keyword
https://read.qxmd.com/read/38140053/circulating-biomarkers-for-monitoring-chemotherapy-induced-cardiotoxicity-in-children
#21
REVIEW
Luigia Meo, Maria Savarese, Carmen Munno, Peppino Mirabelli, Pia Ragno, Ornella Leone, Mariaevelina Alfieri
Most commonly diagnosed cancer pathologies in the pediatric population comprise leukemias and cancers of the nervous system. The percentage of cancer survivors increased from approximatively 50% to 80% thanks to improvements in medical treatments and the introduction of new chemotherapies. However, as a consequence, heart disease has become the main cause of death in the children due to the cardiotoxicity induced by chemotherapy treatments. The use of different cardiovascular biomarkers, complementing data obtained from electrocardiogram, echocardiography cardiac imaging, and evaluation of clinical symptoms, is considered a routine in clinical diagnosis, prognosis, risk stratification, and differential diagnosis...
November 30, 2023: Pharmaceutics
https://read.qxmd.com/read/38129167/-correlation-of-carbon-dioxide-derived-parameters-during-cardiopulmonary-bypass-with-acute-kidney-injury-after-pediatric-cardiac-surgery
#22
JOURNAL ARTICLE
M H Liu, Y Zhang, M Luo, T Liu, F Long, R H Zhou
Objective: To explore the correlation of the ratio of venous-arterial carbon dioxide (CO2 ) tension difference to arterial-venous O2 content difference (Pv-aCO2 /Ca-vO2 ) and venous-arterial CO2 gradient (Pv-aCO2 ) during cardiopulmonary bypass (CPB) with acute kidney injury (AKI) after pediatric cardiac surgery. Methods: The clinical data of children (1 month ≤ age ≤ 3 years old) who underwent open heart surgery under CPB in West China Hospital of Sichuan University from March 2021 to August 2022 were retrospectively analyzed...
December 26, 2023: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38095396/novel-insights-on-acute-myocarditis-in-pediatric-patients
#23
REVIEW
A Popa, C Lazea, L Agoston-Coldea
Acute myocarditis (AM) is an inflammatory affliction of the heart muscle characterized by recent onset with a broad spectrum of clinical manifestations that globally affect millions of individuals, notably children and young adults. The absence of distinct patterns of onset or predictable progression poses a significant threat to survival, potentially leading to advanced heart failure and malignant arrhythmias. Myocardial fibrosis, a hallmark of myocardial remodeling, is increasingly recognized as a contributor to adverse outcomes in acute myocarditis cases...
December 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38094208/aortic-thrombosis-and-subsequent-myocardial-infarction-in-a-previously-healthy-12-year-old-male
#24
Nobuyuki Ikeda, Dhaval Patel, Alexander J Javois, Kristen Nelson-McMillan, Chawki El-Zein, Luca A Vricella, Narutoshi Hibino
Aortic thrombus formation in children is uncommon, particularly in an otherwise healthy pediatric patient. Thromboembolism of such thrombi resulting in subsequent ST-segment elevation myocardial infarction is, thus, exceedingly rare. ( Level of Difficulty: Intermediate. ).
November 1, 2023: JACC. Case reports
https://read.qxmd.com/read/38078705/a-change-of-heart-characteristics-and-outcomes-of-multiple-cardiac-retransplant-recipients
#25
JOURNAL ARTICLE
Jaya Batra, Ersilia M DeFilippis, Kevin Clerkin, David Bae, Kyung Taek Oh, Dor Lotan, Veli K Topkara, Sun Hi Lee, Farhana Latif, Paolo Colombo, Melana Yuzefpolskaya, Jayant Raikhelkar, David T Majure, Gabriel Sayer, Nir Uriel
BACKGROUND: Among heart transplant (HT) recipients who develop advanced graft dysfunction, cardiac re-transplantation may be considered. A smaller subset of patients will experience failure of their second allograft and undergo repeat re-transplantation. Outcomes among these individuals are not well-described. METHODS: Adult and pediatric patients in the United Network for Organ Sharing (UNOS) registry who received HT between January 1, 1990 and December 31, 2020 were included...
December 11, 2023: Clinical Transplantation
https://read.qxmd.com/read/38071276/time-sensitive-healthcare-guidelines-for-youth-with-chronic-diseases-in-custody-gaps-in-care
#26
JOURNAL ARTICLE
Colin Dickens, Ahalya Ramesh, Temiloluwa Adanlawo, Michael R DeBaun
On May 9th, 2023, a U.S. Border Patrol detained a family of five near Brownsville, TX. During processing, one of the family members, an eight-year-old girl, ADRA, was noted to have sickle cell anemia and a heart disease condition. Five days after they arrived at the Donna Facility, on May 14th, ADRA displayed symptoms, including abdominal pain and fever, and tested positive for Influenza A. She was administered medication and transferred to a designated isolation unit at the Harlingen Border Patrol Station...
