PubMed, EMBASE, Cochrane library, CNKI, VIP, Wan Fang, and CBM will be systematically searched their inception to November 2018. Randomized controlled trials that compared the effect of differently pharmacological or non-pharmacological treatments for opioid-induced constipation will be included...
January 2019: Medicine (Baltimore)
Ahilanandan Dushianthan, Rebecca Cusack, Victoria A Burgess, Michael Pw Grocott, Philip C Calder
BACKGROUND: Acute respiratory distress syndrome (ARDS) is an overwhelming systemic inflammatory process associated with significant morbidity and mortality. Pharmacotherapies that moderate inflammation in ARDS are lacking. Several trials have evaluated the effects of pharmaconutrients, given as part of a feeding formula or as a nutritional supplement, on clinical outcomes in critical illness and ARDS. OBJECTIVES: To systematically review and critically appraise available evidence on the effects of immunonutrition compared to standard non-immunonutrition formula feeding on mechanically ventilated adults (aged 18 years or older) with acute respiratory distress syndrome (ARDS)...
January 24, 2019: Cochrane Database of Systematic Reviews
Chai Hong Rim, Young Kim, Chul Yong Kim, Won Sup Yoon, Dae Sik Yang
Introduction Ultra-central (UC) tumors, which are generally defined as tumors directly abutting the proximal bronchial tree, are difficult to treat with stereotactic body radiotherapy (SBRT) owing to possible serious complications. This systemic review and meta-analysis analyzed the early experiences and evaluated the efficacy and feasibility of SBRT for UC tumors. Methods and Materials The present study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Systemic searches of the EMBASE, PubMed, MEDLINE, and Cochrane library electronic databases were performed...
January 24, 2019: International Journal of Radiation Biology
Mathias Maagaard, Marija Barbateskovic, Anders Perner, Janus Christian Jakobsen, Jørn Wetterslev
BACKGROUND: Delirium is a common complication in critically ill patients and carries an increased risk of mortality and morbidity. Dexmedetomidine can potentially prevent delirium by diminishing predisposing factors. The evidence regarding the use of dexmedetomidine in preventing delirium is conflicting. This protocol aims to identify the beneficial and harmful effects of dexmedetomidine in the prevention of delirium. METHODS: This protocol uses the recommendations of the Cochrane Collaboration, the Preferred Report Items of Systematic Reviews with Meta-Analysis Protocols, and the eight-step assessment procedure suggested by Jakobsen and colleagues...
January 23, 2019: Acta Anaesthesiologica Scandinavica
Rita T Lawlor, Nicola Veronese, Alessia Nottegar, Giuseppe Malleo, Lee Smith, Jacopo Demurtas, Liang Cheng, Laura D Wood, Nicola Silvestris, Roberto Salvia, Aldo Scarpa, Claudio Luchini
This study aims at clarifying the prognostic role of high-grade tumor budding (TB) in pancreatic ductal adenocarcinoma (PDAC) with the first systematic review and meta-analysis on this topic. Furthermore, we analyzed with a systematic review the relationship between TB and a recently suggested TB-associated mechanism: the epithelial to mesenchymal transition (EMT). Analyzing a total of 613 patients, 251 of them (40.9%) with high grade-TB, we found an increased risk of all-cause mortality (RR, 1.46; 95% CI, 1...
January 19, 2019: Cancers
Wei Zheng, Jie Ying, Yan Zhou, Zhiwen Lu, Ke Min, Weimin Wang, Yun Zhang, Miao Zhang, Jian Yang
Major chemotherapeutic drugs for advanced biliary tract cancer (ABTC) include gemcitabine, fluoropyrimidines and platinum compounds, but the optimum combination of them remains inconclusive. The main objective of this network meta-analysis was to compare the efficacy and safety of first-line chemotherapies for ABTC. Methods: We searched PubMed, EMBASE, the Cochrane library and Science Direct for relevant controlled trials until May 2017. We estimated the Hazard ratios (HRs) for survival time and odds ratios (ORs) for response rate and toxic effects among different therapies...
2019: Journal of Cancer
Luigino Calzetta, Mario Cazzola, Maria Gabriella Matera, Paola Rogliani
BACKGROUND: Inhaled corticosteroid (ICS)/long-acting β2 -agonist (LABA) combination commonly prescribed to treat chronic obstructive pulmonary disease (COPD). Therefore, we performed a meta-analysis on the impact of adding a long-acting muscarinic receptor antagonist (LAMA) to ICS/LABA combination in COPD. METHODS: Studies were identified by searching in different databases the randomized controlled trials (RCTs) that investigated the effect of ICS/LABA/LAMA combination in COPD...
January 17, 2019: Chest
Angela Ping Hui Kirk, Jinling Yang, Woei Chyi Sim, Lydia Yi Xin Chia, Ying Lau
OBJECTIVE: To evaluate the efficacy of topical application of human breast milk to reduce umbilical cord separation time. DATA SOURCES: We used a three-step search strategy. First, we searched six electronic databases from inception through July 16, 2018: PubMed, Cochrane, CINAHL, Embase, Scopus, and ProQuest Dissertations and Theses Global. We used the following search terms: infant, newborn, baby, babies, colostrum, breast milk expression, breast milk, breastmilk, mother milk, human milk, umbilical cord, and umbilicus...
January 17, 2019: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
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