Philip M Hemken, Eitan Israeli, Russell Taylor, Chris Jacobson, Maria Datwyler, Rene Geissler, Abbas Hadji, Nicolette Jeanblanc, Kinnari Pandya, Marilee Marcinkus, Ryan Piktel, M Felicia Bogdan, Mary Rodgers, Mark Anderson, Robert Ziemann, Bryan C Tieman, David Hawksworth, Jeffrey Moore, Kathy S Otis, Christopher C Marohnic, Josie Corby, Bailin Tu, Zhihong Lin, Alak Kar, James Hartnett, Carolyn Strobel, Svetoslava Gregory, Tracey Rae, A Scott Muerhoff, Susan Brophy, John R Hackett, David Daghfal, Matthew L Faron, Amorina Cruz, Phaedre Mohr, Lori Sokoll, Gerard J Davis
OBJECTIVES: To evaluate pre-analytical challenges related to high-volume central laboratory SARS-CoV-2 antigen testing with a prototype qualitative SARS-CoV-2 antigen immunoassay run on the automated Abbott ARCHITECT instrument. METHODS: Contrived positive and negative specimens and de-identified nasal and nasopharyngeal specimens in transport media were used to evaluate specimen and reagent on-board stability, assay analytical performance and interference, and clinical performance...
February 20, 2023: Clinical Chemistry and Laboratory Medicine: CCLM