December 9, 2023: Pediatric Research
https://read.qxmd.com/read/38062996/pediatric-heart-transplantation-looking-forward-after-five-decades-of-learning
#27
REVIEW
Anne I Dipchand, Steven A Webber
Heart transplantation has become the standard of care for pediatric patients with end-stage heart disease throughout the world. Since the first transplant was performed in 1967, the number of transplants has grown dramatically with 13 449 pediatric heart transplants being reported to The International Society of Heart and Lung Transplant (ISHLT) between January 1992 and June 30, 2018. Outcomes have consistently improved over the last few decades, specifically short-term outcomes. Most recent survival data demonstrate that recipients who survive to 1-year post-transplant have excellent long-term survival with more than 60% of those who were transplanted as infants being alive 25 years later...
February 2024: Pediatric Transplantation
https://read.qxmd.com/read/38059735/evaluating-airway-management-in-patients-with-trisomy-21-in-the-picu-and-cardiac-icu-a-retrospective-cohort-study
#28
JOURNAL ARTICLE
Eric J Wilsterman, Marianne E Nellis, Josep Panisello, Awni Al-Subu, Ryan Breuer, Dai Kimura, Conrad Krawiec, Palen P Mallory, Sholeen Nett, Erin Owen, Simon J Parsons, Ronald C Sanders, Annery Garcia-Marcinkiewicz, Natalie Napolitano, Justine Shults, Vinay Nadkarni, Akira Nishisaki
OBJECTIVES: Children with trisomy 21 often have anatomic and physiologic features that may complicate tracheal intubation (TI). TI in critically ill children with trisomy 21 is not well described. We hypothesize that in children with trisomy 21, TI is associated with greater odds of adverse airway outcomes (AAOs), including TI-associated events (TIAEs), and peri-intubation hypoxemia (defined as > 20% decrease in pulse oximetry saturation [Spo2]). DESIGN: Retrospective database study using the National Emergency Airway Registry for Children (NEAR4KIDS)...
December 7, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38047601/extracorporeal-cardiopulmonary-resuscitation-for-amniotic-fluid-embolism-review-and-case-report
#29
REVIEW
Courtney Stanley Sundin, Laura Gomez, Brian Chapman
Amniotic fluid embolism (AFE) is a rare, sudden, and catastrophic complication of pregnancy that can result in cardiopulmonary arrest, potentially leading to death. The pathophysiology of an AFE includes an inflammatory and coagulopathic response due to fetal materials entering maternal circulation with the hallmark triad of symptoms: acute respiratory distress, cardiovascular collapse, and coagulopathy. Management of AFE should include high-quality cardiopulmonary resuscitation, immediate delivery of the fetus if applicable, early intubation to provide adequate oxygenation and ventilation, fluid volume resuscitation, and ongoing evaluation of coagulopathy...
January 2024: MCN. the American Journal of Maternal Child Nursing
https://read.qxmd.com/read/38046139/description-and-outcomes-of-afro-caribbean-children-treated-for-multisystem-inflammatory-syndrome-in-the-french-west-indies
#30
JOURNAL ARTICLE
Charlène Grabot, Mélanie Brard, Daphnée Hilaire, Moustapha Drame, Gwladys Nadia Gbaguidi, Narcisse Elenga, Saskia Tuttle, Yves Hatchuel, Michaël Levy, Olivier Flechelles, Arthur Felix
INTRODUCTION: Several studies have reported a higher frequency and greater morbidity and mortality of multisystem inflammatory syndrome in children (MIS-C) of black African descent. OBJECTIVES: We aimed to describe the clinical, laboratory and echocardiographic characteristics as well as outcomes of children with MIS-C requiring admission to a pediatric intensive care unit (PICU) in the French West Indies (FWI), where the majority of the population is Afro-Caribbean...
December 2023: Heliyon
https://read.qxmd.com/read/38012001/endothelial-cells-adopt-a-pro-reparative-immune-responsive-signature-during-cardiac-injury
#31
JOURNAL ARTICLE
Hali Long, Jeffrey D Steimle, Francisco Jose Grisanti Canozo, Jong Hwan Kim, Xiao Li, Yuka Morikawa, Minjun Park, Diwakar Turaga, Iki Adachi, Joshua D Wythe, Md Abul Hassan Samee, James F Martin
Modulation of the heart's immune microenvironment is crucial for recovery after ischemic events such as myocardial infarction (MI). Endothelial cells (ECs) can have immune regulatory functions; however, interactions between ECs and the immune environment in the heart after MI remain poorly understood. We identified an EC-specific IFN responsive and immune regulatory gene signature in adult and pediatric heart failure (HF) tissues. Single-cell transcriptomic analysis of murine hearts subjected to MI uncovered an EC population (IFN-ECs) with immunologic gene signatures similar to those in human HF...
February 2024: Life Science Alliance
https://read.qxmd.com/read/37971519/long-term-kidney-outcomes-in-pediatric-continuous-flow-ventricular-assist-device-patients
#32
JOURNAL ARTICLE
Alexandra Idrovo, Seth A Hollander, Tara M Neumayr, Cynthia Bell, Genevieve Munoz, Swati Choudhry, Jack Price, Iki Adachi, Poyyapakkam Srivaths, Scott Sutherland, Ayse Akcan-Arikan
BACKGROUND: Continuous-flow ventricular assist devices (CF-VADs) are used increasingly in pediatric end-stage heart failure (ESHF) patients. Alongside common risk factors like oxidant injury from hemolysis, non-pulsatile flow constitutes a unique circulatory stress on kidneys. Post-implantation recovery after acute kidney injury (AKI) is commonly reported, but long-term kidney outcomes or factors implicated in the evolution of chronic kidney disease (CKD) with prolonged CF-VAD support are unknown...
November 16, 2023: Pediatric Nephrology
https://read.qxmd.com/read/37919530/experience-with-sglt2-inhibitors-in-patients-with-single-ventricle-congenital-heart-disease-and-fontan-circulatory-failure
#33
JOURNAL ARTICLE
Anusha Konduri, Caroline West, Ray Lowery, Tiffany Hunter, Audrey Jarosz, Sunkyung Yu, Heang M Lim, Amanda D McCormick, Kurt R Schumacher, David M Peng
Heart failure is the leading cause of morbidity and mortality in patients with Fontan circulation. Sodium-glucose-cotransporter 2 inhibitors (SGLT2i) have become a mainstay of heart failure therapy in adult patients, however, there remains a paucity of literature to describe its use in pediatric heart failure patients, especially those with single ventricle physiology. We describe our early experience using SGLT2i in patients with single ventricle congenital heart disease surgically palliated to the Fontan circulation...
November 2, 2023: Pediatric Cardiology
https://read.qxmd.com/read/37876955/clinical-profile-and-outcomes-of-childhood-dilated-cardiomyopathy-a-single-center-three-decade-experience
#34
JOURNAL ARTICLE
Gousia Mukhtar, Bijulal Sasidharan, Kavassery Mahadevan Krishnamoorthy, Harikrishnan K N Kurup, Arun Gopalakrishnan, Deepa Sasikumar, Sankara Sarma, Ajit Kumar Valaparambil, Sivasankaran Sivasubramonian
INTRODUCTION AND AIMS: Dilated cardiomyopathy (DCM) is an important cause of heart failure (HF) among children. Research on pediatric DCM remains surprisingly scarce. The primary objective of the study was to evaluate the clinical profile and outcomes of pediatric DCM and the secondary objective was to study the predictors of outcome. METHODS AND RESULTS: We enrolled all patients with cardiomyopathy who presented to us between 1990 and 2020 and were younger than 18 years...
2023: Annals of Pediatric Cardiology
https://read.qxmd.com/read/37870740/clinical-profile-intensive-care-needs-and-predictors-of-outcome-among-children-admitted-with-non-covid-severe-acute-respiratory-illness-sari-during-the-pandemic
#35
JOURNAL ARTICLE
Ashish Agarwal, Muralidharan Jayashree, Suresh Kumar Angurana, Raman Sharma, Arnab Ghosh, Mini P Singh, Karthi Nallasamy, Arun Bansal
OBJECTIVES: To study the epidemiology of non-coronavirus disease-2019 (non-COVID-19) respiratory viral infections with respect to their clinical profile, intensive care needs and predictors of outcome once the non-pharmacological interventions (NPI) during the coronavirus disease-2019 (COVID-19) pandemic were relaxed. METHODS: Retrospective analysis of children with Severe Acute Respiratory Illness (SARI) who were SARS-CoV-2 negative, admitted to the Pediatric Emergency/Intensive Care Unit (PICU) from July 2021 through October 2021 was conducted...
October 23, 2023: Indian Journal of Pediatrics
https://read.qxmd.com/read/37854848/use-of-microaxial-flow-pumps-in-adolescents
#36
JOURNAL ARTICLE
Lauren E Parker, Douglas M Overbey, Lillian Kang, Cathlyn K Medina, Leonie M Kurzlechner, Ziv Beckerman, Nicholas D Andersen, Jacob N Schroder, Joseph Turek
OBJECTIVES: The Impella 5.5 has been successfully used in the adult population; however, safety and efficacy data in patients aged less than 18 years are limited. METHODS: Six pediatric patients, aged 13 to 16 years and weighing 45 to 113 kg, underwent axillary artery graft placement and attempted placement of the Impella 5.5 device at our institution between August 2020 and March 2023. RESULTS: Indications for implantation were heart failure secondary to myocarditis (2), rejection of prior orthotopic heart transplant, idiopathic dilated cardiomyopathy (2), and heart failure after transposition of the great arteries repair...
October 2023: JTCVS techniques
https://read.qxmd.com/read/37829974/severe-covid-19-infection-in-an-infant-with-8p-inverted-duplication-deletion-syndrome-is-vaccination-still-a-debate
#37
Andrew M Joseph, Monica Karas, Ernesto Joubran, Yaseen O Ramadan, Blakley A Fowler
Despite having a milder course of coronavirus disease 2019 (COVID-19) in comparison to adults, children are at risk for more significant complications, including acute neurological, renal, respiratory, and cardiovascular complications. Acute complications can manifest as encephalopathy, renal injury, interstitial pneumonia, and heart failure. However, the most severe complication is multisystem inflammatory syndrome in children, which often requires intensive care to manage the subsequent respiratory failure...
September 2023: Curēus
https://read.qxmd.com/read/37788365/medium-term-outcomes-in-pediatric-heart-transplant-recipients-managed-using-a-steroid-avoidance-immune-suppression-protocol
#38
JOURNAL ARTICLE
Christina Hartje-Dunn, Elizabeth D Blume, Heather Bastardi, Kevin P Daly, Francis Fynn-Thompson, Kimberlee Gauvreau, Tajinder P Singh
BACKGROUND: Short-term outcomes using steroid avoidance immune suppression are encouraging in pediatric heart transplant (HT) recipients at low risk of antibody-mediated rejection. We assessed medium-term outcomes in pediatric HT recipients initiated on a steroid avoidance protocol at our institution using surveillance biopsies. METHODS: All primary HT recipients during 2006-2020 who did not have a donor-specific antibody were eligible for immune suppression consisting of 5-d Thymoglobulin/steroid induction followed by a tacrolimus-based, steroid-free regimen...
October 2, 2023: Transplantation
https://read.qxmd.com/read/37742154/clinical-profile-radiological-findings-and-risk-factors-associated-with-pneumonia-among-children-admitted-in-dhulikhel-hospital
#39
JOURNAL ARTICLE
Pradeep Sharma, Roshan Bhandari, Pranodan Poudel, Ghanashyam Pandey, Richa Paudyal
BACKGROUND: Pneumonia is the commonest lung disease which is a major cause of mortality and morbidity in young children and is a common acute respiratory infection. The presentation varies among the cases. The study was done to know the risk factors, clinical profile, radiological findings, and short-term outcome of the admitted patients with pneumonia between six months to sixteen years at Dhulikhel Hospital. METHODS: A hospital based observational prospective cross-sectional study done in 65 cases over the period of 17 months in children admitted with pneumonia at Pediatrics department of Dhulikhel Hospital...
September 8, 2023: Journal of Nepal Health Research Council
https://read.qxmd.com/read/37721463/nutrition-for-critically-ill-children-with-congenital-heart-disease
#40
REVIEW
Jason S Kerstein, Corie M Klepper, Emily G Finnan, Kimberly I Mills
Children with congenital heart disease often require admission to the cardiac intensive care unit at some point in their lives, either after elective surgical or catheter-based procedures or during times of acute critical illness. Meeting both the macronutrient and micronutrient needs of children in the cardiac intensive care unit requires complex decision-making when considering gastrointestinal perfusion, vasoactive support, and fluid balance goals. Although nutrition guidelines exist for critically ill children, these cannot always be extrapolated to children with congenital heart disease...
October 2023: Nutrition in Clinical Practice
keyword
keyword
163468
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.